Clinical trials: Breast Conserving Surgery
Triple Negative Breast Cancer, HER2-positive Breast Cancer
A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer
Adjuvant radiotherapy is the standard treatment for early breast cancer after breast conserving surgery. Molecular subtypes was significantly associated with the risk of local recurrence of breast cancer.
- Trial name
- NCT05692661
- Testing
- proton plus carbon ion radiotherapy
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Breast Cancer
A Novel Optical Spectral Imaging System for Imaging Breast Tumor Margins
The goal of this research is to further develop novel optical assay systems for intra operative assessment of tumor margins in partial mastectomy or mastectomy specimens.
- Trial name
- NCT01372631
- Testing
- miniature spectral imaging system, Bench-top optical spectrometer, High resolution microendoscope
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- Duke University
Pain Score, Pain Postoperative
Pain Sensitivity Questionnaire Applied in Preoperative Period in Lumpectomy
Objective: The Pain Sensitivity Questionnaire (PSQ) is a clinically valuable tool that has been shown to correlate with various experimental pain sensitivity assessments in healthy individuals and patients with chronic pain.
- Trial name
- Lumpectomy (NCT06928064)
- Testing
- Prediction of Postoperative Pain Severity Using Pain Sensitivity Questionnaire Applied in Preoperative Period in Patients Undergoing Breast-Conserving Surgery (Lumpectomy).
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Retrospective Study
Predicting Outcomes of Breast-Conserving Surgery in Breast Cancer Patients Using the Modified 5-Item Frailty Index
Background: Breast cancer is the most common malignancy among women worldwide, with breast-conserving surgery (BCS) being a key treatment.
- Trial name
- NCT06770647
- Where
- Germany
- Volunteers
- 96,586 people
- Sponsor
- Technical University of Munich
Breast Cancer
Breast Cancer With Low Risk Of Local Recurrence: Partial and Accelerated Radiation With Three-Dimensional Conformal Radiotherapy (3DCRT) Vs. Standard Radiotherapy After Conserving Surgery (Phase III Study
This study was designed and developed in the Emilia Romania research and innovation program (PRI ER). The study does not have commercial sponsors and comes under the independent studies provided for by Ministerial Decree…
- Trial name
- NCT01803958
- Testing
- partial breast irradiation, whole breast irradiation
- Where
- Italy
- Volunteers
- 3,302 people
- Sponsor
- Regione Emilia-Romagna
Breast Neoplasm Female, Breast Cancer
Fluorescence Imaging of Carcinoma During Breast Conserving Surgery
Breast conserving surgery (BCS) is performed on patients with breast cancer to resect and completely remove the cancer while conserving as much of the surrounding healthy tissue as possible.
- Trial name
- NCT04815083
- Testing
- Aminolevulinic Acid Hydrochloride, Eagle V1.2 Imaging System
- Where
- 7 sites in United States
- Volunteers
- 57 people
- Sponsor
- SBI ALApharma Canada, Inc.
Breast Cancer
Study the Role of Positron Emission Mammography in Pre-surgical Planning for Breast Cancer
Women with newly diagnosed breast cancer anticipating breast-conserving surgery are enrolled into the study and will undergo both high-resolution positron emission mammographic (PEM) imaging and contrast-enhanced magnetic…
- Trial name
- NCT00484614
- Testing
- Positron Emission Mammography, Magnetic Resonance Imaging
- Where
- 6 sites in United States
- Volunteers
- 472 people
- Sponsor
- Naviscan PET Systems
Breast-Conserving Surgery, Negative Surgical Margins
Endoscopic Breast Conserving Surgery With Intra-operative Navigation System
A growing number of Chinese breast cancer patients are diagnosed at a young age. The quality of life of young breast cancer patients has been a critical issue.
- Conditions
- Breast-Conserving Surgery, Negative Surgical Margins, Endoscopy, Esthetics
- Trial name
- NCT05458414
- Testing
- Intra-operative Navigation System
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Systemic Immune-inflammatory Index, Erector Spinae Plane Block
Impact of Erector Spinae Plane Block on Systemic Immune-inflammation Index
The primary objective of the study is to determine whether there is a relationship between postoperative SII and erector spinae plane block application.
- Conditions
- Systemic Immune-inflammatory Index, Erector Spinae Plane Block, Breast Conserving Surgery
- Trial name
- NCT07137702
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Taner Abdullah
Breast Cancer
Hypofractionated Vs Conventional Fractionated Radiotherapy After Breast Conserving Surgery
The study was designed to investigate whether hypofractionated radiotherapy(HF-RT) is noninferior to conventionally fractionated radiotherapy (CF-RT) in terms of tumor loco-regional control for patients after breast conserving…
- Trial name
- NCT04025164
- Testing
- Hypofractionated Radiotherapy, Conventional fractionated Radiotherapy
- Where
- 5 sites in China
- Volunteers
- 4,052 people
- Sponsor
- Fudan University
Breast Cancer
Prone Breast Irradiation for Pendulous Breasts
We hypothesize that for large pendulous breasts, breast irradiation in supine and prone position are equivalent with regard to coverage of the PTV, but with a better dose homogeneity in prone position and a smaller radiation…
- Trial name
- NCT00181363
- Testing
- Mamma board
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht Radiation Oncology
Breast Neoplasms, Breast Cancer
External Hypofractionated Radiotherapy With Simultaneous Integrated Boost in Early Breast Cancer Patients
This is a prospective non randomized phase two trial evaluating the feasibility of a ten fraction accelerated hypofractionated radiotherapy schedule with simultaneous integrated boost risk adapted in patients undergoing breast…
- Trial name
- ESIBIRE (NCT06224244)
- Testing
- Ten-fraction hypofractionated breast radiotherapy with 40 Gy simultaneous integrated bed boost, Ten-fraction hypofractionated breast radiotherapy with 43 Gy simultaneous integrated bed boost
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Breast Cancer
Omitting vs. Doing Intraoperative Frozen Section Biopsy for Margin Status in Breast Conserving Surgery
Study phase: 3 Indication: Breast cancer patients undergoing breast conserving surgery Primary objectives: To determine the effect of selective omission of intraoperative margin evaluation via frozen section on margin positive…
- Trial name
- OFF-MAP (NCT03975179)
- Testing
- Omission of intraoperative frozen section biopsy for margin status, Frozen section biopsy for margin status
- Where
- 2 sites in South Korea
- Volunteers
- 1,292 people
- Sponsor
- Samsung Medical Center
Breast Cancer, Postoperative Recovery
ERAS Protocols in Breast Conserving Surgery
Enhanced Recovery After Surgery (ERAS) protocols have been of increasing interest in the surgical community for decades. The emphasis has been development of protocols to maximize pain control post-operatively without the use of…
- Trial name
- ERAS (NCT06938581)
- Testing
- ERAS Protocol, Standard Perioperative Care
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Nebraska
Breast Cancer
Accelerated Hypofractionated Radiotherapy (AHF-RT) for the Treatment of Breast Cancer
The goal of this study is to explore the safety, effectiveness, quality of life, and cost effectiveness of accelerated hypofractionated radiotherapy (AHF-RT) as treatment after lumpectomy in patients with early stage breast…
- Trial name
- NCT01278212
- Testing
- accelerated hypofractionated radiotherapy (AHF-RT)
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Louisville
Breast Cancer
Implant-based Breast Reconstruction and Mastectomy With Fat Grafting After Breast Conserving Surgery and Radiotherapy
Higher rates of complications and poorer cosmetic outcomes have been reported after salvage mastectomy and implant-based versus autologous reconstruction in patients previously exposed to radiation therapy (i) on the breast as…
- Trial name
- NCT06119633
- Testing
- Immediate tissue expander and lipofilling after mastectomy
- Where
- 2 sites in Italy
- Volunteers
- 163 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Breast Cancer
Evaluation of the Safety and Efficacy of Single-Port Robot-Assisted Endoscopic Breast-Conserving Surgery and Nipple-sparing Matectomy With Reconstruction in Early-Stage Breast Cancer Patients
This study is testing a new, less invasive way to perform breast cancer surgery using a single-port robotic system (a robot-assisted surgical tool made in China, called the Shurui SR-ENS-600).
- Trial name
- NCT07781163
- Testing
- single-port robot-assisted surgery
- Volunteers
- 30 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Breast Cancer
Late Toxicity in Breast Cancer Patients Treated With Breast-conserving Surgical Procedures and Radiotherapy Using the Simultaneous Integrated Boost Technique
In summary, breast conserving therapy (BCT) is an effective, save and widely used treatment technique for early breast cancer. Radiotherapy has shown to give better local control and survival benefit and is an integrated part of…
- Trial name
- FUSIB (NCT02505906)
- Testing
- Simultaneous Integrated Boost Technique
- Where
- Netherlands
- Volunteers
- 5,043 people
- Sponsor
- University Medical Center Groningen
Breast Carcinoma
Intraoperative Radiotherapy After Local Recurrence in Breast Cancer
The investigators propose a prospective, multicenter, single arm Phase II design to evaluate the feasibility of repeated breast-conserving surgery combined with re- irradiation using IORT after local recurrence of breast…
- Trial name
- RE-IORT01 (NCT02386371)
- Testing
- tumorectomy, Intra Operative Radiotherapy
- Where
- 8 sites in France
- Volunteers
- 66 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Breast Cancer, Node-negative Breast Cancer
Partial Breast Irradiation Without Sentinel Lymph Node Biopsy in Low-Risk Early Breast Cancer
This is a multicenter, randomized, phase III non-inferiority trial in women aged 40 years or older with clinically node-negative (cN0), pathologically pT1 (≤2 cm), grade 1-2, lymphovascular invasion (LVI)-negative invasive breast…
- Conditions
- Breast Cancer, Node-negative Breast Cancer, Early-Stage Invasive Breast Carcinoma
- Trial name
- APROOB (NCT07757958)
- Testing
- Whole Breast Irradiation, Partial Breast Irradiation
- Where
- South Korea
- Volunteers
- 520 people
- Sponsor
- Samsung Medical Center