Clinical trials: Breast Cancer in Situ
Breast Cancer, DCIS
Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer
This trial will investigate a novel 3-fraction radiation regimen for participants undergoing breast-conserving therapy (BCT) for early breast cancer that will: 1) significantly reduce the duration of treatment and can be…
- Conditions
- Breast Cancer, DCIS, LCIS
- Trial name
- MAPBI (NCT03936478)
- Testing
- MRIdian Radiation Treatment Unit
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Madison
Breast Cancer, Carcinoma in Situ of the Breast
Hypofractionated Versus Standard Fractionated Whole Breast Irradiation to Node-negative Breast Cancer Patients
The purpose of this study is to investigate the difference in late radiation morbidity between hypofractionated and standard fractionated breast irradiation given to women operated with breast conservation for early breast cancer.
- Trial name
- NCT00909818
- Testing
- standard fractionated radiotherapy, hypofractionated radiotherapy
- Where
- Denmark
- Volunteers
- 976 people
- Sponsor
- Danish Breast Cancer Cooperative Group
Breast Cancer
Nipple Secretion Samples in Detecting Breast Cancer in Patients and Healthy Participants Undergoing Breast Cancer Screening, Breast Diagnostic Studies, or Treatment for Benign Breast Disease
RATIONALE: Diagnostic procedures that measure biomarker levels in nipple section and blood samples, may help in the early detection of breast cancer.
- Trial name
- NCT00813878
- Testing
- protein analysis, protein expression analysis, proteomic profiling
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- City of Hope Medical Center
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Metformin and Nightly Fasting in Women With Early Breast Cancer
This phase IIb trial studies the combined effect of prolonged nightly fasting and metformin hydrochloride extended release in decreasing breast tumor cell proliferation and other biomarkers of breast cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Breast Ductal Carcinoma In Situ, Invasive Breast Carcinoma
- Trial name
- NCT05023967
- Testing
- Biospecimen Collection, Extended Release Metformin Hydrochloride, Monitoring
- Where
- 3 sites in United States, Italy
- Volunteers
- 120 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Neoplasm Malignant Primary, Lymphedema Arm
Agentic AI App and Home Bioimpedance Monitoring for Endocrine Therapy Adherence and Lymphedema in Breast Cancer Survivors
As survival rates following breast cancer surgery continue to improve, long-term survivorship management has emerged as a crucial clinical priority.
- Conditions
- Breast Neoplasm Malignant Primary, Lymphedema Arm, Medication Adherence, Ductal Carcinoma In Situ
- Trial name
- Pinkmate (NCT07911839)
- Testing
- Cohort1: Pinkmate Agentic AI-ePRO Active Management Platform, Cohort1: Pinkmate Basic Medication Reminders and Standard Outpatient Care, Cohort2: InBody BWA ON Home Bioimpedance Monitoring and Behavioral App
- Where
- South Korea
- Volunteers
- 264 people
- Sponsor
- Chang-Ik Yoon
Breast Cancer - Ductal Carcinoma in Situ (DCIS), Breast Cancer
Endoscopic Nipple-Sparing Mastectomy Through a Single Axillary Incision in Breast Cancer
This single-center prospective study will evaluate the feasibility and safety of endoscopic nipple-sparing mastectomy (E-NSM) performed through a single axillary incision in selected women with breast cancer undergoing…
- Trial name
- Mini-B (NCT07507890)
- Testing
- Endoscopic Nipple-Sparing Mastectomy (E-NSM)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Breast Cancer, Long-term Effects Secondary to Cancer Therapy in Adults
Partial Breast Radiation Therapy in Treating Women Undergoing Breast Conservation Therapy for Early-Stage Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. PURPOSE: This clinical trial is studying the side effects of partial breast radiation therapy and how well it works in treating women undergoing breast…
- Conditions
- Breast Cancer, Long-term Effects Secondary to Cancer Therapy in Adults, Skin Reactions Secondary to Radiation Therapy
- Trial name
- NCT00599989
- Testing
- adjuvant therapy, conventional surgery, 3-dimensional conformal radiation therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Cancer
Evaluation of the Diagnostic Performance of MRI±Biopsy to Optimize Resection of Ductal Carcinoma In Situ (DCIS) Breast Cancer
The purpose of this study is to evaluate the diagnostic performance of MRI±biopsy to optimize resection of Ductal Carcinoma In Situ (DCIS) breast cancer.
- Trial name
- IRCIS (NCT01112254)
- Testing
- MRI±biopsy
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Standard Verbal Counseling With or Without a Pictorial Educational Tool for the Reduction of Psychological Morbidity in Patients With Stage 0-IIIA Breast Cancer Receiving Radiation Therapy, COPE Study
This clinical trial studies the effect of standard verbal counseling with or without a pictorial educational tool for the reduction of psychological morbidity in patients with stage 0-IIIA breast cancer receiving radiation…
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- NCT04993313
- Testing
- Counseling, Educational Intervention, Questionnaire
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- OHSU Knight Cancer Institute
Breast Cancer With Low to Intermediate HER2 Expression, Breast Cancer (Triple Negative Breast Cancer (TNBC))
Use of Magtrace Bracketing for Excision of Lesion and Sentinel Lymph Node Localization in Breast Conserving Surgery for Breast Cancer
Breast cancer is the commonest cancer affecting women worldwide. Early breast cancer is treated surgically with wide local excision of tumor with axillary staging operations like sentinel node biopsy.
- Conditions
- Breast Cancer With Low to Intermediate HER2 Expression, Breast Cancer (Triple Negative Breast Cancer (TNBC)), Breast Cancer (Triple Negative Type), Breast Cancer - Infiltrating Ductal Carcinoma
- Trial name
- MagBracket (NCT07844473)
- Testing
- Super paramagnetic iron oxide bracketing injection
- Where
- Saudi Arabia
- Volunteers
- 35 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Ductal Carcinoma in Situ, Extensive Disease
Impact of Neoadjuvant Hormonal Therapy on the Surgical Management of Extensive Ductal Carcinomas in Situ
Ductal carcinoma in situ (DCIS) accounts for approximately 20% of newly diagnosed breast cancer cases. Of these women, 20% require radical management in the form of mastectomy because of the extent of the lesions, which most…
- Conditions
- Ductal Carcinoma in Situ, Extensive Disease, Mastectomy
- Trial name
- HORNEO01 (NCT04666961)
- Testing
- Tamoxifen 20 mg, Anastrozole 1Mg Tab
- Where
- 8 sites in France
- Volunteers
- 262 people
- Sponsor
- Institut Cancerologie de l'Ouest
HER2/Neu Negative, Invasive Breast Carcinoma
Endocrine Therapy in Treating Patients With HER2 Negative, Low Risk Breast Cancer
This pilot clinical trial studies how well endocrine therapy works in treating patients with HER2 negative, low risk breast cancer. Estrogen can cause the growth of breast cancer cells.
- Conditions
- HER2/Neu Negative, Invasive Breast Carcinoma, Postmenopausal, Stage 0 Breast Cancer
- Trial name
- NCT03238703
- Testing
- Anastrozole, Exemestane, Laboratory Biomarker Analysis
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Breast Cancer
Assessment of Biosignature Classification of DCIS for RadioTherapy Benefit Post Lumpectomy (ABCD RT)
NRG-CC016 is being done to determine if omission of radiation therapy (RT) for patients with biosignature Low Risk (DCISionRT score less than 2.8) DCIS yields no clinically meaningful increase ipsilateral breast recurrence (IBR)…
- Trial name
- ABCD RT (NCT07554573)
- Testing
- Radiation Therapy, Standard of Care Radiation Therapy, No Intervention
- Volunteers
- 5,270 people
- Sponsor
- NRG Oncology
Ovarian Epithelial Cancer, Carcinoma in Situ
Lavage of the Uterine Cavity for the Diagnosis of Serous Tubal Intraepithelial Carcinoma
The current study aims at answering the scientific question, whether exfoliated cells from STICs get transported into the uterine cavity via the fallopian tube, and whether it is possible to detect those cells in the lavage fluid…
- Conditions
- Ovarian Epithelial Cancer, Carcinoma in Situ, Ovarian Cancer
- Trial name
- LUSTIC (NCT02039388)
- Testing
- Lavage of the Cavum uteri and proximal Fallopian tubes, performed in the luteal phase of the female cycle
- Where
- 14 sites in Austria, Belgium and 6 more
- Volunteers
- 701 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
DCIS Grade 3, Stage I Breast Cancer
Energy Balance and Breast Cancer Aspects-II
The purpose of this study, the EBBA-II trial, is to determine whether a 12 month exercise program comprised of strength and endurance training among newly diagnosed breast cancer patients undergoing adjuvant therapy, will…
- Conditions
- DCIS Grade 3, Stage I Breast Cancer, Stage II Breast Cancer, LCIS, Lobular Carcinoma in Situ
- Trial name
- EBBA-II (NCT02240836)
- Testing
- Intervention. Exercise
- Where
- 2 sites in Norway
- Volunteers
- 545 people
- Sponsor
- Oslo University Hospital
Carcinoma Breast Stage IV
BIBW 2992 (Afatinib) and Vinorelbine
This open-label, single-arm, multicentre phase II trial will be performed in patients with intermediate HER2-positive, metastatic breast cancer (MBC)pretreated with anthracyclines and one first-line therapy in the metastatic…
- Trial name
- NCT01531764
- Testing
- BIBW 2992 in combination with vinorelbine
- Where
- 12 sites in Germany
- Volunteers
- 2 people
- Sponsor
- University of Magdeburg
Breast Cancer
Ductal Lavage in Assessing Women With Early Breast Cancer or at High Risk of Developing Breast Cancer and Who Are Eligible For Tamoxifen Therapy
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of or treat early cancer. Diagnostic procedures, such as ductal lavage, may improve the ability to assess the effectiveness of…
- Trial name
- NCT00083044
- Where
- 2 sites in United States
- Sponsor
- Northwestern University
Persistent Postsurgical Pain, Breast Cancer Female
Preventing Persistent Pain and Reducing Depressive and Anxious Symptoms Following Mastectomy and Lumpectomy
The proposed study will be a pilot randomized controlled trial comparing treatment as usual (TAU) to treatment as usual plus a brief Acceptance and Commitment Therapy (ACT) intervention (TAU + ACT) with mastectomy and lumpectomy…
- Conditions
- Persistent Postsurgical Pain, Breast Cancer Female, Ductal Carcinoma in Situ
- Trial name
- NCT03430765
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Katherine Hadlandsmyth
Prostate Cancer, Breast Cancer
Evaluation of Sleep Quality in Prostate Cancer Patients Undergoing Treatment With Hormonal Therapeutic Approaches and in Patients With Full-resected Early Breast Cancer
This study will use polysomnography, alongside other methodologies such as questionnaires, actigraphic measurements and salivary melatonin samples used in previous studies to investigate sleep quality in patients with i)…
- Trial name
- SIESTA (NCT04543799)
- Testing
- polysomnography, actigraphy, questionnaires
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Oncology Institute of Southern Switzerland
Invasive Breast Cancer Early Stages, Ductal Carcinoma In Situ, DCIS
Personalized Prone Immobilization for Accelerated Partial Breast Radiotherapy
The goal of this clinical trial is to find out whether using a personalized breast holder (called VENUS SHELL™) can improve positioning and patient comfort during prone radiotherapy (radiotherapy given while the patient lies on…
- Trial name
- SHIELD (NCT07711847)
- Testing
- VENUS SHELL™ immobilization device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- HeroSupport SA