Clinical trials: Bunion
Hallux Valgus
Patient Reported Function Following Combined First MTP and First TMT Arthrodesis.
The goal of the study is to gather sufficient patient data to assess real world postoperative function after a first metatarsophalangeal (MTP) joint arthrodesis done in conjunction with first tarsometatarsal arthrodesis (TMT)…
- Trial name
- NCT05527197
- Testing
- Lapiplasty
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Midwest Bunion Center, LLC
Hallux Valgus, Bunion
Clinical Trial on Patient-Specific-Instrumentation Assisted Lapidus Fusion for Hallux Valgus
RCT to compare the effectiveness of PSI assisted Lapidus surgery vs conventional Lapidus surgery in hallux valgus.
- Conditions
- Hallux Valgus, Bunion, Patient Spe
- Trial name
- NCT05602844
- Testing
- PSI Lapidus, Conventional Lapidus
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- Chinese University of Hong Kong
Bunion of Unspecified Foot, Bunionette of Unspecified Foot
Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study
Orthopedic surgeons frequently prescribe and over-prescribe narcotic pain medications during the postoperative period, despite the ongoing opioid crisis in the United States.
- Conditions
- Bunion of Unspecified Foot, Bunionette of Unspecified Foot, Hammertoe, Ankle Fractures
- Trial name
- NCT04771741
- Testing
- Acetominophen, Toradol, Meloxicam
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Prisma Health-Midlands
Hallux Valgus and Bunion
Post-Operative Pain and Opioid Reduction Trial After Bunionectomy
This is a Phase 2b, randomized, double blind, placebo and active controlled study with an Ascending Dose Stage and an optional Dose Expansion Stage in subjects undergoing bunionectomy.
- Trial name
- MERIT-2 (NCT05411861)
- Testing
- Analgesic Non Narcotic
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- Cali Pharmaceuticals LLC
Arthrodesis, Bunion
Multi-Plane Hallux Valgus Correction With the Phantom® Nail
The goal of this research study is to determine the change in frontal plane rotation of the 1st metatarsal from pre to post arthrodesis of the 1st TMT joint with the Phantom® Intramedullary Nail combined with a supinating…
- Conditions
- Arthrodesis, Bunion, Hallux Valgus
- Trial name
- NCT04084262
- Testing
- Intramedullary Nail
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Paragon 28
Pain, Postoperative, Bunion
Study to Evaluate the Safety and Tolerability of FX301 in Patients Undergoing Bunionectomy
This two-part study will be conducted in male and female patients 18 to 65 years of age undergoing bunionectomy. Part I - three-step, single ascending dose study design in which two drug loads (low drug load of funapide and high…
- Trial name
- NCT04826328
- Testing
- FX301, Normal Saline
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Lower Extremity Surgery, Bunion
Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries
This is a Phase 3, multicenter, randomized, double blinded, active controlled study in approximately 120 subjects undergoing lower extremity surgeries.
- Conditions
- Lower Extremity Surgery, Bunion, Metatarsophalangeal Fushion, Midfoot Fusion
- Trial name
- STRIDE (NCT04518462)
- Testing
- Exparel, Bupivacaine Hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 121 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Hallux Valgus and Bunion
Timing of Weight Bearing After Hallux Valgus Surgery
Investigate the optimal timing for weight bearing after Hallux Valgus surgery. Hypothesis: Early weight bearing does not affect outcome after the Endoscopic Distal Soft Tissue Procedure for Hallux Valgus Correction.
- Trial name
- NCT03340415
- Testing
- Accelerated Rehabilitation plan
- Where
- Hong Kong
- Volunteers
- 53 people
- Sponsor
- North District Hospital
Liposomal Bupivacaine, Postoperative Pain
Liposomal Bupivacaine Versus Bupivacaine Plain for Operative Pain Management of Forefoot Surgery
Prospective, randomized, controlled single-blinded trial comparing liposomal bupivacaine with bupivacaine HCl for postoperative management.
- Conditions
- Liposomal Bupivacaine, Postoperative Pain, Forefoot Surgery, Opioid Use
- Trial name
- NCT04751344
- Testing
- Liposomal bupivacaine, Bupivacaine HCl
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandra Black
Bunion
Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety, of EXPAREL Administered as Sciatic Nerve Block (In Popliteal Fossa), for Postsurgical Analgesia in Subjects Undergoing Bunionectomy
This is a pilot, open label, single center study in 40 subjects undergoing bunionectomy. The study will assess and collect information on pharmacokinetics, pharmacodynamics, safety and efficacy of EXPAREL administered as a…
- Trial name
- NCT04002089
- Testing
- Exparel Injectable Product, Bupivacaine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Hallux Valgus (Bunions)
Liposome Bupivacaine for ANKLE Blocks
Postoperative analgesia for hallux valgus surgery (bunionectomy) is inconsistent and may even result in rebound pain when the (ankle) blocks wear off.
- Trial name
- NCT03106545
- Testing
- Liposome bupivacaine
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Catherine Vandepitte, M.D.
Bunion, Metatarsophalangeal Fusion
Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries
This is a Phase 3, multicenter, randomized, double blinded, active controlled study in approximately 81 subjects undergoing lower extremity surgeries with combined sciatic and adductor canal nerve block.
- Conditions
- Bunion, Metatarsophalangeal Fusion, Midfoot Fusion, Hindfoot Fusion
- Trial name
- STRIDE (NCT03954639)
- Testing
- EXPAREL 13.3Mg/mL Suspension for Injection, Bupivacaine Hydrochloride
- Sponsor
- Pacira Pharmaceuticals, Inc
Foot and Ankle Surgeries, Bunion
Efficacy of Tranexamic Acid in Foot and Ankle Surgeries
Epidemiology of foot and ankle surgeries that present to the hospitals in the US are often underestimated. However there has been growing emphasis on identification of these injuries and practice patterns.
- Trial name
- NCT03653429
- Testing
- Tranexamic Acid, Normal saline
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hallux Valgus and Bunion
Minimally Invasive Distal Chevron in Comparison to the Reverdin-Isham Osteotomy for Hallux Valgus Correction
This study analyses the Reverdin Isham procedure, which is the most popular minimally invasive surgical hallux valgus correction method and the minimally invasive chevron osteotomy, representing the standard technique of open…
- Trial name
- NCT04288297
- Testing
- distal minimally invasive chevron osteotomy
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dr.Gerhard Kaufmann
Hallux Valgus and Bunion, Sedation
Dexmedetomidine Sedation in Orthopedic Surgery
60 patients ASA I-III, undergoing orthopedic surgery will be randomly assigned into one of three groups, namely group A (n=20), where dexmedetomidine will be used for sedation (initial bolus dose followed by continuous infusion)…
- Trial name
- NCT04149626
- Testing
- Dexmedetomidine, Midazolam, Remifentanil
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Asklepieion Voulas General Hospital
Hallux Valgus, Instability of the Foot Arch
Measurement of Arch Motion After Bunion Surgery
This study is an observational "change from baseline" outcome measures design. Data is collected for the sake of evaluating treatment (fusion surgery) performed as standard medical care, but the investigator does not assign…
- Trial name
- NCT02074748
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Bunion, Pain
Intravenous Tapentadol in Post-Bunionectomy Pain
The purpose of this trial is to established the safety and efficacy of multiple dose treatment with tapentadol IV in an adult population with moderate to severe pain following bunionectomy.
- Trial name
- NCT01435577
- Testing
- Tapentadol
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Grünenthal GmbH
Hallux Valgus, Hallux Valgus and Bunion
Arthroscopic Assisted Lateral Soft Tissue Release for Hallux Valgus
Lateral soft tissue release is commonly performed as part of the surgical correction of hallux valgus. This study will look at the results form a series of patients whom have underwent the arthroscopic lateral soft tissue release.
- Trial name
- NCT04088214
- Testing
- Arthroscopic lateral soft tissue release
- Where
- Hong Kong
- Volunteers
- 12 people
- Sponsor
- Chinese University of Hong Kong
Bunion
Ketorolac Effects on Post-operative Pain and Bone Healing
This will be a randomized double-blind placebo-controlled clinical trial that will accept all eligible consecutive patients undergoing elective Kalish bunionectomies.
- Trial name
- NCT01133639
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Beth Israel Deaconess Medical Center
Arthrodesis, Bunion
Early Weight-Bearing After Lapidus Arthrodesis
The goal of this research study is to determine if union rates are affected by early weight-bearing after Lapidus Arthrodesis using the Phantom™ Intramedullary Nail.
- Conditions
- Arthrodesis, Bunion, Hallux Valgus
- Trial name
- NCT03257540
- Testing
- Small Bone Intramedullary Nail
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Paragon 28