Clinical trials: CD, open to volunteers
Crohn Disease (CD)
HB-adMSCs for the Treatment of Crohn's Disease
Methodology: Randomized, double-blind, efficacy and safety study of allogeneic HB-adMSCs vs placebo for the treatment of Crohn's Disease with a 16-week treatment period and a safety and efficacy follow up period for 52 weeks post…
- Trial name
- NCT07077746
- Testing
- HB-adMSCs - Hope Biosciences Adipose Derived Mesenchymal Stem Cells, 0.9% sodium chloride
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Hope Biosciences Research Foundation
Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD)
Study on Eating Habits and Association with "omic" Profiles in Families with a Subject Affected by a Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study.
The proposed study is part of a PNRR 2022 project (call "Non-Communicable Chronic Diseases (NCDs) with high impact on healthcare and social assistance systems," currently awaiting funding response) and represents the continuation…
- Conditions
- Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- DIETA-MICIREUM (NCT06862843)
- Testing
- Collecting questionnaires and biological samples
- Where
- 4 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Meyer Children's Hospital IRCCS
Crohn Disease (CD)
Clostridium Butyricum in Stenosing Crohn's Disease
Crohn's disease is a condition of unknown etiology with an immune-mediated pathogenesis. The subgroup of Crohn's disease with a stricturing phenotype represents a particular challenge for clinicians, as currently no effective…
- Trial name
- AUTOCD (NCT07263880)
- Testing
- Clostridum Butyricum Capsule, Trehalose
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- San Giovanni Addolorata Hospital
Ulcerative Colitis, Crohn's Disease
A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)
The main aim of this study is to learn about medical problems (adverse events) if vedolizumab subcutaneously (SC) is given to a child or teenager with UC or CD for a long time.
- Trial name
- NCT06405087
- Testing
- Vedolizumab SC, No Intervention
- Where
- 47 sites in United States, Belgium and 12 more
- Volunteers
- 70 people
- Sponsor
- Takeda
Crohn Disease (CD), IBD (Inflammatory Bowel Disease)
Abdominally Targeted Management Exercises for Crohn's Disease Patients (TAME-CD)
The goal of this clinical trial is to learn if abdominally targeted exercises can assist to manage disease activity in Crohn disease (CD) patients.
- Trial name
- NCT06917443
- Testing
- Abdominally targeted exercises, General exercises
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Shmuel Kivity, MD
Crohn Disease (CD)
Evaluation of Muscle Strength and Muscle Mass in Patients With Inflammatory Bowel Disease
This prospective observational study aims to evaluate the validity of ultrasonographic muscle measurements in patients with inflammatory bowel disease (IBD).
- Trial name
- IBDSARC (NCT07441447)
- Testing
- Muscle Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sakarya University
Crohn Disease (CD), Ulcerative Colitis (UC)
Modafinil For Fatigue in IBD: A Feasibility Randomised Controlled Trial
Fatigue is a big problem in people with inflammatory bowel disease (IBD). Even when IBD is well controlled, 50% of patients remain fatigued most of the time. Fatigue can be physical (e.g. feeling tired or weak) and mental (e.g.
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Fatigue
- Trial name
- MFI (NCT07295834)
- Testing
- Modafinil
- Where
- 4 sites in United Kingdom
- Volunteers
- 70 people
- Sponsor
- Imperial College London
Inflammatory Bowel Disease (IBD), Crohn Disease (CD)
PROactive and Early Infliximab Monitoring and OPTimization in Inflammatory Bowel Disease
Infliximab (IFX) is a Food and Drug administration (FDA)-appoved monoclonal antibody medication targeting tumor necrosis factor (TNF) widely used in inflammatory bowel disease (IBD) to treat intestinal inflammation and improve…
- Conditions
- Inflammatory Bowel Disease (IBD), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- PROMPT-IBD (NCT06758024)
- Testing
- Infliximab
- Where
- Chile
- Volunteers
- 72 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn Disease (CD)
Familial Inflammatory Bowel Disease Early Risk
Brief Summary The aim of the FIBER study is to identify potential triggers associated with the later development of IBD (inflammatory bowel disease) based on baseline characteristics and biosamples (blood, urine, stool, saliva…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- FIBER (NCT07791862)
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Crohn Disease (CD)
The Utility of Hand-held Ultrasound Devices to Detect Bowel Wall Inflammatory Activity in Crohn's Disease
One of the major obstacles in implementing intestinal ultrasound services for inflammatory bowel disease (IBD) patients relates to the costs of acquiring ultrasound (US) machines.
- Trial name
- NCT06686589
- Testing
- Intestinal ultrasound
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Quiescent Crohn's Disease (CD)
Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease
Many individuals with Crohn's disease continue to experience abdominal pain, bloating, or bowel habit changes even when their inflammation is controlled.
- Trial name
- AIMS-CD (NCT07556718)
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Conduct Disorder, Mentalization Based Therapy
Using Mentalization Based Therapy to Support Children and Adolescents Referred to Specialist Mental Health Services in the NHS for Aggressive and/or Violent Behaviour
The MICA Study is a research project that has been designed to work out how helpful mentalisation based therapy is. This is a new type of support that helps young people make sense of their own behaviours and feelings, and those…
- Conditions
- Conduct Disorder, Mentalization Based Therapy, Violent Behavior, Aggressive Behaviour
- Trial name
- MICA (NCT07091721)
- Testing
- Mentalization based therapy (MBT), Support as usual
- Where
- 8 sites in United Kingdom
- Volunteers
- 632 people
- Sponsor
- Anna Freud
Crohn Disease (CD), IBD (Inflammatory Bowel Disease)
Combining Nutritional Therapy and Anti-TNFα Treatment in Pediatric Patients With Crohn's Disease
Children with Crohn's disease (CD), a type of Inflammatory Bowel Disease (IBD), often face serious health challenges, including poor growth, frequent hospital stays, and long-term medication use.
- Conditions
- Crohn Disease (CD), IBD (Inflammatory Bowel Disease), IBD - Inflammatory Bowel Disease
- Trial name
- DISPENSE-T (NCT07314606)
- Testing
- IFX + mCDED
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University of British Columbia
Inflammatory Bowel Diseases (IBD), Fatigue
Adapted Physical Activity for Persistent Fatigue in Patients With Inflammatory Bowel Disease in Remission
The cAPAble study aims to evaluate the impact of an adapted physical activity program on persistent fatigue in patients with inflammatory bowel disease in remission.
- Conditions
- Inflammatory Bowel Diseases (IBD), Fatigue, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- cAPAble (NCT07804511)
- Testing
- Adapted Physical Activity, Usual Care
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Crohn Disease (CD), Ulcerative Colitis (UC)
Multiple Digital Biomarkers for Optimization of IBD Care
To develop digital biomarkers associated with disease activity of inflammatory bowel disease
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD)
- Trial name
- LEGEND-IBD (NCT07159776)
- Testing
- monitoring of wearable data, shopping data, biomarkers and patient reported outcomes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Imelda GI Clinical Research Center
Crohn Disease
Specific Dietary Pattern for Crohn's Disease Patients Following Surgery
Over the past 10 years, there are a large number of dietary treatments related to the CD, such as specific carbohydrate diet, low Fermentable Oligo-, Di-, Mono-saccharides And Polyols (FODMAP) diet, and allergen-free foods.
- Trial name
- NCT05502965
- Testing
- dietary pattern, EEN
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Crohn's Disease (CD), Dysmenorrhea Primary
Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD)
The purpose of this pilot study is to prepare for a larger study that will compare the effectiveness and safety of two common pain medications, ibuprofen and acetaminophen, to help treat period cramps in women with Crohn's…
- Trial name
- AVID-CD (NCT07337902)
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Crohn Disease (CD)
DB-3Q for the Treatment of Medically Refractory Crohn's Disease
This research study is studying DB-3Q as a possible treatment for medically refractory Crohn's disease. The purpose of this study is to research and evaluate safety and effectiveness of the administration of bone marrow…
- Trial name
- NCT07625293
- Testing
- DB-3Q
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Direct Biologics, LLC
Crohn Disease (CD), Ulcerative Colitis (UC)
the REMONO-CD and the REMONO-UC Studies
Infliximab was the first-in-class anti-TNF agent approved for treating patients with IBD, both for Crohn's disease (CD)1 and ulcerative colitis (UC)2.
- Trial name
- REMONO (NCT07564609)
- Where
- 18 sites in France
- Volunteers
- 420 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ulcerative Colitis (UC), Ulcerative Colitis (Disorder)
A Phase I Study to Evaluate the Safety/Tolerability of BDHK-2009 Tablets in Healthy Adult
A Phase 1, 2-part, randomised, double-blind, placebo-controlled, FIH study to determine the safety, tolerability, and PK of single, ascending oral doses (SAD) of BDHK-2009 (Part 1) and multiple oral doses (Part 2) of BDHK-200 in…
- Conditions
- Ulcerative Colitis (UC), Ulcerative Colitis (Disorder), Ulcerative Colitis Acute, IBD (Inflammatory Bowel Disease)
- Trial name
- NCT07632573
- Testing
- BDHK-2009 Tablets
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Benethera (Shaoxing) Biotechnology Co., Ltd.