Clinical trials: Butylphthalide
Chemotherapy-Related Cognitive Impairment, DL-3-n-butylphthalide
Effects of DL-3-n-butylphthalide on Chemotherapy-Induced Cognitive Impairment
Chemotherapy-related cognitive Impairment (CICI) is a series of neurocognitive deficits experienced during and after cancer chemotherapy.
- Trial name
- NCT06508671
- Testing
- DL-3-n-butylphthalide, Empty Medication Capsules
- Volunteers
- 100 people
- Sponsor
- First Hospital of China Medical University
Butylphthalide, Cardiac Arrest
Butylphthalide's Safety and Efficacy for Improving Neurological Function Prognosis in Patients With Cardiac Arrest (BNCA Trial)
Butylphthalide (NBP) is a neuroprotective medication capable of ameliorating neurological dysfunction induced by ischemia, hypoxia, and reperfusion injury in the brain.
- Conditions
- Butylphthalide, Cardiac Arrest, Neuroprotective Drugs
- Trial name
- NCT06353334
- Testing
- Butylphthalide and Sodium Chloride Injection, Saline Solution
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tang Ziren
Acute Ischemic Stroke
Effectiveness of Butylphthalide on Dynamic Cerebral Autoregulation in Patients With Acute Ischemic Stroke.
This is a randomized, triple-blind, placebo-controlled, multicenter clinical trial. Eligible patients will be randomized into either the butylphthalide (NBP) or placebo group in a 2:1 ratio.The main purpose of this study is to…
- Trial name
- EBCAS (NCT03413202)
- Testing
- butylphthalide(NBP)
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Yi Yang
Alzheimer's Disease
DL-3-n-butylphthalide Treatment in Patients With Mild to Moderate Alzheimer's Disease Already Receiving Donepezil
Alzheimer's disease (AD) is the commonest cause of dementia. There is no effective treatment to cure the disease. Cholinesterase inhibitors, such as donepezil, are widely recommended to patients with mild to moderate AD.
- Trial name
- NCT02711683
- Testing
- DL-3-n-butylphthalide, Donepezil
- Where
- China
- Volunteers
- 92 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Ischemic Stroke, Acute, Intracranial Atherosclerosis
Efficacy of Butylphthalide on Symptomatic Atherosclerotic Stenosis in Middle Cerebral Artery
Ischemic stroke with high incidence, mortality, disability and recurrence rate, has become the leading threat to the health worldwide.
- Trial name
- SICAS (NCT06331494)
- Testing
- Butylphthalide
- Where
- China
- Volunteers
- 140 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Stroke, Cerebral Infarction
Using Real-world Evidence to Analyze the Clinical Effects and Adverse Events of Butylphthalide in Stroke Patients
This is a retrospective, multi-center, real-world study. The researchers plan to include 10,000 cases of ischemic stroke patients using butylphthalide and 10,000 cases of ischemic stroke patients using Edaravone.
- Conditions
- Stroke, Cerebral Infarction, Brain Infarction, Brain Ischemia
- Trial name
- NCT05086874
- Testing
- butylphthalide
- Where
- China
- Volunteers
- 81,292 people
- Sponsor
- Xin Huang
Multiple System Atrophy
Efficacy and Safety of Butylphthalide in the Treatment of Multiple System Atrophy
The present study aims to conduct a randomized controlled trial to evaluate the efficacy and safety of 3-n-Butylphthalide (NBP) in improving symptoms in patients with Multiple System Atrophy (MSA).
- Trial name
- ENMSA (NCT07518810)
- Testing
- 3-N-butylphthalide
- Where
- 7 sites in China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cerebral Small Vessel Diseases
A Clinical Study on the Treatment of Cerebral Small Vascular Disease
This study is designed to evaluate the safety and efficacy of butylphthalide (NBP) in the treatment of cerebral small vessel disease through a multicenter, randomized,double-blind, placebo-controlled study.
- Trial name
- MAP-CSVD (NCT04078204)
- Testing
- Butylphthalide Soft Capsules
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Acute Ischemic Stroke
Efficacy and Safety of Early Initiation of Butylphthalide Treatment in Patients With Acute Ischemic Stroke.
This study is a prospective, multicenter, randomized, open-label, blinded-endpoint trial designed to evaluate the difference in efficacy of Butylphthalide Sodium Chloride Injection treatment initiated early (\<3 hours) versus…
- Trial name
- NCT06472921
- Testing
- Butylphthalide treatment initiation time
- Where
- 2 sites in China
- Volunteers
- 204 people
- Sponsor
- Xiangya Hospital of Central South University