Clinical trials: Breathing Mechanics
Acute Respiratory Failure, Invasive Mechanical Ventilation
Assessment of Ventilation Parameters for Extubation Prediction in ICU
The study aims to research the values of mechanical power, driving pressure, and elastic power in predicting the duration of mechanical ventilation in critically ill patients undergoing invasive mechanical ventilation.
- Trial name
- NCT06531005
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara University
Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure
EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS
Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery.
- Conditions
- Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure, Electrical Impedance Tomography, Trauma and Postoperative Pulmonary Insufficiency
- Trial name
- EIT-PEEP-SURG (NCT07313644)
- Testing
- EIT-giuded PEEP, Control
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Nguyen Dang Thu
General Anesthesia Using Endotracheal Intubation
Comparison of Different Inspiratory to Expiratory Ratios on Respiratory Mechanics and Oxygenation in Robot-assisted Laparoscopic Radical Prostatectomy With Steep Trendelenburg Position and Pneumoperitoneum
The steep trendelenburg position and pneumoperitoneum during laparoscopic surgery have the potential to cause an adverse effects on respiratory mechanics and gas exchange.
- Trial name
- NCT01892449
- Testing
- prolonged inspiratory to expiratory (I:E) ratio (1:1), conventional I:E ratio (1:2)
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Acute Respiratory Failure (ARF)
Bed Side Assessment in Patients With Acute Respiratory Failure Under Invasive Mechanical Ventilation
The goal of this study is to learn about the respiratory mechanics in patients undergoing mechanical ventilation. The investigators can achieve this through the offline analysis of data provided by the ventilator.
- Trial name
- BAM (NCT07265882)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Lumbar Disc Herniation, Spinal Surgery
Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery
This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in…
- Conditions
- Lumbar Disc Herniation, Spinal Surgery, Prone Position, General Anesthesia
- Trial name
- PROPEEP (NCT07545733)
- Testing
- Mechanical Ventilation (PEEP)
- Volunteers
- 60 people
- Sponsor
- Harran University
Chronic Obstructive Pulmonary Disease
Effects of Non-invasive Ventilation on Respiratory Mechanics and NRD in Patients With Stable COPD
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by persistent respiratory symptoms and airflow limitation.
- Trial name
- NCT03555097
- Testing
- incremental pressure support
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Atrial Septal Defect, Ventricular Septal Defects
Comparison of Dynamic Compliance and Airway Resistance in Pressure-Controlled Versus Volume-Controlled Ventilation in Children Undergoing Corrective Heart Surgery
The goal of this clinical trial was to compare two settings on a breathing machine used during heart surgery in children. The children in this study were born with a hole inside the heart.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defects, Pulmonary Hypertension, Intracardiac and Septal Defects
- Trial name
- NCT07754591
- Testing
- Pressure Controlled Ventilation, Volume Controlled Ventilation
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Nilratan Sircar Medical College
Respiratory Muscles, Breathing Exercises
Respiratory Muscles and Inspiratory Muscle Training
The effects of inspiratory muscle training (IMT) remain controversial. Many studies have examined the effect IMT has on exercise performance, but any changes to the body that come from IMT have yet to be looked at.
- Trial name
- IMT (NCT02243527)
- Testing
- Inspiratory Muscle Training
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Acute Respiratory Distress Syndrome (ARDS)
Trunk Inclination, Positive End-expiratory Pressure, and Lung Recruitability
This multicenter, physiological, observational study hypothesizes that in moderate to severe ARDS, trunk inclination unloads the chest wall, but its impact on lung mechanics depends on PEEP levels and lung recruitability.
- Trial name
- NCT07504731
- Testing
- Specific lung recruitment maneuvers and decremental PEEP steps
- Where
- 3 sites in China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Acute Respiratory Distress Syndrome
Artificial Increase in Chest Wall Elastance as an Alternative to Prone Positioning in Moderate-to-severe ARDS.
During moderate to severe ARDS, sessions of prone positioning lead to lung and chest wall mechanics changes that modify regional ventilation, with a final redistribution of tidal volume and PEEP towards dependent lung regions…
- Trial name
- ALTERPRONE (NCT03719937)
- Testing
- weight on the anterior chest of the patient
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Catholic University of the Sacred Heart
Prone Position, Acute Respiratory Distress Syndrome
Prone Position With Different Types of Cushions in Patients With ARDS
The prone maneuver is a well-established therapy in ARDS. Traditionally, the maneuver is perform with thoraco-abdominal cushions.
- Trial name
- PronEIT (NCT06184490)
- Testing
- Prone position with thoraco-abdominal cushion
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Lung Infection, Mechanical Ventilation
Ventilator Hyperinflation With Increase of Inspiratory Time
The investigators hypothesis is that the adjustment of the inspiratory time may optimize the distribution of ventilation and increase tidal volume, producing potential therapeutic effects on the displacement of secretions and…
- Trial name
- NCT03630510
- Testing
- Ventilator hyperinflation
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- Brazilian Institute of Higher Education of Censa
Pseudomonas Aeruginosa Meningitis
Ceftazidime Pharmacokinetic in Cerebrospinal Fluid Between Continuous and Intermittent Administration
Meningitis is an infection where morbidity and mortality depend on the delay of the initial treatment for a good prognostic. The antibiotherapy rapidity allows to decrease the mortality.
- Trial name
- NCT00752882
- Testing
- ceftazidime
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Lung Injury, ARDS
The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients
The investigators aim to study the specific elastance in ALI/ARDS patients during invasive mechanical ventilation.
- Trial name
- NCT00143468
- Testing
- mechanical ventilation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
ARDS (Acute Respiratory Distress Syndrome)
Influence of Lung Recruitment Potential on Positive End-Expiratory Pressure (PEEP) Titration Strategies in Acute Respiratory Distress Syndrome (ARDS) Patients.
Acute Respiratory Distress Syndrome (ARDS) is characterized by severe hypoxemia and diffuse alveolar collapse, often requiring invasive mechanical ventilation.
- Trial name
- RECRUIT-PEEP (NCT07603310)
- Testing
- Positive End-Expiratory Pressure (PEEP) Titration guided by Static Compliance, Positive End-Expiratory Pressure (PEEP) Titration guided by Transpulmonary Pressure
- Where
- Chile
- Volunteers
- 52 people
- Sponsor
- Hospital Dr. Franco Ravera Zunino
Obesity, Intra-Abdominal Hypertension
Chest Wall Influence on Respiratory System Mechanics in Morbidly Obese Patients
The goal of this study is to describe the influence of the chest wall on the respiratory system mechanics in morbidly obese patients and in patients with high intra-abdominal pressure.
- Trial name
- NCT02105220
- Testing
- Respiratory mechanics assessment
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Effects of Humidified Ventilation on Arterial Oxygenation and Respiratory Mechanics During One Lung Ventilation
A continuous loss of moisture and heat occurs during mechanical ventilation and prediposes patients to airway damage. Vaporizing humidifier has known to be advantages of improvement of oxygenation and protection of airway damage.
- Trial name
- NCT01636973
- Testing
- Vaporizing humidifier
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Idiopathic Pulmonary Fibrosis
Inspiratory Effort and Respiratory Mechanics in Spontaneously Breathing Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis: a Matched Control Study
Idiopathic pulmonary fibrosis is a life-threatening lung disease characterized by progressive deterioration of lung function and a median survival time of 3-5 years from diagnosis.
- Trial name
- IERATIC (NCT05313672)
- Volunteers
- 20 people
- Sponsor
- Roberto Tonelli
Traumatic Brain Injury
Inhaled Nitric Oxide in Brain Injury
This study will evaluate the changes in respiratory mechanics following traumatic brain injury and determine the effect of inhaled nitric oxide on gas exchange.
- Trial name
- NCT03260569
- Testing
- Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Cincinnati
Sleep Apnea, Obstructive
Predicting Outcomes in Hypoglossal Nerve Stimulation Therapy With Stimulated Upper Airway Mechanics
Obstructive sleep apnea (OSA) is a highly prevalent disease resulting from dynamic upper airway collapse during sleep. Continuous positive airway pressure (CPAP) is highly efficacious but high rates of non-adherence to CPAP…
- Trial name
- NCT05429983
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University