Clinical trials: Brain Trauma
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI
The goal of the proposed project is to improve the treatment of veterans with co-occurring traumatic brain injury (TBI) and hazardous or harmful alcohol use.
- Trial name
- VAT (NCT01750268)
- Testing
- Medical Management Counseling, Topiramate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Post Traumatic Stress Disorder, Mild Traumatic Brain Injury, Concussion
Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI
One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with concurrent mild TBI and PTSD.
- Trial name
- NCT01921179
- Testing
- GOALS (Goal-Oriented Attentional Regulation), EDU (Brain Health Education)
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- VA Office of Research and Development
Brain Injuries, Post-Traumatic Headache
Amitriptyline to Prevent Headache After Traumatic Brain Injury
The investigators propose to conduct a 2-arm, open-label pilot study to determine if early treatment with amitriptyline will decrease the frequency and severity of headaches after mild traumatic brain injury (TBI).
- Trial name
- NCT01856270
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
TBI (Traumatic Brain Injury)
VR Cognitive Rehabiliation for Pediatric TBI
Childhood traumatic brain injury (TBI) poses significant impairment in children's executive functions (EFs) for moderate to severe injuries, yet interventions specifically designed for children's EF rehabilitation post-TBI and…
- Trial name
- NCT04526639
- Testing
- Virtual Reality-based Interactive Cognitive Training Program
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Massachusetts, Lowell
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Spinal Cord Injury, Stroke
Proprioception Testing in Persons With Sensorimotor Impairment
In this study, an FDA-cleared device and type of treatment called "AMES," which stands for Assisted Movement with Enhanced Sensation, will be used to determine whether sensation in the upper limb of individuals with incomplete…
- Conditions
- Spinal Cord Injury, Stroke, Acquired Brain Injury
- Trial name
- NCT01974635
- Testing
- AMES Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Oregon Health and Science University
Mild Traumatic Brain Injury, Balance; Distorted
Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?
Every year 1.7 million people sustain a traumatic brain injury (TBI) in the United States and of these, 84 % are considered mild TBI (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Balance; Distorted, Gait, Unsteady, Quality of Life
- Trial name
- NCT03479541
- Testing
- Timing of Rehabilitation, Biofeedback
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Post-Traumatic Headache
Prazosin for Post-Concussive Headaches
Mild traumatic brain injury (mTBI) caused by blast effects of explosive devices has been called the "signature injury" of soldiers who served in the Iraq and Afghanistan conflicts.
- Trial name
- NCT02965027
- Testing
- Prazosin
- Where
- 2 sites in United States
- Volunteers
- 89 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Concussion, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
This is an open-label, non-randomized, prospective, multi-site, parallel group (segment), hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between…
- Trial name
- mTBI-phase2 (NCT02556177)
- Testing
- MRI
- Where
- 7 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Occupational Therapy, Sexuality
Approach to Sexuality From Occupational Therapy in People With Acquired Brain Injury in Subacute Stage
Objectives: To analyse if people with acquired brain injury in sub-acute situation, as well as their relatives, and/or partners, consider relevant the approach to sexuality during their Occupational Therapy intervention.
- Conditions
- Occupational Therapy, Sexuality, Acquired Brain Injury
- Trial name
- NCT03911752
- Testing
- Semi-structured interviews, Canadian Occupational Performance Measure
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
TBI, Major Depression
Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditions
This research is being done to see if a drug called escitalopram (Lexapro) is helpful to people who are suffering from depression after traumatic brain injury (TBI).
- Conditions
- TBI, Major Depression, Other Psychiatric Disorders
- Trial name
- NCT01368432
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Stroke, Stroke, Acute
Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke
The primary objective of this study is to determine the efficacy of a single intravenous infusion of unrelated donor umbilical cord blood (UCB) for improving functional outcomes in patients with ischemic stroke.
- Conditions
- Stroke, Stroke, Acute, Brain Injury, Acute
- Trial name
- CoBIS 2 (NCT03004976)
- Testing
- Umbilical Cord Blood
- Where
- 6 sites in United States
- Volunteers
- 79 people
- Sponsor
- Joanne Kurtzberg, MD
Head Injury
Adjuvant Acupuncture for Severe Head Injury
The purpose of this study is to determine the therapeutic effect of acupuncture on severe head injury under conventional treatment.
- Trial name
- NCT01773291
- Testing
- acupuncture, laser acupuncture, control
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Chang Gung Memorial Hospital
Concussion
Smart Phone Application for Postconcussion Symptom Reduction
The proposed study will address a very important issue for the VA both currently and in the future -- the high percentage of OIF/OEF/OND Veterans who have been medically diagnosed with a mild traumatic brain injury (mild TBI) and…
- Trial name
- NCT02501642
- Testing
- Concussion Coach, Treatment as usual
- Where
- 2 sites in United States
- Volunteers
- 479 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome
mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms
Purpose of this study is to investigate the mechanisms of action of hyperbaric oxygen therapy for persistent post-concussive symptoms after mild tramatic brain injury
- Trial name
- BIMA (NCT01611194)
- Testing
- Hyperbaric oxygen (HBO2) at 1.5 atms
- Where
- 5 sites in United States
- Volunteers
- 71 people
- Sponsor
- U.S. Army Medical Research and Development Command
Subdural Hematoma, Traumatic
To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients
This randomized, prospective trial will study the effect of very early cooling in patients undergoing surgical evacuation of acute subdural hematomas (35°C prior to opening the dura followed by maintenance at 33°C for a minimum…
- Trial name
- HOPES (NCT02064959)
- Testing
- Temperature management Zoll Intravascular Temperature Management device
- Where
- 14 sites in United States, Japan
- Volunteers
- 32 people
- Sponsor
- The University of Texas Health Science Center, Houston
Venous Thromboembolism, Traumatic Brain Injury
Delayed Versus Early Enoxaparin Prophylaxis After Traumatic Brain Injury (TBI)
Brain injured patients are at high risk for forming blood clots in the legs and lungs. For non-brain injured trauma patients, we decrease the chances of these blood clots forming by placing the patients on a low dose of the blood…
- Trial name
- DEEP (NCT01014403)
- Testing
- enoxaparin
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury
Cold-stored Platelet Early Intervention in TBI
The Cold Stored Platelet Early Intervention in Traumatic Brain Injury (CriSP-TBI) trial is a proposed 3 year, open label, single center, randomized trial designed to determine the feasibility, efficacy, and safety of urgent…
- Trial name
- CriSP-TBI (NCT04726410)
- Testing
- Cold Stored Platelets, Standard Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jason Sperry
Cardiac Arrest
Augmented Multimodal Neurologic Monitoring in High Risk Survivors of Cardiac Arrest
Cardiac arrest is the most common cause of death in the United States and as many as 590,000 Americans suffering a cardiac arrest each year.
- Trial name
- NCT02069353
- Testing
- QFlow 500™ Perfusion Probe (Hemedex, Cambridge, MA), Spencer Probe Depth Electrode (Ad-Tech Medical, Racine, WI)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jonathan Elmer
Traumatic Brain Injury
Carbamazepine for the Treatment of Chronic Post-Traumatic Brain Injury Irritability and Aggression
The purpose of this study is to determine if carbamazepine reduces irritability and aggression among individuals with traumatic brain injury
- Trial name
- NCT00621751
- Testing
- Carbamazepine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Wake Forest University Health Sciences