Clinical trials: Brain Swelling
Acute Ischemic Stroke
Butylphthalide for Brain Edema After Endovascular Treatment
This is a prospective, multicenter, randomized controlled clinical study aimed at evaluating the efficacy of butylphthalide in improving the severity of cerebral edema and prognosis in patients with acute anterior circulation…
- Trial name
- NCT07528456
- Testing
- Butylphthalide
- Where
- 10 sites in China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke
Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)
Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor…
- Conditions
- Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke, Acute Ischemic Stroke, Cardioembolic Stroke
- Trial name
- NCT07013396
- Testing
- Transcranial Doppler (TCD) examination
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Dialysis; Complications, Hemodialysis Complication
Conventional Hemodialysis Versus Post-Dilution Hemofiltration in Incident RRT
Patients with chronic kidney disease (CKD) with criteria for renal replacement therapy (RRT) including uremic syndrome, have a stable state of hyperosmolarity due to urea despite not being an osmotically inactive ion.
- Conditions
- Dialysis; Complications, Hemodialysis Complication, Cerebral Edema, Cognitive Impairment
- Trial name
- DA-VINCI (NCT05060159)
- Testing
- Hemofiltration
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Acute Ischemic Stroke, Cerebral Edema
The Tolerability, Safety, and PK Characteristics of SIM1910-09 in Healthy Chinese Volunteers
This is a single-center, randomized, double-blind, placebo-controlled Phase I clinical study to evaluate the tolerability, safety, and pharmacokinetic characteristics of SIM1910-09 for injection after single/multiple dosing in…
- Trial name
- NCT05200728
- Testing
- SIM1910-09
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Brain Swelling, Brain Edema
Furosemide vs Placebo for Brain Relaxation
Increased brain bulk may be problematic during brain surgery for tumors because it may limit surgical exposure and access to the surgical site.
- Conditions
- Brain Swelling, Brain Edema, Dehydration
- Trial name
- NCT01054404
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Northwestern University
End Stage Renal Disease
Brain Swelling During Dialysis
The proposed controlled, randomized study aims to compare pre-dilution hemodiafiltration (HDF) and low flux hemodialysis (HD) regarding acute changes in the brain. The study consist of two examination days placed one week apart.
- Trial name
- BRASE (NCT01396863)
- Testing
- HDF during the first examination, HD during the first examination
- Where
- 2 sites in Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Aneurysm, Subarachnoid Hemorrhage
SMCV Assessment on Brain Swelling in Patients With SAH
Cerebral swelling is a major complication following aneurysmal subarachnoid hemorrhage.This study is a retrospective cohort aimed to predict the extent of brain swelling.
- Conditions
- Aneurysm, Subarachnoid Hemorrhage, Brain Swelling
- Trial name
- Bayysmcv (NCT05696639)
- Testing
- Aneurysm embolization
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shenzhen Baoan District People's Hospital
Edema Brain
Reducing Edema After intraCerebral Hemorrhage
The REACH trial is a prospective multicenter double-blind randomized placebo-controlled trial with blinded end-point adjudication.
- Trial name
- NCT05263167
- Testing
- Sodium Aescinate
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Stroke, Acute
Phase 1 Study to Assess AER-271
The objective of this Phase 1 trial is to assess the safety, tolerability and pharmacokinetics of AER-271 in health subjects.
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- NCT03804476
- Testing
- AER-271
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aeromics, Inc.
Acute Ischemic Stroke, Mechanical Thrombectomy
Local Ischemic Postconditioning in Acute Ischemic Stroke
This study aims to determine the safety and optimal dose of rapid local ischemic postconditioning in acute ischemic stroke(AIS) patients received successful thrombectomy reperfusion.
- Conditions
- Acute Ischemic Stroke, Mechanical Thrombectomy, Ischemic Postconditioning, Brain Edema
- Trial name
- RAPID-SAVEI (NCT06526429)
- Testing
- rapid local ischemic postconditioning
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Brain Edema
Haemodynamical Optimization During Brain Surgery
The decision to give fluids perioperatively could be based on methods used to identify preload responsiveness, either invasive or noninvasive estimates of stroke volume variation during mechanical ventilation.
- Trial name
- NCT04114799
- Testing
- Hemodynamic management based on invasive fluid responsiveness parameters, Hemodynamic management based on noninvasive cardiac output and SVV measurement
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Hradec Kralove
Cerebral Edema, Ischemic Stroke, Acute
A Trial of Adacolumn on Cerebral Edema After Anterior Circulation Ischemic Stroke
The primary objective is to investigate whether treatment with Adacolumn can ameliorate the progression of cerebral edema within 72 hours in patients with anterior circulation ischemic stroke.
- Conditions
- Cerebral Edema, Ischemic Stroke, Acute, Malignant Cerebral Edema, Anterior Circulation Brain Infarction
- Trial name
- NCT07386262
- Testing
- Adacolumn®, Standard Reperfusion Therapy, Standard Medical Management
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Brain Death, Brain Injuries
Resting Energy Needs in Brain Dead Patients (reSting EneRgy nEeds iN brAin DEad Patients)
The study will examine the resting energy need (REE) in patients suffering from brain damage. For the measurement of REE will be used a metabolic computer (which with continuous recording of breath-to-breath volume (Vt)…
- Conditions
- Brain Death, Brain Injuries, Brain Edema, Brain Hemorrhage
- Trial name
- SERENADE (NCT05070182)
- Testing
- REE - Resting Energy Expenditure, Transcranial Doppler
- Where
- Greece
- Volunteers
- 66 people
- Sponsor
- Aristotle University Of Thessaloniki
Acute Brain Injury, Traumatic Brain Injury
Implementation of Neuro Lung Protective Ventilation
Patients who experience lung injury are often placed on a ventilator to help them heal; however, if the ventilator volume settings are too high, it can cause additional lung injury.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Stroke
- Trial name
- NEUROVENT (NCT03243539)
- Testing
- Lung Protective Ventilation
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Colin Grissom
Cerebral Infarction, Cerebral Edema
Study on the Relationship Between Asymmetric Vascular Sign of Cortex and Prognosis in Massive Cerebral Infarction
Susceptibility weighted imaging (SWI) technology has developed in the decade which is being a kind of cerebrovascular disease diagnostic tools in the clinical application, especially for paramagnetic material (such as DNA…
- Trial name
- NCT04247659
- Testing
- sodium aescinate
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The Second Hospital of Hebei Medical University
Stroke, Hemorrhagic Transformation Due to Acute Stroke
Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke
Astragalus membranaceus (AM) is used to treat stroke for a long period, and a number of studies have known that AM can reduce cerebral infarction area and has anti-oxidation.
- Trial name
- NCT01428401
- Testing
- Chinese Herb Astragalus membranaceus
- Volunteers
- 80 people
- Sponsor
- China Medical University Hospital
Brain Tumor, Brain Edema
The Accuracy of Brain Biological Electrical Impedance Tomography Screen for Supratentorial Tumors
Compared with MRI or CT, brain biological electrical impedance tomography were performed on patients with supratentorial tumors and healthy people .
- Trial name
- ABST (NCT04490954)
- Testing
- brain biological electrical impedance tomography, MRI/CT
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Cerebrovascular Accident, Cerebral Edema
Histamine Glutamate Antagonism in Stroke
Stroke is the 4th leading cause of death in United States with an estimated 1 death every 4 minutes. On average, someone suffers from stroke in United States every 40th second. Stroke recurs in 1 out of 4 stroke patients.
- Trial name
- NCT02142712
- Testing
- Diphenhydramine, Pantoprazole, Famotidine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Acute Ischemic Stroke, Reperfusion Injury
Acute Ischaemic STROKE: From LAboratory to the Patient's BED
Background: Recanalization strategies have radically changed the outcome in a significant part of stroke patients. The unpredictable occurrence of cerebral edema (CE) and hemorrhagic transformation (HT) are frequent events in…
- Conditions
- Acute Ischemic Stroke, Reperfusion Injury, Cerebral Edema, Hemorrhagic Transformation Due to Acute Stroke
- Trial name
- STROKELABED (NCT05725694)
- Volunteers
- 200 people
- Sponsor
- Istituto di Neuroscienze Consiglio Nazionale delle Ricerche
TBI (Traumatic Brain Injury), Brain Edema
Teen Online Problem Solving (TOPS) - An Online Intervention Following TBI
The purpose of this study is to learn if using the World Wide Web to train teens and their families in problem-solving, communication skills, and stress management strategies can help them to cope better following traumatic brain…
- Conditions
- TBI (Traumatic Brain Injury), Brain Edema, Craniocerebral Trauma, Hematoma
- Trial name
- TOPS (NCT00409058)
- Testing
- Teen Online Problem Solving
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati