Clinical trials: Bronchopulmonary Diseases
BPD - Bronchopulmonary Dysplasia, Pulmonary Hypertension
Safety and PK-PD Study of Oral L-CIT in Preterm Infants With BPD±PH and NEC
The purpose of this study is to evaluate the safety and explore the PK/PD of L-CIT supplementation in preterm infants to prevent the development of inflammatory pathways initiated by low levels of plasma CIT, specifically in…
- Conditions
- BPD - Bronchopulmonary Dysplasia, Pulmonary Hypertension, NEC
- Trial name
- NCT05636397
- Testing
- L-Citrulline
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- The Hospital for Sick Children
Bronchopulmonary Dysplasia (BPD), Prematurity
Oral Vitamin A Supplementation for Prevention of Bronchopulmonary Dysplasia in Preterm Infants
Bronchopulmonary dysplasia (BPD) remains a major complication of very low birth weight (VLBW) preterm infants. Vitamin A is essential for lung development and epithelial integrity, and deficiency has been associated with an…
- Conditions
- Bronchopulmonary Dysplasia (BPD), Prematurity, Very Low Birth Weight
- Trial name
- VITA-BPD (NCT07577180)
- Testing
- Vitamin A
- Where
- Turkey (Türkiye)
- Volunteers
- 209 people
- Sponsor
- Erhan Calisici
Bronchopulmonary Dysplasia
Safety of Sildenafil in Premature Infants
Describe the safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia and determine preliminary effectiveness and pharmacokinetics (PK) of sildenafil.
- Trial name
- SIL02 (NCT03142568)
- Testing
- Sildenafil
- Where
- 15 sites in United States, Canada
- Volunteers
- 109 people
- Sponsor
- University of North Carolina, Chapel Hill
Bacteria Infection, Respiratory Tract Infections
Early Versus Expectant Treatment of Ureaplasma Infection in Very Low Birth Weight Neonates
Our hypothesis is that treatment of known Ureaplasma spp. infection of the airways in very low birth weight (VLBW) infants with azithromycin will eradicate the organisms and lessen the proinflammatory state caused by infection…
- Trial name
- NCT00599053
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Alabama at Birmingham
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome in Premature Infant
Intratracheal Budesonide With Surfactant to Prevent Bronchopulmmonary Dysplasia.
This study is designed to determine whether intratracheal administration of budesonide combined with surfactant, as compared to surfactant alone, will modify ecographic (lung ultrasound score) and biological markers (IL-6…
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Distress Syndrome in Premature Infant, Prematurity
- Trial name
- BuS (NCT04862377)
- Testing
- Poractant Alfa Intratracheal Suspension [Curosurf], Budesonide 0.5 MG/ML
- Volunteers
- 50 people
- Sponsor
- Hospital Clinic of Barcelona
Respiratory Distress Syndrome, Intubation; Difficult or Failed
Nasal Intermittent Positive Pressure Ventilation During Neonatal Intubation
The study aims to determine whether the use of nasal intermittent positive pressure ventilation (NIPPV) during neonatal endotracheal intubation increases the rate of successful intubation without physiological instability during…
- Conditions
- Respiratory Distress Syndrome, Intubation; Difficult or Failed, Newborn Morbidity, Desaturation of Blood
- Trial name
- NCT06549283
- Testing
- Nasal intermittent positive pressure ventilation (NIPPV) via binasal cannula during neonatal intubation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Muğla Sıtkı Koçman University
Bronchopulmonary Dysplasia
Epidemiological Study for Bronchopulmonary Dysplasia (BPD) in China
This study will establish a nationwide cohort of very preterm infants in China, to investigate the epidemiological characteristics and short-term outcomes of BPD in different NICUs around the country.
- Trial name
- NCT03850457
- Testing
- No intervention
- Where
- China
- Volunteers
- 3,800 people
- Sponsor
- Children's Hospital of Fudan University
Ventilator Lung; Newborn
NIPE as an Indicator of Pain in Sedated/Ventilated Patient Under 3 Years-old Hospitalized in Intensive Care Unit
The main objective is to assess correlation between Newborn Infant Parasympathetic Index values and external evaluation by Comfort Behaviour Scale during painful medical cares in sedated intubated children admitted in pediatric…
- Trial name
- NIPE (NCT04195672)
- Testing
- NIPE (MDoloris®) and CBS values
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille
Preeclampsia
Anti-Angiogenic Preeclampsia Milieu Impairs Infant Lung and Vascular Development
Pregnant mothers who develop high blood pressure and other vascular problems (preeclampsia) deliver babies with increased neonatal health problems, which include lung disease and vascular complications, later in life.
- Trial name
- NCT02639676
- Testing
- Diffusion Lung Capacity (DLCO), Vascular Challenge, Video Imaging, Specimen Collections
- Where
- United States
- Volunteers
- 292 people
- Sponsor
- Indiana University
Bronchopulmonary Dysplasia
Effects of IVIG for BPD in Preterm Infant Born at 28 Weeks and Below
It is intended to examine the short-term and long-term efficacy and safety of intravenous immunoglobulin(IVIG) for the bronchopulmonary dysplasia in preterms born at 28 weeks and below.
- Trial name
- NCT07561125
- Testing
- intravenous immunoglobulin
- Where
- China
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- International Peace Maternity and Child Health Hospital
Sleep Apnea Syndromes in Children, Obesity in Children
Overview: Use of Respiratory Support At Home in Children
the primary outcome is to describe the perceived success of the use of the respiratory support from the parent's point of view
- Conditions
- Sleep Apnea Syndromes in Children, Obesity in Children, Bronchopulmonary Dysplasia (BPD), Neuromuscular Disease
- Trial name
- ELIPSE (NCT06692660)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Bronchopulmonary Dysplasia
A Safety Study of IV Stem Cell-derived Extracellular Vesicles (UNEX-42) in Preterm Neonates at High Risk for BPD
A multicenter, placebo-controlled, randomized, dose escalation, safety, and tolerability study of UNEX-42 in infants born at <27 weeks of gestational age (GA) at high risk for bronchopulmonary dysplasia (BPD).
- Trial name
- NCT03857841
- Testing
- UNEX-42, Phosphate-buffered saline
- Where
- 6 sites in United States
- Volunteers
- 3 people
- Sponsor
- United Therapeutics
Ventilator Associated Pneumonia, Bronchopulmonary Dysplasia
Frequent Standardized Oral Care Using Human Milk in the Neonatal Intensive Care Unit
Premature infants are susceptible to complications related to infrequent and non-standardized oral care. Although the benefits of frequent standardized oral care are known to reduce oral dysbiosis (increased level of potentially…
- Conditions
- Ventilator Associated Pneumonia, Bronchopulmonary Dysplasia, Respiratory Disease
- Trial name
- NCT06000761
- Testing
- Standardized oral Care
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- University of Florida
Prematurity; Extreme, Inflammation
Anakinra for Preterm Infants Pilot
Phase I/II study of anakinra to prevent the impact of perinatal inflammation in extremely premature infants.
- Trial name
- NCT05280340
- Testing
- Anakinra
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 25 people
- Sponsor
- Monash Medical Centre
Pulmonary Hypertension, Bronchopulmonary Dysplasia
Neolifes Heart - Pulmonary Hypertension in Preterm Children
NeoLifeS is a cohort follow up study that prospectively collects data of regular care of children born preterm in the University Medical Center Groningen (UMCG) and aims to improve the quality of care for these children.
- Trial name
- NCT02729844
- Where
- Netherlands
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Cystic Fibrosis,
Evaluation of Bronchial Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA)
Chronic bronchial inflammation is an important clinical feature in cystic fibrosis. Approximately 10% of patients with cystic fibrosis suffer from Allergic Bronchopulmonary Aspergillosis.
- Trial name
- ABPA (NCT00906568)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Acute Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Invasive Ventilation Strategies for Neonates With Acute Respiratory Distress Syndrome Syndrome (ARDS)
Acute respiratory distress syndrome (ARDS) in neonates has been defined in 2017.The death rate is over 50%. HFOV and CMV are two main invasive ventilation strategies. However, which one is better needing to be further elucidated.
- Conditions
- Acute Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, High Frequency Oscillation Ventilation
- Trial name
- NCT03372525
- Testing
- HFOV, CMV
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Chronic Lung Disease of Prematurity, Respiratory Distress Syndrome in Premature Infant
PAL to Improve Oral Feeding for Infants With Chronic Lung Disease
The purpose of this study is to investigate the effects of the Pacifier Activated Lullaby (PAL) intervention on the transition to oral feeding for preterm infants with chronic lung disease and respiratory distress syndrome that…
- Conditions
- Chronic Lung Disease of Prematurity, Respiratory Distress Syndrome in Premature Infant, Bronchopulmonary Dysplasia, Preterm Birth
- Trial name
- NCT05446389
- Testing
- Pacifier Activated Lullaby ®
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Missouri-Columbia
Bronchopulmonary Dysplasia, Lung Diseases
Inhaled NO in Prevention of Chronic Lung Disease
To test the hypothesis that low-dose inhaled nitric oxide administered to preterm infants who continue to require mechanical ventilation at 14 days of age will reduce the incidence of chronic lung disease.
- Trial name
- NCT00000548
- Testing
- mechanical ventilation
- Sponsor
- University of California, San Francisco
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Study of the Pathobiology of Bronchopulmonary Dysplasia in Newborns
OBJECTIVES: I. Create a clinical sample bank of neonates with lung disease to test hypotheses regarding the pathogenesis of bronchopulmonary dysplasia (BPD). II.
- Trial name
- NCT00006058
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Center for Research Resources (NCRR)