Clinical trials: Burden
Atherosclerosis, Cardiovascular Diseases
Risk Burden of Lipoprotein Metabolic Gene Haplotypes
To investigate the role in coronary heart disease (CHD) of intragenic variation in a network of six genes affecting lipoprotein transport and metabolism.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Disease, Heart Diseases
- Trial name
- NCT00090441
- Volunteers
- 4,303 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Multiple Sclerosis, Cognitive Dysfunction
HOBSCOTCH-MS-Efficacy Trial
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-MS to improve the quality of life and cognitive function in Service Members, Veterans and civilians who have multiple sclerosis with…
- Conditions
- Multiple Sclerosis, Cognitive Dysfunction, Memory Disorders, Memory Impairment
- Trial name
- NCT06951919
- Testing
- Home Based Self- management and Cognitive Training Changes lives in Multiple Sclerosis (HOBSCOTCH-MS)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Bone Tumor, Bone Cancer
Medical Payment Case Management for Financial Toxicity in Patients With Primary Bone Tumors: A Randomized Controlled Trial
The goal of this clinical trial is to learn if adding a medical payment case management service to the hospital's usual follow-up care can reduce the financial hardship of cancer treatment in patients of any age, including…
- Trial name
- NCT07888244
- Testing
- Medical payment case management service
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Shanghai 6th People's Hospital
TAVI, ECG Monitoring
Assessment of Arrhythmic BuRdEn With Post-ProCedural COntinuous ElectRocarDiographic Monitoring in Patients Undergoing Transcatheter Aortic Valve Implantation: The RECORD Study
TAVI recipients exhibit a high burden of arrhythmic events early after the procedure. ECG continuous monitoring could be useful to diagnose and facilitate early implementation of specific therapeutic measures in these patients.
- Trial name
- NCT04298593
- Testing
- Cardiostat
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Cleft Palate, Orofacial Cleft
Neural Network to Calculate Morphology of the Cleft Palate to Reduce Cleft Lip and Palate Treatment Burden.
This study is to develop a neural network to compute palatal three dimensional (3D) geometry by using routinely taken intraoral/palatal photographs and palatal casts of infants with cleft lip and palate deformity for reducing…
- Trial name
- NCT04342234
- Testing
- data collection of palatal casts and palatal images of cleft patients routinely treated at the institution
- Where
- Switzerland
- Volunteers
- 450 people
- Sponsor
- University Hospital, Basel, Switzerland
RSV Infection
Respiratory Syncytial Virus (RSV) Burden in Older Adults in Primary Care in The Netherlands
RSV infection is a leading cause of medical care in older adults, sometimes leading to hospital admission and severe outcomes. Although the majority of RSV infections are managed outside hospitals, little is known on the burden…
- Trial name
- RAPID (NCT06318936)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
Kidney Stones
Durability of Flexible Ureteroscopes and Causes of Infection During Flexible Ureterorenoscopy
This is an observational study in which data on consecutive patients who undergo ureterorenoscopy with the use of a flexible ureterorenoscope are collected.
- Trial name
- NCT03087812
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Clinical Research Office of the Endourological Society
Rotavirus Gastroenteritis, Infections, Rotavirus
Hospital-based Surveillance to Collect Prospective Data to Estimate the Disease Burden of Severe RV GE in Sweden
This study aims to estimate the burden of RV GE. The study will focus on children hospitalized for severe RV GE, Children acquiring RV GE in the hospital and the household contacts of children hospitalized with RV GE.
- Trial name
- NCT00489567
- Testing
- Blood sample collection
- Volunteers
- 642 people
- Sponsor
- GlaxoSmithKline
Caregiver Burden, Bereavement
Caregiver Stress and Bereavement
The death of a spouse is considered one of the most stressful and impactful life events and is associated with increased morbidity and premature mortality.
- Conditions
- Caregiver Burden, Bereavement, Cancer
- Trial name
- NCT05867706
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Type 2 Diabetes Mellitus (T2DM)
Effectiveness of and Implementation Strategies for 'Disfrutando'.
Despite much research that has focused on enhancing type 2 diabetes mellitus (T2DM) health outcomes for high burden populations, more remains to be done.
- Trial name
- Disfrutando 2 (NCT07023406)
- Testing
- Disfrutando
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- University of Missouri-Columbia
Stroke, Caregiver Burnout
Ecological Momentary Intervention for Stroke Caregivers' Psychological Support
The proposed trial aims to evaluate the effectiveness of internet-delivered cognitive behavioural therapy (iCBT) based ecological momentary intervention (EMI) for psychological well-being in stroke family caregivers.
- Conditions
- Stroke, Caregiver Burnout, Depressive Symptoms, Psychological Distress
- Trial name
- NCT04936828
- Testing
- iCBT-based EMI
- Where
- 7 sites in Hong Kong
- Volunteers
- 256 people
- Sponsor
- The University of Hong Kong
Thrombotic Thrombocytopenic Purpura
A Prospective Study on the Long-Term Vascular Burden in Thrombotic Thrombocytopenic Purpura Patients
A prospective cohort study of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome patients who have presented with their acute episode and are in remission within the last 30 days.
- Trial name
- TTP (NCT03187652)
- Testing
- CT Perfusion Study, Echocardiogram, neuro-cognitive assessment
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Colorectal Cancer
Protein Recommendation to Increase Muscle
This is a feasibility study to test the potential efficacy of diets of different amounts of protein and calories for patients with cancer.
- Trial name
- PRIMe (NCT02788955)
- Testing
- Dietary counselling, Dietary Protein
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Atrial Fibrillation
Burden of Ischemic Stroke and Intake of Oral Anticoagulants in Patients With Atrial Fibrillation in the UK Primary Care
This study will characterize patients with ischemic stroke, a condition which occurs when a vessel supplying blood to the brain is obstructed, and a subpopulation of patients with irregular and often rapid heart rate (atrial…
- Trial name
- BEST-AF (NCT04099238)
- Testing
- Oral anticoagulant
- Where
- United Kingdom
- Volunteers
- 3,739 people
- Sponsor
- Bayer
Myelodysplastic Syndromes
Monitoring Mutational Burden in Low Risk MDS Patients Using Sequential Peripheral Blood Samples
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell malignancies. Somatic cytogenetic and molecular aberrations and the evolution of subclonal malignant cell populations are responsible for…
- Trial name
- NCT04251078
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Josep Carreras Leukaemia Research Institute
Atrial Fibrillation, Myocardial Infarction
New-Onset Atrial Fibrillation Complicating Acute Myocardial Infarction in ShangHai
To characterize and estimate the incidence rate of new-onset atrial fibrillation (NOAF) in patients with acute myocardial infarction (MI). To explore the prognostic influences of NOAF on MI patients' clinical outcomes.
- Trial name
- NOAFCAMI-SH (NCT03533543)
- Testing
- CEM
- Where
- China
- Volunteers
- 2,399 people
- Sponsor
- Shanghai 10th People's Hospital
Low Anterior Resection Syndrome, Quality of Life (QOL)
Bowel Dysfunction After Low Rectal Resection. An Pilot Study Using Psyllium Husk In Rectal Cancer Patients.
Rectal cancer constitutes 1/3 of more than 4500 annually diagnosed cases of colorectal (CRC) in Norway. With the advances in radiochemotherapy, and surgical techniques, the long-term survival rate is increasing after surgery…
- Trial name
- NCT06724198
- Testing
- Psyllium husk
- Where
- Norway
- Volunteers
- 24 people
- Sponsor
- Sykehuset Telemark
Lung Cancer
Can a Pulmonologist Reliably Assess the Tumor Burden on ROSE Slides Obtained From Pulmonary Nodules and Lymphadenopathy
The study is aimed at verifying if a pulmonologist can reliably assess the tumor burden for the extractive molecular analysis in ROSE samples obtained with endoscopic sampling procedures from intrathoracic lymphadenopathy and…
- Trial name
- NCT03845764
- Testing
- Rapid on-site evaluation
- Where
- 2 sites in Italy
- Volunteers
- 164 people
- Sponsor
- Maggiore Bellaria Hospital, Bologna
Parkinson Disease, Parkinson
Treatment Burden in Parkinson's
Background: People with Parkinson's (PwP) have many symptoms including tremor, stiffness, slow movements, constipation, urinary incontinence and mental health issues.
- Trial name
- NCT04769973
- Where
- 2 sites in United Kingdom
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Bipolar Disorder, Caregiver Burden
Evaluation of Efficiency of One Day Patient/Caregiver Psychoeducation on the Caregiver's Burden
Bipolar disorder (BD) has a huge impact on the lives of patient and their relatives. Psychoeducation programs on BD has been shown to be effective on the burden of patients and their caregivers.
- Trial name
- BP ONEDAY (NCT05178966)
- Testing
- Bp OneDay psychoeducation program
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier