Clinical trials: Breast Diseases
Hematoma Postoperative, Breast Cancer
Tranexamic Acid for Alloplastic Breast Reconstruction
Hematoma is a common complication of alloplastic breast reconstruction. This can lead to pain and discomfort experienced by the patient, in addition to greater use of valuable healthcare resources.
- Conditions
- Hematoma Postoperative, Breast Cancer, Tranexamic Acid
- Trial name
- NCT04918589
- Testing
- Tranexamic acid, Normal Saline
- Where
- 3 sites in Canada
- Volunteers
- 106 people
- Sponsor
- McMaster University
Breast Cancer, Aromatase Inhibitors
Effect of Aromatase Inhibitors on Ultrasonographic Measurements and Static and Dynamic Balance Scores in Breast Cancer
To evaluate the effects of aromatase inhibitors on lower extremity ultrasonographic measurements, static and dynamic balance scores in breast cancer patients using aromatase inhibitors
- Conditions
- Breast Cancer, Aromatase Inhibitors, Balanced
- Trial name
- NCT06184074
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Cancer
Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections
RATIONALE: White blood cells that have been treated in the laboratory may kill cells that are infected with cytomegalovirus. PURPOSE: This phase I trial is studying how well cytotoxic T cells work in treating patients who have…
- Trial name
- NCT00769613
- Testing
- cytomegalovirus IE-1-specific cytotoxic T lymphocytes, cytomegalovirus pp65-specific cytotoxic T lymphocytes, therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Male Breast Cancer
Finasteride (MK-0906) and Male Breast Cancer - A Register-Based Nested Case-Control Study (MK-0906-162/2003.021).
The objective of this study is to investigate the potential association between finasteride (MK-0906) exposure and the development of breast cancer in men residing in Denmark, Sweden, Finland, and Norway from data in national…
- Trial name
- NCT01703520
- Volunteers
- 575,216 people
- Sponsor
- Organon and Co
Triple Negative Breast Cancer
Grouping Immune-modulation With Cryoablation (LOGIC) for Breast Cancers
Summary Points: 1. High Risk Breast Cancers: Triple negative cancer is considered high risk due to high rate of local and systemic failure.
- Trial name
- LOGIC (NCT05806385)
- Testing
- Cryoablation, Cryoablation combined with PD1 Inhibitor
- Volunteers
- 36 people
- Sponsor
- Texas Tech University Health Sciences Center
Breast Cancer
Evaluation of Group CBT Programme With Breast Cancer Patients
The purpose of this study is to examine whether a group CBT intervention is effective in reducing psychological distress in women with primary breast cancer.
- Trial name
- NCT00426335
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Breast Cancer
Irinotecan in Treating Patients With Metastatic or Recurrent Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of irinotecan in treating patients who have metastatic or…
- Trial name
- NCT00004182
- Testing
- irinotecan hydrochloride
- Where
- 2 sites in United States
- Sponsor
- Northwestern University
Breast Cancer
Interventional Program Educates, Identifies + Overcomes Barriers to Complete Screening Mammography
The purpose of this study is to identify interventions that are designed to better serve women who are homeless, with a specific focus on increasing screening rates and decreasing late stage breast cancer diagnosis among this…
- Trial name
- NCT04348123
- Testing
- Survey, Education Session
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Proton Accelerated Partial Breast Irradiation
This prospective, non-randomized phase II study will evaluate the cosmetic outcome of using pencil beam scanning proton therapy for partial breast irradiation in patients diagnosed with early stage breast cancer.
- Trial name
- APBI (NCT03940248)
- Testing
- Proton Accelerated Partial Breast Irradiation
- Where
- United States
- Sponsor
- University of Cincinnati
Breast Cancer, Pain, Postoperative
IV Dexmedetomidine vs Oral Gabapentin and Their Combination for Postoperative Analgesia in Cancer Patients Undergoing Modified Radical Mastectomy
Breast cancer is the most common malignant tumour among females with an incidence of about 2.1 million women every year.Nearly about 40-60% of breast surgery patients develop severe acute postoperative pain.⁴ Opioids are the…
- Conditions
- Breast Cancer, Pain, Postoperative, Pain, Acute
- Trial name
- NCT06354478
- Testing
- Dexmedetomidine Hydrochloride 0.5 MG/ML, Gabapentin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Genitourinary Syndrome of Menopause
Use of Fractional CO2 Laser Versus Erbium:YAG Laser for the Treatment of GSM in Patients Using Aromatase Inhibitors
To study the efficacy and safety of intravaginal CO2 laser versus intravaginal Er:YAG laser and sham application in alleviating genitourinary symptoms in patients receiving an aromatase inhibitor as adjuvant treatment of breast…
- Trial name
- LASI (NCT05713435)
- Testing
- intravaginal laser
- Where
- Belgium
- Volunteers
- 162 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer
The Role of C1q Tumor Necrosis Factor-related Protein 6 in Breast Cancer
Globally, breast cancer is one of the most prevalent cancers in women and is the second leading cause of cancer death , representing 15% of worldwide deaths per year .
- Trial name
- NCT04611308
- Testing
- C1q tumor necrosis factor-related protein 6 levels
- Volunteers
- 102 people
- Sponsor
- Assiut University
Breast Cancer
ITA - Clinical Study Comparing ARIMIDEX™ With NOLVADEX™ in Women With Breast Cancer Treated With NOLVADEX for at Least 2 Years
The purpose of this study was to assess the difference in disease-free survival between post-menopausal women with hormone receptor-positive early breast cancer who switched from tamoxifen to anastrozole and those who continued…
- Trial name
- NCT00286117
- Testing
- Anastrozole, Tamoxifen
- Where
- 25 sites in Italy
- Volunteers
- 448 people
- Sponsor
- AstraZeneca
Breast Neoplasm
Interventional Study on the Impact of the Hypnosis Used as Sedation or Relaxation in the Breast Oncologic Surgery
The aims of the study are to compare the recovering period between a group of patients with conventional sedation, a group using hypnosis as sedation during the surgery and a third group using hypnosis as a relaxation method and…
- Trial name
- OncoHypnose (NCT03330717)
- Testing
- General anesthesia, Hypnosis sedation, General anesthesia with preoperative session of hypnosis
- Where
- 2 sites in Belgium
- Volunteers
- 284 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Breast Neoplasms
Single Fraction High-Gradient Partial Breast Irradiation in Treating Patients With Low-Risk Stage 0-I Breast Cancer
This phase I/II clinical trial studies the side effects of delivering radiation therapy in a single session instead of multiple treatments over several weeks and to see how well it works in treating patients with low-risk stage…
- Trial name
- NCT02076074
- Testing
- accelerated partial breast irradiation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Fertility Preservation, Breast Cancer
Evaluation of Priming Before in Vitro Maturation for Fertility Preservation in Breast Cancer Patients
Oocyte vitrification after in vitro maturation (IVM) is one of the main techniques for preserving female fertility before chemotherapy for breast cancer.
- Trial name
- PRIMIV (NCT03954197)
- Testing
- No hormone, hCG, GnRH a
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Hôpital Jean Verdier
Breast Cancer
Vitamin D3 for Aromatase Inhibitor Induced Arthralgias
The primary purpose is to determine if high dose vitamin D3 reduces the incidence of musculoskeletal symptoms associated with the aromatase inhibitor letrozole in women with early stage breast cancer and low serum vitamin D…
- Trial name
- VITAL (NCT00867217)
- Testing
- High Dose Vitamin D, Standard Dose Vitamin D3, Letrozole 2.5mg
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Qamar Khan
Breast Cancer
Fluorescence Guided Surgery in Breast Cancer
A need for further investigation for fluorescence image-guided surgery in breast conserving surgery (BCS) has arisen following the results obtained from a phase I feasibility breast cancer trial (BIRDYE study: ABR NL…
- Trial name
- MARGIN (NCT02583568)
- Testing
- Bevacizumab-800CW
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- University Medical Center Groningen
Breast Cancer, Arthralgia
Loss of Grip Strength, BMI, and Adjuvant Endocrine Therapy Breast Cancer
Early stage hormone receptor positive breast cancer is typically treated with adjuvant endocrine therapy in order to decrease risk of breast cancer recurrence and to improve overall survival from the disease.
- Conditions
- Breast Cancer, Arthralgia, Obesity
- Trial name
- LOGRIBMET (NCT01896050)
- Testing
- anastrozole, letrozole, exemestane, Tamoxifen
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Michigan Rogel Cancer Center
Breast Cancer, Breast Neoplasms
Imiquimod for Breast Cancer Patients With Chest Wall Recurrence or Skin Metastases
The purpose of this trial is to determine the safety and efficacy of Imiquimod, a Toll-like receptor 7 agonist in breast cancer (for chestwall recurrences or metastases to the skin).
- Trial name
- NCT00899574
- Testing
- Imiquimod
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health