Clinical trials: Breast Tumour
Breast Cancer
De-Escalation of Axillary Management in Advanced Nodal Disease
This is a prospective, phase 2, single arm trial to evaluate whether Axillary Lymph Node Dissection (ALND) can be safely omitted for patients with cN2 and cN3 breast cancer who achieve a complete clinical response on exam with a…
- Trial name
- DEMAND (NCT07643584)
- Testing
- Axillary Surgery
- Volunteers
- 120 people
- Sponsor
- University of Kansas Medical Center
Breast Cancer
The Radiation Metabolic Signature of Patient Undergoing Radiotherapy. A Pilot Study
Rationale: Local radiotherapy applied in the treatment of tumors changes the metabolic profile in the exposed area and/or systemically and specific radiation biomarkers can be identified in the respective matrices.
- Trial name
- NCT01975558
- Testing
- Sampling at baseline, one week after baseline, two weeks after baseline, Sampling at baseline, during radiotherapy and after
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Breast Cancer Patients Treated With T-DXd
A Study on Nausea and Vomiting Caused by T-DXd in Breast Cancer Patients
This study was a multicenter, prospective, controlled trial involving 120 breast cancer patients receiving T-DXd-based therapy. Participants were randomly assigned to either the experimental group (NEPA plus megestrol acetate) or…
- Trial name
- NCT07254416
- Testing
- NEPA, Dexamethasone, Megestrol Acetate
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Breast Cancer
Phase III Study of BKM120/Placebo With Fulvestrant in Postmenopausal Patients With Hormone Receptor Positive HER2-negative Locally Advanced or Metastatic Breast Cancer Refractory to Aromatase Inhibitor
This study was a multi-center, randomized, double-blind, placebo controlled Phase III study to determine the efficacy and safety of treatment with buparlisib plus fulvestrant versus fulvestrant plus placebo in postmenopausal…
- Trial name
- BELLE-2 (NCT01610284)
- Testing
- Fulvestrant, BKM120
- Where
- 268 sites in United States, Argentina and 27 more
- Volunteers
- 1,147 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Colorectal Cancer
Immunotherapy After Surgery in Treating Patients With Breast Cancer, Colon Cancer, or Melanoma
RATIONALE: Immunotherapy uses different ways to stimulate the immune system and stop cancer cells from growing. Immunotherapy biological extracts may be useful as adjuvant therapy in treating patients who have had surgery for…
- Conditions
- Breast Cancer, Colorectal Cancer, Melanoma (Skin)
- Trial name
- NCT00002455
- Testing
- Corynebacterium granulosum P40, adjuvant therapy
- Where
- Argentina
- Sponsor
- Centro Oncologico de Excelencia
Breast Cancer, Metastatic Breast Cancer
89Zr-DFO*-Trastuzumab PET in Patients With Gastric or Breast Cancer - a Pilot Study
The goal of this clinical trial is to test a new PET tracer in patients with HER2-positive breast or gastric cancer. This tracer is made of radioactively labeled trastuzumab, and can show where HER2 is present in the body using a…
- Conditions
- Breast Cancer, Metastatic Breast Cancer, HER2-positive Breast Cancer, Gastric Cancer
- Trial name
- HER Image (NCT05955833)
- Testing
- 89Zr-DFO*-trastuzumab PET scan
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Amsterdam UMC, location VUmc
Breast Cancer, Sentinel Lymph Node Biopsy
Sentinel Lymph Node Biopsy After Neoadjuvant Treatment in Breast Cancer Patents
This clinical trial is designed as an observational study of 8-9 years of overall duration, but the first results and conclusions could be achieved in 3-4 years.
- Conditions
- Breast Cancer, Sentinel Lymph Node Biopsy, Neoadjuvant Chemotherapy
- Trial name
- NCT03719833
- Where
- Croatia
- Volunteers
- 230 people
- Sponsor
- Clinical Hospital Center Rijeka
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Lymphedema, Breast Neoplasm
Presentation of First Time Attenders at Lymphedema Clinics
The first aim of this research project is to identify what factors motivate patients to seek assessment for early lymphedema and further, to gain insight into the signs and symptoms of developing lymphedema and the concurrent…
- Trial name
- NCT03687749
- Where
- 2 sites in Australia, Belgium
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer Stage I, Breast Cancer Stage II
Patient Reported Outcomes After Oncoplastic Breast Conserving Surgery
The goal of this study is to assess patient satisfaction after oncoplastic breast conserving surgery. With the help of a breast-questionnaire the patient satisfaction will be assessed before the surgery and 4 weeks, 6 months and…
- Conditions
- Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer in Situ
- Trial name
- NCT05724758
- Testing
- Breast-conserving surgery
- Volunteers
- 100 people
- Sponsor
- Brust-Zentrum AG
Breast Cancer
Pilot Study: Combined Molecular Breast Imaging/Ultrasound System for Diagnostic Evaluation of MBI-detected Lesions
A combined molecular breast imaging / ultrasound system will enable coregistration of a functional abnormality seen on Molecular Breast Imaging (MBI) with the corresponding anatomical abnormality seen on ultrasound.
- Trial name
- MBI/US (NCT01806558)
- Testing
- Molecular Breast Imaging
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Breast Cancer
CYP2D6 Genotyping by AmpliChipTM CYP450 for Tamoxifen-Treated Breast Cancer Patients
The aim of the study is to examine whether tamoxifen-treated Israeli breast cancer patients who are CYP2D6 poor metabolizers (CYP2D6*4/*4 genotype) are at higher cancer relapse risk during 2.5-5-year follow-up period from initial…
- Trial name
- NCT00815555
- Testing
- There is no intervention - this is an observational study
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Assaf-Harofeh Medical Center
Colon Cancer, Breast Cancer
A Digimed Oncology PharmacoTherapy Registry
DigiMeds™ are medications with FDA-approved ingestible sensors (IS), a wearable sensor patch (patch), and a mobile app, which records time-stamped medication type and dose alongside biometric activity.
- Conditions
- Colon Cancer, Breast Cancer, Rectal Cancer
- Trial name
- ADOPTR (NCT04088955)
- Testing
- DigiMeds
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Proteus Digital Health, Inc.
Malignant Breast Tissue Neoplasm
Is Dietary Nitrate Effective in Reducing Aerobic Glycolysis in Breast Cancer?
Breast cancer is the most prevalent cancer affecting women, with 1 in 8 women in the UK developing breast cancer in their life time.
- Trial name
- BEET (NCT03944226)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- University of Aberdeen
Breast Cancer
A Real-World Study of Clinical Adoption, Treatment Patterns and Tolerability of Adjuvant Ribociclib in HR+/HER2- Early Breast Cancer Patients
The aim of this study is to assess the clinical adoption, treatment patterns, and safety of adjuvant ribociclib use in hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) early breast cancer…
- Trial name
- CATTALYST (NCT07710716)
- Where
- Switzerland
- Volunteers
- 3,000 people
- Sponsor
- Novartis Pharmaceuticals
Advanced Breast Cancer
Phase II Dasatinib Study in Advanced Breast Cancer
The purpose of this study is to find out if dasatinib will safely reduce the size or spread of your tumor.
- Trial name
- NCT00546104
- Testing
- Dasatinib
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Duke University
Breast Cancer
Tumour Registry Breast Cancer
The registry aims to collect and analyse information on the antineoplastic treatment of breast cancer in daily routine practice of office-based and clinic-based medical oncologists in Germany.
- Trial name
- TMK (NCT01351584)
- Volunteers
- 4,500 people
- Sponsor
- iOMEDICO AG
TNBC - Triple-Negative Breast Cancer, Breast Cancer
Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Gemcitabine and Carboplatin for Metastatic Triple-Negative Breast Cancer (TNBC)
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of trilaciclib versus placebo administered prior to gemcitabine and carboplatin in patients receiving first- or…
- Trial name
- PRESERVE 2 (NCT04799249)
- Testing
- Trilaciclib, Gemcitabine, Carboplatin
- Where
- 71 sites in United States, Australia and 9 more
- Volunteers
- 194 people
- Sponsor
- G1 Therapeutics, Inc.
Breast Cancer, Chemotherapy Effect
The Maintenance Regimen and Revised Regimen for Advanced Breast Cancer Survivors After First-line Salvage Therapy
Worldwide, breast cancer is the most incident and prevalent cancer among women. Despite advances in the treatment of advanced breast cancer (ABC) during the past decade, adjuvant systemic therapy has yield little progression for…
- Conditions
- Breast Cancer, Chemotherapy Effect, Disease-free Survival
- Trial name
- NCT03423849
- Testing
- Vinorelbine, Gemcitabine, Cisplatin
- Volunteers
- 200 people
- Sponsor
- Zhiyong Yu
HR+/HER2- Breast Cancer
Combined Chemo-immunotherapy Plus SBRT in Neoadjuvant Treatment for Luminal Subtype Breast Cancer
This study is a prospective, randomized controlled clinical trial designed to evaluate the efficacy and safety of combining radiotherapy, chemotherapy, and immunotherapy in the neoadjuvant treatment of high-risk HR+/HER2- breast…
- Trial name
- CISN-L (NCT07254858)
- Testing
- Neoadjuvant radiotherapy, Neoadjuvant Chemotherapy (NACT), Immunotherapy (Sintilimab)
- Where
- China
- Volunteers
- 302 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
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