Clinical trials: Brain to Brain Communication
Frontotemporal Dementia, FTD
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
The goal of this clinical study is to learn about an investigational gene therapy product called AVB-101, which is designed to treat a disease called Frontotemporal Dementia with Progranulin Mutations (FTD-GRN).
- Conditions
- Frontotemporal Dementia, FTD, FTD-GRN, Dementia, Frontotemporal
- Trial name
- ASPIRE-FTD (NCT06064890)
- Testing
- Intrathalamic AAV.PGRN administration, Intrathalamic AVB-101
- Where
- 19 sites in United States, Belgium and 7 more
- Volunteers
- 18 people
- Sponsor
- AviadoBio Ltd
Cognitive Abnormality
Evaluation of a Decision-Support Tool for Blood Biomarker Testing for Alzheimer's Disease in Primary Care
The goal of the current study is to evaluate a decision-support tool intended to help primary care providers (PCPs) communicate with patients about blood biomarker testing for Alzheimer's Disease, enhancing shared-decision making…
- Trial name
- NCT07812337
- Testing
- Shared decision-making support tool
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer Disease, Cognitive Impairment
Negotiation Training for Caregiver Communication in AD
The purpose of this study is to design a Negotiation and Dispute Resolution (NDR) training intervention to improve communication and address resolution of conflicts that family caregivers of patients with cognitive impairment…
- Trial name
- NCT04837937
- Testing
- Caregiver vs. Patient [Beginner], Caregiver vs. Caregiver, Caregiver vs. Physician
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasms
- Trial name
- PICSI-H (NCT04283994)
- Testing
- Survey-based Patient/Clinician Jumpstart, EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 756 people
- Sponsor
- University of Washington
Cerebral Palsy, Traumatic Brain Injury
Hybrid Approach to Pediatric Rehabilitation
Children and youth recovering from acquired injuries typically receive therapy via in-patient or outpatient rehabilitation (OPR).
- Conditions
- Cerebral Palsy, Traumatic Brain Injury, Orthopedic Disorder
- Trial name
- NCT06547762
- Testing
- Hybrid approach (in-person and remote) to pediatric rehabilitation: A look beyond the COVID-19 crisis
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell
Project to Improve Communication About Serious Illness - Pilot Study
This two-year pilot study will test whether a one-page "Jumpstart Form" will affect goals-of-care discussions in the hospital. This form will be provided to clinicians and will include patient-specific information about…
- Conditions
- Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Disease Chronic, Congestive Heart Failure
- Trial name
- PICSI-P (NCT03746392)
- Testing
- Jumpstart Intervention
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Washington
Persistent Developmental Stutter, Childhood-Onset Fluency Disorder (Stuttering)
Stimulation of the Thalamus to Ameliorate Persistent Disfluency
Persistent developmental stutter / childhood onset fluency disorder is a disabling condition leading to significant communication and psychological disability.
- Trial name
- SToPeD (NCT05641701)
- Testing
- System On, System off
- Volunteers
- 3 people
- Sponsor
- University of British Columbia
Stroke, Aphasia
Adapting Acceptance and Commitment Therapy for Stroke Survivors With Aphasia
The proposed study is a Stage I successive cohort trial intended to adapt Acceptance and Commitment Therapy (ACT) to meet the specific needs of stroke survivors with aphasia ("ACT for Aphasia").
- Trial name
- NCT04984239
- Testing
- Acceptance and Commitment Therapy for aphasia
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Healthy
Effect of Electrical Stimulation (DC Polarization) to the Brain on Memory
This study will test the effect of direct current (DC) brain polarization (the application of a very weak electrical current to the brain) on learning and memory.
- Trial name
- NCT00471107
- Testing
- DC brain polarization
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Primary Malignant Brain Tumors, Advanced Care Planning
Communication Training for Caregivers In Advanced Care Planning
The purpose of this research study is to develop and test a new communication training to help caregivers communicate more effectively with their loved ones and healthcare professionals about advanced care planning.
- Trial name
- NCT04171895
- Testing
- Questionnaires, Communication training Part 1 (no longer recruiting), Enhanced usual care
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Disease, Neoplasm Metastasis
Facilitating Communication Study
This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their…
- Conditions
- Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive
- Trial name
- FCS2 (NCT03721952)
- Testing
- Facilitator-Based Intervention
- Where
- 3 sites in United States
- Volunteers
- 977 people
- Sponsor
- University of Washington
Traumatic Brain Injury, Word Finding Difficulty
Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury
The purpose of this study is to learn more about how brain stimulation affects word finding problems in people who have a traumatic brain injury (TBI).
- Conditions
- Traumatic Brain Injury, Word Finding Difficulty, Cognitive Symptom, Cognitive Change
- Trial name
- STIM-CTBI (NCT06848140)
- Testing
- Active Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Beth Israel Deaconess Medical Center
Mechanical Ventilation, Nonverbal Communication
Brain Computer Interface for Communication in Ventilated Patients
Objectives: Specific Aim 1: To demonstrate the feasibility of using a Steady State Visual Evoked Potential (SSVEP) based Brain Computer Interface (BCI) device to facilitate communication of common patient needs in alert…
- Conditions
- Mechanical Ventilation, Nonverbal Communication, Intratracheal Intubation, Critical Illness
- Trial name
- NCT02791425
- Testing
- Brain Computer Interface (BCI) device, Communication picture board
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Michigan
Hemiplegia, Aphasia
The Effect of Upper Extremity Motor Function, Trunk Control and Motor Imagery Ability on Turkish Language Skills in Individuals With Stroke
A large number of people have a stroke each year and it is a major cause of disability worldwide. Upper limb motor impairments, aphasia, body control problems and decreased motor imagery ability are common after stroke.
- Conditions
- Hemiplegia, Aphasia, Stroke, Trunk
- Trial name
- NCT06946082
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Izmir Bakircay University
Parkinson's Disease (PD), Essential Tremor
Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients
This study will examine how two important brain circuits - one involving the subthalamic nucleus (STN) and one involving the ventral intermediate nucleus of the thalamus (VIM) - contribute to learning and producing speech…
- Trial name
- NCT07455760
- Testing
- Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Boston University Charles River Campus
Developmental Dyslexia
Using fMRI to Evaluate Instructional Programs for Children With Developmental Dyslexia
Dyslexia is a common reading disorder. Specialized instructional programs can improve reading ability in children with dyslexia.
- Trial name
- NCT00068835
- Testing
- Lindamood-Bell training for dyslexia
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)