Clinical trials: Burn
Burns
Evaluation of Hand Assessments in Children With Severe Hand Burns
This study is designed to see if some tests of hand movement, strength, and function are valid for children with burns.
- Trial name
- NCT00363675
- Testing
- Functional hand tests
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Skin Wound, Burns
StrataGraft® Skin Tissue as an Alternative to Autografting Deep Partial-Thickness Burns
The proposed study is designed as a phase Ib open-label, dose-escalation, multicenter study evaluating the safety, tolerability, and efficacy of StrataGraft skin tissue in promoting the healing of the deep partial-thickness…
- Conditions
- Skin Wound, Burns, Trauma-related Wound
- Trial name
- NCT01437852
- Testing
- StrataGraft Skin Tissue
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Partial-thickness Burn
Investigation of the Clinical Performance of Biatain Fiber Ag on Burns
The goal of this study is to test a new gelling fiber wound dressing with silver on patients with a partial thickness burn wound, which is infected or at risk of infection.
- Trial name
- NCT05824026
- Testing
- Gelling fiber wound dressing with silver
- Where
- 5 sites in United Kingdom
- Volunteers
- 52 people
- Sponsor
- Coloplast A/S
Infections, Gram-Positive Bacterial, Abscess
Phase 2 Trial of TD 6424 (Telavancin) Versus Standard Therapy for Complicated Gram Positive Skin and Skin Structure Infections (Gram Positive cSSSI)
Serious infections caused by resistant bacteria are becoming more of a medical problem throughout the world. One of the ways to deal with this problem is to develop new drugs that can control these bacteria.
- Conditions
- Infections, Gram-Positive Bacterial, Abscess, Burns, Cellulitis
- Trial name
- FAST (NCT00061633)
- Testing
- Telavancin, Vancomycin or antistaphylococcal penicillin
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Cumberland Pharmaceuticals
Deep Partial Thickness Burn
Effect of EGF With Silver Sulfadiazine Cream Compared With Silver Zinc Sulfadiazine Cream for Treatment of Burn Wound
Partial thickness burn wounds are most likely to heal within 2-3 weeks mainly by mechanism of epithelialization. However, it depends on the depth of the wounds and patient condition.
- Trial name
- NCT01553708
- Testing
- Epidermal growth factor with silver sulfadiazine cream, Silver zinc sulfadiazine cream
- Where
- Thailand
- Volunteers
- 34 people
- Sponsor
- Chulalongkorn University
Wound Healing
An Open Single-centre Investigation Evaluating Efficacy in Second Degree Partial Thickness Burns Using a Silicone Contact Layer Containing Silver.
Approximately 10 subjects from one clinic having sustained a burn injury covering 1-25% or the Total Body surface Area (TBSA)and assessed as superficial partial-thickness or superficial deep-partial-thickness.
- Trial name
- NCT01734317
- Testing
- Mepilex Transfer Ag
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Molnlycke Health Care AB
Burns, Wound Care
Comparison of Virtual Reality and Passive Distraction on Burn Wound Care Pain in Adolescents
Relief of severe burn wound care pain may require both medications to relieve pain and non-medication interventions,such as distraction. Little is known about distraction's effectiveness.
- Conditions
- Burns, Wound Care, Pain
- Trial name
- NCT01812655
- Testing
- Virtual Reality, Passive Distraction
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Arkansas
Post-traumatic Stress Disorder
PTSD Prevention Study Examining the Efficacy of Sertraline in Burn Victims
This is a randomized, double-blind, placebo-controlled study to determine whether administration of sertraline to patients who exhibit acute stress disorder secondary to severe burns can contribute to the prevention of…
- Trial name
- NCT02520726
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Thermal Burn
Single-Stage Integra Reconstruction in Burns
This is a prospective, descriptive, pilot case series involving patients with significant burns who are candidates for reconstruction with Integra®.
- Trial name
- Integra (NCT03077087)
- Testing
- thin Integra® (125 cm2)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- HealthPartners Institute
Burns
Indocyanine Green (ICG) and SPY Imaging for Assessment of Burn Healing
Three patients were recruited for assessment of ICG fluorescence in burns.
- Trial name
- NCT02766244
- Testing
- ICG/SPY, Antibiotic Ointment
- Volunteers
- 3 people
- Sponsor
- Texas Tech University Health Sciences Center
Hypertrophic Scar
Use of Autologous Platelet-Rich Plasma to Treat Hypertrophic Burn Scars
Hypertrophic burn scars are experienced by more than 70% of burn victims. They are a major source of decreased quality of life in burn patients due to pain, decreased range of motion, and poor cosmetic appearance.
- Trial name
- NCT03935594
- Testing
- PRP Injection, Saline Injection
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Burns
ReCell® Combined With Meshed Skin Graft in the Treatment of Acute Burn Injuries
This is a randomized, within-subject controlled study to compare the clinical performance of the ReCell device when used as an adjunct to meshed skin graft in subjects requiring skin grafts for closure of burn injuries.
- Trial name
- NCT02380612
- Testing
- ReCell Treatment, Skin Graft
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Avita Medical
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Trauma-related Wound, Burns
StrataGraft® Skin Tissue as an Alternative to Autografting Full-thickness Complex Skin Defects
About 20 participants will be enrolled in this trial if they have had an accident that damages both the dermal (outside) and epidermal (inside) layers of skin on up to 49% of their body.
- Conditions
- Trauma-related Wound, Burns, Skin Wound
- Trial name
- NCT03005054
- Testing
- StrataGraft Skin Tissue, Autograft
- Where
- 4 sites in United States
- Volunteers
- 3 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Burn Injury, Skin Graft
A Soft Silicone Wound Contact Layer Containing Silver in the Treatment of Skin Grafts in Surgical Burn Patients.
Part A The primary objective of Part A will be to verify performance and safety of Mepitel® Ag, a meshed, non- adherent soft silicone wound contact layer containing silver in the treatment of skin grafts in surgical burn…
- Trial name
- MpTAg03 (NCT02210208)
- Testing
- Mepitel® Ag, Mepilex® Transfer Ag
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Molnlycke Health Care AB
Wound Healing, Burns
Hypoxia-inducible Factor-1 (HIF-1) Regulated Circulating Angiogenic Cells (CACs) Recruitment in Burn Wound Healing
This research is being done to increase knowledge about wound healing and different factors that may affect healing in burn patients.
- Trial name
- NCT00796627
- Testing
- Healthy volunteers, Burn volunteers
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Burn Scar, Skin Graft Scar
Fractional Ablative Laser Treatment for Skin Grafts
Doctors and patients refer to all areas of skin changes from burn injury as burn scars. However, different areas of scars from burns can be treated differently.
- Trial name
- NCT04176705
- Testing
- Lidocaine Cream, Triamcinolone Acetonide Cream, Fractional Ablative Laser
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Wake Forest University Health Sciences
Chronic Pain
Effects of Intramuscular Oxytocin on Sensory Function in Healthy Volunteers With Ultraviolet Burn Injury to the Skin
This study proposes to evaluate the effects that a dose of oxytocin given by intramuscular (IM) injection (into the muscle) will have on an area of skin that has been exposed to ultraviolet (UV) light.
- Trial name
- NCT03935399
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pain, Burn Injury
The Effect of Neurontin on Pain Management in the Acutely Burned Patient
Burn patients have extreme pain. Opioids are the main agents used for analgesia. We therefore propose a single center study to fruther assess the efficacy of neuropathic agents in controlling the pain associated with acute…
- Trial name
- NCT01265056
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Lucy A Wibbenmeyer
Hypertrophic Scarring After Burn Injury
Effectiveness of Pressure Garment Therapy After Burns
Purpose - To determine the effectiveness of custom-fit pressure garment therapy in the prevention of hypertrophic scarring in healed burns. Background - Approximately one million people are burned each year in the United States.
- Trial name
- NCT01005732
- Testing
- Custom fabricated pressure garments
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Washington