Clinical trials: Bronchospasm
Anaphylaxis, Hypotension
A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis
Background: Omalizumab is an approved drug for the treatment of asthma by the Food and Drug Administration. Researchers are now studying this drug in a double-blind placebo-controlled manner to assess efficacy in patients with…
- Conditions
- Anaphylaxis, Hypotension, Bronchospasm, Angioedema
- Trial name
- NCT00890162
- Testing
- Epinephrine, Omalizumab (Xolair)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Exercise-induced Bronchospasm
Mechanisms of Exercise-induced Bronchospasm
The term exercise-induced bronchospasm (EIB) describes acute, transient airway narrowing that occurs during, and most often after, exercise.
- Trial name
- NCT00701025
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Asthma, Exercise-Induced
A Study to Investigate the Effects of PT027 (Budesonide/Albuterol Sulfate) Metered-dose Inhaler Compared With Placebo on Exercise-Induced Bronchoconstriction in Adult Patients With Asthma
The purpose of this Phase III, multicentre, randomized, double-blind, single-dose, 2-period, crossover study is to assess the efficacy and safety of PT027 (budesonide/albuterol sulfate) metered-dose inhaler compared with placebo…
- Trial name
- BREATH (NCT06245551)
- Testing
- Budesonide/albuterol metered-dose inhaler 160/180 μg
- Where
- 6 sites in Russia
- Volunteers
- 64 people
- Sponsor
- AstraZeneca
Bronchospasm; Bronchiolitis, Bronchospasm; Bronchitis
Efficacy and Safety Evaluation in Recurrent Wheezing Attacks
The study will be conducted in two hospitals of the same geographic area. It will be included children <3-years-old with recurrent wheezing attacks, confirmed by the review of the medical records, in the previous 12 months or a…
- Trial name
- MV130 (NCT01734811)
- Testing
- Biological vaccine
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Inmunotek S.L.
Asthma
Combivent vs. Salbutamol in Patients With Metacholine Induced Bronchospasm
The purpose of this study was to evaluate whether 2 puffs of fixed combination of aerosolized 120 mcg salbutamol sulphate (equivalent to 100 mcg of the base) + 20 mcg ipratropium bromide confers significant additional protection…
- Trial name
- NCT02182713
- Testing
- Salbutamol sulfate/Ipratropium bromide, Salbutamol
- Volunteers
- 30 people
- Sponsor
- Boehringer Ingelheim
Aspirin Sensitivity
Therapeutic Utility of Xolair in Patients Undergoing Aspirin Desensitization
This is a 24 week double-blind study in which subjects will be randomized 2:1 to receive Xolair (Omalizumab) or placebo. 14 subjects will receive Xolair and 7 will receive placebo. Xolair injections will occur every 2-4 weeks.
- Trial name
- NCT00555971
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- David Lang
Exercise-Induced Bronchospasm
Effects of Montelukast on Occult Exercise-Induced Bronchospasm in Athletes
The purpose of this study is to determine if treatment of exercise-induced Bronchospasm with montelukast will help college athletes train more effectively and thus become more competitive in a non ergogenic manner.
- Trial name
- NCT00375232
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Supraglottic Airway Obstruction, Airway Complication of Anesthesia
Wei Nasal Jet Tube vs Nasal Cannula Oxygen Support in Gastrointestinal Endoscopy Patients
Sedoanalgesia is applied to patients during gastrointestinal endoscopy. Sedoanalgesia may cause respiratory depression and hypoxia in patients.
- Conditions
- Supraglottic Airway Obstruction, Airway Complication of Anesthesia, Airway Obstruction, Anesthesia Complication
- Trial name
- NCT05783050
- Testing
- Wei Nasal Jet Tube, Nasal Cannula Oxygen Support
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis)
Intraoperative Paravertebral Block and Postoperative Complications
This study aims to evaluate the clinical association between intraoperative paravertebral block and the reduction of postoperative complications following thoracic surgery.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis), Pulmonary Infections, Respiratory Failure Without Hypercapnia
- Trial name
- IPVB and POCs (NCT07211529)
- Testing
- Paravertebral Block (PVB)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Exercise Induced Bronchospasm
Hyperventilation Versus Exercise Testing Sensitivity in Exercise Induced Asthma
The diagnosis of exercise-induced bronchospasm (EIB) is difficult. The metacholine challenge test is not enough specific for the diagnosis of EIB.
- Trial name
- HYVES (NCT03063424)
- Testing
- Eucapnic voluntary hyperventilation, Exercise challenge on a cycle ergometer
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Supraglottic Airway Efficiency, Airway Complication of Anesthesia
Wei Nasal Jet Tube vs Gastro Laryngeal Tube in Endoscopic Retrograde Cholangiopancreatography
The most common adverse event in endoscopic procedures is hypoxia. Different airway devices have been investigated in the literature to prevent hypoxia.
- Conditions
- Supraglottic Airway Efficiency, Airway Complication of Anesthesia, Airway Aspiration, Complication of Anesthesia
- Trial name
- NCT05360810
- Testing
- Wei Nasal Jet Tube, Gastro Laryngeal Tube
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Bezmialem Vakif University
Exercise Induced Bronchospasm, Athletes
Diagnosis of EIB in Young Elite Athletes (13-18 y)
The investigators recently observed airway inflammation and increased damage-associated molecular pattern (DAMP) level in sputum of children (age 11-12y) and adolescents (18-23y) from elite sport programs in Belgium with…
- Conditions
- Exercise Induced Bronchospasm, Athletes, Adolescent
- Trial name
- NCT03587675
- Testing
- EVH test
- Where
- Belgium
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Exercise Induced Bronchospasm, Exercise Induced Asthma
Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)
Due to the lack of studies examining the impact of inspiratory muscle training (IMT) on the severity of exercise-induced bronchoconstriction (EIB) and exercise performance, the specific aim of this study is to assess the efficacy…
- Trial name
- IMT_EIB (NCT06336681)
- Testing
- PrO2Fit Device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Acute Respiratory Insufficiency, Chronic Respiratory Insufficiency
Pharmacokinetics of Nebulized Amikacin in Non Invasive Ventilated Healthy Volunteers.
The purpose of the study is to compare the pharmacokinetics of nebulized amikacin administered with three vibrating mesh nebulizers coupled with a single limb circuit bilevel ventilator in healthy volunteers.
- Conditions
- Acute Respiratory Insufficiency, Chronic Respiratory Insufficiency, Bronchospasm and Obstruction
- Trial name
- NIV-NEBU (NCT01901497)
- Testing
- Nebulizer
- Where
- Belgium
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University Hospital St Luc, Brussels
Critical Illness, Asthma
Ketamine Efficacy for Acute Severe Bronchospasm in ICU: MACANUDO Trial
Despite few scientific evidence that could support the use of ketamine in adult patients undergoing acute bronchospasm requiring mechanical ventilation (MV), ketamine is largely employed in this setting.
- Conditions
- Critical Illness, Asthma, Bronchospasm
- Trial name
- MACANUDO (NCT03000413)
- Testing
- Ketamine, Fentanyl
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Exercise Induced Bronchospasm
Exercise Induced Bronchospasm in Children
The purpose of the study is to test how well 2 different medications stop asthma symptoms caused by exercising. The two medications that will be tested are "pretreatment with albuterol" and montelukast (Singulair®).
- Trial name
- NCT00273689
- Testing
- montelukast vs pretreatment with albuterol, montelukast
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of New Mexico
Asthma, Bronchospasm
Dose-Ranging Study of A006 DPI, in Adult Asthma Patients
This study is a randomized, active- and placebo-controlled, single-dose, seven-arm, crossover and dose-ranging design. This study aims to evaluate the efficacy and initial safety profiles, and to identify the optimum dose of…
- Trial name
- NCT01174732
- Testing
- albuterol inhalation powder, albuterol inhalation aerosol
- Where
- 4 sites in United States
- Volunteers
- 26 people
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Asthma, Bronchospasm
Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine Inhalation Aerosol USP, an HFA-MDI (E004), using a stable isotope deuterium-labeled epinephrine (epinephrine-d3) to differentiate the…
- Conditions
- Asthma, Bronchospasm, Wheezing, Shortness of Breath
- Trial name
- NCT01188577
- Testing
- Epinephrine Inhalation Aerosol, HFA, Epinephrine Inhalation Aerosol
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications
Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications
The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in…
- Conditions
- Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications, Postoperative Respiratory Failure, Postoperative Bronchospasm
- Trial name
- NCT07186933
- Testing
- PEEP titration for Minimum Driving Pressure, Lung Protective Ventilation
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University General Hospital of Patras
Asthma (Diagnosis)
Longitudinal Phenotyping and Endotyping Study in Adult Patients With Mild, Moderate, or Severe Asthma
Background and study aims: The purpose of this research registry is to understand how asthma varies from person to person and monitor changes that may occur over time.
- Trial name
- MAPLE-UK (NCT07189806)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Hvivo