Clinical trials: Bypass Bariatric Surgery
Obesity, Hormone Responses
Effect of Gastric Bypass Surgery on Brain Responses
After obesity surgery gastric bypass (GBP) patients usually lose more than 50% of its former preponderance in relative short time (~ 2 years).
- Conditions
- Obesity, Hormone Responses, Cognitive Health
- Trial name
- NCT01815216
- Testing
- Bariatric surgery, Brain activity in resting state, Memory performance
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Uppsala University
Bariatric Surgery, Fat Free Mass
Protein Supplementation and Resistance Training to Prevent Fat-Free Mass Loss Following Metabolic-Bariatric Surgery
The goal of this clinical trial is to investigate the effects of daily protein supplementation and participation in a weekly supervised resistance training program on the prevention of excessive muscle mass loss following…
- Trial name
- ENRICHED (NCT07156552)
- Testing
- Resistance exercise training and protein supplementation
- Where
- 2 sites in Netherlands
- Volunteers
- 400 people
- Sponsor
- Radboud University Medical Center
Gastric Bypass Surgery, Gastric Banding
Mechanisms of Diabetes Control After Weight Loss Surgery, Sub-study #1
Gastric bypass (GBP) and laparoscopic adjustable banding (AGB) are common procedures that can result in significant weight loss and significantly improve type 2 diabetes in 40-80% of cases.
- Conditions
- Gastric Bypass Surgery, Gastric Banding, Type 2 Diabetes
- Trial name
- NCT01930448
- Where
- United States
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Gastric Bypass Surgery, Revisional Bariatric Surgery
Reversal of Roux-en-Y Gastric Bypass: A Swedish National Cohort Study
Objective: To investigates incidence, indications, symptom relief, complications, and weight outcomes after Roux-en-Y gastric bypass (RYGB) reversal.
- Conditions
- Gastric Bypass Surgery, Revisional Bariatric Surgery, Complications After Bariatric Surgery
- Trial name
- NCT07347093
- Where
- Sweden
- Volunteers
- 199 people
- Sponsor
- Vrinnevi Hospital
Bariatric Surgery Candidate, Obesity, Morbid
Korean OBEsity Surgical Treatment Study
This trial is a multi-center, single-arm, prospective, observational cohort study of patients undergoing primary bariatric surgical procedures in Korea.
- Trial name
- KOBESS (NCT03100292)
- Testing
- Sleeve gastrectomy or Roux-en-Y gastric bypass
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Benchmark, Bariatric Surgery
Defining Benchmarks in Bariatric Surgery
Aim: To define benchmark outcomes in minimally-invasive primary bariatric surgery. Design: Multicenter retrospective cohort study.
- Conditions
- Benchmark, Bariatric Surgery, Roux-en-y Gastric Bypass, Sleeve Gastrectomy
- Trial name
- BBenchmarks (NCT03440138)
- Testing
- bariatric surgery (RYGB or SG)
- Where
- Switzerland
- Volunteers
- 5,741 people
- Sponsor
- Marco Bueter
Obese Patients, Bariatric Surgical Pain
Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy
Regional anesthesia is a technique in which a local anesthetic is injected near a nerve or spinal cord to block sensation, motor stimulation, and pain.
- Conditions
- Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy ), Non-Opioid Pain Management
- Trial name
- NCT07084753
- Testing
- Levobupivacaine, Dexamethasone contained in the solution for thoracic paravertebral block, Adrenaline
- Where
- Croatia
- Volunteers
- 36 people
- Sponsor
- IVO JURISIC
Obesity, Bariatric Surgery Candidate
Diet-induced Thermogenesis in Patients With Postoperative Roux-in-Y Gastric Bypass (RYGBP) Weight Regain
Introduction: According to the National Health and Nutrition Examination Survey 2009-2010, 78 million American adults are obese.
- Conditions
- Obesity, Bariatric Surgery Candidate, Protein-energy; Imbalance
- Trial name
- RYGBP (NCT02422212)
- Testing
- patients eat a mixed solid meal
- Where
- 3 sites in Brazil
- Volunteers
- 45 people
- Sponsor
- Silvia Leite Faria
Obesity, Morbid, Diabetes Mellitus, Type 2
Impact of an Increased Restrictive Factor of One Anastomosis Gastric Bypass on Metabolic Outcomes Type 2 Diabetes.
The purpose of the study is to evaluate the effect of an increased restrictive factor of one gastric anastomosis (OAGB) using a "FundoRing" fundoplication on metabolic outcomes in type 2 diabetes mellitus.
- Trial name
- NCT06176443
- Testing
- One anastomosis gastric bypass with combined fundoplication, One anastomosis gastric bypass without combined fundoplication
- Where
- Kazakhstan
- Volunteers
- 300 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Obesity (BMI > 35), Morbid Obesity
Predictive Value of Nutritional and Inflammatory Indices for Postoperative Complications After Bariatric Surgery
Bariatric surgery is an effective treatment for severe obesity, but postoperative complications remain an important cause of morbidity.
- Trial name
- BARI-NUTRI (NCT07747168)
- Testing
- Bariatric Surgery
- Where
- Greece
- Volunteers
- 600 people
- Sponsor
- G.Gennimatas General Hospital
Severe Obesity, Obesity
GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial
The goal of this pilot clinical trial is to determine the effectiveness of Tirzepatide in patients with persistent obesity (BMI \> 30) 12 months after bariatric surgery (Roux-en-Y Gastric Bypass).
- Conditions
- Severe Obesity, Obesity, BMI Greater Than 30
- Trial name
- GRABS-0 (NCT06162715)
- Testing
- Tirzepatide, Standard of Care post-gastric bypass
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Bariatric Surgery Candidate, Bariatric Surgical Procedure
Fat Taste Sensory Study
Fat is the most energy dense macronutrient and consuming fat has been positively correlated to obesity. Individuals afflicted with obesity crave fat more frequently, have a higher preference for fatty taste, and consume a higher…
- Trial name
- FaTSS (NCT03540693)
- Testing
- RYGB, SG, LAGB
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Obesity
Omega Loop Versus Roux-en-Y Gastric Bypass
Several prospective trials and metaanalysis have demonstrated the superiority of bariatric surgery on the medical treatment of obesity.
- Trial name
- YOMEGA (NCT02139813)
- Testing
- Laparoscopic Mini-gastric bypass, Procedure of reference in bariatric surgery
- Where
- 9 sites in France
- Volunteers
- 256 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Bariatric Surgery
Swap Anesthetic Versus Continuous Desflurane in Adults Undergoing Bariatric Surgery
This randomized, parallel-group, non-inferiority clinical trial aims to evaluate whether an anesthetic swap strategy consisting of sevoflurane followed by desflurane 30 minutes before the end of surgery is non-inferior to…
- Trial name
- SWAP (NCT07748247)
- Testing
- Desflurane, Sevoflurane-Desflurane
- Where
- Chile
- Volunteers
- 82 people
- Sponsor
- Clínica Dávila
Type 2 Diabetes Mellitus
The Contribution of Incretin Hormones to the Amelioration of Glucose Metabolism After Roux-en-Y Gastric Bypass
The study is being undertaken to understand how a gastric bypass can affect a subject's diabetes even prior to their losing significant amounts of weight.
- Trial name
- NCT01843855
- Testing
- Exendin 9,39
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Adrian Vella
Diabetes, Insulin Resistance
Physiologic and Functional Adaptations of Insulin Sensitive Tissues
The long-term goal is to understand the mechanisms of intestinal nutrient sensing and signal relays to insulin sensitive tissues (adipose, skeletal muscle, liver) in humans.
- Conditions
- Diabetes, Insulin Resistance, Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03407833
- Testing
- Endoscopy biopsy, Surgical biopsy, Mixed-meal tolerance test
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Type 2 Diabetes
Metabolic Effects of Gastrointestinal Surgery in T2DM
Gastric bypass surgery resolves type 2 diabetes mellitus (T2DM) without the need for diabetes therapy in ~80% of patients. Moreover, improvement in insulin sensitivity and glucose homeostasis occurs within days after surgery…
- Trial name
- NCT01771185
- Testing
- Duodenal jejunal bypass plus sleeve gastrectomy, Best medical treatment (Metformin ; gliclazide)
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Morbid Obesity
One Anastomosis Gastric Bypass for Severe Obesity in 6,722 Patients: Early Outcomes From the Assuta Surgery Registry
Background: One-anastomosis gastric bypass (OAGB) is an emerging type of bariatric metabolic surgery (BMS). Our study aimed to evaluate the short-term (≤30-day) postoperative safety of OAGB.
- Trial name
- NCT05481853
- Testing
- One Anastomosis Gastric Bypass
- Where
- Israel
- Volunteers
- 6,722 people
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Obesity and Overweight, Bariatric Surgery (Gastric Bypass)
Protein Requirements After Bariatric Surgery
The study investigates protein requirements at least 1 year after gastric bypass surgery in adult males, to investigate whether protein requirements are elevated compared to protein requiremens for the general populaiotn.
- Conditions
- Obesity and Overweight, Bariatric Surgery (Gastric Bypass), Protein Requirement
- Trial name
- PROXY (NCT06853652)
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity
Weight Loss Following Gastric Bypass or Sleeve Surgery
The overall aim is to study the multiple factors determining the variation of weight loss after Roux-en-Y Gastric Bypass (RYGB) and Sleeve surgery.
- Trial name
- NCT02070081
- Testing
- Roux-en-Y gastric bypass surgery or sleeve surgery
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- University of Copenhagen