Clinical trials: Brain-Computer Interface
Chronic Stroke, Hemiparesis
Chronic Stroke Rehabilitation With Contralesional Brain-Computer Interface
The purpose of this research study is to show that a computer can analyze brain waves and that those brain waves can be used to control an external device.
- Trial name
- NCT03611855
- Testing
- BCI Rehabilitation, Range of Motion Therapy
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Washington University School of Medicine
Stroke
Assistive Soft Robotic Glove Intervention Using Brain-Computer Interface for Elderly Stroke Patients
This research aims to integrate and develop a novel Brain-Computer Interface (BCI) controlled soft robotic glove, evaluate the ability of the glove in achieving common hand grasping postures and to assess the efficacy of the…
- Trial name
- NCT03277508
- Testing
- BCI Robot Assisted Hand Therapy, CPM Robot Assisted Hand Therapy
- Where
- Singapore
- Volunteers
- 11 people
- Sponsor
- National University Hospital, Singapore
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used in Daily Practice by ALS People
"Brain-computer interfaces (BCIs) are computer-based systems that acquire brain signals, analyze them, and translate them into commands that are relayed to an output device to carry out a desired action.
- Conditions
- Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Spinal Cord Diseases, Alternative Communication Devices
- Trial name
- TECH-ICOPA (NCT04380649)
- Testing
- New headset prototype
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Tetraplegia/Tetraparesis, Quadriplegia
UAE-PRIME: A Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
The UAE-PRIME Study is a feasibility study designed to assess the initial clinical safety and functionality of the Neuralink N1 Implant and R1 Robot.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Quadriplegia/Tetraplegia, Cervical Spinal Cord Injury
- Trial name
- UAE-PRIME (NCT06992596)
- Testing
- N1 Implant, R1 Robot
- Where
- United Arab Emirates
- Volunteers
- 10 people
- Sponsor
- Neuralink Corp
Spinal Cord Injury Cervical, Tetraplegia/Tetraparesis
Implantable Wireless Brain-Computer Interface Systems in Patients With Tetraplegia
Objectives of Study: This trial aims to evaluate the safety and efficacy of an implantable wireless brain-computer interface system in patients with tetraplegia resulting from spinal cord injury.
- Conditions
- Spinal Cord Injury Cervical, Tetraplegia/Tetraparesis, Spinal Cord Injuries (SCI)
- Trial name
- LEAP (NCT07784088)
- Testing
- IWBCIS
- Where
- China
- Volunteers
- 34 people
- Sponsor
- BCIFlex Medical Technology Co., Ltd.
Stroke, Cerebrovascular, Hemiplegia and Hemiparesis
BCI Driving FES and Hand Orthosis for Upper Limb Rehabilitation in Chronic Stroke
Multi-center, randomized, sham-controlled, double-blind, longitudinal, experimental clinical study to investigate functional recovery effects on the upper limb in chronic stroke patients and the accompanying neural plasticity…
- Conditions
- Stroke, Cerebrovascular, Hemiplegia and Hemiparesis, Stroke/Brain Attack
- Trial name
- NCT06179745
- Testing
- EEG-based brain-computer interface, Functional Electrical Stimulation, Active hand orthosis
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Essex
Healthy Volunteers
Sensorimotor Based Brain Computer Interface
Sensorimotor (also know as mu) rhythm based brain-computer interfaces (BCIs) are a tool for controlling electronic devices using only brain signals.
- Trial name
- NCT02169375
- Testing
- Brain computer Interface Mu (SMR) rhythm
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Neurologic Disorder, ALS
Functional Outcomes and Control Using Synchron BCI - Canada
Functional Outcomes and Control Using Synchron BCI - Canada (FOCUS-CAN)
- Conditions
- Neurologic Disorder, ALS, Motor Neuron Disease
- Trial name
- FOCUS-CAN (NCT07446114)
- Testing
- Stentrode
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Synchron, Inc.
Traumatic Brain Injury With Prolonged Loss of Consciousness, Stroke
Evaluation of Consciousness by Brain-computer Interface in Severely Brain Damaged Patients
The objective of this study is to show that the measurement of auditory and vibro-tactile evoked potentials, or the recording of the EEG signal during a motor imaging task, can be used in routine clinical situations to explore…
- Conditions
- Traumatic Brain Injury With Prolonged Loss of Consciousness, Stroke, Brain Hypoxia
- Trial name
- AWAKE (NCT03998930)
- Testing
- Clinical evaluation of consciousness by the Coma Recovery Scale Revised (CRS-R)
- Where
- 4 sites in France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Paralysis; Quadriplegic, Quadraplegia
MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System
This research study is being done to develop a novel brain-computer interface (BCI) technology that can enable severely paralyzed individuals to interact with the world through direct brain-control of a computer.
- Conditions
- Paralysis; Quadriplegic, Quadraplegia, Tetraplegia, Tetraplegic Motor Dysfunction Following Brainstem or Spinal Cord Injury
- Trial name
- NCT05936619
- Testing
- Mind Extender (MindEx)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Nader Pouratian
Quadriplegia
Sensory Motor Transformations in Human Cortex
This research study is being conducted to develop a brain controlled medical device, called a brain-machine interface. The device will provide people with a spinal cord injury some ability to control an external device such as a…
- Trial name
- NCT01964261
- Testing
- Neural Prosthetic System 2 (NPS2)
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Richard A. Andersen, PhD
Functional Brain Mapping
Tapfinger Psychomotor Target
The study aims at mapping the magnetoencephalographic (MEG) activities induced in normal volunteers by tapping the finger .
- Trial name
- TAPFINGER (NCT02574026)
- Testing
- Psychomotor tasks
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Stroke
BCI With Virtual Reality for Stroke Rehabilitation: A Crossover Study
The goal of this clinical trial is to investigate if training sessions of motor imagery associated with brain-computer interface and motor observation through virtual reality (MI-VR-BCI) can help to improve arm and hand recovery…
- Trial name
- NOISyS (NCT07374276)
- Testing
- Motor Imagery-based Brain-Computer Interface coupled with Virtual Reality (MI-BCI-VR), Motor Imagery-based Brain-Computer Interface (MI-BCI)
- Where
- Portugal
- Volunteers
- 12 people
- Sponsor
- Technical University of Lisbon
Rehabilitation, Stroke
the Effectiveness of Brain-computer Interface-pedaling Training System on the Rehabilitation of Stroke
Stroke has become the first cause of death and disability among Chinese adults. 70%-80% of patients cannot live independently due to disability, which has brought a heavy burden to families, medical institutions and society.
- Conditions
- Rehabilitation, Stroke, Brain-computer Interface
- Trial name
- BCI-PT (NCT04612426)
- Testing
- Brain-computer Interface-Pedaling Training System, Traditional Pedaling Training System
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Stroke
Combined Transcranial Direct Current Stimulation and Motor Imagery-based Robotic Arm Training for Stroke Rehabilitation
Stroke is the most common cause of adult disability. Current treatments for functional loss of the upper extremity post-stroke remain limited in efficacy, particularly for those with moderate to severe impairment.
- Trial name
- NCT01897025
- Testing
- real-tDCS with MI-BCI
- Where
- Singapore
- Volunteers
- 42 people
- Sponsor
- National University Hospital, Singapore
Tetraplegia/Tetraparesis, Quadriplegia
Precise Robotically IMplanted Brain-Computer InterfacE
The PRIME Study is a first-in-human early feasibility study to evaluate the initial clinical safety and device functionality of the Neuralink N1 Implant and R1 Robot device designs in participants with tetraparesis or…
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Cervical Spinal Cord Injury, Amyotrophic Lateral Sclerosis
- Trial name
- PRIME (NCT06429735)
- Testing
- N1 Implant, R1 Robot
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Neuralink Corp
Treatment-Resistant Major Depressive Disorder, Major Depressive Disorder
Precision Closed-loop Brain-Computer Interface Neuromodulation for Treatment-Resistant Depression
The goal of this clinical trial is to evaluate whether precision closed-loop neuromodulation treatments can improve depressive symptoms and daily functioning in people with treatment-resistant major depressive disorder (TRD).
- Trial name
- NCT07783906
- Testing
- Closed-loop Deep Brain Stimulation (DBS), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Volunteers
- 70 people
- Sponsor
- Shanghai Mental Health Center
Amyotrophic Lateral Sclerosis
A P300 Brain Computer Interface Keyboard to Control Assistive Technology For Use by People With Amyotrophic Lateral Sclerosis
People with Amyotrophic Lateral Sclerosis (ALS) will use a P300 based brain computer interface (BCI) keyboard to type in assistive technology devices.
- Trial name
- NCT01119001
- Testing
- P300 Brain Computer Interface Keyboard
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Michigan
Quadriplegia, Amputations
A Study on the Safety and Functionality of the Implantable Wireless Brain-Computer Interfaces for Motor Rehabilitation
The objective of this study is to evaluate the safety and efficacy of minimally invasive, wireless brain-machine interface system (WRS) in patients with paralysis (resulting from spinal cord injuries, brainstem strokes…
- Conditions
- Quadriplegia, Amputations, Spinal Cord Injuries (SCI), Brainstem Stroke
- Trial name
- STAIR (NCT06944834)
- Testing
- Implant
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Healthy Subjects, Neuropsychiatric Disorders
Non-invasive BCI for Cognitive Enhancement
People's perceptual skills can significantly affect their abilities to make optimal decisions, judgments, and actions in real-world dynamic environments.
- Trial name
- NCT05311878
- Testing
- EEG-based perceptual training, Behavior based perceptual training
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin