Clinical trials: Breast Cancer, Breast Neoplasms
Metastatic Urothelial Carcinoma, Breast Cancer
Imaging Study in Metastatic UC, HR+ and HER2- Breast Cancer, TNBC, and NSCLC
This imaging study aims to assess the feasibility, biodistribution, and dosimetry of the imaging agent in subjects with metastatic UC, HR+ and HER2- breast cancer, TNBC, or NSCLC.
- Conditions
- Metastatic Urothelial Carcinoma, Breast Cancer, TNBC - Triple-Negative Breast Cancer, Hormone Receptor Positive HER-2 Negative Breast Cancer
- Trial name
- NCT07671092
- Testing
- RYZ211/212
- Where
- 6 sites in Australia, New Zealand and 1 more
- Volunteers
- 40 people
- Sponsor
- RayzeBio, Inc.
Breast Cancer Susceptibility Gene (BRCA1) Mutation, BRCA2 Mutation
Cognitive Behavioral Therapy for Fear of Cancer Recurrence in Women With BRCA1/2 Gene
The goal of this clinical trial is to determine whether an adapted version of a current cognitive-behavioural group therapy (CBT) protocol for cancer survivors to the specific needs of women who are carriers of the BRCA1/2…
- Conditions
- Breast Cancer Susceptibility Gene (BRCA1) Mutation, BRCA2 Mutation, Fear of Cancer Recurrence
- Trial name
- CBT-FCRBRCA1/2 (NCT06817694)
- Testing
- Cognitive-behavioral group therapy
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- CHU de Quebec-Universite Laval
Breast Cancer Metastatic
Efficacy of High Dose Tamoxifen to Advanced Hormone Receptor-High Expressed Breast Cancer
Background: Endocrine therapy is an effective and safe treatment for hormone receptor positive breast cancer. Unfortunately , endocrine treatment resistance occurs and there is an urgent need for treatment alternative.
- Trial name
- NCT03045653
- Testing
- Tamoxifen Oral Product
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Breast Cancer
Intensive Sequential Chemotherapy With Adriamycin Taxol and Cytoxan in the Treatment of Locally Advanced Breast Cancer
Intensive sequential chemotherapy with Adriamycin Taxol and Cytoxan in the treatment of locally advanced breast cancer
- Trial name
- NCT00538395
- Testing
- Adriamycin, Taxol and Cytoxan
- Volunteers
- 100 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Breast Cancer
A Study of Clinical Outcomes for the NanoString® Technologies Prosigna™ Gene Signature Assay
The primary objective of this study is to evaluate the impact of the result of the Prosigna Test (assay) on the therapeutic decision of adjuvant therapy (chemotherapy and hormone therapy) in patients suffering from early-stage…
- Trial name
- NCT02395575
- Where
- France
- Volunteers
- 200 people
- Sponsor
- NanoString Technologies, Inc.
Pain, Chronic, Breast Cancer
Optimizing Psychological Treatment for Pain After Breast Cancer
The present study aims to optimize psychological treatment for pain after breast cancer by identifying active treatment components.
- Trial name
- NCT05444101
- Testing
- Mindful attention, Decentering, Values and committed action
- Where
- Denmark
- Volunteers
- 185 people
- Sponsor
- University of Aarhus
Breast Cancer
External-Beam Partial-Breast Irradiation for Early Breast Cancer 40 Gy QD Over 2 Weeks
Standard therapy for patients with early stage breast cancer consists of surgery to remove the cancer followed by radiation therapy.
- Trial name
- NCT01581619
- Testing
- External Beam Partial-Breast Irradiation
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer, Metastatic Triple Negative
Study to Assess the Efficacy of Pembrolizumab Plus Radiotherapy in Metastatic Triple Negative Breast Cancer Patients
The purpose of this study is to find out what effects, good and/or bad, pembrolizumab has on the patient and areas of cancer in their body that did not receive radiation therapy.
- Trial name
- NCT02730130
- Testing
- Pembrolizumab, Radiotherapy
- Where
- 7 sites in United States
- Volunteers
- 17 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chemotherapy Associated Neutropenia, Breast Cancer
Phase III Study Comparing the Efficacy and Safety of EP2006 and Filgrastim
The study will assess the efficacy of EP2006 compared to Filgrastim with respect to the mean duration of severe neutropenia during treatment with myelosuppressive chemotherapy in breast cancer patients.
- Trial name
- PIONEER (NCT01519700)
- Testing
- EP2006, Filgrastim
- Where
- 26 sites in Czechia, Hungary and 4 more
- Volunteers
- 218 people
- Sponsor
- Sandoz
Breast Cancer
Multimodal Imaging Evaluation System of Axillary Lymph Node Staging and Treatment Strategy for Breast Cancer Neoadjuvant Therapy
In view of the lack of systematic curative effect prediction and early evaluation indicators for breast cancer neoadjuvant chemotherapy, the effective fusion of CEUS（contrast-enhanced ultrasound） and MRI is realized, and a…
- Trial name
- MIES-BCNAT (NCT04661436)
- Testing
- Contrast-Enhanced Ultrasound
- Volunteers
- 300 people
- Sponsor
- Sichuan Provincial People's Hospital
Radiodermatitis, Breast Cancer
Photobiomodulation Therapy for the Prevention of Acute Radiodermatitis in Breast Cancer Patients Undergoing Radiotherapy
Radiodermatitis (RD), an inflammatory skin reaction, occurs in more than 90 percent of cancer patients treated with radiotherapy (RT). This is the result of the radiation causing damage to the epidermal basal skin stem cells.
- Trial name
- LABRA (NCT03924011)
- Testing
- Photobiomodulation therapy (PBMT)
- Where
- 2 sites in Belgium
- Volunteers
- 71 people
- Sponsor
- Hasselt University
Breast Neoplasms, Arthralgia
CYP19 Genetic Polymorphism & Aromatase Inhibitor(AI)
The purpose of this study is to investigate the relationship between the side effects(especially arthralgia and arthritis) which appear in the patients who are prescribed aromatase inhibitor(AI) and the CYP19 genetic…
- Conditions
- Breast Neoplasms, Arthralgia, Arthritis, Genetic Polymorphism
- Trial name
- AI-CYP19 (NCT00973505)
- Testing
- Aromatase Inhibitor(Femara or Arimidex)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Anam Hospital
Breast Cancer
Views on Sharing Family Medical History in Healthy Women Undergoing Mammograms or Breast Evaluation
RATIONALE: Learning about the concerns that individuals may have about providing family medical history online for genetic risk assessment or research may help doctors plan future research.
- Trial name
- NCT00530751
- Testing
- counseling intervention
- Where
- 7 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Impact of Art Therapy on Fatigue and Quality of Life of Patients Treated With Adjuvant Radiotherapy for Breast Cancer
The purpose of this study is to compare intervention by Art-therapy to standard care in patients treated with adjuvant radiotherapy for breast cancer and evaluate the fatigue.
- Trial name
- ART-THERAPIE (NCT01331629)
- Testing
- ART-THERAPIE
- Where
- 6 sites in France
- Volunteers
- 322 people
- Sponsor
- Centre Francois Baclesse
Breast Cancer, Infertility
Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Goserelin may help prevent early menopause in patients undergoing chemotherapy for breast cancer. It is not yet known whether goserelin is effective in preventing early menopause in women undergoing chemotherapy for…
- Conditions
- Breast Cancer, Infertility, Menopausal Symptoms
- Trial name
- NCT00427245
- Testing
- cyclophosphamide, goserelin acetate, adjuvant therapy
- Where
- 66 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- Anglo Celtic Cooperative Oncology Group
Breast Cancer, Hot Flashes
S9626: Megestrol in Treating Hot Flashes Following Treatment for Breast Cancer
RATIONALE: Megestrol may be effective in treating hot flashes following treatment for breast cancer. It is not yet known which regimen of megestrol is most effective for hot flashes.
- Trial name
- NCT00005975
- Testing
- Megestrol Acetate 20mg/day, Megestrol Acetate 40 mg/day
- Volunteers
- 288 people
- Sponsor
- SWOG Cancer Research Network
Breast Cancer, Breast Cancer - Female
TEEL Study- Phase 1 Tamoxifen and Ribociclib (LEE011) in Advanced ER+ (HER2 Negative) Breast Cancer
The purpose of this study is to find out if the investigational drug Ribociclib (LEE011), when taken with standard treatment (Tamoxifen +/- Goserelin) is safe and has beneficial effects in pre-menopausal and post-menopausal women…
- Conditions
- Breast Cancer, Breast Cancer - Female, Breast Cancer - Male
- Trial name
- NCT02586675
- Testing
- Tamoxifen, Ribociclib, Goserelin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Breast Cancer
Effects of Mindfulness Meditation and Stress Management After Breast Cancer
The primary aim of this study is to examine the effects of a mindfulness-based stress reduction training program, delivered in individual web-based sessions, among breast cancer patients.
- Trial name
- NCT02119481
- Testing
- Mindfulness-based stress reduction, Expressive writing condition
- Where
- Sweden
- Volunteers
- 142 people
- Sponsor
- Karolinska Institutet
Breast Cancer
Neoadjuvant Chemotherapy With a Combination of Pegylated Liposomal Doxorubicin (Caelyx®) and Paclitaxel in Breast Cancer
In this study, PLD, an anthracycline encapsulated in stealth liposomes, which are believed to efficiently deliver the doxorubicin within the tumour mass with less toxicity compared with standard doxorubicin formulation was used.
- Trial name
- NCT03221881
- Testing
- Pegylated Liposomal Doxorubicin and docetaxel
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Hebei Medical University Fourth Hospital
Recurrent Breast Carcinoma, Ipsilateral Recurrence
Preoperative Partial Breast Reirradiation and Repeat Breast-conserving Surgery in Patients With Recurrent Breast Cancer: the REPEAT Trial
Over the past decades, interest in second breast-conserving therapy (BCT) has increased due to, among others, advancements in radiotherapy techniques.
- Trial name
- REPEAT (NCT06640881)
- Testing
- ablative single-dose PBI
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Amsterdam UMC, location VUmc
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