Clinical trials: Breast Cancer (Early Breast Cancer)
Triple-negative Breast Cancer, TNBC - Triple-Negative Breast Cancer
Intratumoral INT230-6 Followed by Neoadjuvant Immuno-chemotherapy in Patients With Early TNBC. INVINCIBLE-4-SAKK
About 10-20% of all individuals with breast cancer have a so-called triple-negative tumor (TNBC). This type of breast cancer has a particularly unfavorable course and a higher mortality rate compared to other forms of breast…
- Trial name
- NCT06358573
- Testing
- INT230-6, neoadjuvant immuno-chemotherapy
- Where
- 10 sites in France, Switzerland
- Volunteers
- 61 people
- Sponsor
- Swiss Cancer Institute
Breast Cancer
Precision Medicine in Action: Phase II Trial of Response Adaptive Ablative Pre-operative SPBI (RAPS) and Non-operative Sentinel Lymph Node Biopsy in Patients With Early-stage ER+ Breast Cancer: RAPS Trial
1. Efficacy of PULSAR preoperative radiation 2. Evaluate potential of microbubble CEUS as an alternative to operative SLNBx 3. Evaluate potential of OA to evaluate treatment response of pre-operative radiation on the tumor
- Trial name
- NCT06444269
- Testing
- Radiomics on MRI, microbubble CEUS Contrast Enhanced Ultrasound (CEUS)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Texas Southwestern Medical Center
Cardiac Toxicity, Malignant Neoplasm
MRI in Detecting Heart Damage in Patients With Cancer Receiving Chemotherapy With Exercise Capacity Addendum
This trial studies how well magnetic resonance imaging (MRI) works in detecting heart damage in patients with cancer receiving chemotherapy.
- Conditions
- Cardiac Toxicity, Malignant Neoplasm, Breast Cancer
- Trial name
- NCT01719562
- Testing
- Magnetic resonance imaging, Physical Activity, Healthy Living
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer
Carvedilol for the Prevention of Anthracycline/Anti-HER2 Therapy Associated Cardiotoxicity Among Women With HER2-Positive Breast Cancer Using Myocardial Strain Imaging for Early Risk Stratification
The purpose of this study is to find out the effects, good and/or bad, of a beta blocker (carvedilol) on heart function during treatment with anti-HER2 medication(s) including trastuzumab (Herceptin).
- Trial name
- NCT02177175
- Testing
- Carvedilol
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Prognostic Evaluation of Changing Endocrine Therapy in Women With Breast Cancer
It suggests in the Guideline that the postmenopausal women with breast cancer who have taken selective estrogen receptor modulators (SERMs) therapy for 2-3 years could benefit from changing endocrine therapy to aromatase…
- Trial name
- NCT02097459
- Testing
- Anastrozole, Tamoxifen, Toremifene
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer
Maintenance Treatment With Capecitabine Versus Observation in Breast Cancer Patients
This is a prospective, open-label, randomized phase III study assessing adjuvant capecitabine after standard chemotherapy for patients with early triple negative breast cancer.
- Trial name
- NCT00130533
- Testing
- Capecitabine
- Where
- 48 sites in Spain
- Volunteers
- 876 people
- Sponsor
- Spanish Breast Cancer Research Group
Breast Cancer, Breast Cancer Non-invasive Breast Cancer
Molecular Analysis of Breast Cancer
This is a research-based study that is looking at the biologic features of breast tissue, lymph node tissue, or blood in order to study breast cancer development growth, and spread.
- Conditions
- Breast Cancer, Breast Cancer Non-invasive Breast Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Trial name
- NCT00569049
- Testing
- breast tissue, lymph node tissue or blood
- Where
- United States
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- Stanford University
Early Small (cT1N0) Triple Negative Breast Cancer
Short-term Pre-OPerative Durvalumab (MEDI 4736) in Early Small Triple Negative Breast Cancer Patients (POP-Durva)
This study aims to evaluate the efficacy and safety of preoperative Durvalumab in patients with early small (cT1N0) triple negative breast cancer tumors.
- Trial name
- POP-DURVA (NCT05215106)
- Testing
- Durvalumab
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Breast Cancer, Bone Density
Arimidex Bone Mass Index and Oral Bisphosphonates
To investigate the management of bone health in postmenopausal women with early breast cancer (BCA) scheduled to receive anastrozole.
- Trial name
- ARBI (NCT00809484)
- Where
- Greece
- Volunteers
- 220 people
- Sponsor
- Hellenic Breast Surgeons Society
Early-stage Breast Cancer
Study of Quality of Life and Hormone Levels in Premenopausal Participants With Early Breast Cancer Receiving Triptorelin Plus Additional Cancer Treatment
The main purpose of this study is to evaluate the quality of life of premenopausal participants with Hormone Receptor (HR) positive and Human Epidermal Growth Factor Receptor-2 (HER2) negative breast cancer who are receiving, in…
- Trial name
- ROSE (NCT05377684)
- Where
- 22 sites in Italy
- Volunteers
- 450 people
- Sponsor
- Ipsen
Breast Cancer
Clinical and Biological Study of Early-onset Breast Cancer and the Influence of the Reproductive Cycle on the Aggressiveness of the Disease
The incidence of breast cancer is increasing, particularly among young women. Cancers in young women are associated with a poor prognosis. The causes remain poorly understood.
- Trial name
- ARTEMIS (NCT07601152)
- Testing
- No Intervention: Observational Cohort
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer, Lymph Node Metastasis
Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer
The purpose of this study is to determine how circulating tumor DNA (ctDNA), a sign of minimal residual disease (MRD), is detectable after surgery in patients with early HR+/HER2- breast cancer that has spread to 1-3 lymph nodes.
- Trial name
- NCT07025785
- Testing
- Circulating tumor DNA
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Adjuvant Dynamic Marker-Adjusted Personalized Therapy Trial Optimizing Risk Assessment and Therapy Response Prediction in Early Breast Cancer
Trial for the optimization of risk assessment and therapy success prediction in patients with early breast cancer by the use of biomarkers in advance to therapy decision-making to personalize therapies.
- Trial name
- ADAPT (NCT01781338)
- Testing
- Induction therapy
- Where
- 2 sites in Germany
- Volunteers
- 4,936 people
- Sponsor
- Women's Cancer Study Group GmbH
Breast Cancer
To Evaluate the Cardiac Safety of Pegylated Liposomal Doxorubicin Concurrently Plus Trastuzumab and Pertuzumab in the Adjuvant Setting for Early-stage HER-2-positive Breast Cancer: a Multicenter, Randomized Controlled Clinical Study
To evaluate the safety and efficacy of pegylated liposomal doxorubicin/cyclophosphamide/trastuzumab/pertuzumab followed by docetaxel/ trastuzumab/pertuzumab compared with epirubicin/cyclophosphamide followed by…
- Trial name
- easy laugh (NCT05656079)
- Testing
- Pegylated liposomal doxorubicin, Epirubicin, Cyclophosphamid
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Pudong Hospital
Breast Cancer, Gynecologic Cancer
Evaluation of Hydroxychloroquine to Prevent CIPN
The study is being done to research if hydroxychloroquine can prevent chemotherapy induced peripheral neuropathy. Certain chemotherapy drugs, like paclitaxel, are known to cause neuropathy which can impact quality of life.
- Conditions
- Breast Cancer, Gynecologic Cancer, Early-stage Breast Cancer, Peripheral Neuropathy
- Trial name
- NCT05689359
- Testing
- Hydroxychloroquine
- Sponsor
- University of Arizona
Early-Stage Breast Cancer
Tangential Radiation Therapy Without Axillary Dissection in Breast Cancer
The purpose of this study is to evaluate whether treatment to the axilla (area under the arm) can be safely minimized by omitting axillary surgery and full axillary radiation therapy and replacing it with radiation therapy to the…
- Trial name
- NCT00165243
- Testing
- Tangential radiation
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Assessment of Automated Breast Ultrasound
The investigators are interested in assessing the value of and comparing the use of automated breast ultrasound (ABUS) (either as a primary screening approach or as a supplementary procedure) with digital breast tomosynthesis…
- Trial name
- NCT02386176
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Breast Conserving Surgery, Endoscopic Surgery
Single Port Endoscopic Breast Conserving Surgery
The center plans to carry out a prospective clinical study of single hole total endoscopic breast conserving surgery for early breast cancer compared with open breast conserving surgery, to provide high-level evidence-based…
- Trial name
- NCT06593132
- Testing
- endoscopic breast conserving surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ren,Yu
Female Breast Cancer
PROOFS-Registry - Premenopausal Women With Breast Cancer Optimally Treated With OFS
There is only limited data for premenopausal patients in general, as well as for differences in the use of OFS in the subgroups of pre- and perimenopausal patients, respectively.
- Trial name
- PROOFS (NCT05792150)
- Where
- 71 sites in Germany
- Volunteers
- 1,470 people
- Sponsor
- Women's Cancer Study Group GmbH
Breast Cancer, Adjuvant Chemotherapy
Relationship Between Gut Microbiome and Adjuvant Chemotherapy in Patients With Early Breast Cancer
Breast cancer is the most common cause of cancer death in women. Adjuvant chemotherapy significantly reduces the risk of recurrence of high-risk breast cancer.
- Trial name
- NCT03702868
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Sun Yat-sen University
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