Clinical trials: C Section
Pre-Eclampsia, Cesarean Section
Combined Colloids And Crystalloids Versus Crystalloids in Women With Preeclampsia Undergoing Cesarean Delivery
This study will compare between combination of colloids/crystalloids and crystalloids in women with preeclampsia undergoing elective cesarean delivery under spinal anesthesia
- Trial name
- NCT03252496
- Testing
- Spinal Anesthesia, Intrathecal Bupivacaine, Intrathecal Fentanyl
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Mansoura University
Pruritus
Serum Serotonin and Pruritus After Intrathecal Morphine in Cesarean Section
Pruritus is the commonest side effect of intrathecal morphine especially in parturient, but the exact mechanism of pruritus is not clear. Many mechanisms have been suggested.
- Trial name
- NCT03209427
- Testing
- Morphine 100 μg, Morphine 200 μg
- Volunteers
- 40 people
- Sponsor
- Assiut University
Surgical Site Infection Following Cesarean Delivery
Comparison of Surgical Skin Preps During Cesarean Deliveries
In women that undergo non-emergency cesarean delivery, we are comparing the skin preparation solutions for best outcome of surgical site infection.
- Trial name
- NCT01870583
- Testing
- Iodine povidone, Chlorhexidine, Combination iodine and chlorhexidine
- Where
- 2 sites in United States
- Volunteers
- 1,404 people
- Sponsor
- Montefiore Medical Center
Maternal Mortality, Cesarean Section
The ASOS-2 Trial Maternal Mortality Sub-study
This sub-study is a mixed-methods analysis of a prospective case-series of maternal deaths within the African Surgical OutcomeS-2 trial cohort.
- Conditions
- Maternal Mortality, Cesarean Section, Africa
- Trial name
- NCT04029207
- Testing
- Cesarean section
- Where
- South Africa
- Volunteers
- 100 people
- Sponsor
- University of Cape Town
Spinal Anaesthesia Induced Hypotension
Role of Ondansetron in Spinal Anaesthesia Induced Hypotension
The objective of this study is to determine the effect of ondansetron on the total consumption of norepinephrine infusion needed to prevent spinal anaesthesia induced hypotension in cesarean section.
- Trial name
- NCT06727201
- Testing
- Ondansetron (Zofran)
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Pain
PK and Safety After C-Section
The main goal of the study was to measure the amount of the active ingredients and other components of HTX-011 in plasma and expressed breast milk over time following postpartum administration in women undergoing a planned…
- Trial name
- NCT03955211
- Testing
- HTX-011, ZYNRELEF kit components for administration, MMA regimen
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Heron Therapeutics
Induction Time, Apgar Score
The Balloon Project for Birth Induction
The use of prostaglandin E2 (PGE2) for induction of labour in women with unfavourable cervices is well-established1. There are, however, potential side effects to prostaglandins, in particular the risk of uterine hypertonicity…
- Conditions
- Induction Time, Apgar Score, Admission to Neonatal Unit, Vaginal Delivery
- Trial name
- NCT01255839
- Testing
- Double Balloon, Minprostin
- Where
- Denmark
- Volunteers
- 825 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Postpartum Hemorrhage (Primary)
Carbetocin Versus Oxytocin for the Prevention of Postpartum Hemorrhage in Emergency Caesarean Delivery
Postpartum haemorrhage keeps to be the leading cause of maternal mortality in middle and low-income countries, including Iraq. Much advancement had been made in the field of treatment for postpartum haemorrhage but no much…
- Trial name
- NCT03755531
- Testing
- Carbetocin, Oxytocin
- Where
- Iraq
- Volunteers
- 300 people
- Sponsor
- Al-Kindy College of Medicine
Cesarean Delivery
Immune and Physical Recovery Following Cesarean Delivery
Pregnancy results in an altered immune state compared to the nonpregnant population. A significant proportion of women undergoing cesarean delivery recover poorly.
- Trial name
- NCT04358757
- Testing
- Elective cesarean delivery
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Hypotension
Can Passive Leg Raise Prevent Spinal Anesthesia-induced Hypotension During Cesarean Section?
All over the world, spinal anesthesia is widely used in cesarean sections due to its superiority over general anesthesia. Due to reasons such as increased sensitivity to local anesthetics and increased intra-abdominal pressure in…
- Trial name
- NCT04673253
- Testing
- Passive leg Raise, control
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Antalya Training and Research Hospital
Visual Analogue Scale
Neural Therapy in Cesareans
In the management of pain after Caesarean section (C/S), opioid or nonsteroidal anti-inflammatory parenteral drugs are applied. These drugs are insufficient in some cases and may cause pain attacks during the day.
- Trial name
- NCT06999200
- Testing
- neural therapy
- Volunteers
- 156 people
- Sponsor
- Haseki Training and Research Hospital
Splinter of Gum
The Effect of Gum Chewing on Bowel Function After Cesarean Section
This study is a randomised controlled trial that included 150 pregnant women undergoing cesarean in Sisli Ethal Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.
- Trial name
- NCT02497794
- Testing
- chew gum
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Shivering, Post-Spinal Shivering
Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean Section
Spinal anesthesia is the preferred anesthetic method for elective cesarean deliveries, but it frequently causes post-spinal shivering.
- Conditions
- Shivering, Post-Spinal Shivering, Hypothermia, Cesarean Section
- Trial name
- NCT07855523
- Testing
- Midazolam and Ketamine, 0.9% Sodium Chloride
- Volunteers
- 120 people
- Sponsor
- Assiut University
Nausea, Vomiting
Minimizing Nausea and Vomiting During Spinals for CS
In parturients undergoing Cesarean section under spinal anesthesia, co-loading of 1 liter of crystalloids, with placing the spinal, along with administering a phenylephrine infusion and glycopyrrolate, enables placing a spinal…
- Trial name
- NCT02872935
- Testing
- Glycopyrrolate, Normal Saline
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Kokila N Thenuwara
the Influence of Intra- vs Extra-abdominal Removal of Placenta, Duration of Operation
Extra-abdominal Removal of Placenta During CS
During cesarean section, it is important to provide hemostasis as well as to decrease the amount of hemorrhagic fluid and fibrin in the abdominal cavity.
- Conditions
- the Influence of Intra- vs Extra-abdominal Removal of Placenta, Duration of Operation, the Amount of Aspirated Fluid During the Operation, Difference Between Pre- and Post-operative CBC
- Trial name
- NCT02101450
- Testing
- Extra-abdominal removal of the placenta
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Isthmocele, Cesarean Scar Diverticula
Comparing Decidual Inclusion vs. Exclusion in Uterine Suture Techniques During Cesarean Section to Improve Scar Thickness and Reduce Isthmocele Risk in Primiparous Women
This study compares two ways of closing the uterus during cesarean delivery. In one group, the decidual layer near the uterine cavity is included in the suture. In the other group, this layer is left out.
- Trial name
- DISSUC (NCT07608874)
- Testing
- Single-Layered Non-Locked Closure with Decidual Inclusion, Single-Layered Non-Locked Closure with Decidual Sparing
- Where
- Switzerland
- Volunteers
- 374 people
- Sponsor
- Kantonsspital Baden
Post Partum Haemorrhage, Cesarean Section Surgery
Role of Intravenous Calcium to Decrease Blood Loss During Intrapartum Cesarean Section
To determine the effectiveness of prophylactic intravenous calcium chloride administered after cord clamping in reducing postpartum blood loss during intrapartum cesarean section.
- Trial name
- NCT07550413
- Testing
- Calcium Chloride
- Where
- Pakistan
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
Post-Dural Puncture Headache
Effectiveness of Nebulized Dexmedetomidine for Treatment of Obstetric Post-Dural Puncture Headache
Postdural puncture headache (PDPH) is a common complication, following neuraxial techniques. The obstetric population is particularly prone to PDPH. Therefore, treatment of PDPH is a key issue in obstetric anesthesia.
- Trial name
- NCT04327726
- Testing
- Dexmedetomidine Nebulization, 0.9% Saline Nebulization
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Zagazig University
Pregnancy, Anaesthesia
Audit of the Response Time of the Anaesthetic and Surgical Techniques for Crash Caesarean Section
A decision-to-delivery interval of 30 minutes for category-1 Caesarean section deliveries is the standard of practice recommended by clinical guidelines.
- Trial name
- Crash (NCT02314078)
- Where
- Singapore
- Volunteers
- 390 people
- Sponsor
- KK Women's and Children's Hospital
Pain, Postoperative, Depression, Postpartum
Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)
The purpose of this study is to identify a tolerable dose for postpartum ketamine infusion using a maximum tolerated dose (MTD) 3+3 design.
- Trial name
- NCT05907213
- Testing
- Ketamine (Ketalar) Dose Level 1, Ketamine (Ketalar) Dose Level 2, Ketamine (Ketalar) Dose Level 3
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
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