Clinical trials: Breast Surgery, active
Breast Cancer, Triple Negative Breast Cancer
Vabb After Neoadjuvant Therapy to Avoid Surgery-pCR to Avoid Breast Surgery
This single arm study aims to evaluate the efficacy and safety of a non-surgical approach, consisting of radiotherapy (RT) alone, for patients who have achieved a complete pathological response (pCR) following neoadjuvant…
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, HER2-positive Breast Cancer, Neoadjuvant Chemotherapy
- Trial name
- BETTY-CRASY (NCT06281210)
- Testing
- Omission of surgical treatment
- Where
- 2 sites in Italy
- Volunteers
- 77 people
- Sponsor
- European Institute of Oncology
Breast Cancer Female, Postoperative Pain
Study of Lipid Mediators in Chronic Postoperative Pain - LICP
This interventional prospective study aims firstly to investigate variations in lipid levels in blood samples and their potential relationship with the duration and/or intensity of post-operative pain.
- Trial name
- LICP (NCT06907810)
- Testing
- Blood sample + questionnaire
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Université Catholique de Louvain
Breast Cancer
Comparison of the Safety and Aesthetic Outcomes of a Novel Endoscopic-Assisted Breast-Conserving Surgery (SRRSHzb-EABCS) With Those of Conventional Breast-Conserving Surgery
This multicenter, open-label, prospective, randomized controlled study compares a novel endoscopy-assisted breast-conserving surgery technique (SRRSHzb-EABCS) with conventional open breast-conserving surgery (CBCS) in women with…
- Trial name
- ZACA001 (NCT07920094)
- Testing
- Endoscopy-assisted breast-conserving surgery (SRRSHzb-EABCS), Conventional open breast-conserving surgery (CBCS)
- Where
- 22 sites in China
- Volunteers
- 422 people
- Sponsor
- Sir Run Run Shaw Hospital
Breast Cancer Recurrent
Registry of Local Recurrences After Breast-conserving Surgery
The ReLoCC project is a prospective, multicenter, clinical study to register cases of local recurrence after breast-conserving surgery, in centers dedicated to the treatment of breast cancer, in Portugal and Spain.
- Trial name
- R_ReLoCC (NCT05406661)
- Volunteers
- 3,000 people
- Sponsor
- Universidade do Porto
Breast Surgery
Serratus Posterior Superior Intercostal Plane Block, Versus Erector Spinae Facial Plane Blocks
Mastectomy is currently the most effective treatment for breast cancers in women. postoperative pain management carries a high degree of difficulty, as the breast has complex innervation involving the intercostal (T1-T7)…
- Trial name
- NCT06989372
- Testing
- serratus posterior superior block, erector spinae block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Breast Implants
Study of the Safety and Effectiveness of Motiva Implants®
This study evaluates the safety and effectiveness Motiva Implants® in women who are undergoing primary breast augmentation, primary breast reconstruction or revision breast surgery.
- Trial name
- NCT03579901
- Testing
- Silicone gel-filled breast implants - Motiva Implants® Investigational breast implants
- Where
- 29 sites in United States, Germany and 1 more
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Motiva USA LLC
Breast Cancer (Early Breast Cancer)
A Study on the Treatment of Early Small Breast Cancer With Ultrasound-guided Vacuum-assisted Excision Combined With Surgery
The aim of this clinical trial is to assess the feasibility and safety of ultrasound-guided vacuum-assisted excision (VAE) in the treatment of early breast cancer with Tis (carcinoma in situ) or T1 (maximum tumor diameter ≤2cm)…
- Trial name
- NCT07071402
- Testing
- Ultrasound-guided vacuum-assisted excision combined with surgical treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Triple Negative Breast Cancer
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
The goal of this study is to find out if the experimental product, sacituzumab govitecan-hziy (SG) in combination with pembrolizumab given after surgery, is effective and safe compared to the treatment of physician's choice (TPC)…
- Trial name
- NCT05633654
- Testing
- Sacituzumab govitecan-hziy (SG), Pembrolizumab, Capecitabine
- Where
- 378 sites in United States, Australia and 10 more
- Volunteers
- 1,514 people
- Sponsor
- Gilead Sciences
Ductal Carcinoma in Situ of the Breast
Avoiding Surgery in Estrogen Receptor Positive Atypical Ductal Hyperplasia and In-situ Carcinoma Treated With Endocrine Treatment Trial
This study aims to evaluate the 5-year invasive ipsilateral breast cancer incidence rate in patients with hormone-receptor positive, HER-2 negative atypical ductal hyperplasia or in-situ carcimona who omitted surgery and received…
- Trial name
- ASAIN (NCT07245316)
- Testing
- Avoiding surgery
- Where
- South Korea
- Volunteers
- 340 people
- Sponsor
- Jeong Eon Lee
Breast Cancer Stage IV, Radiotherapy
Locoregional Treatment and Palbociclib in de Novo, Treatment Naive, Stage IV ER+, HER2- Breast Cancer Patients
Approximately 3.5% to 6% of newly diagnosed breast cancer patients are stage IV metastatic. De novo metastatic breast cancer accounts for 20% to 25% of these cases.
- Conditions
- Breast Cancer Stage IV, Radiotherapy, Surgery
- Trial name
- PALATINE (NCT03870919)
- Testing
- Palbociclib, locoregional treatment
- Where
- 26 sites in France
- Volunteers
- 200 people
- Sponsor
- UNICANCER
Postoperative Analgesia in Breast Reduction Surgery, Postoperative Pain
Comparison of Serratus Plane Block and Rhomboid Intercostal Plane Block for Postoperative Analgesia in Breast Reduction Surgery
This prospective, randomized clinical study aims to compare the analgesic efficacy of serratus plane block (SPB) and rhomboid intercostal plane block (RIPB) for postoperative analgesia in patients undergoing elective bilateral…
- Conditions
- Postoperative Analgesia in Breast Reduction Surgery, Postoperative Pain, Postoperative Pain Breast Reduction, Pain, Postoperative
- Trial name
- SAPB-RIPB (NCT07229092)
- Testing
- Serratus Anterior Plane Block (SAPB), Rhomboid Intercostal Plane Block (RIPB), No Regional Block (Control)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Konul Karaja
Breast Cancer (Early Breast Cancer), Postoperative Shoulder Dysfunction
Prehabilitation in Breast Cancer Surgery
This prospective, randomized, assessor-blinded, parallel-group clinical trial evaluates the effectiveness of a home-based upper extremity-focused prehabilitation program in women undergoing breast cancer surgery.
- Conditions
- Breast Cancer (Early Breast Cancer), Postoperative Shoulder Dysfunction, Lymphedema Arm, Cancer Rehabilitation
- Trial name
- NCT07425379
- Testing
- Home-Based Prehabilitation Exercise Program, Usual Care
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Safety of Breast Coservative Multicenteric Breast Cancer, Breast Neoplasms
Oncological Safety of Oncoplastic Breast Surgery in Multicentric Breast Cancer
The purpose of the study is to evaluate Oncological safety of oncoplastic breast surgery in multicentric breast cancer
- Conditions
- Safety of Breast Coservative Multicenteric Breast Cancer, Breast Neoplasms, Breast Cancer, Multicentric
- Trial name
- NCT06926335
- Testing
- Breast consevative surgery
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Surgical Site Infection, Surgical Complication
A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™
Goal of the Clinical Trial: The purpose of this clinical trial is to learn whether Xperience™ surgical irrigation solution is more effective than a standard dilute povidone-iodine solution in reducing surgical site infections…
- Conditions
- Surgical Site Infection, Surgical Complication, Implant Infection, Implant Complication
- Trial name
- NCT06649890
- Testing
- Xperience™ Advanced Surgical Irrigation, Dilute Povidone-Iodine
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Triple-negative Breast Cancer
A Prospective, Phase II Trial Using ctDNA to Initiate Post-operation Boost Therapy After NAC in TNBC
Positive circulating tumor DNA(ctDNA) status is associated with worse prognosis in breast cancer, especially triple-negative breast cancer(TNBC).
- Trial name
- Apollo (NCT04501523)
- Testing
- Tislelizumab, capecitabine
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Surgery
The Impact of Breast Surgery on Patients' Quality of Life
The investigators aim to document the surgery-specific and overall Quality of life parameters of patients undergoing all types of breast surgery at the University Hospital of Basel
- Trial name
- NCT07283120
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Fibroadenoma, Breast Fibroadenoma
Management of Breast Fibroadenoma: Comparing Observation, Microwave Ablation, and Surgical Excision
The purpose of this study is to evaluate and compare three different management strategies for benign breast fibroadenoma: conservative management with clinical and radiological follow-up (observation), ultrasound-guided…
- Conditions
- Fibroadenoma, Breast Fibroadenoma, Benign Breast Disease
- Trial name
- NCT07890766
- Testing
- Ultrasound-guided percutaneous microwave ablation, Conventional open surgical excision
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Breast Reconstruction Surgery
Tissue Reinforcement for Breast Reconstruction (TRBR) Pivotal Clinical Study (REDEFINE)
The GORE Tissue Reinforcement for Breast Reconstruction (TRBR) research study will look at breast reconstruction during mastectomy procedures.
- Trial name
- NCT06556654
- Testing
- TRBR Device
- Where
- 20 sites in United States
- Volunteers
- 180 people
- Sponsor
- W.L.Gore & Associates
Breast Cancer Invasive
A Phase II Clinical Trial of Artificial Intelligence-assisted One-stop Radiotherapy for Breast Cancer After Breast-conserving Surgery
Background: Breast cancer became the most prevalent cancer globally in 2020, and post-surgery radiotherapy is crucial for most patients. Traditional radiotherapy is complex and time-consuming, affecting patient experience.
- Trial name
- BC-AIO (NCT06686459)
- Testing
- ALL-in-one radiotherapy, IMRT
- Where
- China
- Volunteers
- 860 people
- Sponsor
- Sun Yat-sen University
Breast Cancer
Hypofractionated Radiation Fractionation in Breast Cancer Patients With Implant-Based Reconstruction
It is a randomized trial to assess the safety and efficacy between hypofractionation radiation and conventional radiation in women who have undergone mastectomy and immediate breast reconstruction.
- Trial name
- HFIBR (NCT06830083)
- Testing
- Hypofractionated Radiation Therapy, Conventional fraction radiotherapy
- Where
- China
- Volunteers
- 840 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University