Clinical trials: Bronchopulmonary Diseases
Bronchopulmonary Dysplasia (BPD), Mortality Prediction
Chloride Imbalance in Preterm Infants
In adults and children low or high blood chloride levels are linked to the risk of death. The aim of this observational study is to determine whether there is a relationship between low or high blood chloride levels and the risk…
- Conditions
- Bronchopulmonary Dysplasia (BPD), Mortality Prediction, Chloride Disorder
- Trial name
- NCT06940856
- Testing
- Incomplete response, Complete response, Bad response
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Lung Disease, Chronic Obstructive Pulmonary Disease (COPD)
Lung Disease Collection (Qatar): Evaluation of the Lungs of Individuals With Lung Disease
The purpose of this protocol is to obtain biologic samples from the blood and lungs from patients with lung diseases in order to study the causes and indications of these disorders, learn how these lung disease manifest and…
- Conditions
- Lung Disease, Chronic Obstructive Pulmonary Disease (COPD), Asthma
- Trial name
- Q-LD (NCT00504738)
- Where
- Qatar
- Volunteers
- 75 people
- Sponsor
- Weill Medical College of Cornell University
Smoking, Lung Diseases
Evaluation of Lungs of Normal Individuals by Lung Lavage, Brushing and Bronchial Wall Biopsy
The purpose of this study is to obtain biologic materials from the blood and lungs of normal individuals to establish a set of normal range for various parameters.
- Trial name
- NCT00224185
- Testing
- Bronchopulmonary Lung Lavage, Bronchial Brushing, Bronchial Wall Biopsy
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Healthy, Cystic Fibrosis (CF)
MRI for Non-Invasive Imaging in Neonates and Children
The purpose of this study is to develop rapid MRI techniques for imaging the lung with hyperpolarized helium-3 gas as an inhaled contrast agent.
- Conditions
- Healthy, Cystic Fibrosis (CF), Asthma, Bronchopulmonary Dysplasia (BPD)
- Trial name
- NCT02163681
- Testing
- Hyperpolarized Helium-3 MRI of the chest
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Bronchopulmonary Dysplasia
Cellular Therapy for Extreme Preterm Infants at Risk of Developing Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD) is a common and chronic lung disease that occurs in preterm infants following ventilator and oxygen therapy and is associated with long-term health consequences.
- Trial name
- NCT04255147
- Testing
- Allogeneic Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells
- Where
- 2 sites in Canada
- Volunteers
- 9 people
- Sponsor
- Ottawa Hospital Research Institute
Infant, Newborn, Infant, Low Birth Weight
Delivery Room CPAP in Extremely Low Birth Weight Infants
This pilot study was designed to determine the feasibility of randomizing extremely low birth weight (ELBW) infants <28 weeks' gestation who required resuscitation to one of two resuscitation methods, either: (a) 100% oxygen by…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- DR-CPAP (NCT01223274)
- Testing
- CPAP/PEEP, Standard management practices
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- NICHD Neonatal Research Network
Bronchopulmonary Dysplasia, Premature
THE EFFECT OF NEBULIZED AZITHROMYCIN AS THERAPY FOR BRONCHOPULMONARY DYSPLASIA
The aim of the study is to determine the effectiveness of nebulized azithromycin therapy in prevention of BPD in very low birth weight preterm infants when compared with placebo.
- Conditions
- Bronchopulmonary Dysplasia, Premature, Ventilation, Mechanical
- Trial name
- NCT06584474
- Testing
- Azithromycin neubilization, Lung ultrasound
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Bronchopulmonary Dysplasia (BPD)
Combined Oscillation-Volume guarantEe Study
Respiratory Distress Syndrome (RDS) remains the most common respiratory complication in the early postnatal period among preterm infants born before 32 weeks' gestational age.
- Trial name
- NCT07377955
- Testing
- HFOV, HFOV+VG
- Volunteers
- 348 people
- Sponsor
- Xingwang Zhu
Anemia of Prematurity
Premature Infants in Need of Transfusion (PINT)
Hypothesis: That a high hemoglobin threshold for transfusion in extremely low birth weight (ELBW) infants is associated with a lower rate of survival without severe morbidity (defined as one or more of retinopathy of prematurity…
- Trial name
- NCT00182390
- Testing
- Red blood cell transfusion
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 424 people
- Sponsor
- McMaster University
Bronchopulmonary Dysplasia
Respiratory Oscillometry for the Prediction of Bronchopulmonary Dysplasia
The goal of this observational study is to learn about the correlation between respiratory system reactance, as assessed by respiratory oscillometry, and respiratory outcomes in preterm infants born before 32 weeks of gestation.
- Trial name
- REACT (NCT05986032)
- Testing
- Respiratory Oscillometry
- Where
- 6 sites in Austria, Italy and 3 more
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Infant, Premature, Bronchopulmonary Dysplasia
Assessment of the Pulmonary Diffusion Capacity in Healthy Infants and Infants With Chronic Lung Disease
The purpose of this study is to evaluate how easily gas can be taken up by the lung. We are comparing infants born premature <32 weeks gestation to infants born full term >37 weeks.
- Conditions
- Infant, Premature, Bronchopulmonary Dysplasia, Asthma
- Trial name
- NCT00428038
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Indiana University
Prematurity, Respiratory Disease
Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress
Use of caffeine citrate in late-preterm infants with respiratory distress is questionable. Oliphant and colleagues found in a recently published study that caffeine therapy use in late-preterm infants at a loading dose of 20 and…
- Conditions
- Prematurity, Respiratory Disease, Ventilator Lung; Newborn
- Trial name
- CAT/LPT (NCT06026163)
- Testing
- Caffeine citrate
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 134 people
- Sponsor
- Ministry of Health, Saudi Arabia
Allergic Bronchopulmonary Aspergillosis (ABPA), Machine Learning
Multi-Omics Inflammatory Phenotype for ABPA Recurrence Risk Prediction
To develop and externally validate a machine learning model for predicting the 1-year risk of relapse in patients with stable ABPA, and to further evaluate its value in risk stratification and clinical decision-making.
- Conditions
- Allergic Bronchopulmonary Aspergillosis (ABPA), Machine Learning, Multi-omics, Multicenter Study
- Trial name
- NCT07611838
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Qianfoshan Hospital
Bronchopulmonary Dysplasia
Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants
Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this…
- Trial name
- GENBPD (NCT00904774)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Preterm Birth, Ventilator Lung; Newborn
Cerebral Oxygenation in Preterm Neonates with Respiratory Support During Skin-to-skin Care on the First Day After Birth
This is a prospective observational pilot study investigating if skin-to-skin care (SSC) has an influence on cerebral oxygenation and perfusion measured with near-infrared spectroscopy (NIRS) compared to incubator care in…
- Trial name
- Kangaroo (NCT04865302)
- Testing
- SSC
- Where
- Austria
- Volunteers
- 43 people
- Sponsor
- Medical University of Graz
Invasive Pulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis
Voriconazole Inhalation Powder for the Treatment of Pulmonary Aspergillosis
Voriconazole Inhalation Powder is available on an expanded access basis to patients with pulmonary aspergillosis for up to 12 weeks.
- Conditions
- Invasive Pulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis, Chronic Pulmonary Aspergillosis, Aspergillus Tracheobronchitis
- Trial name
- NCT05897294
- Testing
- Voriconazole Inhalation Powder
- Sponsor
- TFF Pharmaceuticals, Inc.
Bronchopulmonary Dysplasia
Hypercapnia and Its Association With Long-term Respiratory Morbidities in Premature Infants With Chronic Lung Disease
This is a prospective, longitudinal observational study to provide data regarding the natural course of hypercapnia in premature infants with bronchopulmonary dysplasia using both available blood pCO2 and measured capnography, as…
- Trial name
- NCT02996162
- Testing
- Massimo Root Monitoring System, ISA-Infrared Sidestream Gas Analyzer
- Where
- United States
- Sponsor
- Boston Children's Hospital
Lung Diseases, Bronchopulmonary Dysplasia
Late Sequelae of Bronchopulmonary Dysplasia
To measure the cardiopulmonary function in individuals who developed bronchopulmonary dysplasia (BPD) at Stanford University Medical Center from 1964-1973 and to determine the factors associated with the presence of…
- Trial name
- NCT00005287
- Sponsor
- Stanford University
Respiratory Distress Syndrome, Chronic Lung Disease of Prematurity
Prevention of Chronic Lung Disease (CLD) in Preterm Infants
Pulmonary inflammation plays an important role in the early development of CLD. Postnatal glucocorticoids have been shown effective in the prevention or treatment of CLD with various success.
- Trial name
- NCT00883532
- Testing
- budesonide
- Where
- China
- Volunteers
- 300 people
- Sponsor
- China Medical University, China