Clinical trials: Breast Cancer, Breast Neoplasms
Breast Cancer
Phase 2 Window Study of SAR439859 (Amcenestrant) Versus Letrozole in Post-menopausal Patients With ER+, HER2- Pre-operative Post-menopausal Primary Breast Cancer
Primary Objective: To determine whether amcenestrant given at 2 different doses improved the antiproliferative activity when compared to letrozole.
- Trial name
- AMEERA-4 (NCT04191382)
- Testing
- Amcenestrant (SAR439859), Letrozole
- Where
- 32 sites in United States, Belgium and 7 more
- Volunteers
- 105 people
- Sponsor
- Sanofi
Breast Cancer Females
Short-term Impacts of Endocrine Therapy on Cardiovascular and Brain Health Outcomes in Breast Cancer
Aromatase inhibitors are the most used endocrine therapy for hormone-positive breast cancer. While there is a clear linear relationship between the duration of aromatase inhibitor use and the cumulative incidence of…
- Trial name
- STRIVE (Acute) (NCT06781762)
- Testing
- N/A (Usual Care)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Breast Cancer
Non-Invasive Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy Techniques (MRS) for Assessing Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
The goal of this clinical research study is to learn if magnetic resonance imaging (MRI) with magnetic resonance spectroscopy (MRS) can show the effects of pre-surgical chemotherapy in breast cancer patients who are eligible to…
- Trial name
- NCT00490503
- Testing
- Magnetic Resonance Imaging (MRI), Magnetic Resonance Spectroscopy (MRS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer Ductal Infiltrating Metastatic
Circulating Tumor Cells to Guide Chemotherapy for Metastatic Breast Cancer
Evaluation of the use of Circulating tumour Cells to guide chemotherapy from the 3rd line of chemotherapy for metastatic breast cancer.
- Trial name
- CirCé01 (NCT01349842)
- Testing
- Blood sampling, Usual clinical and radiological criteria
- Where
- 7 sites in France
- Volunteers
- 265 people
- Sponsor
- Institut Curie
Graft vs Host Disease
High Dose Chemotherapy and Autologous Transplant for Breast Cancer
To determine survival outcomes for patients with chemosensitive brest cancer after treatment with high dose chemotherapy
- Trial name
- NCT00186641
- Testing
- high dose chemo and auto hematopoietic cell transplant
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Stanford University
Cancer Recurrence
Fear of Recurrence Pilot Intervention for Women With Breast Cancer
The primary objective of this pilot study is to examine the feasibility and acceptability of a randomized, controlled study of a mindfulness and values-based living intervention targeted at reducing fear of recurrence in breast…
- Trial name
- WiLLoW (NCT01354041)
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Francisco
HER2-positive Breast Cancer
A Study to Measure the Expression of the HER2-HER3 Dimer in Tumour and Blood (Exosomes) Samples From Patients With HER2 Positive Breast Cancer Receiving HER2 Targeted Therapies
The treatment of breast cancer is determined by its 'receptor (or signal) status'. Receptors are signals present on all cells and if abnormal can drive cancer growth.
- Trial name
- HERdi PREDICT (NCT04288141)
- Testing
- Acquisition of blood samples and tumour tissue samples (biopsies)
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College London
Triple Negative, HER2+, Luminal B Breast Tumors (Stages II-III)in Female Patients
CPR Prediction After Neoadjuvant Using Excisional Biopsy By Radiofrequency In Breast Cancer From II-III UICC Stages.
This project aims to determine whether biopsy using radiofrequency is a procedure suitable for this patient selection. Findings from biopsy will be correlated with the conventional surgery ones.
- Trial name
- NCT01984866
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Breast Cancer
Study of Blood Samples in Patients With Breast Cancer
RATIONALE: Studying the genes expressed in samples of blood from patients with cancer may help doctors identify biomarkers related to cancer. It may also help doctors predict how patients will respond to chemotherapy.
- Trial name
- NCT00959556
- Testing
- laboratory biomarker analysis
- Where
- France
- Sponsor
- Centre Oscar Lambret
Breast Cancer
Bisphosphonate and Anastrozole Trial - Bone Maintenance Algorithm Assessment
The purpose of this study is to evaluate the use of an oral bisphosphonate (alendronate) in preventing bone loss in postmenopausal women with early breast cancer who are receiving anastrozole therapy, and to determine how long…
- Trial name
- BATMAN (NCT00122356)
- Testing
- Alendronate sodium
- Where
- 8 sites in Australia
- Volunteers
- 303 people
- Sponsor
- Barwon Health
Breast Cancer, Cancer
Breast Cancer Liquid Biopsy Trial
The purpose of this study is to continue to develop a liquid biopsy (minimally invasive blood test) that can be used to confirm if breast cancer has spread throughout the body and if this liquid biopsy test can provide comparable…
- Trial name
- NCT04962529
- Testing
- Blood Draw
- Where
- 8 sites in United States, Canada
- Volunteers
- 450 people
- Sponsor
- Anthony Magliocco
Breast Cancer, Cancer Related Fatigue
Feasibility of 'Exercise for CAncer Patients and Healthy EAting Timeframes' .
This study evaluates the feasibility and preliminary effects of a home based exercise and activity program for individuals with cancer.
- Trial name
- EXCAP-hEAT (NCT07529353)
- Testing
- EXCAP Exercise Program, 10-Hour Healthy Eating Timeframe (hEAT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Advanced HER2 Negative Breast Carcinoma HRD+Breast Cancer
Fluzoparib in Combination With or Without Camrelizumab for Homologous Recombinant Deficiency (HRD) HER2 Negative Advanced Breast Cancer
This study is planned to include 80 patients with HRD positive HER2-negative advanced breast cancer to receive fluzoparib alone or fluzoparib combined with camrelizumab to observe and evaluate the efficacy and safety of…
- Trial name
- NCT05656131
- Testing
- Fluzoparib, Fluzoparib+Camrelizumab
- Where
- China
- Volunteers
- 80 people
- Sponsor
- wang shusen
Breast Cancer, Breast Neoplasms
Combination Chemotherapy (FLAC) Combined With Granulocyte-Macrophage Colony Stimulating Factor in Locally Advanced and Metastatic Breast Cancer
To evaluate a dose intensive chemotherapy regimen for the treatment of locally advanced and metastatic breast cancer using granulocyte-macrophage colony-stimulating factor (GM-CSF) to ameliorate chemotherapy-induced toxicity.
- Trial name
- NCT00001239
- Testing
- FLAC with GM-CSF
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Paclitaxel Plus Monoclonal Antibody Therapy in Treating Women With Recurrent or Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them…
- Trial name
- NCT00003539
- Testing
- trastuzumab, paclitaxel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer Related Lymphedema
Factors Associated With Health-related Quality of Life in Patients With Breast Cancer-Related Lymphedema Undergoing Prospective Surveillance
Breast cancer-related lymphedema (BCRL) is a chronic condition that affects more than 1 in 5 breast cancer survivors. It causes swelling, pain, and reduced arm function, which can significantly impact quality of life.
- Trial name
- NCT07165275
- Where
- South Korea
- Volunteers
- 203 people
- Sponsor
- Samsung Medical Center
Breast Cancer, Lymph Node Metastasis
Serum and Tissue Metabolite-based Prediction of Sentinel Lymph Node Metastasis in Breast Cancer
Breast cancer is a malignant tumor with the highest morbidity and mortality among women worldwide. Accurate staging of axillary lymph nodes is critical for metastatic assessment and decisions regarding treatment modalities in…
- Trial name
- NCT06001528
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- Shantou Central Hospital
Metastatic Breast Cancer
Treatment of Metastatic Breast Cancer With Fulvestrant Plus Palbociclib or Tamoxifen Plus Palbociclib
To assess longitudinal changes in allele frequency of ESR1 mutation in plasma in patients treated with Fulvestrant plus palbociclib compared to tamoxifen plus palbociclib
- Trial name
- NCT02913430
- Testing
- Fulvestrant, Tamoxifen, Palbociclib
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Shannon Puhalla
Breast Neoplasms, Insomnia
Efficacy of Acupuncture Treatment for Breast Cancer-associated Insomnia
Through a scientific and standardized multicenter, randomized, and controlled study method, the investigators evaluated the clinical efficacy and safety of acupuncture in the treatment of breast cancer-related insomnia, with a…
- Trial name
- NCT05510700
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Yin Ping
pCR Rate, BCT Rate
NeoMET Study in Neoadjuvant Treatment of Breast Cancer
To evaluate docetaxel, epirubicin and cyclophosphomide (TEC) with TEC plus metformin in neoadjuvant treatment of breast cancer patients.
- Conditions
- pCR Rate, BCT Rate, Safety
- Trial name
- NeoMET (NCT01929811)
- Testing
- Metformin, Docetaxel, Epirubicin
- Where
- 2 sites in China
- Volunteers
- 92 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
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