Clinical trials: Bronchoscopy Biopsy
Disorder Related to Lung Transplantation, Central Airway Stenosis
Hyperbaric Oxygen Therapy for Lung Transplantation
The objective of this study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) on airway complications in post-lung transplant recipients with evidence of restricted levels of blood and oxygen in the airway tissue.
- Conditions
- Disorder Related to Lung Transplantation, Central Airway Stenosis, Airway Exudative Plaques, Airway Complications Post-Lung Transplantation
- Trial name
- NCT02363959
- Testing
- Hyperbaric Oxygen Therapy, Endobronchial Biopsy of Airway Epithelium
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Lung Cancer
ENB-GS-TBLB for the Diagnosis of PPLs
The purpose of this study is to evaluate the efficacy and safety of electromagnetic navigation bronchoscopy with a Guide Sheath(ENB-GS) for the diagnosis of peripheral pulmonary lesions (PPLs) .
- Trial name
- NCT02207478
- Testing
- ENB, GS-TBLB-X-ray
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Chest Hospital
Sarcoidosis, Pulmonary
Peripheral Airway Biopsy in Sarcoidosis
Airway involvement in sarcoidosis was demonstrated in a meaningful, albeit variable, proportion of patients through biopsy of the central, endoscopically visible airways.
- Trial name
- Sopranos (NCT05759221)
- Testing
- Bronchoscopy with airway biopsy
- Where
- Italy
- Volunteers
- 79 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Healthy Young Adults, Influenza Vaccines
Characterizing the Human Airway Immune Response to FluMist Vaccination
The goal of this clinical trial is to measure the immune response in the blood, nose, and lungs after participants receive either the FDA-approved inactivated influenza vaccine or the FDA-approved intranasal FluMist vaccine.
- Conditions
- Healthy Young Adults, Influenza Vaccines, Influenza Vaccine Response
- Trial name
- EVax-3 (NCT07177417)
- Testing
- FluMist, inactivated influenza vaccine, bronchoscopy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Lung Nodules, Biopsy
Efficacy and Safety of Robotic-assisted Bronchoscopy Combined With the ICNVA Strategy in Biopsy of Peripheral Pulmonary Nodules
To assess the efficacy and safety of robotic-assisted bronchoscopy system (bronchial navigation and positioning device) combined with ICNVA strategy for peripheral pulmonary nodule biopsy through a prospective, single-center…
- Conditions
- Lung Nodules, Biopsy, Navigation, Spatial
- Trial name
- NCT07136961
- Testing
- Robot-Assisted Bronchoscopy (RAB)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Lung Biopsy
A Multicenter Study in Bronchoscopy Combining Stimulated Raman Histology With Artificial Intelligence for Rapid Lung Cancer Detection - The ON-SITE Study
The ON-SITE study represents a prospective, observational study focused on the training/tuning and pivotal validation of deep learning algorithms that detect cell/tissue morphology suspicious for cancer in biopsies of peripheral…
- Trial name
- ON-SITE (NCT07045103)
- Where
- 7 sites in United States
- Volunteers
- 900 people
- Sponsor
- Invenio Imaging Inc.
Lung Cancer, Lung Cancer (Diagnosis)
Evaluation of the Synergistic Impact of Needle and Forceps Biopsy With Electromagnetic Navigation Bronchoscopy
This randomized crossover study aimed to evaluate whether a multimodal biopsy strategy using both needle and forceps can provide additive benefits compared with a single device for diagnosing peripheral pulmonary lesions with…
- Trial name
- NCT05110131
- Testing
- Device for performing biopsy via electromagnetic navigation bronchoscopy
- Where
- South Korea
- Volunteers
- 142 people
- Sponsor
- Seoul National University Bundang Hospital
Peripheral Pulmonary Lesions (PPLs), Lung Nodules
Shape-sensing Versus Electromagnetic Robotic Bronchoscopy for Evaluation of PulmoNary LEsions
This is an investigator-initiated, multicenter, non inferiority, cluster randomized controlled trial. The primary objective is to compare the diagnostic yield of the electromagnetic robotic assisted bronchoscopy with digital…
- Trial name
- SERENE (NCT07411989)
- Testing
- Bronchoscopy for peripheral pulmonary lesion biopsy
- Where
- 2 sites in United States
- Volunteers
- 346 people
- Sponsor
- The Cleveland Clinic
Non Small Cell Lung Cancer
Molecular Diagnosis of Lung Cancer Via Bronchoscopy: The Significance of Bronchial Liquid Biopsy (ctDNA and ctRNA)
The management of lung cancer is a major public health challenge. Molecular anomaly testing is recommended from the early stages for optimal and personalized care of all lung adenocarcinomas and non-smoker lung cancers.
- Trial name
- BiliBro (NCT06228508)
- Where
- France
- Volunteers
- 79 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bronchi--Diseases, Lung Diseases, Obstructive
Feasibility of Performing Peripheral Pulmonary Lesion Biopsy Using Robotic Bronchoscopy-Guided Cryoprobe
This research is being done to evaluate the feasibility, and biopsy quality, of using a 1.1mm disposable cryoprobe that is passed through the working channel of the Ion Robotic bronchoscope to collect biopsy tissue.
- Conditions
- Bronchi--Diseases, Lung Diseases, Obstructive, Lesions Mass
- Trial name
- NCT05399082
- Testing
- Cryoprobe biopsy, Forceps biopsy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Endobronchial Bleeding, Hemoptysis
The Efficacy of Tranexamic Acid and Adrenaline to Control Endobronchial Bleeding
During bronchoscopy (a procedure using a thin, flexible camera to look inside the airways), doctors sometimes take small tissue samples (biopsies) to diagnose lung conditions. This can cause bleeding in the airway.
- Trial name
- CATER (NCT07759089)
- Testing
- Adrenaline, Tranexamic Acid
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Lung Cancer, Lung Diseases
Adequacy Assessment of Bronchoscopic Biopsy Samples Using a Novel Instrument
The goal of this study is to learn whether the Ruby Robotics system enables pathologists to determine whether a bronchoscopic biopsy sample is adequate for diagnosis.
- Trial name
- NCT06499454
- Testing
- Ruby ROSE evaluation
- Volunteers
- 50 people
- Sponsor
- Ruby Robotics Inc
Bronchial Endoscopy
Interest of in Situ Terlipressin Administration Before the Realisation of Bronchial Biopsy
The diagnostic yield of flexible bronchoscopy for the diagnosis of lung cancer depends on the location and the histological type of the lesion, as well as on the number of biopsy samples performed.
- Trial name
- TERLAB (NCT02970175)
- Testing
- Terlipressin administration, bronchoscopy under local anesthesia, Biopsy sampling
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Rouen
Asthma
Bronchoscopy With Bronchial Biopsies Sub-study of: Persistence of Airway Inflammation and Remodeling in Asthma Remission
This study aims at determining the patterns of asthma remission, the prevalence of these different patterns and the various factors associated with such remissions and possible recurrences of asthma, in order to determine the…
- Trial name
- NCT00526344
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Laval University
Lung Cancer
Piloting a Virtual Navigation (VN) System for Bronchoscopic Lung Nodule Sampling
The overall goal is to evaluate the role of a Virtual Navigation (VN) system (the Virtual Navigator) in the bronchoscopic evaluation and tissue sampling of lung cancer and other chest lesions at the Penn State Hershey Medical…
- Trial name
- NCT05599321
- Testing
- Virtual Navigation System
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Penn State University
Lung Neoplasms
Endobronchial Ultrasound Guided Transbronchial Lung Biopsy With or Without Guide Sheath in Lung Tumors and the Analysis of Echoic Patterns of Lung Tumors and Mediastinal Lymph Nodes, and the Association Between Diagnostic Yield of Transbronchial Lung Biopsy and EBUS Echoic Features.
1. Endobronchial ultrasonography (EBUS) is useful in localizing peripheral lung lesions. The EBUS, further combined with the guide sheath (GS) technique, has been reported to increase the yield of transbronchial biopsy.
- Trial name
- NCT00415337
- Testing
- endobronchial ultrasound
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Pulmonary Lesions, Pulmonary Nodules
Ultrathin Bronchoscope and Radial Endobronchial Ultrasound (R-EBUS) With Fluoroscopy Versus Standard Fiberoptic Bronchoscopy (FB) (P00029233 )
The purpose of this study is to compare the yield of two methods for obtaining a lung tissue sample: Procedure #1: standard fiberoptic bronchoscopy (FB) with fluoroscopy, and Procedure #2: ultrathin bronchoscope procedure with…
- Conditions
- Pulmonary Lesions, Pulmonary Nodules, Pulmonary Mass
- Trial name
- NCT02146131
- Testing
- Standard FB with fluoroscopy, R-EBUS with ultrathin bronchoscope
- Where
- 5 sites in United States
- Volunteers
- 339 people
- Sponsor
- Medical University of South Carolina
Pulmonary Nodule, Lung Cancer
Transbronchial Biopsy Assisted by Robot Guidance in the Evaluation of Tumors of the Lung
This study is designed to evaluate clinical safety and diagnostic accuracy of the robotic-assisted bronchoscopy with biopsy performed with the Monarch™ Endoscopy Platform in a broad range of patients with pulmonary lesions.
- Trial name
- TARGET (NCT04182815)
- Testing
- Robotic assisted bronchoscopy
- Where
- 19 sites in United States, Canada and 1 more
- Volunteers
- 691 people
- Sponsor
- Auris Health, Inc.
Mediastinal Lymphadenopathy, Sarcoidosis, Pulmonary
Diagnostic Yield of Intranodal Forceps Biopsies in Mediastinal Adenopathy
The investigators will compare endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) with intranodal forceps biopsy (EBUS-IFB) as it relates to the rate of diagnosis of suspected sarcoidosis.
- Conditions
- Mediastinal Lymphadenopathy, Sarcoidosis, Pulmonary, Mediastinal Diseases
- Trial name
- NCT05374447
- Testing
- Endobronchial Ultrasound-Guided Intranodal Forceps Biopsy
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- George Washington University
Healthy
Normal Control Cohort Sample Bank
This study is designed to collect lung washing samples and small pieces of tissue (biopsies) from the lungs of people who do not have any allergies or asthma.
- Trial name
- NCT00388765
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison