Clinical trials: CAD
Aortic Stenosis, Coronary Artery Disease
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement
Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant coronary artery disease (CAD) which may adversely affect prognosis.
- Conditions
- Aortic Stenosis, Coronary Artery Disease, Coronary Stenosis
- Trial name
- COMPLETE TAVR (NCT04634240)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- 72 sites in United States, Canada
- Volunteers
- 4,000 people
- Sponsor
- University of British Columbia
Ischemic Heart Disease, Angina Pectoris
Physiology and Residual Ischemia After Percutaneous Coronary Intervention
Despite optimal angiographic result after stent implantation, a number of patients will undergo repeat angiography within 1 year of index procedure.
- Conditions
- Ischemic Heart Disease, Angina Pectoris, Chest Pain, Coronary Artery Disease
- Trial name
- EASY-PRIPCI (NCT04494750)
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Laval University
Coronary Artery Disease
Effect of Rotablator on Balloon Resistant Calcified Coronary Lesion
The optimal treatment of calcified coronary lesion remained to be elucidated. A Prospective, randomized controlled trial was perform to explore the immediate effect and long-term outcome of rotational atherectomy in patients with…
- Trial name
- NCT01887704
- Testing
- Rotablator, conventional angioplasty, stenting
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Capital Medical University
Coronary Artery Disease
Efficacy Study of Two Different Strategies for Restenosis in Sirolimus-Eluting Stents
For lesions which develop restenosis after a drug-eluting stent, it is not known which the right strategy to use is, implantation of the same type of DES as the initial one or a DES with a different drug.
- Trial name
- DESIRE-2 (NCT00598715)
- Testing
- Sirolimus eluting stent, Paclitaxel-eluting stent
- Where
- 2 sites in Germany
- Volunteers
- 450 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Cardiac Surgery, CAD
Heparin Reversal With Two Different Protamine Ratios After Cardiopulmonary By-pass.
Protamine is routinely used as a heparin reversal agent in cardiac surgery. However, its use may be associated with adverse events, while protamine excess may have additional anti-coagulant affect.
- Conditions
- Cardiac Surgery, CAD, Valve Heart Disease, Coagulation Disorder
- Trial name
- NCT06154018
- Testing
- Protamin
- Where
- Greece
- Volunteers
- 98 people
- Sponsor
- University of Ioannina
Coronary Artery Disease, Therapeutics
PEACE Prospective Study of Patients With Three-vessel Disease
Coronary heart disease (CHD) pose a serious health threaten to population. Optimal revascularization strategy in multiple vessel coronary artery disease patients remains a subject of debate between interventional cardiologists…
- Conditions
- Coronary Artery Disease, Therapeutics, Outcome Assessment
- Trial name
- PEACE3VD (NCT01617785)
- Where
- China
- Volunteers
- 4,500 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
Ezetimibe and Atorvastatin Therapy on TCFA
After successful coronary angiography and OCT examination, patients with TCFAs in non-culprit, mild-to-moderate stenotic lesions will be enrolled.
- Trial name
- NCT02588235
- Testing
- Ezetimibe and Atorvastatin, Atorvastatin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Radiographic Contrast Agent Nephropathy, Renal Failure
Prevention of Contrast Nephropathy During Diagnostic Coronary Angiogram or PCI With Hydratation Based on LEVDP
The goal is to determine if prehydration based on LEVDP is superior to a standard hydratation with NaCl 0.9% or NaHCO3 for the prevention of contrast nephropathy related to a diagnostic coronary angiogram or to PCI.
- Conditions
- Radiographic Contrast Agent Nephropathy, Renal Failure, Coronary Heart Disease
- Trial name
- NEPHRON (NCT00584350)
- Testing
- Hydratation according LVEDP + NaHCO3, normal saline, Sodium bicarbonate
- Where
- Canada
- Volunteers
- 330 people
- Sponsor
- Université de Sherbrooke
Coronary Artery Stenosis
COmplex BifuRcation Lesions: A Comparison Between the AXXESS Device and Culotte Stenting: An Optical Coherence Tomography (OCT) Study
The aim of this study is to compare vessel healing at 9 months using OCT imaging for two different treatment techniques for treating bifurcation lesions.
- Trial name
- COBRA (NCT00895791)
- Testing
- AXXESS Biolimus A9-eluting bifurcation stent, culotte stenting (Xience V)
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Multi Vessel Coronary Artery Disease
Medical Management vs Partial Revascularization in Diffuse Multivessel Coronary Artery Disease
This randomized controlled trial will compare the clinical outcomes of partial revascularization with percutaneous coronary intervention (PCI) versus optimal medical therapy (OMT) alone in patients with diffuse multivessel…
- Trial name
- MPR-CAD (NCT07866404)
- Testing
- Partial per cutaneous coronary intervention, Optimal medical therapy (OMT)
- Where
- Pakistan
- Volunteers
- 140 people
- Sponsor
- CH. Pervaiz Elahi Institute of Cardiology, Multan
Chronic Periodontitis, Coronary Artery Disease
Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease
The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further.
- Conditions
- Chronic Periodontitis, Coronary Artery Disease, miRNA
- Trial name
- NCT04583085
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Coronary Artery Disease
Rubidium-82 - An Alternative Radiopharmaceutical for Myocardial Imaging(Rb-ARMI)
Cardiovascular (CV) disease is the leading cause of death in Canada. Fifty percent of all Tc-99m used in nuclear medicine is for the diagnosis of coronary artery disease (CAD) with SPECT myocardial perfusion imaging (MPI).
- Trial name
- Rb-ARMI (NCT01128023)
- Testing
- Myocardial perfusion imaging using Rb-82 PET or Tc-99m or Tl SPECT
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Heart Disease, Angina Pectoris
Safety Study of Kudiezi (a Chinese Medicine Injection) Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in October 2011.
- Trial name
- RSCMI-Ⅱ (NCT01612559)
- Volunteers
- 30,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Coronary Artery Disease
Magnetic Resonance Imaging (MRI) Viability: Comparison of Myocardial Viability by Positron Emission Tomography and MRI
The purpose of this study is to compare cardiac MRI with positron emission tomography (PET) with fluorodeoxyglucose (FDG) to determine if cardiac MRI images are as good as, or better, than PET with FDG.
- Trial name
- NCT00166179
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Emory University
Coronary Artery Disease
Correlation of Clinical Types and Complexity of Coronary Artery Disease With Patients' Metabolic Profile
The purpose of the research project is to investigate the potential association of the complexity and the severity of coronary artery disease (as assessed via SYNTAX score) with patients' metabolic profile.
- Trial name
- CorLipid (NCT04580173)
- Testing
- metabolomics analysis
- Where
- Greece
- Volunteers
- 1,050 people
- Sponsor
- AHEPA University Hospital
Coronary Artery Disease, Acute Kidney Injury
Endothelial Glycocalyx Damage in Acute Kidney Injury
Abstract Significance: Cardiac surgery-associated acute kidney injury (CSA-AKI) is common and has serious immediate and long-term sequelae.
- Trial name
- NCT05471583
- Testing
- Main group
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- King's College London
Cardiovascular Diseases, Coronary Arteriosclerosis
Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)
To determine if supplements of vitamin C, vitamin E, beta-carotene, and B-vitamins (a combination of folic acid, vitamins B6 and B12) reduce risk of major cardiovascular events in high risk women with a prior history of…
- Conditions
- Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart Diseases
- Trial name
- WAFACS (NCT00000541)
- Testing
- dietary supplements, vitamin C, vitamin E
- Sponsor
- Brigham and Women's Hospital
Coronary Arteriosclerosis
Scoreflex TRIO - Scoring PTCA Catheter
To evaluate the acute safety and device procedural success of the Scoreflex TRIO Scoring PTCA catheters versus Scoreflex NC Scoring PTCA catheters in subjects with stenotic coronary arteries during percutaneous coronary…
- Trial name
- NCT05929313
- Testing
- OrbusNeich Scoreflex TRIO, OrbusNeich Scoreflex NC
- Where
- 4 sites in China
- Volunteers
- 210 people
- Sponsor
- OrbusNeich
Coronary Artery Disease,
Pathophysiology and Prevention of Perioperative Myocardial Injury: A Prospective Randomized Controlled Trial
Working hypothesis and aims: 1) To explore the pathophysiology of postoperative troponin elevations and 2) whether ranolazine, a new anti-ischemic drug that has no effect on blood pressure or heart rate, prevents postoperative…
- Trial name
- NCT01810796
- Testing
- Ranolazine
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Coronary Atherosclerosis
CRESTOR Athero Imaging Head to Head IVUS Study
A 104-week, randomized, double-blind, parallel group, multi-center Phase IIIb study comparing the effects of treatment with rosuvastatin 40 mg or atorvastatin 80 mg on atherosclerotic disease burden as measured by intravascular…
- Trial name
- SATURN (NCT00620542)
- Testing
- Rosuvastatin, Atorvastatin
- Where
- 195 sites in United States, Argentina and 12 more
- Volunteers
- 2,333 people
- Sponsor
- AstraZeneca