Clinical trials: Buprenorphine Dependence
Prescription Opioid Dependence
Effective Treatment for Prescription Opioid Abuse
There has been an alarming increase in abuse of prescription opioids in recent years. This project aims to develop an effective outpatient treatment for prescription opioid (PO) abuse that combines an intensive behavioral therapy…
- Trial name
- NCT00719095
- Testing
- buprenorphine taper followed by naltrexone maintenance, Behavioral therapy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Vermont Medical Center
Opioid-Related Disorders
Evaluation of Liquid vs. Tablet Buprenorphine - 6
The purpose of this study is to evaluate the steady-state pharmacokinetics and bioavailability of buprenorphine sublingual tablets vs. sublingual solution.
- Trial name
- NCT00000341
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Dependence
Intensive Outpatient Versus Outpatient Treatment With Buprenorphine Among African Americans
The purpose of this study is to compare the effectiveness of different levels of counseling (intensive outpatient versus standard outpatient) on treatment outcomes for African American adult patients receiving buprenorphine in 2…
- Trial name
- NCT01096550
- Testing
- Outpatient, Intensive Outpatient
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Friends Research Institute, Inc.
Opioid-Related Disorders, Substance-Related Disorders
Buprenorphine Dose Escalation Trial for Treatment of Non-Dependent Opiate Users - 2
The purpose of this study is to evaluate the effect, pharmacokinetics and dose proportionality of buprenorphine when administered to non-dependent opiate users.
- Trial name
- NCT00015041
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Dependence, Buprenorphine Withdrawal Syndrome
Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patients
The primary objective of this study is to assess lofexidine related effects on QTc (an interval of the heart rhythm) in subjects receiving buprenorphine maintenance.
- Trial name
- NCT01820442
- Testing
- Lofexidine HCl, Lofexidine-matching sugar pill
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- USWM, LLC (dba US WorldMeds)
Opioid Dependence
Probuphine Innovations for Clinical Effectiveness (PRINCE)
HITLAB will conduct a crossover study wherein participants will be asked to wear an actigraphy device continuously for 12 weeks.
- Trial name
- PRINCE (NCT02896660)
- Testing
- ActiGraph Link
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Healthcare Innovation Technology Lab
Opiate Dependence, Stimulant Dependence
Atomoxetine for ATS and Opioid Dependence During Buprenorphine Maintenance Treatment in Malaysia
To evaluate the tolerability, acceptability and potential effect size of the efficacy of 4 months of atomoxetine treatment for patients with co-occurring ATS and heroin dependence (COATS) receiving buprenorphine maintenance…
- Trial name
- NCT01863251
- Testing
- Atomoxetine
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- Yale University
Opioid-Related Disorders, Heroin Dependence
Buprenorphine Maintenance Treatment of Opioid Dependence in Primary Care: A Randomized Clinical Trial
The study will assess the effectiveness of at-home vs. in-office induction for patients entering buprenorphine maintenance at Associates in Internal Medicine (AIM) primary care clinic.
- Trial name
- NCT00684554
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York State Psychiatric Institute
Opioid Abuse, Opioid Dependence
A Within Subject Comparison of Opioid Withdrawal in Opioid Dependent Individuals
Buprenorphine is an approved medication for the treatment of opioid dependence. It is typically administered once daily as a sublingual tablet combined with naloxone (i.e., Suboxone).
- Trial name
- NCT01136356
- Testing
- buprenorphine, morphine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Addiction Opiate, Chronic Pain
Suboxone User Perioperative Early Referral and Enhanced Recovery After Surgery- Orthopaedic Trauma Surgery Population
This is a randomized controlled trial. Patients will be randomly assigned to either the control or treatment group, with equal allocation using block randomization.
- Conditions
- Addiction Opiate, Chronic Pain, Fractures, Bone, Buprenorphine Dependence
- Trial name
- SUPER-ERAS (NCT04464512)
- Testing
- Sufentanil
- Where
- United States
- Sponsor
- West Virginia University
Opioid-related Disorders
Buprenorphine's Dose Response Curve
This is a residential study that looks at the effects of buprenorphine in persons who abuse but are not dependent on opioids. Animal studies show that very high doses of buprenorphine produce less effects than mid-range doses.
- Trial name
- NCT00460239
- Testing
- Buprenorphine, Morphine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Heroin Dependence, Morphine Dependence
Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1
The purpose of this study is to assess buprenorphine/naloxone versus clonidine for inpatient opiate detoxification.
- Conditions
- Heroin Dependence, Morphine Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00032955
- Testing
- Buprenorphine/naloxone
- Where
- 6 sites in United States
- Volunteers
- 163 people
- Sponsor
- University of California, Los Angeles
Cigarette Smoking Among Patients Currently Receiving Methadone or Buprenorphine Treatment for Opioid Dependence
Incentive-based Smoking Cessation for Methadone Patients
The prevalence of cigarette smoking among patients receiving opioid agonist treatment, such as methadone or buprenorphine maintenance, is more than three-fold that of the general population and is associated with increased…
- Trial name
- NCT00718835
- Testing
- incentive-based contingency management
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- University of Vermont Medical Center
Chronic Pain, Opioid Addiction
Yoga for Pain and Opioid Dependence
This study is designed to develop an effective adjunctive treatment using yoga for chronic pain and opioid dependence.
- Trial name
- Yoga (NCT01590251)
- Testing
- Yoga, Educational Counseling
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Opioid-Related Disorders, Substance-Related Disorders
Trial of Buprenorphine/Naloxone for Opiate Dependence - 2
The purpose of this study is to determine the efficacy and safety of a buprenorphine/naloxone sublingual tablet formulation as an office-based therapy for opiate dependence treatment.
- Trial name
- NCT00000353
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)