Clinical trials: Breast Cancer Surgery
Breast Cancer, Mastectomy
Effect of Patient-Anesthesiologist Gender Concordance and Analgesia Method on Postoperative Pain in Mastectomy Patients
This prospective observational study aims to evaluate the effect of anesthesiologist gender and patient-anesthesiologist gender concordance, as well as the analgesia method, on postoperative pain levels and analgesic requirements…
- Conditions
- Breast Cancer, Mastectomy, Postoperative Pain, Analgesic Use
- Trial name
- NCT07035275
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Morphine Consumption
The Effect of Intraoperative Dexmedetomidine on Postoperative Morphine Requirements After Breast Cancer Surgery
Dexmedetomidine is an α2 receptor agonist with sedative and analgesic properties. In previous reports, dexmedetomidine improves smoothness of postoperative recovery and reduces intraoperatory imflammatory responses.
- Trial name
- NCT04454515
- Testing
- Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Breast Neoplasms, Pain,Postoperative
Chlorhydrate of Ropivacaine and Breast Cancer Surgery
The aim of the study is to evaluate the effect of local anesthetic (chlorhydrate of ropivacaine) to prevent chronic pain after breast surgery for cancer.
- Trial name
- NCT00370240
- Testing
- Chlorhydrate de Ropivacaine
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Institut Curie
Breast Cancer
"The Efficacy of 'Radioguided Occult Lesion Localization' (ROLL) Versus 'Wire-guided Localization' (WGL) in Breast Conserving Surgery for Non-palpable Breast Cancer: a Randomized Clinical Trial"
Rationale: Approximately 25% of breast cancers detected are non palpable. Accordingly, a localization technique is required to help the surgeon to find and remove the cancer.
- Trial name
- ROLL (NCT00539474)
- Testing
- Radio guided occult lesion localisation
- Where
- 4 sites in Netherlands
- Volunteers
- 316 people
- Sponsor
- UMC Utrecht
Breast Cancer Surgery Pain
The Effect of Nerve Blocks on Analgesia in Breast Cancer Surgery
Postoperative pain following modified radical mastectomy remains a significant clinical concern and may adversely affect patient recovery, opioid consumption, and overall patient satisfaction.
- Trial name
- breast surgery (NCT07601490)
- Testing
- Serratus Posterior Superior Intercostal Plane Block, Serratus anterior plane block (SAP)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Breast Cancer Patients
Efficacy and Safety of Dexmedetomidine Added to Modified Pectoral's Block in Breast Cancer Patients
To Evaluate the effect of addition of Dexmedetomedine to ultrasound guided modified Pecs block on post operative analgesia \& stress response in patient undergoing modified radical mastectomy.
- Trial name
- NCT03046238
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- South Egypt Cancer Institute
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Radiation Therapy Boost Before Surgery for the Treatment of Non-metastatic Breast Cancer
This phase II trial investigates the safety of delivering a part (boost) of radiation treatment before breast surgery in treating patients with breast cancer that has not spread to other places in the body (non-metastatic).
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- NCT04871516
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Radiation Boost
- Where
- 11 sites in United States
- Volunteers
- 103 people
- Sponsor
- Rutgers, The State University of New Jersey
Breast Cancer
A Pilot Study of a Brief Pre-Operative Intervention for Patients Undergoing Breast Surgery
This study is to assess the feasibility of using a positive activities intervention, Positive Piggy Bank, in newly diagnosed women with breast cancer who will soon undergo surgery.
- Trial name
- NCT02939040
- Testing
- Positive Activities
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Michigan
Breast Cancer Female
Selective Omission of Axillary Surgery in Triple-negative and HER2-positive Breast Cancer After NACT
Neoadjuvant chemotherapy (NACT) is standard treatment for many triple-negative (TNBC) and HER2-positive breast cancer. Study showed about half of the biopsy-proven axillary disease will be eradicated by NACT and converted to ypN0…
- Trial name
- NCT05314114
- Testing
- No axillary surgery
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Peking University
Breast Cancer, Lifestyle
Prehabilitation and Rehabilitation in Breast Cancer Surgery Patients - a Pilot Study
Prehabilitation and rehabilitation through personalized lifestyle counseling in patients with breast cancer.
- Conditions
- Breast Cancer, Lifestyle, Rehabilitation, Prehabilitation
- Trial name
- BREHAB (NCT06076616)
- Testing
- Prehabilitation and rehabilitation
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Franciscus Gasthuis
Breast Neoplasm Female, Lymphatic Metastasis
Omitting Biopsy of SEntinel Lymph Node With Radiation After Neoadjuvant Chemotherapy in Breast Cancer (OBSERB) Trial
The OBSERB study is a multi-center, non-blinded, pragmatic, parallel, randomized controlled trial in which patients with cT1-3N1 and ycN0 breast cancer.
- Trial name
- OBSERB (NCT04116125)
- Testing
- Radiotherapy
- Volunteers
- 1,380 people
- Sponsor
- Kyungpook National University Chilgok Hospital
Lymphedema, Lymphedema Arm
The Robot-LVA Study: Robot-assisted Microsurgical Lymphaticovenous Anastomosis in Breast Cancer-related Lymphedema
This study assesses the performance of robot-assisted microsurgery. Lymphaticovenous anastomosis (LVA) is the most difficult procedure in microsurgery at this moment.
- Conditions
- Lymphedema, Lymphedema Arm, Lymphedema of Upper Arm, Lymphedema of Upper Limb
- Trial name
- NCT06532955
- Testing
- Lymphaticovenous anastomosis using Microsure Motion Stabilizer, Lymphaticovenous anastomosis (manual)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Maastricht University Medical Center
Breast Cancer
High Five (HiFi) Accelerated Partial Breast Irradiation Study
To establish the role of adjuvant multicatheter interstitial high-dose-rate brachytherapy in doubly accelerated and radiobiologically equivalent irradiation scheme of 5 x 5,4 Gy in 3 days of treatment (High Five, HiFi-APBI)…
- Trial name
- HiFi (NCT05142202)
- Testing
- Breast Irradiation after Breast-Conserving Surgery
- Where
- Poland
- Volunteers
- 147 people
- Sponsor
- The Greater Poland Cancer Centre
Patient Reported Outcome, Oncological Safety
Patient Report Outcome and Oncological Safety -Oncoplastic and Conventional BCS Cohort
Breast-conserving surgery (BCS) is the traditional surgical treatment for early-stage breast cancer patients. There are evidences indicating that oncoplastic BCS could improve cosmetic outcomes and/or quality of life, and has…
- Conditions
- Patient Reported Outcome, Oncological Safety, Breast-conserving Surgery, Breast Cancer Female
- Trial name
- NCT05054777
- Testing
- oncoplastic breast-conserving surgery, conventional breast-conserving surgery
- Volunteers
- 5,000 people
- Sponsor
- Shandong Cancer Hospital and Institute
Breast Cancer, Reconstructive Breast Surgery
Using A Dissolved Oxygen Enriched Dressing in Nipple-sparing Mastectomy
This study will evaluate the effect of OxyGenesys Dissolved Oxygen Dressing in wound complication rates of the nipple areolar complex after a nipple sparing mastectomy.
- Trial name
- NSM (NCT01796977)
- Testing
- OxyGenesys Dissolved Oxygen Dressing, Standard Gauze Dressing
- Where
- 7 sites in United States
- Volunteers
- 27 people
- Sponsor
- Halyard Health
Stage IIA Breast Cancer, Stage IIB Breast Cancer
Chemotherapy Before Surgery and Tissue Sample Collection in Patients With Stage IIA-IIIC Breast Cancer
This pilot clinical trial studies chemotherapy before surgery and tissue sample collection in patients with stage IIA-IIIC breast cancer.
- Conditions
- Stage IIA Breast Cancer, Stage IIB Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer
- Trial name
- NCT01897441
- Testing
- Cyclophosphamide, Cytology Specimen Collection Procedure, Doxorubicin Hydrochloride
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Albert Einstein College of Medicine
Breast Cancer Female, Lobular Breast Carcinoma
18F FES-PET/MRI for Tailoring Treatment of Luminal A and Lobular Breast Cancer
Study hypothesis is that combining the advantages of hybrid PET/MRI and the high sensitivity/specificity of 16-alpha-18F-fluoro-17-beta-estradiol(FES), a radiolabeled form of estrogen binding to functionally active ER, the…
- Conditions
- Breast Cancer Female, Lobular Breast Carcinoma, PET/MRI, Axillary Lymphadenopathy
- Trial name
- FESTA (NCT05982496)
- Testing
- FES, PET/MRI A, Translational analysis
- Where
- Italy
- Volunteers
- 119 people
- Sponsor
- Università Vita-Salute San Raffaele
Breast Neoplasms
A Study of Local Therapy for the Treatment of Brain Metastases From HER2 Positive Breast Cancer
This study aims to show that brain metastases from Human Epidermal Growth Factor Receptor Type 2 (HER2) positive breast cancers are able to be controlled by local therapies, Stereotactic Radiosurgery (SRS) and/or Neurosurgery…
- Trial name
- Local HER-O (NCT02898727)
- Testing
- Local Therapy
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Breast Cancer Surgery
Evaluation of Mobiderm Intimate Bra in the Management of Breast Edema Related to Breast Cancer Treatment
The aim of this exploratory study is to assess the performance and tolerability of the MOBIDERM Intimate Bra in the management of breast edema related to breast cancer treatment.
- Trial name
- MOBIBRA (NCT06303154)
- Testing
- Mobiderm Intimate Bra group
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Thuasne
Breast Cancers
Partial Breast Re-irradiation for Breast Cancer
Breast cancer is the most common malignancy in women. Breast-conserving surgery (BCS) with adjuvant whole-breast irradiation (WBI) is currently the standard of care in the oncological treatment of primary breast cancer and offers…
- Trial name
- BREAST (NCT06954623)
- Testing
- Radiation Therapy
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg