Clinical trials: Breast Density
Breast Cancer, Low Bone Mineral Density
AMG 162 in the Treatment of Bone Loss in Subjects Undergoing Aromatase Inhibitor Therapy for Non-metastatic Breast Cancer
The purpose of this trial is to evaluate AMG 162 in the treatment of bone loss in subjects undergoing Aromatase Inhibitor Therapy for Non-metastatic Breast Cancer.
- Conditions
- Breast Cancer, Low Bone Mineral Density, Osteopenia
- Trial name
- NCT00089661
- Testing
- AMG 162 / Denosumab
- Volunteers
- 252 people
- Sponsor
- Amgen
Breast Neoplasms
Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial
The purpose of the ALPHA Trial is to examine the physiologic changes that occur in a woman's body when she begins exercising that may be related to a change in her risk of getting breast cancer.
- Trial name
- NCT00522262
- Testing
- Aerobic exercise intervention
- Where
- 2 sites in Canada
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- AHS Cancer Control Alberta
Mammographic Density
Enobosarm and Anastrozole in Pre-menopausal Women With High Mammographic Breast Density
To evaluate the impact of a selective androgen receptor modulator combined with an aromatase inhibitor in reducing high mammographic breast density.
- Trial name
- NCT03264651
- Testing
- enobosarm
- Where
- Australia
- Volunteers
- 9 people
- Sponsor
- Havah Therapeutics Pty Ltd
Breast Cancer
Dose Density FU 75 and FU 90 as Adjuvant Therapy for Early Breast Cancer
This is an open -label randomized phase II study of dose-dense Fluorouracil/Epirubicin/Cyclophosphamide (FEC) administered with Epirubicin of 75mg/m2 (FEC75) and Epirubicin 90mg/m2 (FEC90) in untreated patients with early breast…
- Trial name
- NCT00286819
- Testing
- the FEC75 and 95 regimen
- Where
- 5 sites in Austria, Hungary and 2 more
- Volunteers
- 50 people
- Sponsor
- Central European Cooperative Oncology Group
Metabolic Syndrome, Obesity Associated Disorder
Dedicated Breast CT for Quantitative Breast Density Measurements in Mexican-origin Women in Southern Arizona
The overall objective of this clinical study is to determine the feasibility of breast CT for breast density assessment and association of CT-derived density measures with metabolic syndrome in overweight/obese Mexican-origin…
- Trial name
- NCT04799665
- Testing
- Breast CT
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Primary Hormone Receptor Negative Breast Cancer in Premenopausal Women
A Study of Zoledronic Acid in the Prevention of Cancer Therapy-induced Bone Loss
Breast cancer and osteoporosis are two of the most frequent diseases in women. Estrogen may be associated with bone loss and the risk of breast cancer because of its potent effects on the mitotic activity of breast epithelium and…
- Trial name
- NCT00333229
- Testing
- Zoledronic Acid
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer
Breast Screening - Risk Adaptive Imaging for Density
BRAID is a randomised, multi-centre study assessing the impact of supplementary imaging in the detection of breast cancer in women participating in the UK national breast screening programme who have dense breast tissue.
- Trial name
- BRAID (NCT04097366)
- Testing
- ABUS, CEM, ABB-MRI
- Where
- 10 sites in United Kingdom
- Volunteers
- 9,000 people
- Sponsor
- University of Cambridge
To Establish a Standardized Background Parenchimal Enhancement Classification System
From Variability to Standardization: The Impact of Breast Density on Background Parenchymal Enhancement in Contrast-Enhanced Mammography and the Need for a Structured Reporting System
This retrospective study includes 213 patients who underwent CEM, mammography (MG), and ultrasound (US) between May 2022 and June 2023 at the P.O. 'A. Perrino' Hospital, Brindisi.
- Trial name
- NCT06838117
- Where
- Italy
- Volunteers
- 213 people
- Sponsor
- Graziella di Grezia
Breast Cancer (Triple Negative Breast Cancer (TNBC)), Renal Cell Carcinoma (Kidney Cancer)
Pilot Study of Bone Mineral Density Changes During Anti-PD-1 Immunotherapy
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment and work by blocking protein interactions that normally prevent the immune system from recognizing and destroying cancer cells.
- Conditions
- Breast Cancer (Triple Negative Breast Cancer (TNBC)), Renal Cell Carcinoma (Kidney Cancer), Melanoma (Skin Cancer), Non-Small Cell Lung Cancer
- Trial name
- NCT07555210
- Testing
- Dual-Energy X-ray Absorptiometry (DXA), High Resolution peripheral Quantitative Computed Tomography (HRpQCT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Jessica Mezzanotte Sharpe
Breast Cancer
Breast Cancer, Breast Disease, and Pesticides
This study will collect information on the height and weight of women who participated in a 1998 study in Triana, Alabama, on the risk of breast cancer and benign breast disease in relation to environmental exposure to the…
- Trial name
- NCT00341315
- Where
- United States
- Volunteers
- 228 people
- Sponsor
- National Cancer Institute (NCI)
Benign Breast Disease
VITamin D and OmegA-3 TriaL: Effects on Mammographic Density and Breast Tissue
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids…
- Trial name
- VITAL (NCT02239874)
- Testing
- Vitamin D and fish oil
- Where
- United States
- Volunteers
- 3,894 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Breast Neoplasms
The Ultrasound Study of Tamoxifen
Background: Studies have shown that changes in breast density (the amount of white area on a woman's mammogram) may be related to changes in breast cancer risk.
- Trial name
- NCT01582074
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Mammographic Breast Density
PERsonalized Mammographic Screening in Norway
The aim of this study is to assess attendance among women invited to additional breast imaging because they were identified as having an increased risk of breast cancer at screening.
- Conditions
- Breast Cancer, Mammographic Breast Density, Risk Stratification
- Trial name
- PERMS (NCT07371702)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Breastfeeding, Dietary Intake
NUTRIPROTECT-Children Nutrition as a Protective or Health-risk Factor
Despite the intensive worldwide research dedicated to the nutrition and faecal microbiota, the studies that follow the link between the early nutrition, initial intestinal microbiota, and development of children over a longer…
- Conditions
- Breastfeeding, Dietary Intake, Health, Body Composition
- Trial name
- My-Milk-2 (NCT04076592)
- Where
- Slovenia
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Women With Primary Breast Cancer
A Phase II Study of Dose Density Regimen With Fluorouracil, Epirubicin and Cyclophosphamide at Days 1, 4 Every 14 Days With Filgrastim Support Followed by Weekly Paclitaxel in Women With Primary Breast Cancer.
TITLE: A Phase II Study of Dose Density Regimen with Fluorouracil, Epirubicin and Cyclophosphamide at Days 1, 4 Every 14 Days with Filgrastim Support followed by Weekly Paclitaxel in Women with Primary Breast Cancer.
- Trial name
- NCT02225652
- Testing
- FEC (Fluorouracil, Epirubicin, Cyclophosphamide) + filgrastim + paclitaxel
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Post-Menopausal, Breast Cancer
Letrozole in Postmenopausal Women at Increased Risk for Breast Cancer
The purpose of this study to see what happens to breast density in healthy postmenopausal women after treatment with letrozole in one year, compared with treatment with placebo for one year.
- Trial name
- NCT00280930
- Testing
- Letrozole
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Vitamin D in Postmenopausal Women at High Risk for Breast Cancer
This is a phase II study which will enroll 20 postmenopausal women who are at high risk for breast cancer development. The goal is to determine whether a one-year intervention of high-dose vitamin D at 2 different doses (20,000…
- Trial name
- NCT00859651
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Breast Neoplasms
Breast Mammogram and Tissue Study
Background: Women whose mammograms show a lot of dense areas are more likely to develop breast cancer and to have cancers that are missed by mammograms.
- Trial name
- NCT00475761
- Where
- United States
- Volunteers
- 466 people
- Sponsor
- National Cancer Institute (NCI)
Mammographic Breast Density
Trial of 4-Hydroxytamoxifen (4-OHT) Gel in Women Aimed at Reducing Dense Breast Tissue
A study to determine the efficacy of 8 mg/day (4 mg/breast) of BHR-700 gel compared to placebo for reducing breast tissue density in women identified as having dense breast tissue upon analysis of screening mammography.
- Trial name
- 4WARD (NCT03199963)
- Testing
- 4-OH tamoxifen
- Where
- 19 sites in United States, Germany and 1 more
- Volunteers
- 223 people
- Sponsor
- BHR Pharma, LLC
Breast Diseases
Abbreviate or FAST Breast MRI for Supplemental Breast Cancer Screening for Black Women at Average Risk and Dense Breasts
500 patients will be prospectively recruited to undergo a fast breast MRI examination. The women will be recruited for the study will meet the following criteria: 1. African American 2.
- Trial name
- NCT04854304
- Testing
- Fast Breast Abbreviated Magnetic Renounce Imaging
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine