Clinical trials: Breast Cancer Risk Factors
Breast Cancer Females
Short-term Impacts of Endocrine Therapy on Cardiovascular and Brain Health Outcomes in Breast Cancer
Aromatase inhibitors are the most used endocrine therapy for hormone-positive breast cancer. While there is a clear linear relationship between the duration of aromatase inhibitor use and the cumulative incidence of…
- Trial name
- STRIVE (Acute) (NCT06781762)
- Testing
- N/A (Usual Care)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Toronto
HER2-positive Breast Cancer
Neratinib in Extended Adjuvant Treatment for HER2+ Early Breast Cancer With pCR But High-Risk Features: A Hebei Multi-Center Real-World Study
Neratinib is an oral, irreversible pan-HER tyrosine kinase inhibitor. Current treatment guidelines recommend neratinib as an extended adjuvant therapy for HER2-positive breast cancer patients to further reduce the risk of…
- Trial name
- NCT07019272
- Testing
- Neratinib (HKI-272)
- Volunteers
- 170 people
- Sponsor
- Hebei Medical University Fourth Hospital
Breast Cancer Prevention
MELIORA Virtual Coach Intervention for Breast Cancer Prevention
Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide, with early-onset cases increasing due to genetic and lifestyle factors.
- Trial name
- MELIORA (NCT07200427)
- Testing
- MELIORA Virtual Coach Intervention, Control (generic advice)
- Where
- 7 sites in Greece, Lithuania and 2 more
- Volunteers
- 2,080 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Breast Neoplasms, Breast Cancer
Paclitaxel-induced Polyneuropathy in Breast Cancer: Early Detection, Risk Factors, Quality of Life and Lifestyle Outcomes
This is a single center prospective observational cohort study that aims to: examine and identify possible risk and susceptibility factors for the incidence and progression of chemotherapy-induced polyneuropathy (CIPN) in female…
- Conditions
- Breast Neoplasms, Breast Cancer, Early-stage Breast Cancer, Non-Metastatic Breast Carcinoma
- Trial name
- CIPN-REBECCA (NCT06052345)
- Testing
- Garmin smartwatch, REBECCA Mobile application, REBECCA PC plug-in
- Where
- Sweden
- Sponsor
- Theodoros Foukakis
Breast Cancer
Coronary Artery Calcium and Cardiovascular Risk Factors Analysis After RT or Breast Cancer
This is a no-profit, national, monocenter, retrospective, and prospective low-intervention study. It is a low-intervention study in terms of diagnostic additional procedure (CT scan).
- Trial name
- RadioTherapy (NCT05775822)
- Testing
- CT scan and blood sample collection
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- Centro Cardiologico Monzino
Breast Cancer, Aromatase Inhibitors
Prevalence and Risk Factors for Pain and Related Adverse Reactions Among Breast Cancer Survivors on Aromatase Inhibitors
We obtained the occurrence of pain sensation, pain mood, sleep, etc. during endocrine therapy in breast cancer patients through telephone follow-up, and analyzed risk factors through artificial intelligence
- Conditions
- Breast Cancer, Aromatase Inhibitors, Endocrine Therapy, Pain
- Trial name
- NCT05628077
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Peking University People's Hospital
Weight Loss, Breast Cancer Risk Factors
Addressing Modifiable Breast Cancer Risk Factors With Project CONECT
The objective of this protocol is to adapt and pilot test an existing lifestyle modification intervention for weight loss for women with overweight or obesity who have had a recent false positive mammography screen.
- Trial name
- NCT02871388
- Testing
- CONECT
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Metabolic Syndrome as Breast Cancer Risk Factor
Metabolic Syndrome as Modifiable Risk Factor for Breast Cancer
Healthy women and women with breast cancer have been enrolled in our nested case-control study between 2008 and 2009 in order to evaluate the association between metabolic syndrome and breast cancer, analyzing anthropometric…
- Trial name
- NCT01172886
- Where
- Italy
- Volunteers
- 777 people, healthy volunteers welcome
- Sponsor
- Sbarro Health Research Organization
Colon Cancer, Breast Cancer
An Integrated Genomic Approach to Assess Genetic Risk and Drug Sensitivity
National multicenter prospective study, involving the enrollment of approximately 1,500 patients with ovarian cancer, 1,500 patients with breast cancer, and 1,000 patients with colorectal cancer.
- Conditions
- Colon Cancer, Breast Cancer, Ovarian Cancer, Genetic Risk Factors
- Trial name
- GERSOM (NCT07555639)
- Testing
- Genomic profile
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Health Knowledge, Attitudes, Practice, Alcohol Consumption
Increasing Knowledge of Alcohol as a Risk Factor for Breast Cancer Among Women Attending Breast Screening Services
Alcohol is a major modifiable risk factor for breast cancer in women, yet this is not widely understood by health practitioners or policy makers, let alone the general population.
- Trial name
- Health4Her (NCT04715516)
- Testing
- alcohol brief intervention, lifestyle health promotion
- Where
- Australia
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Turning Point
Breast Cancer
Breast Tissue Study of Breast Diseases Among Women in Hong Kong
Background: The Chinese University of Hong Kong and the National Cancer Institute are conducting a breast tissue study in connection with another study on breast health.
- Trial name
- NCT01885039
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Ethnic Predisposition, Risk Factors & Breast Cancer Presentation.
Breast cancer, a leading cause of mortality among females, has been the center of research for many decades. Work is in progress to further advance the research worldwide and in our region.
- Trial name
- BC (NCT05458570)
- Testing
- Breast Cancer positive patients
- Where
- Pakistan
- Volunteers
- 500 people
- Sponsor
- Bahria University
Breast Cancer
Partial Breast Proton Therapy for Early Stage Breast Cancer
The purpose of this is to determine the efficacy and toxicity of proton therapy when used to deliver partial breast radiotherapy in patients with early stage breast cancer with low or intermediate risk factors.
- Trial name
- NCT01310530
- Testing
- Proton Beam Radiotherapy
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Loma Linda University
Breast Neoplasms, Pain, Postoperative
Persistant Post-mastectomy Pain in Breast Cancer : Incidence and Risk Factors
Post Mastectomy Pain Syndrome (PMPS) is a major complication of breast surgery responsible for depression and disability. The project consists of a prospective cohort on patients going for oncological breast surgery at National…
- Conditions
- Breast Neoplasms, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT04676438
- Where
- 2 sites in Morocco
- Volunteers
- 722 people
- Sponsor
- Moroccan Society of Surgery
Breast Cancer, Chemotherapy Effect
Efficacy of Supplement Adjuvant Capecitabine in HR+/HER2- Breast Cancer Patients With High Risks
According to the latest data from the World Health Organization's International Agency for Research on Cancer (IARC) for 2020, breast cancer has been the most prevalent cancer with 2.26 million new cases.
- Trial name
- NCT05212454
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer Risk Factors
Night-shift Work and Breast Cancer
Scientific evidence established about the effects of night work on health both in the short term (insomnia, excessive sleepiness, difficulty concentrating or lack of energy) and in the long term (moderately high risk of…
- Trial name
- BC-NSW-02/2023 (NCT06786949)
- Testing
- Questionnaire, Blood samples for biomarker measurement
- Where
- 2 sites in Italy
- Volunteers
- 6,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Breast Neoplasm Female, Nutrition Related Cancer
Study for the Knowledge of Risk Factors Associated With Breast Cancer in Women
Breast cancer is the most frequent tumor in Western women. In Spain about 26,000 new breast cancers are diagnosed each year. This type of tumor is increasing worldwide with an increase in aggressive neoplasms in young women.
- Conditions
- Breast Neoplasm Female, Nutrition Related Cancer, Habits, Diet, Cancer, Breast
- Trial name
- Mamanut (NCT03918668)
- Testing
- Women with recent diagnosis of breast cancer
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Breast Neoplasm, Primary Prevention
Project Breast47: Effect of an Educational Intervention
Breast cancer is the most frequently diagnosed malignant tumor in women. In 2018, in Spain, the estimated incidence was 101/100,000 women.
- Conditions
- Breast Neoplasm, Primary Prevention, Risk Factors, Telemedicine
- Trial name
- Breast47 (NCT05267171)
- Testing
- Web access
- Where
- Spain
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Axillary Web Syndrome, Breast Cancer
Axillary Web Syndrome After Breast Cancer Surgery: Incidence, Risk Factors, and Functional Outcomes
Axillary web syndrome (AWS), sometimes called "cording," is a condition that can develop after breast cancer surgery in which the lymph nodes under the arm are removed or sampled.
- Conditions
- Axillary Web Syndrome, Breast Cancer, Breast Cancer Lymphedema, Postoperative Complications
- Trial name
- NCT07780240
- Testing
- Axillary surgery (sentinel lymph node biopsy or axillary lymph node dissection)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Antalya City Hospital
HER2-positive Breast Cancer
Identification of Risk Factors for Brain Recurrence in Patients With HER2-positive Localised Breast Cancer
HER2 gene amplification, detected in 20% to 30% of breast cancers, was a poor prognostic factor before the advent of anti-HER2 therapies.
- Trial name
- CRANIUM (NCT06358625)
- Testing
- Pre-treatment biopsy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Center Eugene Marquis