Clinical trials: C-Section
Postoperative Infection
RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section
Background Women undergoing Caesarean Section (CS) have an increased risk of postpartum infections compared to women undergoing vaginal delivery. In Denmark the incidence of post-CS infections is 7-10%.
- Trial name
- APIPICS (NCT02009098)
- Testing
- Cefuroxime
- Where
- 3 sites in Denmark
- Sponsor
- Odense University Hospital
Anesthesia; Functional
Effects of Analgesics in Cesarean Section Elective
Two approved treatments for spinal anesthesia will be compared in women undergoing cesarean section. It is usual to perform cesarean sections using spinal anesthesia with a local anesthetic (bupivacaine) plus some opioid, such as…
- Trial name
- CES (NCT03386630)
- Testing
- Hyperbaric bupivacaine+Sufentanil, Hyperbaric bupivacaine+Morphine
- Where
- Spain
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Postoperative Pain
Spinal Hydromorphone Versus Morphine for Post-Cesarean Delivery Analgesia
Morphine is usually used for pain relief after cesarean delivery. However, sometimes it is not available, the patient might be allergic to morphine or intolerant to its side effects.
- Trial name
- NCT03592992
- Testing
- Spinal Hydromorphone, Spinal Morphine
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Surgical Site Infection, Obesity
SUpPress SSI - Single Use Negative Pressure Wound Therapy (NPWT) to Reduce Surgical Site Infections
Our goal is to provide data that will give surgeons and hospitals clear recommendations on the use of NPWT for Cesarean section, abdominal hysterectomy and colon surgeries in patients with diabetes and/or obesity.
- Conditions
- Surgical Site Infection, Obesity, Diabetes, Cesarean Section Complications
- Trial name
- SUpPressSSI (NCT03816293)
- Testing
- Negative Pressure Wound Therapy
- Where
- 5 sites in United States
- Volunteers
- 3,680 people
- Sponsor
- University of Illinois Chicago
Adhesion Formation After Primary Cesarean Delivery
Seprafilm® for Prevention of Adhesions at Repeat Cesarean
Adhesion formation is a result of abdominal and pelvic surgery and is a cause of such diseases as chronic pain syndrome, bowel obstruction and infertility.
- Trial name
- SPARC (NCT00697606)
- Testing
- Seprafilm®, Control
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Abington Memorial Hospital
Depression, Postpartum
Effect of Peripartum 40 Hz Audiovisual Stimulation on Postpartum Depression in Women Undergoing Elective Cesarean Section: A Randomized Clinical Trial
Postpartum depression (PPD) is a common mental health condition affecting 10%-30% of new mothers, with serious consequences for both mother and child.
- Trial name
- NCT07807462
- Testing
- 40 Hz Audiovisual Stimulation
- Where
- China
- Volunteers
- 204 people
- Sponsor
- The First People's Hospital of Lianyungang
Adverse Effect
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia.
The purpose of this study is to investigate the suitable infusion dose of norepinephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.
- Trial name
- NCT04556370
- Testing
- Normal saline, Norepinephrine
- Where
- China
- Volunteers
- 180 people
- Sponsor
- General Hospital of Ningxia Medical University
Cesarean Section Complications
Sharp Versus Blunt Uterine Incision Expansion
comparison between blunt versus sharp expansion of uterine incision at lower segment cesarean section in primigravida as regards the intra-operative blood loss \& postoperative pain
- Trial name
- NCT03377894
- Testing
- blunt uterine incision expansion, sharp uterine incision expansion
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Kasr El Aini Hospital
Abdominal Adhesion
Prediction of Intraoperative Adhesions Before CS
To predict the presence of intra-abdominal adhesions among women undergoing repeated cesarean section using several parameters.
- Trial name
- NCT06164522
- Testing
- Abdominal ultrasound
- Volunteers
- 146 people
- Sponsor
- Assiut University
Cesarean Section Complications, Regional Anesthesia Morbidity
Novel Predictors of Post Spinal Hypotension in Cesarean Sections: Evaluating Jugular Vein Collapsibility Index and Shock Indices
Jugular vein collapsibility index and shock indices (Shock index, Modified Shock Index, Diastolic Shock Index) may be useful in estimating post spinal hypotension in cesarean section operations.
- Conditions
- Cesarean Section Complications, Regional Anesthesia Morbidity, Hemodynamic Instability, Shock
- Trial name
- NCT05953129
- Testing
- Right Jugular Vein Collapsibility Index
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Cesarean Section Complications
Norepinephrine Infusion Different Doses in Cesarean Delivery
three doses (0.025 mcg/Kg/min, 0.050 mcg/Kg/min, and 0.075 mcg/Kg/min) of norepinephrine will be compared for prophylaxis against Post-spinal anesthesia hypotension during Cesarean delivery.
- Trial name
- NCT03182088
- Testing
- norepinephrine infusion (0.025 mcg/Kg/min), norepinephrine infusion (0.050 mcg/Kg/min), norepinephrine infusion (0.075 mcg/Kg/min)
- Where
- Egypt
- Volunteers
- 284 people
- Sponsor
- Cairo University
Major Puerperal Infection, Postpartum, Wound Complications
Negative Pressure Wound Therapy After Cesarean Delivery
This study is aimed at determining whether or not the use of a wound suction device placed on the cesarean incision instead of a standard sterile dressing will decrease the prevalence of wound complications and wound infections…
- Conditions
- Major Puerperal Infection, Postpartum, Wound Complications, Wound Seroma, Caesarean Section Wound Separation
- Trial name
- NCT01637870
- Testing
- Prevena negative pressure wound system
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Abbey Hardy-Fairbanks
Pain Management, Sleep Quality
The Effects of Acupressure and Massage Following Cesarean Section
Cesarean section births have rapidly increased both in our country and worldwide in recent years. According to OECD data, one in four births worldwide and one in two births in our country is a cesarean section.
- Conditions
- Pain Management, Sleep Quality, Massage Effect, Acupressure
- Trial name
- NCT07432074
- Testing
- Acupressure to points HT7, LI4, SP6 and ST36, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Marmara University
Cesarean Section
Fluid Volume-hypotension Association in Cesarean Under Neuraxial Anesthesia
Hypotension resulted from neuraxial block is a common problem, of which is a special issue in patients undergoing Cesarean section.
- Trial name
- VOHOCUNA (NCT01013090)
- Testing
- Ringer's Lactate, Six percent hydroxyethyl starch
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing Medical University
Postoperative Pain
Ropivacaine Through Continuous Infusion Versus Epidural Morphine for Postoperative Analgesia After Emergency Cesarean Section
The cesarean section is one of the most commonly performed surgeries in the world and it represents 20% of the births in France. Postoperative pain is moderate-to-severe during the first 48 hours after this procedure.
- Trial name
- ROMANCE (NCT02410317)
- Testing
- Ropivacaine, Morphine
- Where
- France
- Volunteers
- 101 people
- Sponsor
- University Hospital, Grenoble
Postpartum Hemorrhage \(PPH\)
Comparison of the Effect of Carbetocin Versus Oxytocin in the Prevention of Postpartum Hemorrhage After Emergency Caesarean Section in Antenatal Low-risk Patients
This study will be conducted to compare the effects of pabal and oxytocin administered to prevent postpartum hemorrhage in patients who were followed in the delivery room due to vaginal labor but underwent cesarean section due to…
- Trial name
- EMERGE-CS (NCT07380529)
- Testing
- Carbetocin, Oxytocin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Anesthesia, Analgesia
Conversion of Labor Analgesia for Intrapartum Cesarean Delivery: DPE v CSE v Epidural
As the dural puncture epidural (DPE) is increasing in popularity for labor analgesia, it is important to understand how it impacts outcomes in parturients.
- Trial name
- NCT05514431
- Testing
- Epidural, Dural Puncture Epidural (DPE) technique, Combined Spinal-Epidural (CSE) technique
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Vomiting, Postoperative, Postoperative Complications
The Effect of Intravenous Granisetron and Ondansetron in Patients Undergoing Cesarean Section
This study compared the effects of prophylactic intravenous (IV) infusion of ondansetron and granisetron before the spinal anesthesia on hemodynamic parameters in patients undergoing elective cesarean section.
- Conditions
- Vomiting, Postoperative, Postoperative Complications, Hypotension
- Trial name
- NCT04613726
- Testing
- ondansetron, Granisetron, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Surgical Site Infection, Surgical Wound Infection
Antibacterial-coated Sutures at Time of Cesarean
Abdominal closure with antibacterial-coated sutures has been shown to reduce wound infections after a number of surgical procedures, but none of the previous trials included cesarean delivery.
- Conditions
- Surgical Site Infection, Surgical Wound Infection, Cesarean Section; Infection, Cesarean Section Complications
- Trial name
- ASTC (NCT03386240)
- Testing
- Vicryl-plus, monocryl-plus, PDS-plus (Triclosan-coated Sutures), Vicryl, monocryl, PDS (not coated with triclosan)
- Where
- United States
- Volunteers
- 1,169 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Labor Onset and Length Abnormalities, 37 or More Completed Weeks of Gestation
Comparative Study Between Using WHO Labour Care Guide & Modified WHO Partograph
This randomized clinical trial is based on comparing the efficiency of modified WHO partographs vs. the new WHO labour care guide in monitoring and assessing the outcome of labour.
- Conditions
- Labor Onset and Length Abnormalities, 37 or More Completed Weeks of Gestation, First Birth
- Trial name
- NCT06537089
- Testing
- Supportive care measures, LCG guided labour interference
- Where
- Egypt
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Hend Mahmoud Abdelghany
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