Clinical trials: Burns
Burn Patients
Pharmacokinetics Ertapenem Burns
This study will examine the pharmacokinetics of ertapenem in ventilated badly (> 30% SCT) burn patients.
- Trial name
- NCT01497990
- Testing
- Ertapenem
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Nantes University Hospital
Microbial Colonization, Burns
Understanding the Burn Wound Microbiome: Comparing Traditional Wound Cultures to Next Generation Sequencing Technology
The purpose of this investigation is to better understand the wound microbiome in burn wounds and the role it plays in outcomes and complications related to treatment.
- Trial name
- NCT05275335
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Acute Pain, Pediatric ALL
VR-PAT and fNIRS to Identify CNS Biomarkers of Pain
This study aims to use functional near-infrared spectroscopy (fNIRS) to identify and quantify pain biomarkers during burn dressing changes and pain relief induced by virtual reality (VR).
- Conditions
- Acute Pain, Pediatric ALL, Procedural Pain, Burns
- Trial name
- NCT06303687
- Testing
- VR-PAT
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Nationwide Children's Hospital
Burn
Video-Guided Jaw Relaxation and Breathing Exercises in Children With Burns
This randomized controlled trial aims to evaluate the effects of video-guided jaw relaxation and video-guided breathing exercises on anxiety, fear, and dressing duration in children with burns.
- Trial name
- NCT07796243
- Testing
- Video-Guided Jaw Relaxation, Video-Guided Breathing Exercise
- Volunteers
- 60 people
- Sponsor
- Izmir Katip Celebi University
Diabetic Ulcers, Arterial Ulcers
Multicenter, Randomized, Non-inferiority Study to Compare the Performance and Safety of Debrisoft® Duo With Debrisoft® Pad in the Debridement of Wounds
The aim of this post market clinical follow up (PMCF) study is to confirm the performance of Debrisoft® Duo, to collect safety data regarding expected adverse events and to detect potential unexpected adverse events associated…
- Conditions
- Diabetic Ulcers, Arterial Ulcers, Venous Ulcers, Pressure Ulcers
- Trial name
- NCT07312513
- Testing
- two sided debridement pad, one sided debridment pad
- Where
- 5 sites in Poland
- Volunteers
- 100 people
- Sponsor
- Lohmann & Rauscher
Hyperthermia, Burn Injury
IEEM- Work:Rest Cycles in Burn Survivors- Humidity
The purpose of this project is to identify the effects of a severe burn injuries in humans on core temperature responses during work:rest cycles while in a heated environment.
- Trial name
- NCT06966336
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Burn Injury
SN514-066b Enzyme in Deep Partial Thickness Burns
This study will examine the tolerability of a gel formulation of the enzyme SN514 in patients with burns suitable for enzymatic debridement.
- Trial name
- NCT06628037
- Testing
- SN514-066b
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- SERDA bv
Burn Injury, Thermal Burn
Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) Trial
The Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) trial will be a 5-year (3-year enrollment), open label, phase-3, multi-center, early in-hospital phase randomized trial…
- Trial name
- PREEVEnT (NCT07212998)
- Testing
- Plasma, Standard care
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Jason Sperry
Burns, Skin Graft Complications
Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft
Investigators hypothesize that topical tranexamic acid will have better or comparable efficacy to topical thrombin in reducing hematoma formation at the wound base.
- Trial name
- NCT06379724
- Testing
- Tranexamic acid, Thrombin JMI, skin graft
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Kansas Medical Center
Partial Thickness Burn
Evaluation of Safety and Efficacy of Dehydrated Human Amnion-Intermediate-Chorion Membrane (dHAICM) Allograft in Treatment of Partial Thickness Thermal Burns
This study will evaluate the efficacy of a dehydrated human placental tissue product, commercially labeled as AmCoreMatrix Burn ™ versus SOC in the closure of partial thickness burns.
- Trial name
- PHOENIX (NCT07489560)
- Testing
- Amnion-Intermediate-Chorion, Standard of Care (SOC)
- Sponsor
- Cellution Biologics
Diagnostic Role, Prognostic Role
Diagnostic and Prognostic Roles of Procalcitonin and Highly Sensitive C-Reactive Protein in Early Detection of Burn Sepsis
This study aimed to evaluate the value of procalcitonin and highly sensitive c-reactive protein as biomarkers for early detection of sepsis in patients with major burns.
- Conditions
- Diagnostic Role, Prognostic Role, Procalcitonin, Highly Sensitive
- Trial name
- NCT07791030
- Testing
- Measurement of Procalcitonin level, Measurement of c-reactive protein level
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Burn, Hypertrophic Scars
Carbon Dioxide Laser-Assisted Delivery of Triamcinolone With or Without 5-Fluorouracil for Hypertrophic Burn Scars
Burn scars can sometimes heal in a way that causes them to become thick, raised, and stiff. These scars may itch, feel uncomfortable, limit movement, and affect how the skin looks.
- Conditions
- Burn, Hypertrophic Scars, Scar Improvement by Laser, CO2 Laser in Scars
- Trial name
- NCT07660120
- Testing
- Fractional Ablative CO₂ Laser, Triamcinolone Acetonide, Fluorouracil (5-FU)
- Volunteers
- 65 people
- Sponsor
- University of California, Davis
Burns and Scalds
Nurse Led Aromatherapy
The goal of this trial is to see if aromatherapy in addition to pain medication, will help manage pain in pediatric burn patients during their first burn dressing change.
- Trial name
- NCT07773181
- Testing
- Aromatherapy
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- KK Women's and Children's Hospital
Burn Injuries
Red Cell Distribution Width/Albumin Ratio as a Predictive Tool for Mortality of Patients With Burn Injuries
The aim of this study is to evaluate the prognostic utility of the red cell distribution width/albumin ratio (RAR), measured within 24 hours of hospital admission, in predicting 30-day mortality among patients with burn injuries.
- Trial name
- NCT07761845
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Burn Scar
Nonsilicone Gel Sheet for Burn Hypertrophic Scars
Overview: The application of gel sheets holds promise for both the prevention and treatment of hypertrophic scar after deep dermal injuries.
- Trial name
- NCT05429411
- Testing
- Silicone gel
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pain, Postoperative, Trauma
Reducing Pain and Anxiety During Dressing Changes After Burn Surgery Using Virtual Reality
Burn injury and its treatment is an intensely painful experience. Most severely injured patients require numerous dressing changes and skin grafting procedures (removing skin from healthy part of the body and moving it to damaged…
- Conditions
- Pain, Postoperative, Trauma, Burns
- Trial name
- BURN-360 (NCT04820400)
- Testing
- Immersive VR Video
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Sunnybrook Health Sciences Centre
Wound of Skin, Burns
Manual Implantation of Full-Thickness Skin Microcolumns
The objective of this study is to validate the proof of concept regarding the approach of manual implantation of full-thickness skin microcolumns (FTSMs) as coverage for open wounds without creating an additional donor scar and…
- Trial name
- NCT05223998
- Testing
- Full-thickness skin microcolumns implantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Metis Foundation
Wound of Skin, Burns
Suprathel® Use During Prolonged Field Care to Promote Healing and Reduce the Need for Grafting of Burn Wounds
The purpose of this study is to determine the effect to which Suprathel® (Polymedics Innovations GmbH, Denkendorf, Germany) can reduce the need for grafting compared to Standard of Care (SoC).
- Trial name
- NCT05462860
- Testing
- Suprathel®
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The Metis Foundation
Surgical Wound, Burns
A Prospective Study Using SupraSDRM® in Promoting Healing and Reducing the Time to Grafting of Full-thickness Wounds
This is a prospective, randomized, controlled, multi-center clinical study comparing SupraSDRM® to standard of care wound dressing, BTM, in the treatment of full-thickness wounds deemed not immediately suitable for definitive…
- Conditions
- Surgical Wound, Burns, Trauma Injury
- Trial name
- NCT06503406
- Testing
- SupraSDRM®, NovoSorb® BTM
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The Metis Foundation
Burns
Phase III Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents
This multicentre phase III clinical trial will target adults and adolescents of 12 years and older with severe burns to confirm the efficacy and functionality of denovoSkin™ in achieving wound closure and reducing scarring in…
- Trial name
- NCT06745557
- Testing
- denovoSkin(TM), STSG
- Where
- 19 sites in Belgium, France and 7 more
- Volunteers
- 70 people
- Sponsor
- CUTISS AG