Clinical trials: Breast Neoplasms, completed
Chemotherapy-induced Nausea and Vomiting
A Study to Assess the Safety and the Efficacy of IV Fosnetupitant/Palonosetron (260 mg/0.25 mg) Combination Compared to Oral Netupitant/Palonosetron (300 mg/0.5 mg) Combination for the Prevention of CINV in AC Chemotherapy in Women With Breast Cancer
Multicenter, randomized, double-blind, double-dummy, parallel group, stratified study assessing the safety and describing the efficacy of a single dose of intravenous (IV) fosnetupitant/palonosetron (260 mg/0.25 mg) infusion…
- Trial name
- NCT03403712
- Testing
- fosnetupitant/ palonosetron, netupitant/palonosetron, dexamethasone
- Where
- 40 sites in United States, Georgia
- Volunteers
- 404 people
- Sponsor
- Helsinn Healthcare SA
Breast Cancer Female, Side Effects
Rehabilitation Through Hippotherapy for the Management of Women After Primary Treatment of Breast Cancer
Breast cancer is the most common women's cancer and the third leading cause of death. Advances in prevention, detection and primary treatment have improved overall survival leading to its growing acceptance as a long-term…
- Conditions
- Breast Cancer Female, Side Effects, Psychological Distress, Physical Disability
- Trial name
- HippoBreastCa (NCT04350398)
- Testing
- Hippotherapy, Conventional therapy
- Where
- France
- Volunteers
- 83 people
- Sponsor
- Alliance Equiphoria
Triple Negative Breast Neoplasms, Triple Negative Breast Cancer
Triple-negative Breast Cancer: a New Perspective on Biomarkers
A single-institutional cohort to determine the prevalence of new immunohistochemical panel in advanced triple-negative submitted to neoadjuvant chemotherapy and its association with response and survival.
- Trial name
- TNBCbrazil (NCT03539965)
- Where
- Brazil
- Volunteers
- 239 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Metastatic Breast Cancer, Lung Metastases
Stereotactic Body Radiation and Monoclonal Antibody to OX40 (MEDI6469) in Breast Cancer Patients With Metastatic Lesions
This study will test the investigational antibody, MEDI6469 (anti-OX40), in combination with stereotactic body radiation in breast cancer patients that have liver or lung metastases and have received systemic therapy and have…
- Conditions
- Metastatic Breast Cancer, Lung Metastases, Liver Metastases
- Trial name
- OX40 Breast (NCT01862900)
- Testing
- MEDI6469
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Providence Health & Services
hCG, BRCA1 Mutation
Use of Recombinant hCG to Prevent Breast Cancer in BRCA1 and BRCA2 Carriers
Specific aim: To establish the proof of principle that treatment of "high breast cancer risk" women with recombinant human chorionic gonadotropin (r-hCG) will change their breast epithelium's high risk genomic profile to one…
- Conditions
- hCG, BRCA1 Mutation, BRCA2 Mutation
- Trial name
- NCT03495609
- Testing
- Ovitrelle
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- University Hospital, Ghent
Breast Neoplasms
Exemestane (Aromasine) + Tamoxifen - Breast Neo-Adjuvant
This is a Phase II non-randomized, open, uncontrolled and bi-centric study of hormonal induction by exemestane (Aromasin) + tamoxifen to evaluate the effectiveness of exemestane (Aromasin) with tamoxifen on the rate of clinical…
- Trial name
- TAMARO (NCT00919399)
- Testing
- Exemestane, tamoxifen
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- Institut Claudius Regaud
HER2 Negative Breast Cancer
Trial of Eribulin/Cyclophosphamide or Docetaxel/Cyclophosphamide as Neoadjuvant Therapy in Locally Advanced HER2-Negative Breast Cancer
The investigators propose a randomized phase II study evaluating the pCR and toxicity profiles of combination eribulin/cyclophosphamide (ErC) and docetaxel /cyclophosphamide (TC) as neoadjuvant therapy for locally advanced…
- Trial name
- NCT01527487
- Testing
- Eribulin, Cyclophosphamide, Docetaxel
- Where
- 15 sites in United States
- Volunteers
- 76 people
- Sponsor
- SCRI Development Innovations, LLC
Cancer
Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer
RATIONALE: Suberoylanilide hydroxamic acid may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth.
- Trial name
- NCT00045006
- Testing
- vorinostat
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Healthy Adults
A PK Study to Assess the Drug-drug Interaction of a BCRP Inhibitor on Adagrasib
A Phase 1, Open-label, One-sequence Crossover Study to Investigate the Effect of a Breast Cancer Resistance Protein Inhibitor on the Single-dose Pharmacokinetics of Adagrasib in Healthy Adult Subjects
- Trial name
- NCT05924152
- Testing
- Adagrasib, Eltrombopag + adagrasib
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mirati Therapeutics Inc.
High Risk, Breast Cancer
Phase III Comparison of Adjuvant Chemotherapy W/High-Dose Cyclophosphamide Plus Doxorubicin (AC) vs Sequential Doxorubicin Fol by Cyclophosphamide (A-C) in High Risk Breast Cancer Patients With 0-3 Positive Nodes (Intergroup, CALGB 9394)
To compare disease-free survival (DFS), overall survival (s), and toxicity of high-isk primary breast cancer patients with negative axillary lymph nodes or with one to three positive nodes treated with adjuvant high-dose…
- Conditions
- High Risk, Breast Cancer, Positive Nodes, Cyclophosphamide
- Trial name
- NCT00590785
- Testing
- Doxorubicin, Cyclophosphamide, G-CSF
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Cognitive Dysfunction, Breast Cancer Survivors
Physical Activity and Neuropsychological Outcomes in a Cancer Population
Many cancer survivors experience treatment-related impairments in mental abilities such as memory, attention, and concentration (known as cognition).
- Trial name
- NCT02332876
- Testing
- Exercise, Control
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, San Diego
Hodgkin's Disease, Cervical Cancer
Psychosocial Impact of Cancer-Related Female Infertility
The success of cancer treatment combined with the trend to delay childbearing is increasing the numbers of women survivors whose childbearing has been interrupted by cancer. For some, treatment has resulted in infertility.
- Conditions
- Hodgkin's Disease, Cervical Cancer, Breast Cancer, Lymphoma
- Trial name
- NCT00386217
- Testing
- Telephone Survey
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Weekly Gemcitabine, Epirubicin, and Docetaxel in Locally Advanced or Inflammatory Breast Cancer
Treatment strategies that include induction chemotherapy have several potential advantages: early initiation of systemic chemotherapy, in vivo assessment of response, and down-staging of both the primary tumor and regional…
- Trial name
- NCT00193050
- Testing
- Gemcitabine, Epirubicin, Docetaxel
- Volunteers
- 110 people
- Sponsor
- SCRI Development Innovations, LLC
Breast Cancer, Cervical Cancer
Breast and Cervical Cancer Educational Intervention for Latinas in Western New York
This pilot clinical trial studies a breast and cervical cancer educational intervention for Latinas in Western New York. An outreach program may help minority cancer patients overcome problems that keep them from receiving cancer…
- Trial name
- NCT01760850
- Testing
- educational intervention, questionnaire administration
- Where
- United States
- Volunteers
- 959 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Metastatic Breast Cancer
Phase I Combination w/ Epirubicin
Tumor response information was obtained for all participants who received at least 2 cycles of study drug, underwent requisite baseline and on-treatment disease assessments and had at least one post-treatment assessment.
- Trial name
- NCT00322374
- Testing
- Ixabepilone, Epirubicin
- Where
- 2 sites in France, Italy
- Volunteers
- 42 people
- Sponsor
- R-Pharm
Radiation Dermatitis
LUT014 for the Treatment of Radiation Induced Dermatitis in Breast Cancer Patients
The study will evaluate the safety, tolerability and efficacy of LUT014 gel topically administered in breast cancer patients who developed radiation dermatitis.
- Trial name
- NCT04261387
- Testing
- LUT014 Gel
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Lutris Pharma Ltd.
Breast Cancer, Chronic Myeloproliferative Disorders
Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell Transplant
RATIONALE: Antiemetic drugs, such as aprepitant, granisetron, and dexamethasone, may help lessen or prevent nausea and vomiting in patients treated with chemotherapy.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Leukemia
- Trial name
- NCT00293384
- Testing
- Aprepitant, Cyclophosphamide, Dexamethasone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Analgesia, Breast Cancer
US Guided Erector Spinae Plane Block in Breast Cancer Surgery: Analgesia, Spread and Immunomodulation
Prospective interventional study
- Trial name
- NCT04796363
- Testing
- Erector Spinae Plane Block with Bubivacaine, Standard General Anaesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Breast Cancer
Epirubicin and Docetaxel Combination (ET) or Epirubicin Followed by Docetaxel (E/T) for Node Negative (N0) High Risk Breast Cancer Patients
The combination of taxanes, and especially docetaxel, with an anthracycline seems to be an important part of the chemotherapy regimens used in the adjuvant setting of patients with early-stage node-positive breast cancer…
- Trial name
- NCT00424606
- Testing
- Docetaxel, Epirubicin
- Where
- 12 sites in Greece
- Volunteers
- 658 people
- Sponsor
- Hellenic Oncology Research Group
Metastatic Breast Cancer, Metastatic Colon Cancer
Dose Escalating Study of Foxy-5 in Breast-, Colon- or Prostate Cancer Patients
The Wnt proteins belong to a family of proteins that have been demonstrated to play a role in the formation and dissemination of tumours.
- Conditions
- Metastatic Breast Cancer, Metastatic Colon Cancer, Metastatic Prostate Cancer
- Trial name
- NCT02655952
- Testing
- Foxy-5
- Where
- 4 sites in Denmark, United Kingdom
- Volunteers
- 17 people
- Sponsor
- WntResearch AB
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