Clinical trials: C-peptide
Myocardial Infarction
The Influence of Glycaemia and Insulinemia on Vasomotor Endothelial Function After Myocardial Infarction
The objective of this study is to investigative the influence of different levels of glycaemia or insulinemia in vascular endothelium in ischemia/reperfusion lesion after myocardial infarction
- Trial name
- INGLIVEF (NCT02250989)
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- University of Campinas, Brazil
Colonic Cancer, Metastasis to Lymph Node
EMI-137 in Laparoscopic Colonic Resections
EMI-137 in laparoscopic colonic resections is a single-centre stage IIa developmental study. Ten adult participants with a diagnosis of colon adenocarcinoma undergoing laparoscopic colonic will be recruited to the trial.
- Trial name
- NCT03360461
- Testing
- EMI-137
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Leeds
Achondroplasia
A Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia
The intent and design of this Phase 3 study is to assess BMN 111 as a therapeutic option for the treatment of children with Achondroplasia.
- Trial name
- NCT03197766
- Testing
- BMN 111
- Where
- 24 sites in United States, Australia and 5 more
- Volunteers
- 121 people
- Sponsor
- BioMarin Pharmaceutical
Chronic Hepatitis C
Phase II Study of Immunization With a Hepatitis C Virus (HCV) Antigen Peptide Vaccine
The objectives are 1. to determine the immunological profile (CD4+, CD8+ cells, DTH) induced by immunization with HCV antigen peptide vaccine with polyarginine. 2.
- Trial name
- NCT00602784
- Testing
- IC41
- Volunteers
- 66 people
- Sponsor
- Valneva Austria GmbH
Irritable Bowel Syndrome Constipation Predominant
Effects of ROSE-010 on GI Transit in Constipation Predominant Irritable Bowel Syndrome (C-IBS) Patients
This trial will study the effects of an investigational (not FDA approved) medication, ROSE-010, on the movement of food through the stomach, small intestine and colon in females with constipation predominant irritable bowel…
- Trial name
- NCT01056107
- Testing
- ROSE-010
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Mayo Clinic
Diabetes
Predictive Parameters for Efficacy of Sitagliptin and Metformin Combination
It is well established that inhibition of dipeptidyl peptidase (DPP)-IV reduces glucose levels in both fasting and postprandial states and preserves pancreatic beta cell function in patients with type 2 diabetes.
- Trial name
- COSMETIC (NCT00969566)
- Testing
- sitagliptin, metformin
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Bundang Hospital
Type2 Diabetes
Predicting Response to Incretin Based Agents in Type 2 Diabetes
Type 2 diabetes is a major and rapidly increasing health problem worldwide. Keeping the blood glucose (sugar) from going too high helps prevent complications.
- Trial name
- PRIBA (NCT01503112)
- Testing
- No intervention, observational study
- Where
- 18 sites in United Kingdom
- Volunteers
- 957 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Insulin Resistance, Deteriorated Glucose Homeostasis
Insulinotropic Effect of GIP and GLP-1 Before and After Reduced Glucose Tolerance
The incretin effect in patients with type two diabetes is reduced. The investigators have previously shown that it is possible to induce a defect in the incretin effect in healthy individuals.
- Conditions
- Insulin Resistance, Deteriorated Glucose Homeostasis, Inactivity
- Trial name
- NCT01173978
- Testing
- Steroid hormone, No intervention
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Diabetes Mellitus, Type 1
Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells
The goal of this study is to determine the safety and efficacy of fresh metabolically active allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) for the treatment of new-onset type 1 diabetes (T1D) and to…
- Trial name
- NCT04061746
- Testing
- Mesenchymal Stem Cells (MSCs)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Diabetes, Type 1 Diabetes
The Effects of Alpha-1 Antitrypsin (AAT) on the Progression of Type 1 Diabetes
The purpose of this study is to determine if the drug Alpha-1 Antitrypsin (AAT, Aralast NP) will preserve beta-cell function and help slow the progression of type 1 diabetes.
- Trial name
- NCT01319331
- Testing
- Alpha 1-Antitrypsin (AAT, Aralast NP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnea, Cardiovascular Diseases
Obstructive Sleep Apnoea and Cardiac Arrhythmias
This study is a prevelance trial looking at how sleep apnoea affects the heart especially heart rhythms. Previous research shows that patients suffering from sleep apnoea are much more likely to get heart disease and abnormal…
- Conditions
- Obstructive Sleep Apnea, Cardiovascular Diseases, Arrhythmia, Atrial Fibrillation New Onset
- Trial name
- OSCA (NCT03866148)
- Testing
- Reveal LINQ
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Achondroplasia
A Clinical Trial to Evaluate Safety of Vosoritide in At-risk Infants With Achondroplasia
Study 111-209 is a Phase 2 randomized, open-label clinical trial of BMN 111 in infants and young children with a diagnosis of Achondroplasia at a heightened risk of requiring cervicomedullary decompression surgery
- Trial name
- NCT04554940
- Testing
- vosoritide
- Where
- 3 sites in Australia, United Kingdom
- Volunteers
- 20 people
- Sponsor
- BioMarin Pharmaceutical
Diabetes Mellitus, Diabetes Type 1
ACZ885 in Type 1 Diabetes Mellitus
This study will assess the safety and efficacy of ACZ885 on stimulated C-peptide during a mixed meal test in patients with newly-diagnosed type 1 diabetes mellitus.
- Trial name
- NCT01322321
- Testing
- ACZ885
- Where
- 10 sites in United States, Canada and 2 more
- Sponsor
- Novartis Pharmaceuticals
Inflammation, Insulin Sensitivity
Effects of Dietary Fats on Cardiovascular Health and Insulin Sensitivity in Subjects With Abdominal Obesity
Rationale: It is well established that increased intake of saturated fatty acids (SFA) is associated with incidence of cardiovascular heart disease (CHD).
- Trial name
- NCT01665482
- Testing
- A 2000 kcal test meal, A 2000 kcal test meal which accounts for 7% fat exchange with carbohydrate
- Where
- Malaysia
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
Healthy
Effects of Canagliflozin on C-peptide Clearance in Healthy Volunteers
The purpose of this study is to assess whether treatment with a single oral 300 mg dose of canagliflozin alters the kinetics (ie, clearance/removal from body) of serum C-peptide (a protein released from the pancreas during…
- Trial name
- NCT01665638
- Testing
- Canagliflozin 300 mg, Somatostatin, C-peptide
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Janssen-Cilag International NV
Diabetes Mellitus, Type 1
Protective Effects of Saxagliptin (And Vitamin D3) on β Cell Function in Adult-onset Latent Autoimmune Diabetes
The main purpose of this study is to evaluate whether saxagliptin or (and vitamin D3) with metformin (and insulin) therapy can better protect islet β cell function than metformin(and insulin) .
- Trial name
- NCT02407899
- Testing
- Saxagliptin, Vitamin D3, Insulin
- Where
- 39 sites in China
- Volunteers
- 300 people
- Sponsor
- Second Xiangya Hospital of Central South University
Type 1 Diabetes
The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes
To investigate whether saxagliptin could reduce the fluctuation of glycemia and improve the glycemic control in those type 1 diabetes through mechanisms of suppressing glucagon secretion, improving beta cell function, and…
- Trial name
- NCT02307695
- Testing
- Saxagliptin, Insulin
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Nanjing Medical University
Melanoma
Continuation Booster Trial After a Vaccine Combining Tyrosinase/GP100/MART-1 Peptides Emulsified With Montanide ISA 51 With or Without GM-CSF for Patients With Melanoma
This is a study of a melanoma vaccine. Study participants will have melanoma that invaded deeply and spread to lymph nodes or another location.
- Trial name
- NCT00184067
- Testing
- Montanide ISA 51
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Southern California
Type 1 Diabetes Mellitus
An Innovative Approach Towards Understanding and Arresting Type 1 Diabetes (INNODIA)
INNODIA is a global consortium linking 26 academic institutions, 4 industrial partners, a small to medium enterprise (SME), and 2 patient organisations, bringing their knowledge and experience together with one common goal: "To…
- Trial name
- INNODIA (NCT03936634)
- Where
- 19 sites in Austria, Belgium and 11 more
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Polycystic Ovary Syndrome, c Type Natriuretic Peptide
Comparison of Serum C Type Natriuretic Peptide Levels Between Polycystic Ovary Syndrome Patients and Healthy Women
Recent studies have shown that C natriuretic peptide is produced from granulosa cells, increasing cumulative guanosine monophosphate (cGMP) production by affecting cumulus cells through natriuretic peptide receptors.
- Conditions
- Polycystic Ovary Syndrome, c Type Natriuretic Peptide, Menstrual Irregularity, Hyperandrogenism
- Trial name
- CNP (NCT04006171)
- Testing
- C type natriuretic peptide
- Where
- Cyprus
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey