Clinical trials: Brain Stroke
Dysphagia, Oral Phase, Stroke, Ischemic
Lingual Endurance Exercise in Treating Post-Stroke Dysphagia
Aim 1: Determine feasibility of lingual endurance training for individuals with persistent dysphagia after ischemic stroke. Primary outcome measures: % patient adherence (# of attempted repetitions/# prescribed repetitions) and %…
- Trial name
- NCT05523973
- Testing
- Lingual Endurance Training
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Cincinnati
Stroke, Muscle Spasticity
Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function
The purpose of this study is to evaluate the safety of injections of botulinum toxin Type A in patients with reduced lung function and focal upper limb poststroke spasticity
- Conditions
- Stroke, Muscle Spasticity, Motor Neuron Disease
- Trial name
- NCT00076687
- Testing
- botulinum toxin Type A, saline
- Where
- 4 sites in United States, Czechia and 2 more
- Volunteers
- 155 people
- Sponsor
- Allergan
Stroke
Mirror-Box Training in Adults With Chronic Hemiparesis Secondary to Stroke
The purpose of this project is to assess the effects of four weeks of mirror-box training on weakness of one arm secondary to stroke. Primary measures are function and strength.
- Trial name
- NCT00643864
- Testing
- mirror training
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
Stroke
Exercise and Brain Stimulation for Post-stroke Depression
This project will assess the effects of aerobic exercise training (AET), repetitive transcranial magnetic stimulation (rTMS) or their combination on depressive severity as well as locomotor function in persons with post-stroke…
- Trial name
- NCT03056287
- Testing
- Aerobic exercise, Repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Medical University of South Carolina
Arthritis, Cancer
MoveStrong at Home: A Feasibility Study of a Model for Remote Delivery of Functional Strength and Balance Training Combined With Nutrition Education for Older Pre-frail Adults.
Sufficient muscle strength helps to get out of a chair and can prevent falls. Up to 30% of older adults experience age-related loss of muscle strength, which can lead to frailty and health instability.
- Conditions
- Arthritis, Cancer, Cardiovascular Diseases, Chronic Lung Disease
- Trial name
- NCT04663685
- Testing
- Exercise program, Nutrition education
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Waterloo
Carotid Artery Disease, Carotid Stenosis
Carotid Angioplasty and Stenting Versus Endarterectomy in Asymptomatic Subjects Who Are at Standard Risk for Carotid Endarterectomy With Significant Extracranial Carotid Stenotic Disease (ACT I)
The study is being conducted to demonstrate the non-inferiority of carotid artery stenting (CAS) using the Emboshield® Embolic Protection System with the Xact® Carotid Stent System to carotid endarterectomy (CEA) for the…
- Conditions
- Carotid Artery Disease, Carotid Stenosis, Stroke, Atherosclerosis
- Trial name
- ACT I (NCT00106938)
- Testing
- Carotid artery stenting with filter (interventional), Carotid artery endarterectomy (surgical)
- Where
- 62 sites in United States
- Volunteers
- 1,663 people
- Sponsor
- Abbott Medical Devices
Stroke, Frailty
Pilot of Cognitive Stimulation Therapy for Pre-frail Stroke Survivors
Frailty is described as a type of vulnerability where one can struggle to recover fully from things that can put stress on one\'s body, e.g., cold weather or bronchitis.
- Conditions
- Stroke, Frailty, Carers
- Trial name
- NCT06733103
- Testing
- Stroke Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Stroke
Forced Aerobic Exercise for Stroke Rehabilitation
The purpose of the study is to determine if performing different types of aerobic exercise (cycling) before upper extremity exercises will help to improve outcomes after stroke.
- Trial name
- NCT02494518
- Testing
- Forced Exercise & Upper Extremity Repetitive Task Practice, Voluntary Exercise & Upper Extremity Repetitive Task Practice, Stroke Education & Upper Extremity Repetitive Task Practice
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The Cleveland Clinic
Aphasia
Using Transcranial Direct Current Stimulation (tDCS) to Improve Post-Stroke Aphasia
This study tests whether weak electrical stimulation of the brain is effective in improving language or reading difficulties occurring after a brain injury or stroke.
- Trial name
- NCT01709383
- Testing
- Transcranial Direct Current Stimulation
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Georgetown University
Stroke
Improving Holding Function of the Hemiplegic Hand
Relevant to patients with spastic hemiparesis in the hand and upper limb, this pilot project proposes to measure the effects of botulinum toxin injections through observation of performance on a functional task known as 'hand as…
- Trial name
- NCT02459951
- Testing
- clenched fist
- Volunteers
- 10 people
- Sponsor
- Nathaniel Mayer
Stroke, CVA
Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke.
PURPOSE: The purpose of this study will be to identify whether patients in the subacute stage of stroke, who demonstrate foot drop, will have better gait outcomes when using a Double Adjustable AFO, or a Posterior Leaf Spring…
- Conditions
- Stroke, CVA, Hemiplegia, Hemiparesis
- Trial name
- NCT02693834
- Testing
- Posterior Leaf spring AFO, Double adjustable AFO
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Texas Woman's University
Aging
Neural Underpinnings of Turning
Older adults and stroke survivors often have difficulty performing complex walking tasks, due in part to changes in the brain. One task often overlooked is turning, which can lead to injury when performed poorly.
- Trial name
- NCT05475236
- Testing
- Experimental: Locomotor Learning
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Stroke
Development of Walk Assist Device to Improve Community Ambulation
Hypothesis/Specific Aims: The purpose of this study is to determine the effect of training with the Stride Management Assist (SMA) device vs.
- Trial name
- NCT01994395
- Testing
- The Stride Management Assist (SMA) System, Impairment based therapy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Inflammation
Inflammatory Abnormalities in Muscle After Stroke: Effects of Exercise
The purpose of this study is to first define whether abnormalities of skeletal muscle are related to the presence of inflammation and to poor motor performance and whether this can be modified by exercise interventions.
- Trial name
- NCT00387712
- Testing
- Velocity based treadmill training, Duration based treadmill training
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- VA Office of Research and Development
Stroke, Brain Injuries
Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity
The study seeks to compare the effectiveness of three preparations of BOTOX-A® in treating muscle tightness and spasms in the feet and ankles of people with stroke.
- Conditions
- Stroke, Brain Injuries, Spasticity
- Trial name
- NCT00178646
- Testing
- Botox
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Stroke
Extending Acute Stroke Trials to the Aerial Inter-hospital Transfer Setting
We are inviting patients who have been diagnosed with an ischemic or hemorrhagic stroke and are being transferred by Air Care helicopters to the University of Iowa Hospitals and Clinics (UIHC) for further care to participate in…
- Trial name
- AIRDOC (NCT00585351)
- Testing
- Ranitidine, Advanced notification, No advanced notification
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Iowa
Stroke
Cerebellar Transcranial Direct Current Stimulation and Aphasia Treatment
People with post-stroke aphasia are left with some degree of chronic deficit for which current rehabilitative treatments are variably effective.
- Trial name
- NCT02901574
- Testing
- Anodal or Cathodal tDCS, Computerized naming therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Johns Hopkins University
Stroke, Physical Disability
Concomitant Sensory Stimulation During Therapy to Enhance Hand Functional Recovery Post Stroke
The objective of this study is to determine if combining vibration with hand task practice is superior to hand task practice alone.
- Trial name
- NCT04569123
- Testing
- real stimulation, No stimulation
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Medical University of South Carolina
Stroke
Exercise-primed Upper Extremity Motor Practice in Chronic Stroke
The purpose of this project is to establish initial feasibility and tolerability of a combined aerobic exercise (AEx) and upper extremity motor practice intervention on upper extremity (UE) function in chronic stroke survivors.
- Trial name
- PUMP-Ex (NCT04259424)
- Testing
- Aerobic Exercise + Duck Duck Punch
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
Patients With Atrial Fibrillation at Risk for Thrombus Formation, Thromboembolism, Stroke
Registry on WATCHMAN Outcomes in Real-Life Utilization
The WATCHMAN LAA Closure Technology is designed to prevent embolization of thrombi that may form in the LAA, thereby preventing the occurrence of ischemic stroke and systemic thromboembolism.
- Trial name
- EWOLUTION (NCT01972282)
- Testing
- WATCHMAN Left Atrial Appendage Closure
- Where
- 47 sites in Belgium, France and 11 more
- Volunteers
- 1,025 people
- Sponsor
- Boston Scientific Corporation