Clinical trials: Breast Reductions
Hematoma Postoperative
A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery
This trial is being completed to evaluate the safety and efficacy of topical tranexamic acid use in preventing hematomas in routine breast plastic surgery operations.
- Trial name
- NCT05441592
- Testing
- Tranexamic acid injection, No additional irrigation
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Michigan
Macromastia
PEAK PlasmaBlade 4.0 in Bilateral Breast Reduction
The objective of this clinical study is to evaluate the operative performance of the PEAK PlasmaBlade 4.0 during bilateral breast reduction; to monitor and record post-operative pain, adverse events and skin scarring following…
- Trial name
- PRECISE (NCT00986453)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 7 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Breast Cancer
Breast Cancer Risk Reduction: A Patient Doctor Intervention
The proposed research combines the scientific advances in breast cancer research with health information technology (IT) to design a personalized intervention that assesses breast cancer risk for women, disseminates important…
- Trial name
- BreastCARE (NCT01830933)
- Testing
- BreastCARE
- Where
- 2 sites in United States
- Volunteers
- 1,235 people
- Sponsor
- University of California, San Francisco
Hyperplasia
Harmonic Scalpel Vs. Electrocautery in Breast Reduction Surgery
Purpose: The aims of this randomized clinical trial are to assess and compare 3 different outcomes in women undergoing breast reduction surgery using two different surgical devices: the Harmonic Scalpel and electrocautery.
- Trial name
- NCT00819260
- Testing
- Harmonic Scalpel, Electrocautery
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Feeding, Exclusive
Childhood Risk Reduction Program in Hispanics
Childhood obesity is a serious problem in the United States, as it increases the risk for various cardiometabolic, pulmonary, and psychosocial complications for children, which often continue into adulthood.
- Trial name
- ECOR-H (NCT03903146)
- Testing
- Early Childhood Obesity Risk-Reduction Program in Hispanics
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ana Maria Linares
Delayed Healing
PICO Breast Reduction Clinical Study Looking at Incision Healing Complications
The purpose of this study is to see if the use of a single-use negative pressure wound therapy system (NPWT) will have an effect on the reduction of post-surgical incision healing complications following breast reduction surgery…
- Trial name
- NCT01640366
- Testing
- PICO
- Where
- 6 sites in United States, France and 2 more
- Volunteers
- 200 people
- Sponsor
- Smith & Nephew, Inc.
Pain, Metastatic Breast Cancer
Quell Opioid Reduction and Pain Relief in Patients With Cancer
To study effects the Quell device has on opioid consumption and pain relief in patients with cancer.
- Conditions
- Pain, Metastatic Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT02809846
- Testing
- Quell
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Scripps Translational Science Institute
Breast Carcinoma, Breast Ductal Carcinoma In Situ
EMBr Wave for the Reduction of Hot Flashes in Women With a History of Breast Cancer
This trial studies how well EMBr Wave technology works in reducing hot flashes in women with a history of breast cancer. Hot flashes are a common symptom experienced by menopausal women.
- Conditions
- Breast Carcinoma, Breast Ductal Carcinoma In Situ, Breast Lobular Carcinoma In Situ, Hot Flashes
- Trial name
- NCT05086705
- Testing
- EMBr Wave, Questionnaire Administration
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Macromastia
A Study to Evaluate Cutaneous Scar Quality Following Bilateral Breast Reduction With the PEAK PlasmaBlade 4.0
The objective of this clinical study is to evaluate scar quality following incision with the PEAK PlasmaBlade 4.0 using the Patient and Observer Scar Assessment Scale (POSAS), and to compare these results to equivalently-aged…
- Trial name
- PRECISE (NCT01284491)
- Testing
- PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Medtronic Surgical Technologies
Pain, Acute, Nausea
Enhanced Recovery Strategies in Elective Breast Surgery
Postoperative pain, nausea, and vomiting are frustrating sequelae of elective breast surgery. Poorly managed postoperative pain can lead to increased opioid use, increased postoperative nausea and vomiting (PONV), delayed return…
- Conditions
- Pain, Acute, Nausea, Vomiting, Postoperative, Opioid Use
- Trial name
- NCT03187080
- Testing
- Paravertebral block procedure using either local anesthetic (0.25% bupivacaine) or sterile saline, Enhanced recovery after breast surgery (ERABS) strategies, Paravertebral block using local anesthetic
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Risk Reduction, Mammographic Density Reduction
Low Dose Tamoxifen for Mammographic Density Reduction
KARISMA2 is a randomized, double-blinded, six-armed placebo controlled study to identify a low dose of tamoxifen, with less side-effects and a density reduction non-inferior to the standard dose of 20 mg.
- Trial name
- KARISMA2 (NCT03346200)
- Testing
- Tamoxifen Oral Tablet
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- Per Hall
Gender Dysphoria, Opioid Use
The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery
Despite recent advancements with regional and local anesthesia, postoperative pain continues to be a major concern for patients undergoing breast surgery.
- Conditions
- Gender Dysphoria, Opioid Use, Pain, Postoperative
- Trial name
- NCT04474366
- Testing
- Ropivacaine 0.2% Injectable Solution, Saline (0.9%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Breast Cancer
Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer
The goal of this clinical research study is to learn if metformin can help to control nerve damage (loss of motor or sensory function) that may be caused by treatment with paclitaxel in patients with breast cancer.
- Trial name
- NCT02360059
- Testing
- Metformin, Questionnaires, Sensory and Fine-Motor Tests
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Mammographic Density
Karolinska Interventional Study of Mammograhic Density (Karisma-1)
A feasibility study, randomising to either 10 or 20 mg of tamoxifen. The primary aim is to identify the time to mammographic density change and piloting the procedures.
- Trial name
- Karisma-1 (NCT04079517)
- Testing
- Tamoxifen
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Breast Cancer
Penguin Cold Caps in the Prevention of Hair Loss in Breast Cancer Patients
The goal of this study is to estimate the efficacy of Penguin cold caps in preventing or reducing hair loss in patients receiving (neo)adjuvant chemotherapy (one of four common regimens) for early stage breast cancer.
- Trial name
- NCT03289364
- Testing
- Penguin Cold Caps
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Providence Health & Services
Pain, Postoperative, Postoperative Nausea and Vomiting
A Comparison of Tumescence in Breast Reduction Surgery
The investigators' main hypothesis is that in breast reduction surgery, the use of tumescent solution containing both dilute lidocaine and epinephrine will lead to better control of postoperative pain, nausea, vomiting, shorter…
- Trial name
- NCT01602692
- Testing
- Tumescent solution with dilute lidocaine and epinephrine, Tumescent Solution with dilute epinephrine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Anxiety, Breast Cancer
Music Therapy as a Tool for Anxiety Reduction in Localized Breast Cancer
Breast cancer is the number one cancer in women worldwide, with 58,500 new cases in metropolitan France in 2018. The announcement of the cancer, the treatment methods and their side effects can generate unpleasant emotions, such…
- Conditions
- Anxiety, Breast Cancer, Chemotherapy
- Trial name
- CENSORIAL (NCT05856656)
- Testing
- Music therapy
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer
REduction of Physical Inactivity Facing the CAncer
Study 1: The investigator hypothesizes that the level of knowledge about the benefits of physical activity, physical activity level and physical fatigue level observed in cancer patients, would influence their beliefs about…
- Trial name
- RESCA (NCT02867475)
- Testing
- Intrinsic Physical activity motivation, Extrinsic Physical activity motivation
- Where
- France
- Volunteers
- 420 people
- Sponsor
- Centre Antoine Lacassagne
Reduction of Hypertrophic Skin Scarring
Safety and Efficacy Study of PF-06473871 to Reduce Hypertrophic Scars From Recurring Post-Revision Surgery
The study will compare how well PF-06473871 works versus placebo in reducing skin scarring after scar revision surgery of existing breast scars. The study will also evaluate the safety of PF-06473871 in healthy adult subjects.
- Trial name
- NCT01730339
- Testing
- PF-06473871
- Where
- 40 sites in United States, Germany and 2 more
- Volunteers
- 103 people
- Sponsor
- Pfizer
Breast Biopsy
Diagnostic US for Reduction of Benign Breast Biopsies Using US-guided Optical Tomography
Ultrasound-guided diffuse optical tomography (DOT) has demonstrated its potential role in differentiating malignant and benign breast abnormalities and in predicting and monitoring the neoadjuvant chemotherapy (NAC) response of…
- Trial name
- NCT03842358
- Testing
- Hand-held hybrid probe
- Where
- United States
- Volunteers
- 298 people
- Sponsor
- Washington University School of Medicine