Clinical trials: Brain Structural Connectivity
Failed Back Surgery Syndrome
STructural And FunCTional Brain Alterations by HIgh FrequenCy Spinal Cord Stimulation
This study is an interventional prospective observatory single center trial, investigating the supraspinal effects of long term paresthesia-free high frequency SCS in FBSS patients with back and leg pain completed with resting…
- Trial name
- TACTIC (NCT02650362)
- Testing
- fMRI
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment
Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases
The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative…
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment, Parkinson's Disease With Mild Cognitive Impairment
- Trial name
- NCT07449117
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- Masaryk University
Essential Tremor
Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract
The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulation
- Trial name
- NCT04758624
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Northwell Health
Transcranial Direct Current Stimulation, Ankle
Investigating the Effects of Transcranial Direct Current Stimulation to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke
Ankle control is essential to safe over-ground navigation for humans. Middle- aged and older adults and patients with stroke whose ankle control is poor often lose their balance or fall.
- Conditions
- Transcranial Direct Current Stimulation, Ankle, Motor Learning, Adaptation
- Trial name
- tDCS (NCT06556043)
- Testing
- cM1 transcranial direct current stimulation, cPPC transcranial direct current stimulation, iCBM transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Tinnitus, Hearing Loss
Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss
Tinnitus, the perception of sound in the absence of an external acoustic stimulus. Tinnitus is often perceived inside the head rather than the ear and is a common condition with a prevalence estimated between 10 and 15% in…
- Trial name
- IGNITE (NCT04862572)
- Testing
- MRI scanning
- Where
- 3 sites in United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity
Responses to Appetite and Taste in the Brain Circuits That Control Eating Behaviour
The aim of this study is to gain insight into brain structure and the neural networks that control taste and eating behaviour in patients with severe obesity undergoing a primary sleeve gastrectomy (SG) or a lifestyle…
- Trial name
- TASTER (NCT03547063)
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University College, London
Parkinson Disease
Subthalamic Nucleus Connectivity in Parkinson's Disease With Ultra-high Field Magnetic Resonance Imaging
The purpose of this study is to investigate the segregation of the subthalamic nucleus into its motor and non-motor regions in patients with Parkinson's disease and healthy controls with the aid of ultra-high field magnetic…
- Trial name
- NCT01981577
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Alzheimer Disease, Mild Cognitive Impairment
TPSAlz - Transcranial Pulse Stimulation in Alzheimer's Disease
The goal of this study is to evaluate the effects of transcranial pulse stimulation (TPS) in modulating cognitive functions as well as structural and functional connectivity in individuals with mild cognitive impairment and early…
- Trial name
- TPSAlz (NCT07883148)
- Testing
- Transcranial pulse stimulation (TPS)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- IRCCS San Raffaele Roma
Failed Back Surgery Syndrome
StruCtuRal And FuncTional Brain Alterations by Conventional Spinal Cord Stimulation And High DensitY Stimulation
This study is an interventional prospective observatory single center trial, investigating the supraspinal effects of long term conventional SCS (60 Hz) and paresthesia-free high density SCS in failed back surgery syndrome (FBSS)…
- Trial name
- SCRATCHY (NCT02650349)
- Testing
- fMRI
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- Universitair Ziekenhuis Brussel
Schizophrenia, Psychosis
Glutamate, Brain Connectivity and Duration of Untreated Psychosis
The early stages of schizophrenia are associated with significant decreases in social and intellectual abilities, with more declines in chronic disease.
- Conditions
- Schizophrenia, Psychosis, Schizoaffective Disorder
- Trial name
- DUP (NCT02034253)
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Stroke, Motor Activity
Altered Structural-functional Connectivity Coupling on Chronic Subcortical Stroke
The current study aims to reveal the SC-FC coupling pattern and its relationship with motor function in post-stroke survivors with motor dysfunction by multimodal MRI.
- Trial name
- NCT05648552
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Brain Structural Connectivity, Cognitive Function
Developmental Trajectory of Brain Structural Connectivity and Cognitive Function From Childhood to Adulthood
Magnetic resonance imaging (MRI) is a premier modality to investigate structures and functions of human brain. In studies of children and adolescents, noninvasiveness of MRI makes it especially applicable.
- Trial name
- NCT01677793
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Traumatic Coma
Brain Network Disruptions Related to Traumatic Coma
To provide a fine-grained description of the brain network dysfunctions induced by severe traumatic brain injury (TBI) or anoxic encephalopathy, that are responsible for the acute state of unarousable unawareness, named coma…
- Trial name
- Coma3D (NCT03482115)
- Testing
- PET examination with radiopharmaceutical drug [18F] DPA-714, MRI examination, Blood samples
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Parkinsons Disease (PD)
Neuroimaging of Parkinson's
Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network…
- Trial name
- NCT07024875
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pregnancy, Neurodevelopment
Maternal Risk, Fetal-Neonatal Brain Connectivity, and Early Neurodevelopment: A Longitudinal Observational Study
This study aims to understand how a pregnant woman's health, lifestyle, and psychological state-especially when associated with known risk factors-might influence the developing brain of her baby, both before and after birth.
- Conditions
- Pregnancy, Neurodevelopment, Brain Connectivity, Neurodevelopment Outcome
- Trial name
- MaMRI-NeUCogI (NCT07059286)
- Testing
- Maternal Frailty Inventory (MaFra) Questionnaire, Fetal Resting-State Functional MRI, Maternal Emotional Reactivity
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- IRCCS San Raffaele
Epilepsies, Focal, Pediatrics
Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain
Focal epilepsy is associated with widespread alterations in structural brain connectivity, often present at the disease onset and related to learning disabilities.
- Conditions
- Epilepsies, Focal, Pediatrics, Drug Resistant Epilepsy
- Trial name
- EPITRACT (NCT03268824)
- Testing
- Electroencephalogram (EEG), Diffusion Tensor imaging, Language assessment
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acquired Brain Injury, Traumatic Brain Injury
Connectivity in Cranioplasty
An Exploratory Interventional study to assess the effects of cranioplasty on brain network connectivity, neuropsychological and motor functioning in patients with severe acquired brain injury with pre-, post-cranioplasty and 6…
- Conditions
- Acquired Brain Injury, Traumatic Brain Injury, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT05440682
- Testing
- CP group
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Azienda Usl di Bologna
Brain Tumours
Investigating Visual Verticality Disorder and Lateropulsion in a Neurosurgical Cohort of Patients With Brain Tumours
The overall objective of this research is to investigate the clinical characteristics pre- and post-brain tumour resection with a focus on visual verticality disorder, and lateropulsion, including neuroimaging analysis, of a…
- Trial name
- NCT06951659
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- The University of Western Australia
Migraine Disorders
Resting-state Functional Connectivity Changes During Migraine Treatment
The purpose of this study is to determine whether reduced frequency of migraine attacks are associated with signal alternation and connectivity of cerebral cortex.
- Trial name
- NCT03484871
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Insomnia, Alzheimer Disease
Transdermal Trigeminal Electrical Neuromodulation on Mild Cognitive Impairment With Insomnia
This study aims to validate the safety and impact of transdermal trigeminal electrical neuromodulation(Cefaly) on mild cognitive impairment patients with insomnia on brain functional and structural connectivity as well as sleep…
- Conditions
- Insomnia, Alzheimer Disease, Mild Cognitive Impairment, Amyloid
- Trial name
- NCT05200897
- Testing
- Transdermal trigeminal electrical neuromodulation(Cefaly)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Saint Vincent's Hospital, Korea