Clinical trials: Breast Mass
Colon Cancer, Breast Cancer
SurgicAl Metabolic Phenotyping Longitudinal Evaluation Study
This work will use a new approach to measure how surgery effects human biochemistry and metabolism. It will create a metabolic signature or 'phenotype' for surgical injury that will help clinicians choose the right surgical…
- Conditions
- Colon Cancer, Breast Cancer, Trauma, Inflammatory Bowel Disease
- Trial name
- SaMPLE (NCT01378013)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy
Effects of a Non-nutritive Sweetener Reduction Intervention in Pregnancy and Lactation on Maternal and Infant Outcomes
The effects of consuming non-nutritive sweeteners (NNS) during pregnancy and lactation on infant obesity and cardiometabolic disease risk are not well understood.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy, Non-nutritive Sweeteners Consumption in Pregnancy and/or Lactation
- Trial name
- NCT06548828
- Testing
- NNS Restriction Intervention, Control Intervention
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- George Washington University
Breast Mass
Spot Compression Ultrasound Compared to Traditional Breast Ultrasound
The purpose of this study is to determine the efficacy of targeted breast ultrasound ("ultrasound in the grid") performed concurrently with diagnostic mammogram during breast compression with an open mammogram paddle in lesion…
- Trial name
- NCT07471672
- Testing
- Targeted ultrasound in the grid
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Breast Masses, Breast Cancer
Photoacoustic/Ultrasound Imaging for Breast Nodule Diagnosis, Molecular Classification, and Neoadjuvant Chemotherapy Response Evaluation
Photoacoustic (PA) imaging (PAI) emergerd as a rapidly evolving biomedical imaging modality, which combines the merits of optical imaging and ultrasound (US) imaging, and has a capacity in morphological, functional and molecular…
- Conditions
- Breast Masses, Breast Cancer, Breast Cancer Treated with Neoadjuvant Chemotherapy
- Trial name
- NCT06908291
- Testing
- Multi-modal photoacoustic/ultrasonic (PA/US) imaging system
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Diagnostic Imaging
PET/CT Imaging for Radiation Dosimetry, Plasma Pharmacokinetics, Safety and Tolerability in Healthy Volunteers and Safety, Tolerability and Diagnostic Performance of BAY86-9596 in Patients With Non-small Cell Lung Cancer, Breast Cancer, Head and Neck Cancer and Patients With Inflammations
Visual assessment of diagnostic PET/CT (positron emission tomography/computed tomography) images obtained after a single intravenous injection of BAY86-9596 in patients with cancer and inflammation
- Trial name
- NCT01089998
- Testing
- BAY86-9596, Fludeoxyglucose (18F)-IBA
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Lantheus Biosciences Ltd.
Symptomatic Breast Lump
Clinical Utility of a Low-Cost Hand-Held Breast Scanner
Early detection of breast cancer improves the survival rate and makes treatment less costly. This study would measure the accuracy a low-cost hand-held commercially viable device, iBE, for the detection of clinically relevant…
- Trial name
- NCT02762565
- Testing
- PEFS system (Product Name: Intelligent Breast Exam™ or iBE™
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Cancer
Photoacoustic Imaging for Characterizing Breast Masses and Breast Tumor Response to Neoadjuvant Chemotherapy
Our objective in this pilot study will be to identify PA parameters that can distinguish benign vs. malignant lesions, and also, if PA parameters change with within breast tumors during chemotherapy treatment over time.
- Trial name
- NCT04428528
- Testing
- Photoacoustics Imaging System
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Clear Cell Renal Cell Cancer (ccRCC), Pancreatic Ductal Adenocarcinoma (PDAC)
A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors
The main purpose of Part A of the study is to evaluate safety, tolerability and tracer uptake after a single intravenous (IV) administration of [68Ga]Ga-DPI-4452 for each tumor type such as clear cell renal cell cancer (ccRCC)…
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Pancreatic Ductal Adenocarcinoma (PDAC), Colorectal Cancer (CRC), Urothelial Carcinoma (UC)
- Trial name
- NCT05706129
- Testing
- [68Ga]Ga-DPI-4452, [177Lu]Lu-DPI-4452
- Where
- 10 sites in Australia, France
- Volunteers
- 270 people
- Sponsor
- Lumara Bio Oncologics GmbH
Neoadjuvant Chemotherapy
Muscle Parameters and Pathological Response in Breast Cancer Patients
The investigators aimed to accurately measure muscle mass and predict pCR to NAC and its effect on clinical outcomes.
- Trial name
- NCT06151379
- Testing
- Neoadjuvant therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Acıbadem Atunizade Hospital
Advanced Metastatic Breast Cancer
Study for Women and Men With Hormone-receptor Positive Locally Advanced or Metastatic Breast Cancer
This was a national, multi-center, open-label, phase IIIb trial to determine the efficacy and safety of treatment with ribociclib (LEE011) plus letrozole in patients with HR+, HER2-negative advanced (recurrent or metastatic)…
- Trial name
- NCT03096847
- Testing
- ribociclib, letrozole, goserelin
- Where
- 84 sites in Germany
- Volunteers
- 502 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Screening
Artificial Intelligence in Breast Cancer Screening Programs
The use of artificial intelligence software in breast screening (Transpara®) makes it possible to identify studies with a very low probability of cancer.
- Trial name
- AITIC (NCT04949776)
- Testing
- Mammograms
- Where
- Spain
- Volunteers
- 31,301 people, healthy volunteers welcome
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Breast Cancer
Evaluation of Mailers Promoting Mammogram Screening
In this evaluation, 3 different versions of mailers promoting annual mammograms are being sent to women on the month of their 50th and 64th birthdays.
- Trial name
- NCT04555902
- Testing
- Postcard, Small Gift, Loss Frame and Fear Appeals
- Where
- United States
- Volunteers
- 1,342 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Breast Neoplasms
Multi-center Study of Deep Learning AI in Breast Mass
This multi-center study intends to evaluate the value of the detection and differential diagnosis of breast mass using deep learning AI-based real-time ultrasound examination.
- Trial name
- NCT05443672
- Testing
- Yizhun BUSMS
- Where
- China
- Volunteers
- 1,122 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Breast Cancer
Application of Ultrasound Artificial Intelligence and Elastography in Differential Diagnosis of Breast Nodules
The application of computer-aided diagnosis (CAD) technology "S-Detect" enables qualitative and quantitative automated analysis of ultrasound images to obtain objective, repeatable and more accurate diagnostic results.
- Trial name
- NCT03887598
- Testing
- Ultrasound diagnosis
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Xin-Wu Cui
Breast Cancer Female
Identification of Benign and Malignant Breast Nodules Using Ultrasound-modulated Optical Tomography: A Multicenter Study
Ultrasonic light scattering imaging is a new functional imaging technology that combines traditional B-mode ultrasound imaging and light scattering tomography (DOT).
- Trial name
- NCT06468566
- Testing
- Ultrasound light scattering imaging equipment
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Xin-Wu Cui
Breast Fibroadenoma
Case Collection Study in the Evaluation of Doubling Time Rates in Non-Suspicious Breast Masses Using QT Ultrasound Technology
This is a prospective case collection study to collect cases for subsequent statistical studies and future reader studies.
- Trial name
- EVALUATE (NCT03470051)
- Testing
- QT Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- QT Ultrasound LLC
Cancer
Continued HER2 Suppression With Lapatinib Plus Trastuzumab Versus Trastuzumab Alone
This was a randomized, open-label, multi-center Phase III study evaluating the efficacy and safety of lapatinib in combination with trastuzumab versus trastuzumab alone as continued HER2 suppression therapy in women with…
- Trial name
- NCT00968968
- Testing
- Lapatinib, Trastuzumab
- Where
- 116 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Osteoporosis, Osteopenia
Vivomixx for Prevention of Bone Loss in Women With Breast Cancer Treated With an Aromatase Inhibitor
This study evaluates the efficacy of the probiotic food supplement Vivomixx in the prevention of bone loss occurring in post menopausal women with breast cancer treated with an aromatase inhibitor.
- Trial name
- NCT03518268
- Testing
- Vivomixx
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Sarcopenic Obesity in Breast Cancer Survival, Muscle Strength Quantitative Trait Locus 1
Effect of Combined Exercise Post-treatment Intervention in Lean Mass Recovery in Breast Cancer Survival.
Breast cancer survival it is affected by the side effects related to the illness, the treatments or even the behavioral factors (e.g.
- Conditions
- Sarcopenic Obesity in Breast Cancer Survival, Muscle Strength Quantitative Trait Locus 1, Cardiopulmonary Capacity, Quality of Life
- Trial name
- WIM1 (NCT01843608)
- Testing
- Physical Intervention
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Universidad Politecnica de Madrid
Breast Neoplasms, Breast Cancer
Comparison of Ultrasound and Breast MRI for Breast Cancer Detection
The goal of this randomized clinical trial is to compare diagnostic results of secondary breast cancer surveillance using breast ultrasound abbreviated MRI and full protocol MRI.
- Trial name
- NCT05797545
- Testing
- Breast MRI for Breast Cancer Detection
- Where
- 3 sites in South Korea
- Volunteers
- 1,756 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center