Clinical trials: Bronchoalveolar Lavage
Acute Hypoxemic Respiratory Failure, Sepsis
EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS
Sepsis-associated acute respiratory distress syndrome (ARDS) remains a major cause of respiratory failure and mortality in critically ill patients.
- Conditions
- Acute Hypoxemic Respiratory Failure, Sepsis, ARDS (Acute Respiratory Distress Syndrome)
- Trial name
- EARLY-SARDS (NCT07281911)
- Testing
- Serial bronchoalveolar lavage and biological-physiological assessment
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Invasive Fungal Infection, Hematological Malignancy
Prospective Clinical Evaluation of Beta-D-Glucan Assay in Blood and BAL
In patients with invasive fungal infection (IFI) rapid diagnosis is essential for early initiation of appropriate antifungal therapy and thereby survival. Conventional culture is still the Gold-Standard for diagnosis of IFI.
- Conditions
- Invasive Fungal Infection, Hematological Malignancy, Receipt of Solid Organ Transplant
- Trial name
- NCT01576653
- Testing
- Fungitell Assay in BAL
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Robert Krause, MD
Pneumonia, Viral, Ventilator Associated Pneumonia
Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BAL
Almost 90 out of 100 people carry herpes simplex viruses (HSV). Once a person has been infected with the herpes viruses, he or she can't get rid of them for the rest of her/his life.
- Conditions
- Pneumonia, Viral, Ventilator Associated Pneumonia, Community-acquired Pneumonia, Herpes Simplex
- Trial name
- HerpMV (NCT06134492)
- Testing
- Acyclovir
- Where
- 28 sites in Germany
- Volunteers
- 616 people
- Sponsor
- Jena University Hospital
Pneumoconiosis
A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells
Pneumoconiosis is a kind of lung disease due to inhalation of dust such as silica(common named Silicosis), coal and rock dust, characterized by inflammation, coughing, and fibrosis. Currently there is no effective drug treatment.
- Trial name
- NCT02668068
- Testing
- large volume whole-lung lavage (WLL), clinical grade umbilical cord mesenchymal stem cells
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Jianwu Dai
Bronchoalveolar Lavaage, Diffuse Lung Disease
Comparison of Procedural Yield of Bronchoalveolar Lavage Using Three Different Techniques in Subjects Undergoing Flexible Bronchoscopy
Bronchoalveolar lavage (BAL) via flexible bronchoscopy is a method used to sample the cellular and microbiological components of the alveolar space.
- Trial name
- BAL-3T (NCT05425875)
- Testing
- Bronchoalveolar lavage using wall mount suction, Bronchoalveolar lavage using manual suction, Bronchoalveolar lavage using manual suction with rubber tubing
- Where
- 2 sites in India
- Volunteers
- 942 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Lung Neoplasms, Tumor Immune Microenvironment
Association of BAL Fluid T-Cell Immune Activity With Tumor PD-L1 Expression and Its Prognostic Value: A Prospective Observational Study
This prospective observational study aims to evaluate whether immune profiles of T-cell subsets in bronchoalveolar lavage fluid can complement tumor PD-L1 expression, assessed by immunohistochemistry in tumor tissue specimens, in…
- Trial name
- NCT07331701
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Fiberoptic Bronchoscopy (FOB), Bronchoalveolar Lavage (BAL)
Fiberoptic Bronchoscopy and Bronchoalveolar Lavage in Critically Ill Ventilated Patients
Fiberoptic bronchoscopy (FOB) is widely used as a diagnostic or therapeutic procedure in intensive care units. Patients with ARDS or COVID-19 disease often undergoes to these procedures.
- Conditions
- Fiberoptic Bronchoscopy (FOB), Bronchoalveolar Lavage (BAL), Respiratory Disease
- Trial name
- NCT04502368
- Testing
- Fiberoptic Bronchoscopy (FOB), Bronchoalveolar Lavage (BAL), Electrical Impedance Tomography (EIT)
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Erasme University Hospital
Lung Diseases, Intensive Care
Bronchoalveolar Lavages for Cytologic Assessment in Intensive Care Unit Patients
Little is known about bronchoalveolar lavages performed for cytological assessment during bronchial fibroscopy in critically ill patients.
- Trial name
- REA-LBA (NCT03098888)
- Testing
- bronchoalveolar lavage
- Where
- 16 sites in France
- Volunteers
- 483 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Lung Disease, Chronic Obstructive Pulmonary Disease (COPD)
Lung Disease Collection (Qatar): Evaluation of the Lungs of Individuals With Lung Disease
The purpose of this protocol is to obtain biologic samples from the blood and lungs from patients with lung diseases in order to study the causes and indications of these disorders, learn how these lung disease manifest and…
- Conditions
- Lung Disease, Chronic Obstructive Pulmonary Disease (COPD), Asthma
- Trial name
- Q-LD (NCT00504738)
- Where
- Qatar
- Volunteers
- 75 people
- Sponsor
- Weill Medical College of Cornell University
Ventilator Associated Pneumonia
Study of Different Etiologic Diagnostic Methods in Ventilator Associated Pneumonia (VAP)
The study is designed to evaluate sensitivity, specificity and accuracy of non-bronchoscopic bronchoalveolar lavage and endotracheal aspirate in comparison with bronchoscopic bronchoalveolar lavage (gold standard), as methods for…
- Trial name
- NCT02363023
- Testing
- Collect tracheal and pulmonary secretions
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Uberlandia
Tuberculosis, Pulmonary
Conventional Bronchoscope With BAL vs. Thin Bronchoscope With BW to Diagnose Pulmonary TB
This study aims to compare the diagnostic yield of bronchoalveolar lavage (BAL) using a thick conventional bronchoscope and bronchial washing (BW) using a thin bronchoscope in the diagnosis of pulmonary tuberculosis.
- Trial name
- NCT06159023
- Testing
- bronchial washing using a thin bronchoscope
- Where
- South Korea
- Volunteers
- 132 people
- Sponsor
- Pusan National University Hospital
Healthy
Intrapulmonary Pharmacokinetics of Antibiotics
The major objectives of this research are to see how much, and for how long, telithromycin and azithromycin get into the fluids and cells of the lung.
- Trial name
- NCT00315601
- Testing
- Telithromycin, azithromycin, bronchoalveolar lavage
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Non Small Cell Lung Cancer
Olmutinib Trial in T790M (+) NSCLC Patients Detected by Liquid Biopsy Using BALF Extracellular Vesicular DNA
The purpose of this study is to evaluate the efficacy of Olmutinib(Olita®) in patients with T790M-positive non-small cell lung cancer (NSCLC) confirmed using DNA extracted from extracellular vesicles of bronchoalveolar lavage…
- Trial name
- NCT03228277
- Testing
- Olmutinib
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Konkuk University Medical Center
Pneumonia
Measuring Auto-fluorescence of White Corpuscles for the Early Diagnosis and the Monitoring of Pneumonia in ICU
The diagnosis of pneumonia is challenging in Intensive Care Unit. The auto-fluorescence of white corpuscles is altered during pneumonia.
- Trial name
- BIONAGA (NCT02717767)
- Testing
- Autofluorescence of white corpuscle
- Where
- 4 sites in France
- Volunteers
- 69 people
- Sponsor
- Nantes University Hospital
Vaping Related Disorder
Radiology and BAL in Vaping Associated Lung Injury
Radiology and BAL in Vaping associated lung disease
- Trial name
- NCT07499557
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Lung Transplant Infection, Molecular Diagnostic
Molecular vs Conventional Microbiologic Diagnosis for Infections in Lung Transplantation
The goal of this prospective study is to compare rapid molecular technique BioFire Pneumonia Panel Filmarray and conventional culture-based methods in the microbiologic diagnosis on bronchoalveolar lavage of lung transplant…
- Conditions
- Lung Transplant Infection, Molecular Diagnostic, Bacterial Infections, Pneumonia
- Trial name
- PNEUMOARRAY (NCT05960383)
- Testing
- BioFire Pneumonia Panel Plus
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Non Small Cell Lung Cancer
Neoadjuvant Lazertinib Therapy in EGFR-Mutation Positive Lung Adenocarcinoma Detected by BALF Liquid Biopsy
Complete surgical resection is the standard treatment in early-stage lung cancer. However, the patients with early resected Epidermal Growth Factor Receptor(EGFR)-mutated lung cancers have high recurrence rate.
- Trial name
- NCT05469022
- Testing
- Neoadjuvant lazertinib
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Konkuk University Medical Center
Rapid Detection, Pseudomonas Aeruginosa Infection
Rapid Detection of Pseudomonas Aeruginosa in Bronchoalveolar Lavage Fluid Using Label-free Single-particle Imaging Technology and Assessment of Post-treatment Efficacy in Patients With Pseudomonas Aeruginosa Infection
The aim of this study is to observe specimens of bronchoalveolar lavage fluid from patients using a reflection enhanced dark-field scattering microscopy.
- Trial name
- NCT06986512
- Testing
- bronchoscopy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Lung Transplant, Chronic Allograft Rejection
Mechanisms of Lung Allograft Rejection
This study will explore the ways in which lung transplants are rejected. A series of experiments will evaluate the differences in airway gene expression.
- Trial name
- NCT00340418
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
ARDS, Human
Study of the Effects of Bronchoalveolar Lavage Liquid in the ARDS on the Functioning of the Neutrophil Polynuclear System
Firstly, the study assesses the effect of bronchoalveolar lavage fluid (BAL) from patients in (acute respiratory distress syndrome (ARDS) on the life span of PNNs and on the phagocytosis of apoptotic cells by macrophages and…
- Trial name
- BALARDS (NCT04008225)
- Testing
- Bronchoalveolar lavage
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Rennes University Hospital