Clinical trials: Brain and Nervous System
Stroke
Evaluation of the Arm Rehabilitation Device for Patients With Stroke
The usability assessment focuses on the actual use of the proposed rehabilitation system to clarify issues users would face in actual system operation, thus providing a reference for subsequent system improvement.
- Trial name
- NCT02698605
- Testing
- Usability test study of the MirrorPath
- Where
- Taiwan
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Hereditary Ataxia
Telerehabilitation for Core Stability and Strength in Hereditary Ataxia
This is a two-arm, controlled clinical trial with a parallel design. Participants will be randomly assigned to an intervention or control group.
- Trial name
- TRCORE-AH2 (NCT07200505)
- Testing
- TR Mixed CORE Exercices, TR Asyncronous CORE Exercices
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Universitat de Lleida
Ischemic Stroke, Acute
Lumbrokinase vs Placebo in Moderate-to-Severe Ischemic Stroke
LUMEN is a multicenter, randomized, double-blind, placebo-controlled superiority trial designed to evaluate whether oral lumbrokinase enteric-coated capsules combined with aspirin improve functional outcomes compared with aspirin…
- Trial name
- NCT07763405
- Testing
- Lumbrokinase
- Volunteers
- 1,196 people
- Sponsor
- Xinqiao Hospital of Chongqing
Stroke
Autologous Cell Therapy After Stroke
This study will examine the safety of two different cellular therapies in the treatment of stroke.
- Trial name
- NCT00908856
- Testing
- autologous bone marrow mononuclear cell transfusion, marrow stromal cells
- Where
- United States
- Sponsor
- University of California, Irvine
Transient Ischemic Attack, Atrial Fibrillation
Early Detection Of Atrial Fibrillation In Patients With Transient Ischemic Attack
The purpose of this study is to determine the frequency of atrial fibrillation in patients with transient ischemic attack (TIA).
- Trial name
- NOTICE (NCT02011256)
- Testing
- Implantable loop-recorder
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Stroke, Hemiparesis
Neural Mechanisms of Music Intervention Chronic Arm Hemiparesis Following Stroke: A Single Case Series EEG Study
The aims of the study are to recruit five participants with stroke upper limb hemiparesis and determine the effects on neural reorganisation of a three-week music intervention using electroencephalogram measures.
- Conditions
- Stroke, Hemiparesis, Home-based
- Trial name
- NCT06223529
- Testing
- Therapeutic Instrumental Music Performance
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Anglia Ruskin University
Dementia, Memory Impairment
Cultural and Linguistic Adaptation and Normative Study of the Turkish Version of the Free and Cued Selective Reminding Test: 16-Word Version (FCSRT-T)
An Adaptation Study of Free and Cued Selective Reminding Test in Turkish
- Trial name
- FCSRT-T (NCT05756231)
- Testing
- SIHT-16
- Where
- Turkey (Türkiye)
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Auditory Processing Disorder
Hearing Aids for Veterans With Functional Hearing Difficulties
Every year, approximately 100,000 Veterans seek help at VA Audiology clinics for hearing and communication difficulties only to learn that they have normal hearing sensitivity.
- Trial name
- NCT06117254
- Testing
- Communication Counseling, Hearing Aids, Remote Microphones
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- VA Office of Research and Development
Cognitive Dysfunction, Cognition Disorder
Nutrition-based Interventions to Prevent Cognitive Decline
This study intends to evaluate the feasibility and the effectiveness of an innovative and integrated nutrition-based intervention addressing key modifiable risk factors for dementia while meeting participants' preferences for…
- Conditions
- Cognitive Dysfunction, Cognition Disorder, Memory Disorders, Cognitive Impairment
- Trial name
- NUTRIMIND (NCT06853405)
- Testing
- Nutrition-related lifestyle group sessions, Cognitive training, Clinical nutrition consultations
- Where
- 2 sites in Portugal
- Volunteers
- 120 people
- Sponsor
- Instituto de Saude Publica da Universidade do Porto
Dementia Alzheimers
Accelerated Intermittent Theta-burst Stimulation to Modify Cognitive Function and Balance in Dementia and Memory Loss
The process of aging is accompanied by normal deterioration of body systems, leading to a decline in various functional domains including cognitive, visual, vestibular, somatosensory, and motor function.
- Trial name
- NCT06445894
- Testing
- Active Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McMaster University
Stroke, Superior Sagittal Sinus Thrombosis
Comparison of the Radiological Pattern Between the Cerebral Stroke of Arterial and Venous Origin
There are few published data on the patterns of parenchymal imaging abnormalities in a context of cerebral venous thrombosis (CVT).
- Conditions
- Stroke, Superior Sagittal Sinus Thrombosis, Venous Thromboses
- Trial name
- PATTERN (NCT03611894)
- Testing
- radiological comparison
- Where
- 2 sites in France
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Traumatic Brain Injury
Repeatability Assessment of Neurovisual Tasks for the Construction of a New Concussion Monitoring Tool (SPORTICARE)
Traumatic brain injury (TBI) is a condition that occurs when a mechanical blow to the head causes damage to the brain. The diagnosis of this pathology requires the evaluation of several dimensions, including clinical symptoms…
- Trial name
- SPORTiCARE (NCT05992194)
- Testing
- multimodal oculomotor measurements
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
GBM, Glioblastoma Multiforme
Expanded Access Protocol for GBM Patients With Already Manufactured DCVax®-L Who Have Screen-Failed Protocol 020221
The study is an open-label expanded access study for patients for whom vaccine was manufactured during the Northwest Biotherapeutics' 020221 DCVax-L for GBM screening process, but who subsequently failed to meet specific…
- Trial name
- DCVax-L EAP (NCT02146066)
- Testing
- DCVax-L
- Where
- 27 sites in United States
- Sponsor
- Northwest Biotherapeutics
Metabolism - Cerebral Energy
The Efficient Brain Study
Cerebral energy metabolism declines with advanced aging, and is implicated in age-related cognitive decline, Alzheimer's disease (AD), and other forms of neurodegenerative disease (Parkinson's disease).
- Trial name
- NCT02771366
- Testing
- Fermented Papaya Preparation, Granulated Sugar
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Acquired Brain Injury
Effect of Methylphenidate on Ecologic Function in Paediatric Acquired Brain Injury Population
The purpose of this study is to investigate the influence of Methylphenidate in pediatric acquired brain injury population, regarding ecologic (every day) function.
- Trial name
- NCT02227056
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 34 people
- Sponsor
- Loewenstein Hospital
Adult Giant Cell Glioblastoma, Adult Glioblastoma
Gossypol in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme
This phase II trial is studying how well gossypol works in treating patients with progressive or recurrent glioblastoma multiforme.
- Conditions
- Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Tumor
- Trial name
- NCT00540722
- Testing
- R-(-)-gossypol acetic acid, laboratory biomarker analysis
- Where
- 8 sites in United States
- Volunteers
- 56 people
- Sponsor
- National Cancer Institute (NCI)
Migraine
Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)
Migraine is a common neurological disorder typically characterized by attacks of throbbing, moderate to severe headache, often associated with nausea, vomiting, and sensitivity to light and sound.
- Trial name
- Ubro Peds (NCT05125302)
- Testing
- Ubrogepant
- Where
- 129 sites in United States, Puerto Rico
- Volunteers
- 1,059 people
- Sponsor
- AbbVie
Stroke
Cognitive & Motor Training After Stroke For Everyday Walking Restoration
The purpose of this study is to test a unique, combined cognitive and motor intervention designed to restore safe, more normal coordinated gait components into the real world environment for individuals with stroke.
- Trial name
- NCT01160653
- Testing
- FES-IM, Cognitive training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Neuropathy, Cerebellar Ataxia
Evaluation of the Peripheral Nerve Ultrasound as a Diagnostic Tool in CANVAS Neuropathies
Cerebellar ataxia with neuropathy and bilateral areflexia syndrome (CANVAS) is a late onset neurodegenerative disorder with a slowly progressive ataxia.
- Conditions
- Neuropathy, Cerebellar Ataxia, Neurodegenerative Diseases
- Trial name
- CANVAS (NCT05095870)
- Testing
- No intervention
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation
Heat Shock Protein 47 in Thrombosis
The goal of this observational study is to learn if the novel biomarker Heat shock protein 47 (HSP47) can be used as a prognostic marker for vascular disease in people with acute venous thromboembolism (VTE), myocardial…
- Conditions
- Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation, Stroke (in Patients With Atrial Fibrillation)
- Trial name
- NCT06731673
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Aarhus