Clinical trials: Brown Adipose Tissue, Human
Brown Adipose Tissue, Human
Does Cold Provocation Increase Brown Adipose Tissue Volume?
About 28 healthy subjects are randomized to 1 hour/day of coldprovocation or to the best of ability to avoid feeling cold, for 6 weeks.
- Trial name
- NCT01797328
- Testing
- cold arm, warm arm
- Where
- Sweden
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Obesity
Collection of Human Tissue Samples From the Neck Region for Characterization of Its Molecular and Biochemical Signatures
The purpose of the study is to gather tissue (from the neck region), specimens (blood and urine) and medical record data from many patients and store them in one place so that scientists have the information they need to conduct…
- Trial name
- Human BAT (NCT02274805)
- Testing
- Adults presenting for surgery in the neck area
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity and Overweight
Adaptation of Human Brown Adipose Tissue to Calorie Restriction
The BATON study investigates how human brown adipose tissue (BAT) adapts to a controlled caloric restriction diet in young adults with obesity.
- Trial name
- BATON (NCT06878989)
- Testing
- Caloric restriction diet, Weight maintenance diet
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Granada
Brown Adipose Tissue (BAT) Physiology, Phenotyping
Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism
Background: The body uses energy from calories for basic functions like breathing and digesting food. Over time, when a person eats more calories than they burn, they may become overweight or obese.
- Conditions
- Brown Adipose Tissue (BAT) Physiology, Phenotyping, Brown Adipocytes
- Trial name
- NCT02692885
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes, Obesity
Activation of Brown Adipose Tissue Thermogenesis in Humans Using Formoterol Fumarate (GB10)
One emerging, highly modifiable homeostatic mechanism for energy expenditure in humans is brown adipose tissue (BAT) thermogenesis.
- Trial name
- GB10 (NCT05553184)
- Testing
- Formoterol Fumarate 12 micrograms Inhalation Powder, Nicotinic Acid 50 MG Oral Tablet, Acute Cold Exposure
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Adipose Tissue, Brown, Brown Adipose Tissue
Cold Induced Activation of Brown Adipose Tissue in Humans
This study investigates cold-induced brown fat activation assessed using PET/MR scans. Subjects will participate in an acute cooling intervention day and a thermoneutral intervention day with PET/MR scans on both days.
- Conditions
- Adipose Tissue, Brown, Brown Adipose Tissue, Brown Fat, Uncoupling Protein 1
- Trial name
- COLDBAT (NCT03096535)
- Testing
- Cooling, Thermoneutral
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Susanna Søberg
Insulin Sensitivity, Obesity
The Effect of Brown Adipose Tissue Activation on Insulin Sensitivity in Humans
Recent findings document the presence of active brown adipose tissue (BAT) in humans. Cold exposure via adrenergic stimulation activates BAT, which combusts significant amounts of blood glucose and free fatty acid (FFA) to…
- Trial name
- NCT01791114
- Testing
- Cold exposure, Cold exposure plus propranolol, Thermoneutral Conditions
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Regulation of Energy Expenditure
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1
Brown adipose tissue becomes activated during cold conditions to increase thermogenesis (i.e., energy expenditure). Topical menthol application increases resting energy expenditure but it is unclear whether brown adipose tissue…
- Trial name
- NCT07030725
- Testing
- Menthol Gel, Time control
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obesity
Adenosine and A2A Receptors in Human Brown Adipose Tissue
This study investigates the significance of adenosine and A2A receptors in human brown adipose tissue (BAT) in vivo. Using positron emission tomography (PET), perfusion and the density of A2A receptors will be measured in…
- Trial name
- AdenoBAT (NCT03327168)
- Testing
- Adenosine, Cold exposure
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Adipose Tissue, Brown, Adipose Tissue
The Physiology of Human Brown Adipose Tissue
Brown fat is a type of fat, found in both children and adults, which can produce heat and regulate the body's metabolism and energy use. White fat is the more common type of fat which is used to store extra calories.
- Conditions
- Adipose Tissue, Brown, Adipose Tissue, Obesity
- Trial name
- NCT04352244
- Testing
- Fat biopsy, Blood sampling, Blood sample for DNA analysis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity
Secretin Activates Human Brown Fat and Induces Satiation.
15 healthy males will be studied with PET/CT, using FDG to investigate glucose metabolism, and radiowater to investigate perfusion.
- Trial name
- GUTBAT (NCT03290846)
- Testing
- Secretin Human, Saline Solution, Cold exposure
- Where
- Finland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Breast Cancer
The Effects of HER2 Receptor Signaling on Human Brown Fat Activity
The objective of this observational study is to investigate the significance of the HER2 receptor for brown fat activity in humans.
- Trial name
- HEAT (NCT06222957)
- Testing
- None (Observational study)
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Nonshivering Thermogenisis
Human Neck Brown Adipose Tissue mRNA Profile, a Seasonal Variation Study.
The primary objective in this study is to examine the seasonal variation in genetic markers in the deep neck adipose tissue in humans.
- Trial name
- NCT02486419
- Testing
- Outdoor weather
- Where
- Denmark
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Healthy
Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study
Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance.
- Trial name
- MIBAT (NCT02682706)
- Where
- 2 sites in Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
The Incidence and Factors of Brown Adipose Tissue in Chinese
Previous studies have shown active brown adipose tissue (BAT) is present in adults and may play important roles in regulating energy homeostasis.
- Trial name
- NCT01381042
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Huashan Hospital
Healthy
Chronic Cold Exposure and Energy Metabolism in Humans
Background: Researchers are studying how metabolism and hormone levels change in response to mild changes in environmental temperature. Changes in metabolism may lessen with time because of hormonal adaptations.
- Trial name
- NCT01730105
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Mitochondrial Metabolism Disorders, Adipose Tissue, Brown
Human Brown Adipose Tissue and Mitochondrial Respiration
This study is focused on measuring mitochondrial activity of human brown adipose tissue. During surgery, adipose tissue biopsies from white and brown adipose tissue will be collected from the deep neck area.
- Conditions
- Mitochondrial Metabolism Disorders, Adipose Tissue, Brown, Aging, Obesity
- Trial name
- NCT03111719
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Maastricht University Medical Center
Hyperthyroidism
Thyroid Hormones Effect on Brown Adipose Tissue
Brown adipose tissue (BAT) is important in energy expenditure through thermogenesis although the regulatory factors are not well known in humans.
- Trial name
- NCT01376648
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital