Clinical trials: Breast Tumor Tissue
Inflammation, Cancer
NSAID Effects on Clinical and Imaging Breast Biomarkers
This study has two purposes. One is to determine if daily sulindac decreases breast density; a risk factor for breast cancer development.
- Conditions
- Inflammation, Cancer, Pain, Hypertension
- Trial name
- NCT01761877
- Testing
- Sulindac
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Stony Brook University
Breast Cancer, Metastatic Breast Cancer
Radioactive Iodide (131I) Treatment of 124I PET/CT Detected Breast Cancers
This is a treatment protocol designed to accompany the ongoing institutional 124I PET/CT pilot imaging study for patients with invasive breast cancer.
- Trial name
- NCT01360177
- Testing
- 124 PET/CT imaging, Na134I, Tri-iodothyronine
- Where
- United States
- Sponsor
- Stanford University
Geriatric Assessment, Adjuvant Drug Therapy
Aspects of Adjuvant CDK4/6 Inhibitors in Older Breast Cancer Patients - Focusing on Geriatric Screening
Older breast cancer patients should not be categorically excluded from adjuvant therapies, including the recommended CDK4/6 inhibitors (CDK4/6i) administered in combination with endocrine therapy.
- Conditions
- Geriatric Assessment, Adjuvant Drug Therapy, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Trial name
- FUTURE (NCT07273357)
- Where
- 5 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Region Jönköping County
Invasive Breast Cancer, HER2-positive Breast Cancer
fREEDOM: REsonance for Early Detection Of Breast Cancer Metastases
The aim of this study is to understand whether DWB-MRI (Diffusion Whole Body-Magnetic Resonance Imaging) is useful for early detection of locoregional or distant recurrence and whether early diagnosis influences the prognosis in…
- Conditions
- Invasive Breast Cancer, HER2-positive Breast Cancer, Triple Negative Breast Cancer
- Trial name
- fREEDOM (NCT06328465)
- Testing
- Diffusion whole body MRI
- Where
- Italy
- Volunteers
- 145 people
- Sponsor
- European Institute of Oncology
HER2-positive Breast Cancer
The Use of FES-PET Imaging as a Tool to Detect a Possible Reversion of Estrogen Receptor (ER)-α Status in Patients With Metastatic Breast Cancer HER2 + and ERα Neg Treated With Trastuzumab + Pertuzumab + Taxane.
This is an exploratory, prospective and multicentric study aiming to highlight by FES-PET imaging that an anti-HER2 treatment by trastuzumab + pertuzumab can reverse the ERα status in patients with metastatic breast cancer HER2 +…
- Trial name
- REVER (NCT03619044)
- Testing
- 2 FES-PET Imaging will be performed:
- Where
- 6 sites in France
- Volunteers
- 4 people
- Sponsor
- Institut Claudius Regaud
Breast Cancer
Tolerability and Efficacy of Adjuvant T-DM1 in Patients with HER2 Positive Breast Cancer After Incomplete Pathological Response to Neoadjuvant Chemotherapy Including Anti-HER2 Agents.
Multicenter, retrospective-prospective, real-world observational study, with the aim of evaluating tolerability and efficacy in a population of patients treated according to clinical practice outside of studies randomized.
- Trial name
- ATD (NCT06272799)
- Testing
- T-DM1 adjuvant
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Regina Elena Cancer Institute
Breast Cancer
Study of Safety and Efficacy of Durvalumab in Combination With Paclitaxel in Metastatic Triple Negative Breast Cancer Patients
The expression of PD-L1 in breast cancer has been previously demonstrated (Ghebeh et al 2006). In addition, PD-L1 has been shown to work as a "molecular shield", by protecting cancer cells from cytotoxic T-cells and chemotherapy…
- Trial name
- NCT02628132
- Testing
- Paclitaxel, Durvalumab
- Where
- Saudi Arabia
- Volunteers
- 22 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Breast Cancer
BIOPSY SCANNER LLTECH© Technology for Diagnosis of Breast Cancer
Breast cancer is a frequent pathology and the speed of initial diagnosis makes it possible to improve the course of care and to reduce the anxiety of the patients.
- Trial name
- LLTECHBreast (NCT04292821)
- Where
- France
- Volunteers
- 217 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer
C11 AMT Positron Emission Tomography (PET) Imaging in Patients With Metastatic Invasive Breast Cancer
The purpose of this research project is to create images of where and how the amino acid (the building blocks of proteins)Tryptophan is processed in normal and abnormal tissue in the patient's body.
- Trial name
- NCT01302821
- Testing
- Adenovirus-p53 transduced dendritic cell vaccine, 1-methyl-D-tryptophan, Carbon C 11 alpha-methyltryptophan
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Breast Cancer, Colon Cancer
Stress-Reducing Intervention in Patients With Colorectal and Breast Cancer
The goal of this interventional study is to test the heart-rate variability biofeedback intervention (HRV BI) in 2 cohorts of patients.
- Trial name
- SRI-BrCa_CRC (NCT06281145)
- Testing
- Heart-rate variability biofeedback intervention
- Where
- Slovakia
- Volunteers
- 100 people
- Sponsor
- Comenius University
Breast Cancer Survivors, Postmenopause
Resistance-type Exercise Training in Postmenopausal Women Survivors of Breast Cancer
Background: In postmenopausal women, an alteration in body composition occurs as a consequence of the secretion of low levels of serum estrogens by the ovaries.
- Conditions
- Breast Cancer Survivors, Postmenopause, Resistance Training
- Trial name
- MUSCLE-CLIM (NCT05690295)
- Testing
- Prolonged resistance-type exercise training
- Where
- Chile
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universidad de La Frontera
Breast Cancer
Evaluation of the Use of AZD6244 to Induce Increased ER Expression and Anti-Estrogen Response in ER-Negative/Low Breast Cancer
If AZD6244 is able to increase ER expression in ER-negative/low cancers then it may be possible to effectively use hormonal therapy in these patients resulting in improved outcomes.
- Trial name
- NCT01313039
- Testing
- AZ6244
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Miami
Early-stage Breast Cancer, Invasive Ductal Carcinoma of Female Breast
Radiation After No Axillary Nodal Sampling
This is a single arm, pilot, prospective study to evaluate the safety of partial breast irradiation in women who undergo breast conserving surgery without sentinel lymph node biopsy (SLNB) or axillary lymph node dissection…
- Trial name
- RADIANS (NCT07723209)
- Testing
- Partial Breast Irradiation (PBI)
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- NYU Langone Health
Breast Neoplasms
Analysis of Multimodal Psychosomatic Comorbidity Burden in Breast Cancer and Benefit Evaluation of Acupuncture Collaborative Management Regimen
This study adopts a multicenter, pragmatic, umbrella randomized controlled trial design integrated with the shared decision-making (SDM) model.
- Trial name
- NCT07763587
- Testing
- Acupuncture
- Where
- 3 sites in China
- Volunteers
- 216 people
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Breast Cancer
Pilot Trial to Assess 68Ga Bombesin PET/CT (NeoB) Imaging for Staging of Breast Cancer
This phase IIb pilot study will enrol 20 patients (women) presenting with metastatic breast cancer (ER/PR + HER2- on histology) who require imaging for staging or re-staging of their disease.
- Trial name
- NCT05889728
- Testing
- [68Ga]GA-NeoB
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- St Vincent's Hospital, Sydney
Breast Cancer, Breast Reconstruction
Closed Incision Disposable Negative Pressure Wound Therapy in Immediate Postmastectomy Breast Reconstruction
The study aimed to assess the impact of the use of closed incision negative pressure wound therapy (ciNPWT) after immediate breast reconstruction on the number of surgical-site complications, skin surface temperature, objective…
- Trial name
- NCT04808765
- Testing
- Immediate Breast reconstruction
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- University in Zielona Góra
Breast Cancer, Postmenopausal
Effect of Aromatase Inhibitors on Bones and Genes
The primary objective of this 2-year pilot project is to test the hypothesis that skeletal response to aromatase inhibitors is determined by polymorphisms of the CYP19 gene.
- Trial name
- NCT00603967
- Testing
- Dual x-ray absorptiometry (DXA), Blood draw, Questionnaire
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Washington University School of Medicine
Breast Advanced Malignancies
TDXD in Metastatic HER2-Positive Breast Cancer
A single-center observational study (retrospective + prospective) evaluating the real-world efficacy and toxicity profile of Trastuzumab Deruxtecan (T-DXd) in adult female patients with HER2-positive metastatic breast cancer…
- Trial name
- NCT07778407
- Testing
- Trastuzumab deruxtecan (T-DXd)
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- Mansoura University
Omitting Sentinel Lymph Node Biopsy in Early-stage Breast Cancer
De-escalation in Axillary Surgery for Early-stage Breast Cancer
The goal of this clinical trial is to determine if the omission of sentinel lymph node biopsy is safe for early-stage breast cancer patients in our institution (Clinical Hospital Centre Rijeka).
- Trial name
- RIDES (NCT07098507)
- Testing
- sentinel lymph node biopsy, omission of sentinel lymph node biopsy
- Where
- Croatia
- Volunteers
- 620 people
- Sponsor
- Clinical Hospital Center Rijeka
Breast Cancer, Chemotherapeutic Toxicity
AC vs TC in Patients With HR-positive, HER2-negative Early Breast Cancer
Anthracycline-paclitaxel sequential combination therapy is the standard regimen for perioperative chemotherapy in breast cancer. The strategy of perioperative chemotherapy is based on breast cancer subtype, i.e.
- Trial name
- NCT05302336
- Testing
- Liposomal doxorubicin + Cyclophosphamide vs Docetaxel + Cyclophosphamide
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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