Clinical trials: C Section
Spinal Induced Hypotension in Cesarean Delivery
Up-Down Determination of the ED90 of Phenylephrine for Hypotension Prophylaxis in Cesarean Delivery
This study is designed to determine the ED90 for an infusion of phenylephrine to prevent spinal induced low blood pressure in parturients presenting for an elective cesarean delivery.
- Trial name
- NCT00796328
- Testing
- Phenylephrine infusion
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Surgical Site Infections
The Skin Prep Study
The investigators propose a randomized controlled clinical trial to determine the comparative effectiveness of chlorhexidine-alcohol and iodine-alcohol preoperative skin preparation for preventing surgical site infections at…
- Trial name
- NCT01472549
- Testing
- Iodine-alcohol, Chlorhexidine-alcohol
- Where
- United States
- Volunteers
- 1,147 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pre-eclampsia
Phenylephrine Versus Ephedrine in Pre-eclampsia
Phenylephrine administration is associated with reductions in CO and SctO2 compared with ephedrine when used for blood pressure management in women with pre-eclampsia undergoing cesarean delivery under spinal anesthesia.
- Trial name
- NCT02025426
- Testing
- Phenylephrine, Ephedrine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Pregnancy Related, Cesarean Delivery
Accupressure of P6 to Reduce Nausea During Cesarean Section
The purpose of this study is to evaluate if the addition of P6 pressure point stimulation as opposed to sham-point stimulation will decrease intraoperative and postoperative nausea and vomiting (IONV and PONV) for patients…
- Conditions
- Pregnancy Related, Cesarean Delivery, Nausea, Vomiting
- Trial name
- NCT04799587
- Testing
- Magnet at P6, Magnet applied to arm not at P6 pressure point.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Complications; Cesarean Section, Pregnancy
Mobius® Post-cesarean Pain Randomized Control Trial
The purpose of this study is to investigate whether the use of the Mobius® retractor decreased post-operative pain after cesarean section verses conventional retractor use.
- Trial name
- NCT00685932
- Testing
- Mobius Retractor
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Abbey Hardy-Fairbanks
Cesarean Section Complications, Post Partum Hemorrhage
DAISY Uterine Drain Device Evaluation
The goal of this study is to obtain user feedback while placing and observing the DAISY uterine drain with wall suction. This study defines the obstetrical surgeons as "users" and the patients in whom the drain is placed as…
- Conditions
- Cesarean Section Complications, Post Partum Hemorrhage, Uterine Atony With Hemorrhage, Uterine Bleeding
- Trial name
- NCT06219538
- Testing
- DAISY Uterine Drain
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Raydiant Oximetry, Inc.
Obesity, Complications; Caesarean Section, Wound
Silver Impregnated Dressings to Reduce Wound Complications in Obese Patients at Cesarean Section
Obese patients undergoing cesarean section are at high risk for wound complications, which occur in approximately 20% of patients.
- Trial name
- NCT01528696
- Testing
- Silverlon, Standard Dressing
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Wound Infection
Topical Silver for Prevention of Wound Infection After Cesarean Delivery
A common concern in any surgical procedure is the occurrence of infection. Silver-containing treatments are popular and used in wound treatment; however, there is presently little evidence of the effectiveness of…
- Trial name
- NCT01169064
- Testing
- Silver-containing surgical dressing, Cloth adhesive dressing
- Where
- United States
- Volunteers
- 475 people
- Sponsor
- Vanderbilt University
Obesity, Surgical Site Infections
Do Single Use Negative Pressure Dressings Reduce Wound Complications in Obese Women After Cesarean Delivery
The investigators aim to show that single use negative pressure dressings can decrease the rate of wound complications in obese women (BMI > 40 kg/m2) undergoing cesarean delivery at a tertiary medical center by randomizing women…
- Conditions
- Obesity, Surgical Site Infections, Wound Complications, Complications; Cesarean Section
- Trial name
- NCT02799667
- Testing
- Standard Dressing, Negative Pressure Wound Therapy Dressing
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Twin Pregnancy
The Twin Birth Study: A Trial Comparing Planned Vaginal Birth to Elective Caesarean Section of Twins
For twin pregnancies at 32-38 weeks gestation, where twin A is head down, does a policy of planned caesarean section (CS) lower the likelihood of death or serious illness, during the first 28 days after birth, compared to a plan…
- Trial name
- NCT00187369
- Testing
- Method of Delivery
- Where
- Canada
- Volunteers
- 2,804 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pain
Use of On-Q Pump for Pain Post C-Section
The main purpose of this study is to examine if pain levels treated with intrathecal (IT) preservative-free morphine (PFM) after a cesarean section improve with the additional use of continuous subfascial wound infiltration with…
- Trial name
- NCT02579629
- Testing
- Ropivacaine 0.1%, Ropivacaine 0.2%, Normal saline
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Emory University
Postoperative Nausea
How Pregnant Women and Their Babies Metabolize Ondansetron Compared to a Group of Non-pregnant Women
This is called "Aim 1" of the investigators' NIH grant. Ondansetron (Zofran) is a safe and effective drug used in pregnant women to prevent nausea but the investigators do not know what effect pregnancy may have on the metabolism…
- Trial name
- Zofran_PK (NCT01801475)
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Bladder Injury, Complications; Cesarean Section
Cystoinflation to Prevent Bladder Injury in Obstetrics and Gynaecology Surgery
Part1:The healthy pregnant women with previous operative deliveries admitted for elective C-section will be counselled and conditioned informed consent will be taken to be included in either study group if dense pelvic adhesions…
- Conditions
- Bladder Injury, Complications; Cesarean Section, Adhesions Pelvic
- Trial name
- NCT04302545
- Testing
- Cystoinflation
- Where
- Pakistan
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Shazia Saaqib
Opioid Use, Pain, Postoperative
Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section
Postpartum patients delivered by cesarean section will be randomized to NSAIDS Vs NSAIDS plus opioid
- Trial name
- IVY (NCT03372382)
- Testing
- Ibuprofen, Acetaminophen, Norco
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Obstetric Labor Complications, Cesarean Section
Evaluation of a Quality Improvement Project on Impacted Fetal Head at Cesarean Section
This study is an evaluation of a Quality Improvement (QI) project addressing delivery of the impacted fetal head being conducted at Regions Hospital.
- Trial name
- NCT03387189
- Testing
- Quality Improvement Project
- Where
- United States
- Volunteers
- 409 people
- Sponsor
- HealthPartners Institute
Pain
Multimodal Pain Management for Cesarean Delivery
Opioid use and abuse has become a major medical problem in the United States. Over prescription of opioid medications is a major contributor to this growing problem.
- Trial name
- NCT02922985
- Testing
- Intravenous acetominophen, Ketorolac, intramuscular, Bupivacaine, subcutaneous
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cesarean Section, Complication
A Skin Glue Versus Subcuticular Suture for Cesarean Closure Study
The aim of this study is to compare cesarean incision outcomes between patients with incision closed with the Dermabond Prineo system compared to standard subcuticular suture.
- Conditions
- Cesarean Section, Complication, Wound
- Trial name
- NCT05903547
- Testing
- Dermabond Prineo, Suture
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Columbia University
Obstetric Pain, Postpartum Depression
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
The objective of this study is evaluate the breastmilk transfer and pharmacokinetics (Part 1) and effectiveness (Part 2) of a post-cesarean delivery intravenous ketamine bolus-and-infusion strategy, as a preventive analgesic…
- Conditions
- Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute
- Trial name
- KINETIC (NCT04037085)
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Operative Time, Wound Heal
Subcuticular Absorbable Staples Versus Conventional Skin Closure in Women Undergoing Cesarean Delivery
Despite the high numbers of cesareans being performed, scientific evidence behind which surgical techniques are best remains uncertain.
- Trial name
- NCT05112640
- Testing
- INSORB: subcuticular stapling device, Subcuticular monocryl suture manufactured by Ethicon
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cesarean Section, Endometritis
Vaginal Cleansing at Cesarean Delivery to Reduce Infection: A Randomized, Controlled Trial
The objective of the project is to find out whether cleansing the vagina before a cesarean delivery decreases the risk of complications and infections after having the baby.
- Conditions
- Cesarean Section, Endometritis, Surgical Wound Infection
- Trial name
- NCT00386477
- Testing
- Vaginal cleansing before cesarean delivery
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Indiana University