Clinical trials: Bronchopulmonary Diseases
Bronchopulmonary Dysplasia, Extreme Prematurity
Relationship Between Fungal Colonization and Severe Bronchopulmonary Dysplasia
The aim of this study is to determine if fungal colonization is associated to severe bronchopulmonary dysplasia in premature infants less than 29 weeks of gestation, and to determine if an association exists between fungal…
- Conditions
- Bronchopulmonary Dysplasia, Extreme Prematurity, Fungal Infection
- Trial name
- FunDyP (NCT05152875)
- Testing
- biological
- Where
- France
- Volunteers
- 153 people
- Sponsor
- Centre Hospitalier Sud Francilien
Respiratory Distress Syndrome in Premature Infant, Bronchopulmonary Dysplasia
Safety, Pk and Anti-inflammatory Effects of CC10 Protein in Premature Infants With Respiratory Distress Syndrome (RDS)
Bronchopulmonary Dysplasia (BPD) is a multi-factorial disease process that is the end result of an immature, surfactant deficient lung that has been exposed to hyperoxia, mechanical ventilation and infection.
- Trial name
- NCT01473264
- Testing
- recombinant human CC10 (rhCC10)
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Clarassance, Inc.
Bronchopulmonary Dysplasia, Chronic Lung Disease of Newborn
Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD
Investigators want to learn the role of indoor environmental exposures on respiratory symptoms, and, separately, on lung function deficits in school-aged children with bronchopulmonary dysplasia (BPD).
- Conditions
- Bronchopulmonary Dysplasia, Chronic Lung Disease of Newborn, Environmental Exposure
- Trial name
- AeroBPD (NCT04107701)
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Boston Children's Hospital
ABPA, Allergic Bronchopulmonary Aspergillosis
A Study of the Efficacy and Safety of Bronchoscopic Airway Clearance and Amphotericin B Spraying in Patients With ABPA
To evaluate the efficacy and safety of bronchoscopic airway clearance and amphotericin B spraying in the treatment of allergic bronchopulmonary aspergillosis
- Conditions
- ABPA, Allergic Bronchopulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis (ABPA), Airway Clearance
- Trial name
- NCT07362667
- Testing
- The patients were treated with bronchoscopic airway clearance and amphotericin B spraying
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Qianfoshan Hospital
Bronchopulmonary Dysplasia, Retinopathy of Prematurity
Oral Vitamin A Supplementation in Neonates With Birth Weight < 1500 g
Vitamin A is essential for optimal growth, and development. In the newborn, especially if preterm, it is necessary for the cellular differentiation, for the health of the anterior eye, it is a constituent of visual pigment, and…
- Trial name
- NCT02102711
- Testing
- Vitamin A oral drops
- Where
- 2 sites in Italy
- Volunteers
- 62 people
- Sponsor
- Francesca Garofoli
Infant, Premature, Diseases, Respiratory Insufficiency Syndrome of Newborn
Impact of CPAP Level on V/Q Mismatch in Premature Infants
Continuous positive airway pressure (CPAP) is used in premature infants to maintain lungs open and facilitate gas exchange. When ventilation/perfusion (V/Q) mismatch is present, areas of the lung that are open for gas exchange do…
- Trial name
- NCT02983825
- Testing
- Continuous positive airway pressure (CPAP); level changes
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Children's Hospital of Philadelphia
Infant, Newborn, Infant, Low Birth Weight
Benchmarking Initiative to Reduce Bronchopulmonary Dysplasia
This study tested whether Neonatal Intensive Care Unit (NICU) teams trained in benchmarking -- comparing care practices between different NICUs to see which practices prevent bronchopulmonary dysplasia (BPD) -- and quality…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Benchmarking (NCT00067613)
- Testing
- Benchmarking Management Practices, Standard Management Practices
- Where
- 17 sites in United States
- Volunteers
- 4,095 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Bronchopulmonary Dysplasia
Inhaled Tobramycin in BPD
This study is an open-label, phase 1, sequential dose escalation trial seeking to establish preliminary tolerability, efficacy, and pharmacokinetic data for up to 4 different doses of inhaled tobramycin administered to very…
- Trial name
- NCT04560179
- Testing
- Tobramycin solution for inhalation 78mg dose, Tobramycin solution for inhalation 150mg dose, Tobramycin solution for inhalation 216mg dose
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Erik Allen Jensen
Bronchopulmonary Dysplasia
Phase II Pilot Study of Early Cortisol Replacement to Prevent Bronchopulmonary Dysplasia
OBJECTIVES: I. Estimate the efficacy of cortisol replacement therapy during the first 12 days of life for prevention of bronchopulmonary dysplasia. II.
- Trial name
- NCT00004669
- Testing
- hydrocortisone
- Volunteers
- 40 people
- Sponsor
- National Center for Research Resources (NCRR)
Bronchopulmonary Dysplasia
Restricted Versus Liberal Fluid Intake for Prevention of Bronchopulmonary Dysplasia
The aim of this study is to determine whether restricted fluid intake (135 ±5 mL/kg/day) compared to liberal fluid intake (165 ±5 mL/kg/day) from day 8 of life reduces the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks…
- Trial name
- RELIEF (NCT06954142)
- Testing
- Fluid restriction, Liberal fluid intake
- Where
- 9 sites in Switzerland
- Volunteers
- 750 people
- Sponsor
- University Children's Hospital Basel
Chronic Lung Disease, Chronic Obstructive Pulmonary Disease
Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise
This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with…
- Conditions
- Chronic Lung Disease, Chronic Obstructive Pulmonary Disease, Acute Lymphoblastic Leukemia, Heart Transplant
- Trial name
- FLASHLITE (NCT05025774)
- Testing
- Physical activity
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Surfactant Deficiency Syndrome Neonatal, Respiratory Distress Syndrome, Newborn
Fast Assessment of Surfactant Deficiency in Preterm Infants to Speed up Treatment
Recently the investigators have developed a point of care test (LS-test) to measure surfactant as lecithin in gastric aspirates from preterm infants.
- Conditions
- Surfactant Deficiency Syndrome Neonatal, Respiratory Distress Syndrome, Newborn, Bronchopulmonary Dysplasia
- Trial name
- FAST2 (NCT05638568)
- Testing
- LS test
- Where
- 4 sites in Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Allergic Bronchopulmonary Aspergilloses
Diagnostic Value of MRI for Allergic Broncho-Pulmonary Aspergilloses
The aim of the study is to compare the concordance between chest computerized tomography-scan (CTscan) and Magnetic resonance Imaging (MRI) for the description of the abnormalities seen in Allergic BronchoPulmonary Aspergillosis…
- Trial name
- ABPA-MR (NCT03265366)
- Testing
- MRI, CT scan (standard reference)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Bordeaux
Endotracheal Tube Tip Position, Bronchopulmonary Dysplasia
Estimating Length of Endotracheal Tube Insertion Using Gestational Age or Nasal-Tragus Length in Newborn Infants
Endotracheal intubation is a life-saving intervention that few infants need after birth. Although an endotracheal tube is the most reliable way of providing positive-pressure breath, the critical factor that determines the…
- Conditions
- Endotracheal Tube Tip Position, Bronchopulmonary Dysplasia, Pneumothorax, Death
- Trial name
- ELEGANT (NCT04393337)
- Testing
- Gestational Age Chart Method, Nasal-Tragus Length Method
- Where
- 3 sites in Saudi Arabia
- Volunteers
- 454 people
- Sponsor
- Princess Nourah Bint Abdulrahman University
Lung Diseases, Bronchopulmonary Dysplasia
Antecedents of Bronchopulmonary Dysplasia
To identify risk factors for bronchopulmonary dysplasia/chronic pulmonary disease of prematurity and to estimate proportions of this group of disorders attributable to antenatal risk factors, perinatal events, and neonatal care…
- Trial name
- NCT00005293
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants
The purpose of this study is to determine if an investigational drug can prevent Bronchopulmonary Dysplasia, reducing the burden of chronic lung disease in extremely premature infants, as compared to extremely premature infants…
- Conditions
- Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity, Intraventricular Hemorrhage, Retinopathy of Prematurity (ROP)
- Trial name
- NCT03253263
- Testing
- OHB-607
- Where
- 62 sites in United States, Australia and 11 more
- Volunteers
- 295 people
- Sponsor
- OHB Neonatology Ltd.
Lung Diseases, Respiratory Distress Syndrome
Clinical Interventions in Respiratory Distress Syndrome and Neonatal Lung Injury - SCOR in Lung Biology and Diseases in Infants and Children
To conduct clinical interventions directed at neonatal lung disease and injury, with a focus on infants having surfactant-deficiency or inactivation as a component of pathophysiology.
- Conditions
- Lung Diseases, Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
- Trial name
- NCT00005683
- Sponsor
- University of Rochester
Bronchopulmonary Dysplasia
Pilot Study of Topical Steroid for Prevention of Chronic Lung Disease in Extremely Premature Infants.
A Pilot study to evaluate the safety and the efficacy of endotracheal instillation of pulmonary surfactant, with or without topical steroid (Budesonide), as a prophylactic treatment for Bronchopulmonary Dysplasia (a form of…
- Trial name
- NCT01268215
- Testing
- Infasurf, Pulmicort
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- East Carolina University
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)
This multicenter clinical trial tested whether minimal ventilation decreases death or BPD. Infants with birth weight 501g to 1000g and mechanically ventilated before 12 hours were randomly assigned to minimal ventilation (partial…
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight
- Trial name
- SAVE (NCT00005777)
- Testing
- Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 220 people
- Sponsor
- NICHD Neonatal Research Network