Clinical trials: Breast Cancer, Female
Breast Cancer Female
Validation of Prone Crawl Radiotherapy for Whole-breast Irradiation After Breast Conserving Surgery
The aim of this study is to validate the obtained results of setup precision, comfort and setup time. The possibility of using breath hold for heart sparing in combination with prone crawl position will be tested.
- Trial name
- NCT05179161
- Testing
- Prone crawl positioning
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Genetic Testing, BRCA1/2
Responses to Genetic Risk Modifier Testing Among Women With Pathogenic Variants in Breast Cancer Predisposition Genes
The purpose of this study is to describe how women with BRCA1/2 mutations react to genetic risk modifier testing, and to examine how they make decisions about their healthcare.
- Trial name
- NCT03396341
- Testing
- Salvia sample, Questionnaires, Buccal swab sample
- Where
- 7 sites in United States
- Volunteers
- 806 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
BRCA1 Mutation Carrier, BRCA2 Mutation Carrier
Transdermal or Oral Telapristone Acetate in Treating Patients Undergoing Mastectomy
This randomized trial studies transdermal or oral telapristone acetate in treating patients undergoing surgery to remove the breast (mastectomy).
- Conditions
- BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Ductal Breast Carcinoma In Situ, Lobular Breast Carcinoma In Situ
- Trial name
- NCT02314156
- Testing
- Telapristone Acetate, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- 3 sites in United States
- Volunteers
- 67 people
- Sponsor
- Northwestern University
Breast Cancer Survivor, Pediatric Cancer Survivor
Assessment of Ovarian Reserve in Female Cancer Survivors
Chemotherapy can damage the ovaries and cause premature menopause. In women treated before the age of 40 years, menopause does not usually occur.
- Trial name
- NCT01062542
- Testing
- Blood Draw and Ultrasound
- Where
- Canada
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8
Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer
This clinical trial tests feasibility, acceptability and how well a virtual mental health intervention, compared to enhanced usual care consisting of an educational intervention, works to address fear of progression for women…
- Conditions
- Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Endometrial Carcinoma, Endometrial Endometrioid Adenocarcinoma
- Trial name
- NCT07226102
- Testing
- Behavioral Intervention, Educational Intervention, Internet-Based Intervention
- Where
- 12 sites in United States
- Sponsor
- City of Hope Medical Center
Breast Cancer, Ovarian Epithelial Cancer Recurrent
Mifepristone and Eribulin in Patients With Metastatic Triple Negative Breast Cancer or Other Specified Solid Tumors
This is a study to assess the safety of the combination of mifepristone and eribulin in patients with metastatic or locally advanced unresectable breast or other specified solid tumors, and determine preliminary efficacy of the…
- Conditions
- Breast Cancer, Ovarian Epithelial Cancer Recurrent, Sarcoma, Non-small Cell Lung Cancer
- Trial name
- NCT02014337
- Testing
- Mifepristone and Eribulin in combination
- Where
- 11 sites in United States
- Volunteers
- 37 people
- Sponsor
- Corcept Therapeutics
Breast Cancer, Neoadjuvant Chemotherapy
The Effect of Neoadjuvant Chemotherapy on Physical Functions
The aim of this observational study was to investigate the effect of neoadjuvant chemotherapy on physical functioning in individuals with breast cancer.
- Conditions
- Breast Cancer, Neoadjuvant Chemotherapy, Neoadjuvant Therapy
- Trial name
- NCT06986005
- Testing
- No intervention will be performed as part of this study. However, regardless of the study, all participants will receive neoadjuvant chemotherapy.
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- ATİYE KAŞ ÖZDEMİR
NRG1 Fusion, Pancreatic Cancer
Early Access Program Providing HER2/HER3 Bispecific Antibody, MCLA-128, for a Patient With Advanced NRG1-Fusion Positive Solid Tumor
Merus is providing single patient/named access to the HER2/HER3 bispecific antibody, MCLA-128, to patients with advanced NRG1-fusion positive solid tumor under this early access program who are ineligible for an ongoing MCLA-128…
- Conditions
- NRG1 Fusion, Pancreatic Cancer, Non Small Cell Lung Cancer, Solid Tumor, Unspecified, Adult
- Trial name
- NCT04100694
- Testing
- MCLA-128
- Sponsor
- Merus B.V.
Breast Cancer
Radiation Therapy After Surgery in Treating Women With Early Stage Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which regimen of radiation therapy is more effective following surgery for breast cancer.
- Trial name
- NCT00005588
- Testing
- radiation therapy
- Where
- 32 sites in United Kingdom
- Sponsor
- Medical Research Council
Breast Cancer
Improving Uptake of Genetic Cancer Risk Assessment in African American Women- Video
Genetic counseling and testing (GCT) provides invaluable information for women who are at-risk of hereditary breast and/or ovarian cancer (HBOC). Black women underutilize GCT compared to White women.
- Trial name
- NCT04476654
- Testing
- YouTube Video Arm
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Virginia Commonwealth University
Malignant Solid Tumour, Breast Cancer
Vaccine Therapy in Treating Patients With Metastatic Solid Tumors
This phase I trial studies the side effects and best dose of vaccine therapy in treating patients with metastatic solid tumors. Vaccines made from antibodies and peptides combined with tumor cells may help the body build an…
- Conditions
- Malignant Solid Tumour, Breast Cancer, Malignant Tumor of Colon, GIST
- Trial name
- NCT01376505
- Testing
- HER-2 vaccine, Extension HER-2 vaccine trial at OBD
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Robert Wesolowski
Breast Cancer Survivors
Concurrent Exercise in Combination With Music Listening in Female Breast Cancer Survivors
This clinical trial aims to compare the effects of a concurrent physical exercise program (aerobic and resistance training) combined with music medicine versus exercise alone on self-perception (self-esteem and body image)…
- Trial name
- NCT07045961
- Testing
- Supervised Station-Based Strength Circuit Training & Self-directed aerobic training, Music Medicine
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Ana Trigueros Murillo
Breast Cancer, Ovarian Cancer
Study of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors.
This is a Phase 1, open-label, multicenter, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of PF-07224826, as a single agent or in…
- Conditions
- Breast Cancer, Ovarian Cancer, Liposarcoma, Non-small Cell Lung Cancer (NSCLC)
- Trial name
- NCT05905341
- Testing
- PF-07224826, Fulvestrant
- Sponsor
- Pfizer
Breast Cancer
Prevention of Breast Cancer: As Simple as hCG-A Randomized Clinical Trial in High Risk Women
The purpose of the study is to evaluate whether hCG will result in a decrease in breast density. High breast density has been associated with an increased risk in breast cancer.
- Trial name
- NCT00808522
- Testing
- hCG
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- New York Presbyterian Hospital
Depression, Anxiety
Validation of the Russian and Kazakh Versions of the Beck Depression Inventory and Beck Anxiety Inventory
Depression and anxiety in female patients with cancer are serious comorbidities that affect the quality of life for patients and their survival rates as they have poorer health outcomes.
- Conditions
- Depression, Anxiety, Breast Cancer, Ovarian Cancer
- Trial name
- NCT04630327
- Testing
- Beck Depression Inventory-21 (diagnostic survey), Beck Anxiety Inventory, Interview using The International Classification of Diseases in tenth edition (ICD-10) criteria
- Where
- 2 sites in Kazakhstan
- Volunteers
- 226 people
- Sponsor
- Kazakh Medical University of Continuing Education
Breast Neoplasms
Prevention of Female Cancers by Optimization of Selenium Levels in the Organism.
Hypothesis to be tested: Oral supplementation or diet modifications of selenium to a specified range will be effective in reducing the risk of developing cancer of any type in women with high risk of breast cancer, as compared to…
- Trial name
- SELINA (NCT04014283)
- Testing
- Diet modification
- Where
- Poland
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Read-Gene S.A.
Breast Cancer Detection, Dense Breast Parenchyma
Delphinus SoftVue™ ROC Reader Study
The purpose of this multi-reader, multi-case (MRMC) reader study is to evaluate reader performance when SoftVue™ automated breast ultrasound and screening mammography are combined, compared to screening mammography alone, in…
- Conditions
- Breast Cancer Detection, Dense Breast Parenchyma, Benign Breast Findings, Normal Breast Screening
- Trial name
- DMT SV RRS2 (NCT03972605)
- Testing
- Reading of Automated Breast Ultrasound in conjunction with Screening Mammography
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Delphinus Medical Technologies, Inc.
Breast Cancer
Breast Cancer Risk Assessment in Women Aged 40-49
In a randomized controlled trial, the investigators will test the effect of a novel strategy for breast cancer risk assessment and risk-based management of women in their 40s seen in primary care.
- Trial name
- NCT03180086
- Testing
- Breast cancer risk report
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- Beth Israel Deaconess Medical Center
Breast Cancer Female
Physical Training on Patients With Breast Cancer
The treatment of breast cancer at any given time can be through surgery, as well as adjuvant treatments (radiotherapy, chemotherapy and hormone therapy) alone or together.
- Trial name
- NCT03061773
- Testing
- Exercise, Conventional hospital treatment
- Volunteers
- 2 people
- Sponsor
- Federal University of Maranhao
Breast Density, Breast Cancer Female
ENGAGED 2 Study: Experiences With Mammography Screening and Breast Density 2
This trial will test a decision support web based intervention for women at increased risk for breast cancer due to breast density and other risk factors (age, race/ethnicity, family history of breast cancer, history of prior…
- Trial name
- NCT03029286
- Testing
- Usual Care Arm, Personalized Web Intervention Arm
- Where
- United States
- Volunteers
- 995 people
- Sponsor
- Georgetown University
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