Clinical trials: CABG
Diabetes, Coronary Artery Disease
United States Coronary Artery Bypass Surgery (CABG) Diabetes Project (USCDP) Pilot Study
Standard care for patients with diabetes having CABG surgery at Providence St. Vincent Medical Center includes strict control of blood sugar (glucose) levels for 3 days after surgery.
- Trial name
- USCDP (NCT00646438)
- Testing
- Strict Glycemic Control for one year post-op CABG
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Providence Heart & Vascular Institute
Ischaemic Heart Disease, Heart Failure
First-in-Human Pilot Study of Epicardial Circular RNA-HM2002 Injection in CABG for Ischemic Heart Failure
This exploratory, single-center, open-label clinical trial assesses the safety, tolerability, and potential efficacy of a single 5 mg dose of HM2002 injection administered via multiple-point epicardial injections for treating…
- Trial name
- NCT06621576
- Testing
- HM2002 injection
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Ruijin Hospital
Coronary Artery Atherosclerosis
Radial vs Vena No-Touch Assessment
This study examines the outcomes of coronary artery bypass grafting (CABG) in women at 1 year after surgery. A randomized controlled trial is planned, including a comparative analysis of two observed groups depending on the…
- Trial name
- RAVENTA (NCT07552948)
- Testing
- radial artery graft, no-touch vein graft
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Tomsk Cardiology Research Institute
Pain
Pain Prevention and Treatment Through the Enhancement of the Anti-nociceptive Component of Pain Modulation Profiles
To utilize the plasticity of the central pain pathways in order to (i) shift individuals with a pro-nociceptive pain modulation profile towards an anti-nociceptive one, and (ii) assess its relevance in minimizing pain-derived…
- Trial name
- NCT02020122
- Testing
- Duloxetine, Pregabalin
- Where
- Israel
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Stroke
Stroke Study: Operative Strategies to Reduce Cerebral Embolic Events During Coronary Artery Bypass Surgery
One of the most devastating complications of coronary artery bypass surgery (CABG) is postoperative stroke. While there are multiple causes of stroke after CABG, particles generated during handling of the aorta is believed to…
- Trial name
- NCT01502683
- Testing
- No aortic clamping, partial occluding clamp, single cross clamp
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- Emory University
Coronary Artery Bypass, Cardiac Rehabilitation
Effect of Walking Exercise on Functional Capacity and Productivity in Patients After Coronary Artery Bypass Graft
The goal of this clinical trial is to assess the effect of walking exercise on functional capacity and productivity in patients after Coronary Artery Bypass Graft who have completed phase II cardiac rehabilitation.
- Trial name
- NCT06013605
- Testing
- Walking Exercise and Leg Straightening, Leg Straightening
- Where
- Indonesia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Coronary Artery Disease, Ischemic Heart Disease
Coronary Revascularization Outcomes Within Necessary Sex and Gender Aspects
The aim of this observational single-centre study is the optimization of coronary artery bypass grafting (CABG) tactics considering gender and sex approach on the basis of complex comparative evaluation of surgical…
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Coronary Artery Bypass Grafting
- Trial name
- CROWN-SAGA (NCT06749171)
- Testing
- coronary artery bypass grafting
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Federal State Budgetary Institution "Federal Center for Cardiovascular Surgery named after S.G. Sukh
Cardiovascular Diseases, Lidocaine Causing Adverse Effects in Therapeutic Use
Evaluation of the Effect of 10% Lidocaine Spray Undergoing Coronary Artery Bypass Graft Operation
In patients undergoing coronary bypass surgery; 10% topical lidocaine administered endotracheally before intubation is to investigate the effect of hemodynamic response and EKG paramater after intubation.
- Conditions
- Cardiovascular Diseases, Lidocaine Causing Adverse Effects in Therapeutic Use, Tracheal Intubation Morbidity
- Trial name
- ELCABG (NCT03304431)
- Testing
- Orotracheal Lidocaine Oral Spray application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Coronary Artery Bypass Graft Surgery, Aortic Valve Replacement
Outcomes After Albumin Vs Lactated Ringer's Solution in CABG and AVR Procedures
This is a prospective, randomized, double-blinded study to compare the use of albumin versus lactated Ringer's solution in patients undergoing coronary artery bypass graft surgery and in patients undergoing aortic valve…
- Trial name
- NCT04652375
- Testing
- Albumin Solution, Lactated Ringer's Solution
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Yale University
Postoperative Delirium
Dexmedetomidine vs Midazolam in Coronary Artery By-pass Surgery
The aim is to compare the incidence of postoperative delirium following coronary artery bypass grafting (CABG) between patients receiving dexmedetomidine and those receiving midazolam infusions.
- Trial name
- NCT07411794
- Testing
- Intravenous Dexmedetomidine infusion + Standard Anesthesia, intravenous midazolam infusion + Standard anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Cumhuriyet University
Ischemic Heart Disease, Post-Operative Complications
On-Pump vs. Off-Pump CABG in High-Risk Patients (EuroSCORE 6+)
Previous studies comparing on-pump and off-pump operating strategy did only partially demonstrate benefits of the off-pump myocardial revascularisation.In primary end-points (MI, death, renal failure, and so on) there was no…
- Trial name
- PRAGUE 6+ (NCT00606372)
- Testing
- OPCAB - the off-pump coronary artery bypass
- Where
- 2 sites in Czechia
- Volunteers
- 220 people
- Sponsor
- Charles University, Czech Republic
Coronary Heart Disease
Effect of Remote Ischaemic Preconditioning on Clinical Outcomes in CABG Surgery
Coronary heart disease (CHD) is the leading cause of death in the UK, accounting for 124,000 deaths (2006) and costing the UK economy over £7.9 billion a year.
- Trial name
- ERICCA (NCT01247545)
- Testing
- Remote ischaemic preconditioning, Control
- Where
- 28 sites in United Kingdom
- Volunteers
- 1,612 people
- Sponsor
- University College, London
Pain, Anxiety
Progressive Relaxation Exercises Before Mobilization:Effects on Pain, Anxiety and Physiologic Parameters CABG Patients
This study is planned as a randomized controlled experimental study to determine the effect of progressive relaxation exercises applied before mobilization on pain, anxiety and physiological parameters in patients undergoing…
- Conditions
- Pain, Anxiety, Physiological Parameter, Mobilization
- Trial name
- NCT06726239
- Testing
- Progressive relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Istanbul University - Cerrahpasa
Elective Coronary Artery Bypass Grafting (CABG) Surgery, Coronary Artery Disease
Sleep-disordered Breathing and Perioperative Atrial Fibrillation in Cardiac Surgery
In patients undergoing elective coronary artery bypass grafting (CABG) surgery, coronary artery disease, sleep-disordered breathing (SDB), atrial fibrillation (AF) perioperative atrial fibrillation and complications will be…
- Conditions
- Elective Coronary Artery Bypass Grafting (CABG) Surgery, Coronary Artery Disease, Sleep-disordered Breathing (SDB), Atrial Fibrillation
- Trial name
- CONSIDER-AF (NCT02877745)
- Testing
- Stratification, no intervention
- Where
- Germany
- Volunteers
- 1,200 people
- Sponsor
- Michael Arzt
Left Ventricular Ejection Fraction, Myocardial Revascularization
Revascularization in Heart Failure Trial - REHEAT 2
REHEAT 2 study is designed as a prospective, randomised trial comparing two strategies of myocardial revascularisation (PCI vs CABG) in patients with ischemic cardiomyopathy and low left ventricular ejection fraction.Patients…
- Conditions
- Left Ventricular Ejection Fraction, Myocardial Revascularization, Ischemic Heart Disease
- Trial name
- NCT00388245
- Testing
- Percutaneous Coronary Intervention, Coronary Artery Bypass Grafting
- Where
- 4 sites in Poland
- Volunteers
- 150 people
- Sponsor
- Ministry of Science and Higher Education, Poland
CAD - Coronary Artery Disease, CABG
Soft Foam Dressings for Pressure Injury Prevention of Cardiac Surgery
The purpose of this study is to evaluate whether the application of soft foam dressings can reduce the occurrence of surgery-related pressure injuries among patients undergoing cardiac surgery.
- Conditions
- CAD - Coronary Artery Disease, CABG, Valve Disease, Heart, Aortic Diseases
- Trial name
- NCT07379294
- Testing
- CONVAFoam Hydrofiber Dressing, Standard Pressure Injury Prevention Care
- Volunteers
- 80 people
- Sponsor
- Shih,Wen-Chi
Coronary Artery Disease
CABG Based on CT-FFR Versus Conventional Coronary Angiography
The aims of study are (1) to compare early and 1-year graft patency rates in patients who underwent coronary artery bypass grafting (CABG) based on conventional coronary angiography(CAG) versus cardiac computed…
- Trial name
- NCT06028165
- Testing
- Coronary artery bypass grafting based on conventional coronary angiography, Coronary artery bypass grafting based on cardiac computed tomography-derived fractional flow reserve.
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Myongji Hospital
Coronary Artery Disease
CompArison of PCI in NaTive Arteries Versus ByPAss Grafts In PatieNts With Prior CABG (CAPTAIN)
Coronary atherosclerotic heart disease (CAD) has been considered the leading cause of death in both developed and developing countries.
- Trial name
- NCT05368597
- Testing
- PCI in native vessel or in bypass graft
- Where
- China
- Volunteers
- 1,491 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease, Percutaneous Coronary Intervention
Assessment of Adverse Outcome in Asymptomatic Patients With Prior Coronary Revascularization Who Have a Systematic Stress Testing Strategy Or a Non-testing Strategy During Long-term Follow-up.
Due to the lack of randomized controlled trials, the best follow-up strategy of asymptomatic patients after coronary artery revascularization is controversial.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Coronary Artery Bypass Grafting
- Trial name
- ARCACHON (NCT04566497)
- Testing
- No stress testing, stress testing
- Where
- France
- Volunteers
- 2,664 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Bypass Grafting
Analgesic Efficacy of Parasternal Block Versus Parasternal Plus Serratus Anterior Plane Block After Coronary Bypass Surgery
This single-centre randomized clinical trial will compare two regional anaesthesia techniques for postoperative pain control in adult patients undergoing elective coronary artery bypass grafting (CABG) with sternotomy.
- Trial name
- NCT07299760
- Testing
- parasternal block, parasternal block + serratus anterior plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital