Clinical trials: Brain-dead Organ Donors
Brain-dead Organ Donors
Potassium Canrenoate in Brain-dead Organ Donors: Randomized Controlled Clinical Trial
Given the current organ shortage, improving the quality/efficacy of harvested grafts from expanded criteria donors is essential to substantially increase the number of potential donors.
- Trial name
- CANREO-PMO (NCT04714710)
- Testing
- IV Potassium Canrenoate, IV Sodium Chloride 0.9 %
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Pr. Nicolas GIRERD
Intestinal Manipulation
Study on the Effect of Surgical Intestinal Manipulation
The aim of this study is to study the impact of brain death and surgical small bowel manipulation on the release of different types of monocytes.
- Trial name
- IMMO (NCT02189512)
- Testing
- blood sampling
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Brain Death
Incidence of Complications of Brain Death
The purpose of the study is to describe the incidence of complications in brain death adult organ donors.
- Trial name
- NCT04404972
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Brno University Hospital
Brain Death, Organ Donor
The Effect of Nebulized Albuterol on Donor Oxygenation
The purpose of this study is to test the effectiveness of albuterol versus placebo with the following specific aims: a) Treatment of brain dead organ donors with albuterol will reduce pulmonary edema, improve donor oxygenation…
- Conditions
- Brain Death, Organ Donor, Pulmonary Edema
- Trial name
- NCT00310401
- Testing
- Albuterol, Saline
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- Vanderbilt University Medical Center
Ischemic Reperfusion Injury
Efficacy Evaluation of Normothermic Perfusion Machine Preservation in Liver Transplant Using Very Old Donors
The purpose of this study is to evaluate the impact of normothermic machine perfusion in liver transplantation using grafts of brain death donors older or equal than 70 years
- Trial name
- CEFEMA (NCT02940600)
- Testing
- Normothermic machine perfusion, Static cold storage
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Brain-dead Organ Donors
Anesthesia sTrategy foR Organ Procurement In braiN dEath
The optimal anesthetic strategy during organ procurement in brain-dead donors remains unknown. The administration of anesthetic drugs in this setting aims to preserve hemodynamic stability in the face of reflex responses mediated…
- Trial name
- ATROPINE (NCT07166991)
- Testing
- Volatile anesthetic, Opioid Anesthesia, Intraoperative brain-dead donor management
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Grenoble
Brain Death, Organ Donation
Goal of Open Lung Ventilation in Donors
The primary goal of this study is to assess whether ventilation of deceased organ donors with an open lung protective ventilatory strategy will improve donor lung utilization rates and donor oxygenation compared to a conventional…
- Conditions
- Brain Death, Organ Donation, Organ Transplant Failure or Rejection
- Trial name
- GOLD (NCT03439995)
- Testing
- Open lung protective ventilation, Conventional ventilation
- Where
- 4 sites in United States
- Volunteers
- 154 people
- Sponsor
- Vanderbilt University Medical Center
Brain Death, Organ Donation
Donation Network to Optimize Organ Recovery Study
This study consists in an cluster-randomized clinical trial involving near 60 Brazilian intensive care units (ICUs) with a high notification rate of potential donors of organs and tissues.
- Trial name
- DONORS (NCT03179020)
- Testing
- Checklist use, Usual care
- Where
- 63 sites in Brazil
- Volunteers
- 1,535 people
- Sponsor
- Hospital Moinhos de Vento
Brain Death, Heart Failure
Intravenous Thyroxine for Heart-Eligible Organ Donors
This randomized controlled trial will evaluate whether intravenous thyroxine infusion given to brain-dead organ donors who are eligible to donate hearts for 12 hours will result in more hearts transplanted than saline placebo
- Trial name
- NCT04415658
- Testing
- Thyroxine, Saline
- Where
- 14 sites in United States
- Volunteers
- 838 people
- Sponsor
- Washington University School of Medicine
Post-transplantation Liver Allograft Function
Effects of Preconditioning With Sevoflurane During Organ Procurement From Brain Dead Donors: Impact on Early Function of Liver Allografts
The aim of the investigators study is to investigate the effects of anaesthetic preconditioning with sevoflurane during organs harvesting in brain dead donors.
- Trial name
- NCT02341833
- Testing
- Sevoflurane
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- University of Liege
Brain Death
Thyroid and Adrenocortical Hormone Replacement in Organ Donors
Brain death inevitably leads to hemodynamic instability and prolonged hypotension that compromises viability of potentially transplantable organs.
- Trial name
- NCT04528797
- Testing
- Levothyroxine, Methylprednisolone
- Volunteers
- 199 people
- Sponsor
- Medical University of South Carolina
Brain Death
Thyroxine Replacement in Organ Donors
To compare oral versus intravenous administration of thyroid hormone: 1) for reversibility of hemodynamic instability in organ donors, and, 2) the pharmacokinetics of oral vs iv thyroid administration
- Trial name
- NCT00238030
- Testing
- L-thryoxine, iv thryoxine
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Kidney Graft
Impact of Perioperative Organ Resuscitation of Brain-dead Deceased Organ Donor on Kidney Graft Function in the Recipient
Brain-dead patients are the primary source of grafts for those awaiting organ transplantation. Recommendations exist for the management of these potential donors, based on the concept of organ resuscitation, according to which…
- Trial name
- OPTI-PMO 2 (NCT06907758)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Stress Disorders, Post-Traumatic
Post Traumatic Stress Among Relatives of Brain-dead, Withdrawal of Life Support, and Sudden Death Patients
This study concerns the nearest relatives of patients who have passed away within 3 days of admission to an ICU due to: (1) brain death with multiple organ donation +/- tissues or (2) death via limitation and / or cessation of…
- Trial name
- NCT01412502
- Testing
- IES-R and HDAS scores
- Where
- 6 sites in France
- Volunteers
- 119 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Disorder Related to Lung Transplantation, Brain Death
Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation
The recent introduction of ex-vivo lung perfusion (EVLP) as a tool to evaluate and recondition lungs from marginal donors has opened a new era in the field of lung transplantation.
- Conditions
- Disorder Related to Lung Transplantation, Brain Death, Graft Failure, Primary Graft Dysfunction
- Trial name
- EVLP_MI (NCT01967953)
- Testing
- EVLP Group
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- Policlinico Hospital
Organ Preservation, Brain Reperfusion or Regain of Brain Function During Normothermic Regional Perfusion
Multimodal Neuromonitoring During Normothermic Regional Perfusion for Organ Donors Determined Dead by circuLatory Criteria Following Withdrawal of Life Sustaining Measures
The aim of this study is to demonstrate that cerebral blood flow and brain function do not resume after death declaration in organ donors who undergo normothermic regional perfusion to restore organ function following death…
- Trial name
- NONOFLOW (NCT07423936)
- Testing
- Neuromonitoring
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Brain Death, Chronic Renal Insufficiency
N-acetyl-cysteine (NAC) and Kidney Graft Function
The goal of this study is to evaluate the effect of N-acetyl-cysteine (NAC) administration in organ donors on the kidney graft function of recipients.
- Trial name
- NCT00998972
- Testing
- N-acetylcysteine
- Where
- France
- Volunteers
- 236 people
- Sponsor
- Institut d'Anesthesiologie des Alpes Maritimes
Organ Transplantation From Brain-dead Donors
Cooling to Optimize Organ Life in Donor Study
The purpose of this study is to assess the feasibility and safety of mild-to-moderate hypothermia as an in-vivo organ preservation strategy compared to normothermia in 60 brain-dead organ donors.
- Trial name
- COOLDonor (NCT01544530)
- Testing
- Cold isotonic fluid and central venous hypothermia catheter
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Pittsburgh
Organ Transplant Failure or Rejection, Brain Death
Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY)
The investigators hypothesize that preconditioning neurologically deceased organ donors with the calcineurin inhibitor tacrolimus will improve short and long-term transplant survival without causing harm.
- Conditions
- Organ Transplant Failure or Rejection, Brain Death, Ischemic Reperfusion Injury
- Trial name
- CINERGY (NCT05148715)
- Testing
- Tacrolimus
- Where
- 9 sites in Canada
- Volunteers
- 414 people
- Sponsor
- Université de Sherbrooke
Lung, Organ Donation
Pacing In Organ Donors (the POD Trial)
The goal of this clinical trial is to test the feasibility of pacing the phrenic nerve to stimulate the diaphragm in order to improve the lung function in brain dead organ donors.
- Conditions
- Lung, Organ Donation, Mechanical Ventilation
- Trial name
- POD (NCT07505589)
- Testing
- Lungpacer AeroPace catheter and device
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Fraser Health