Clinical trials: Bronchiolitis, open to volunteers
Pneumonia, Tuberculosis, Pulmonary
The LalelaLung Study: Digital Stethoscope Clinical Evaluation
Pneumonia is the leading infectious cause of death in children under five years of age worldwide, and most of these deaths occur in low- and middle-income countries.
- Conditions
- Pneumonia, Tuberculosis, Pulmonary, Respiratory Tract Infections, Bronchiolitis
- Trial name
- LaLeLa (NCT07631377)
- Testing
- StethoMe AI-enabled digital stethoscope system, Standard IMCI assessment
- Volunteers
- 350 people
- Sponsor
- Johns Hopkins University
Chronic Graft Versus Host Disease, Acute Graft Versus Host Disease
Dental Cleaning to Prevent Chronic Graft-Versus-Host Disease
This clinical trial evaluates the feasibility and effectiveness of a post-transplant dental cleaning for the prevention of chronic graft versus host disease (GVHD) in patients undergoing an allogeneic hematopoietic cell…
- Conditions
- Chronic Graft Versus Host Disease, Acute Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm
- Trial name
- NCT07535008
- Testing
- Dental Cleaning, Dental Plaque sampling
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fred Hutchinson Cancer Center
Chronic Graft Versus Host Disease
Gecacitinib for cGVHD: Safety and Efficacy in Patients After ≥2 Lines of Prior Therapy
Chronic Graft-versus-Host Disease (cGVHD) is a common late complication following allogeneic hematopoietic stem cell transplantation and a leading non-relapse cause of death.
- Trial name
- NCT07012304
- Testing
- Gecacitinib Hydrochloride Tablets
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Yujun DONG
Spinal Cord Injuries (SCI), Spinal Cord Injury, Chronic
BCI-Assisted SCS-EXS for Gait Optimization
The goal of this clinical trial is to evaluate the safety and technical feasibility of a novel brain-machine interface (BCI)-assisted spinal cord stimulation (SCS) and exoskeleton (EXS) system in patients with spinal cord injury…
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Chronic, Spinal Cord Injury, Spinal Cord Injury Cervical
- Trial name
- BASEGO (NCT06939660)
- Testing
- BCI-SCS-EXS
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Xuanwu Hospital, Beijing
Bronchiolitis
Low-value Care, and Variation in Practice for Children Hospitalized With Bronchiolitis
Low-value care is defined as the use of a health service, such as diagnostics and treatments, for which the harms or costs outweigh the benefits.
- Trial name
- CareBEST (NCT06506474)
- Testing
- Provision of any of six different low-value health services for treatment of bronchiolitis
- Where
- 15 sites in Canada
- Volunteers
- 3,000 people
- Sponsor
- St. Justine's Hospital
Hematologic Neoplasms
Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies
Background: Certain blood cancers can be treated with blood or bone marrow transplants. Sometimes the donor cells attack the recipient's body, called graft-versus-host disease (GVHD).
- Trial name
- NCT04959175
- Testing
- Mycophenolate Mofetil, Allogeneic HSCT, Fludarabine
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Chronic Graft Versus Host Disease
A Study to Investigate Safety of Belumosudil in Participants Aged 12 Years and Above, With Chronic Graft-versus-host Disease (cGVHD)
This is an interventional phase IV clinical study which is single-arm study for assessing the safety of belumosudil in Indian patients who are12 years and older.
- Trial name
- NCT07135973
- Testing
- Belumosudil
- Volunteers
- 26 people
- Sponsor
- Sanofi
Healthy, Lupus
Direct to Patient Minimal Risk Biospecimen and Data Collection Research
This study aims to help researchers better understand health conditions and develop improved tests, treatments, and cures for diseases.
- Conditions
- Healthy, Lupus, Celiac, Kidney Disease
- Trial name
- JBMR (NCT07128966)
- Testing
- Observation
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Joined Bio
Respiratory Syncytial Virus Infection, Acute Bronchiolitis Due to Respiratory Syncytial Virus
RSV-Positive Children <5 Years Presenting to Pediatric Emergency Departments in Türkiye: TRUST-RSV
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in infants and young children and contributes substantially to pediatric emergency department (ED) visits and hospitalizations.
- Conditions
- Respiratory Syncytial Virus Infection, Acute Bronchiolitis Due to Respiratory Syncytial Virus, Pneumonia, Upper Respiratory Tract Infection
- Trial name
- TRUST-RSV (NCT07346963)
- Volunteers
- 4,000 people
- Sponsor
- Eskisehir Osmangazi University
Chronic Graft-Versus-Host Disease (cGVHD)
A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)
The purpose of this study is to determine if vimseltinib is safe, tolerable and works effectively to treat adults with active moderate to severe cGVHD.
- Trial name
- NCT06619561
- Testing
- Vimseltinib
- Where
- 26 sites in United States
- Volunteers
- 48 people
- Sponsor
- Deciphera Pharmaceuticals, LLC
Chronic Hepatitis B
A Study of Sequential Therapy With AHB-137 Injection Followed by TVAX-008 Injection in Participants Living With Chronic Hepatitis B (CHB)
This is a study of sequential therapy with AHB-137 injection followed by TVAX-008 injection in participants living with Chronic Hepatitis B (CHB).
- Trial name
- NCT07897448
- Testing
- AHB-137, TVAX-008
- Volunteers
- 105 people
- Sponsor
- Grand Theravac Life Sciences (Hangzhou) Co., Ltd.
Uremia; Chronic
The Effect of LIPUS on the Maturation of Newly Constructed Autogenous AVF
This study aims to evaluate the effect of 12 week low-intensity pulse ultrasound (LIPUS) intervention on the maturation of newly constructed autologous arteriovenous fistulas in uremic patients.
- Trial name
- NCT06249373
- Testing
- Low intensity pulse ultrasound （LIPUS） intervention for arteriovenous fistula anastomosis
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Suzhou Municipal Hospital
Bronchiolitis, Bronchodilator Agents
Characterization of Bronchodilator Response in Children With Bronchiolitis Using Phenotypic and Genotypic Features
Bronchiolitis is the leading cause of pediatric morbidity and healthcare costs. Despite the commonplace use of bronchodilator treatments, like albuterol, in conditions like asthma, their efficacy in bronchiolitis remains…
- Trial name
- NCT06946264
- Testing
- Albuterol Sulfate, 2.5 Mg/3 mL (0.083%) Inhalation Solution, Sodium Chloride 0.9% Inhl 3Ml
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Nemours Children's Clinic
Bronchiolitis Acute Viral
Oral Prednisolone for Acute Rhinovirus Induced Wheezing in Children Less Than 2 Years of Age
The aim of the trial is to evaluate whether the use of oral prednisolone directed by point-of-care testing is useful in acute wheezing caused by rhinovirus in children aged 6-24 months.
- Trial name
- RhinoPOCRCT (NCT05444699)
- Testing
- Prednisolone Sodium Phosphate, Sugar syrup
- Where
- 2 sites in Finland
- Volunteers
- 210 people
- Sponsor
- University of Oulu
Chronic Myeloid Leukemia (CML)
Chronic Myeloid Leukemia (CML) Real-Life Database
Establish the largest possible real-life cohort collecting long-term follow-up of a maximum number of CML patients in order to carry out observational studies: epidemiological, identification of subgroups according to their…
- Trial name
- NCT05963061
- Where
- 14 sites in France
- Volunteers
- 3,500 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Upper Respiratory Tract Infections, Nasal Obstruction
Influence of Patient Positioning During Nasal Lavage
Acute upper respiratory tract infections are the primary cause of pediatric visits and hospitalizations in young children. Nasal congestion and mucus accumulation often cause discomfort, feeding difficulties, and respiratory…
- Conditions
- Acute Upper Respiratory Tract Infections, Nasal Obstruction, Bronchiolitis
- Trial name
- nasal lavage (NCT07921680)
- Testing
- Supine position nasal lavage, Semi-sitting position nasal lavage
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Hospital Universitario La Paz
Bronchiolitis Obliterans Syndrome, Chronic Lung Allograft Dysfunction
LAM-001 in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome.
The goal of this clinical trial is to learn about the safety and effectiveness of LAM-001 in patients who have developed bronchiolitis obliterans syndrome (BOS), a form of chronic rejection, after lung transplantation.
- Conditions
- Bronchiolitis Obliterans Syndrome, Chronic Lung Allograft Dysfunction, Lung Transplantation
- Trial name
- INSPO-BOS (NCT06018766)
- Testing
- LAM-001
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Steven Hays, MD
Bronchiolitis, Bronchitis
Effect of AI-Assisted Discharge Education on Parents of Children With Bronchitis/Bronchiolitis
This randomized controlled trial aims to evaluate the effects of artificial intelligence-assisted discharge education on mothers of children hospitalized with bronchitis/bronchiolitis.
- Trial name
- NCT07774494
- Testing
- AI-Assisted Written Discharge Education, AI-Assisted Video Discharge Education, Routine Discharge Education
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Osmaniye Korkut Ata University
Nausea, Vomiting
Chronic Nausea and Vomiting in Patients With Normal Gastric Emptying Using the Enterra® Therapy System (NAVIGATE)
The purpose of this research study is to determine if the Enterra® Therapy System can decrease nausea and vomiting symptoms and improve the quality of life for patients with chronic nausea, with or without vomiting, that have…
- Trial name
- NAVIGATE (NCT06464926)
- Testing
- Enterra Therapy System
- Where
- 22 sites in United States, Belgium and 3 more
- Volunteers
- 148 people
- Sponsor
- Enterra Medical, Inc.
Bronchiolitis Obliterans Syndrome (BOS), HSCT
Efficacy of an Anti-TSLP Monoclonal Antibody in the Management of Chronic Bronchial Disease Induced by Bronchiolitis Obliterans Syndrome in Allogeneic Hematopoietic Stem Cells Transplantation Recipients
Allogeneic hematopoietic stem cell transplantation (HSCT) is burdened with a high morbidity and mortality rates. Graft versus host disease (GVHD) is the clinical manifestation of an immune conflict.
- Conditions
- Bronchiolitis Obliterans Syndrome (BOS), HSCT, Bronchial Disease
- Trial name
- IMMUNO-BOS (NCT07771855)
- Testing
- Tezepelumab
- Where
- 6 sites in France
- Volunteers
- 36 people
- Sponsor
- Hopital Foch