Clinical trials: CD, active
Inflamatory Bowel Disease, Crohn Disease (CD)
Comparison of the Efficacy of Different Biologic Agents in Preventing Postoperative Endoscopic Recurrence of Crohn's Disease
This retrospective cohort study aims to compare the efficacy of different biologics in preventing postoperative endoscopic recurrence in Crohn's disease (CD).
- Trial name
- NCT07694674
- Testing
- Infliximab, Adalimumab, Vedolizumab
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai 10th People's Hospital
Castleman Disease, Castleman's Disease
International Registry for Patients With Castleman Disease
The purpose of this study is to collect clinical, laboratory, and patient survey data from patients with Castleman disease to improve understanding, diagnosis, and treatment of the disease. Funding source - FDA OOPD.
- Conditions
- Castleman Disease, Castleman's Disease, Giant Lymph Node Hyperplasia, Angiofollicular Lymph Hyperplasia
- Trial name
- ACCELERATE (NCT02817997)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
A Study to Evaluate Non-invasive Measurements of the Inflammatory Status in Patients with IBD
Patients with IBD, including both Crohn's disease and ulcerative colitis, require accurate monitoring of intestinal inflammation for optimal follow-up and treatment.
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), Crohn Disease (CD)
- Trial name
- VERSATILE (NCT06900738)
- Testing
- Inflammometer
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
Prospective Evaluation of Flare Detection in IBD With Digital Biomarkers: Bring Your Own Device Study
The aim of this study is to identify HRV changes predictive of IBD flares using patient-own wearable devices in a large cohort supplemented by additional data layers including sleep parameters, step count and clinical data…
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), Crohn Disease (CD)
- Trial name
- BYOD (NCT07647640)
- Testing
- Wearing their own wearable device.
- Where
- 3 sites in Netherlands
- Volunteers
- 600 people
- Sponsor
- Maastricht University Medical Center
CD - Crohn's Disease, Stricture; Bowel
Guselkumab Vs Ustekinumab in Stricturing Crohn's Disease
This study intends to select patients with confirmed moderate-to-severe Crohn's disease (CD) and obstructive symptoms of intestinal stenosis, who have clear evidence of lumen stenosis caused by the disease itself through…
- Conditions
- CD - Crohn's Disease, Stricture; Bowel, IBD - Inflammatory Bowel Disease
- Trial name
- NCT07444060
- Testing
- Guselkumab (GUS), Ustekinumab (UST)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Crohn Disease (CD)
Hybrid Endoscopic Stricturotomy Plus Balloon Dilation Versus Stricturotomy Alone for Short Crohn's Disease Strictures
Crohn's disease is a chronic condition that can lead to inflammation and narrowing (strictures) of the intestine, causing symptoms like pain, bloating, and difficulty with bowel movements.
- Trial name
- HEIST (NCT06958159)
- Testing
- Endoscopic Stricturotomy, Endoscopic Balloon Dilation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Crohn Disease (CD)
DB-3Q for the Treatment of Medically Refractory Crohn's Disease
This research study is studying DB-3Q as a possible treatment for medically refractory Crohn's disease. The purpose of this study is to research and evaluate safety and effectiveness of the administration of bone marrow…
- Trial name
- NCT07625293
- Testing
- DB-3Q
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Direct Biologics, LLC
Crohn Disease (CD)
Evaluation of the Acceptability and Therapeutic Maintenance After Substitution of Ustekinumab With a Biosimilar
In a population of adult patients followed for Crohn's disease, who had previously agreed to replace Stelara® with a biosimilar of ustekinumab (Uzpruvo®) and were followed over a period of 12 months under usual medical practice…
- Trial name
- NCT07077681
- Where
- 11 sites in France
- Volunteers
- 246 people
- Sponsor
- EG Labo
Crohn Disease (CD), Ulcerative Colitis (UC)
IBD Biomarker Discovery and Validation Platform
The goal of this observational study is to establish a multicenter prospective clinical and biospecimen platform for biomarker discovery and validation in inflammatory bowel disease, including Crohn's disease and ulcerative…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD)
- Trial name
- IBD-BIOP (NCT07686406)
- Where
- 2 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn Disease (CD), Cryptoglandular Perianal Fistula
A Study Comparing Transperineal Ultrasound, Magnetic Resonance Imaging, Endoscopic Ultrasound, and Examination Under Anesthesia to Detect and Classify Perianal Fistulas in Patients With Crohn's Disease or Fistulas of Unknown Cause
The goal of this study is to learn how well different imaging tests detect and describe perianal fistulas in adults with Crohn's disease or fistulas with no known cause (cryptogenic).
- Trial name
- TRANSIT CD (NCT07794410)
- Testing
- Transperineal Ultrasound (TPUS), Magnetic Resonance Imaging (MRI), Endoscopic Ultrasound (EUS)
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Crohn Disease
Surgery vs Biologics for Treating Stricturing CD--a RCT
The management of stricturing Crohn's disease (CD) remains challenging. Although surgical resection may be the final way to solve it, the efficacy of biologics for symptomatic CD associated strictures was acceptable.
- Trial name
- NCT05421455
- Testing
- Group A, Group B
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Zhu Weiming
Diffuse Large B-Cell Lymphoma, B-Cell Malignancies
A Study Investigating the Safety and How the Trispecific T-Cell Engaging Antibody BG-T0050 Works in Adults With Diffuse Large B-cell Lymphoma (DLBCL) and Other Aggressive B-Cell Malignancies
The purpose of this study is to test the safety and tolerability of BG-T0050 and to identify the recommended dose and dosing schedule (including dose levels and timing) that can be taken without having serious side effects in…
- Trial name
- NCT07881211
- Testing
- BG-T0050
- Volunteers
- 70 people
- Sponsor
- BeOne Medicines
Sexual Addiction
Prevalence of Sexual Addiction in an Inmate Population at the Muret Detention Center in Haute-Garonne (PAS-CD)
Sexual addiction, also known as hypersexuality or compulsive sexuality, is a human sexual behavior that results in a continuous and persistent search for sexual pleasure.
- Trial name
- PAS-CD (NCT05483426)
- Testing
- semi-structured Interviews
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Federation Regionale de Recherche en Psychiatrie et Sante Mentale Occitanie
Crohn's Disease (CD)
Unraveling the Blood Microbiome in Postoperative Recurrence of Crohn's Disease
Crohn's disease, a chronic inflammation of the gastro-intestinal tract, is a disease with a complex pathogenetic background. Hereditary factors, environmental factors and the gut flora play a varying role in its onset, however…
- Trial name
- IBDbloom (NCT06770140)
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Advanced Solid Tumors
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of CD-001 in Patients With Advanced Solid Tumors
To assess the safety, tolerability, PK and preliminary efficacy of CD-001 in patients with advanced solid tumors. and to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D).
- Trial name
- NCT06801470
- Testing
- CD-001
- Where
- China
- Volunteers
- 137 people
- Sponsor
- CD (Suzhou) Biopharma Co., Ltd.
Crohn Disease
Autologous Stem Cell Transplant for Crohn's Disease
Crohn's Disease (CD) is an inflammatory bowel disease. It can lead to significant complications and discomfort in the stomach and intestines.
- Trial name
- NCT03219359
- Testing
- Autologous stem cell transplant, Cyclophosphamide, Thymoglobulin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Aaron Etra
Crohn Disease (CD)
Tolerance of Local Administration of Cryopreserved Autologous Stromal Vascular Fraction Combined With Micrograft for the Treatment of Refractory Ano-perineal Fistulas in Crohn's Disease
The ADICROHN-3 study is a prospective, multicenter, open-label cohort study. Its design is supported by the following elements: The results of the ADICROHN pilot study (EudraCT No.
- Trial name
- ADICROHN3 (NCT07629245)
- Testing
- injection of thawed SVF
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA)
German Spondyloarthritis Inception Cohort
The German Spondyloarthritis Inception cohort (GESPIC) was started 2000 as a prospective, longitudinal, multicentre, nationwide study in Germany on patients with early SpA including ankylosing spondylitis (AS, also known as…
- Conditions
- Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA), Axial Psoriatic Arthritis (axPsA), Acute Anterior Uveitis (AAU)
- Trial name
- GESPIC (NCT01277419)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Charite University, Berlin, Germany
Inflammatory Bowel Disease (IBD), CD - Crohn's Disease
Prophylactic Dexamethasone Before Infliximab in Moderate-to-Severe IBD
This comparative observational cohort clinical study aims to investigate the necessity of premedication for allergy prevention prior to infliximab injection, and is designed to evaluate whether non-routine administration of…
- Conditions
- Inflammatory Bowel Disease (IBD), CD - Crohn's Disease, UC - Ulcerative Colitis
- Trial name
- PA (NCT07385131)
- Testing
- Dexamethasone (IV)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Immunology, Hematologic Malignancies
A Clinical Study to Evaluate the Safety and Efficacy of Anti-human CD 7 CAR-NK Cell Injection in Subjects With Relapsed and Refractory CD7-positive Hematological Malignancy
This study is a single-arm, open-label, dose-escalation clinical trial to explore the safety, tolerability, pharmacokinetics and pharmacodynamics characteristics of the drug; The efficacy of the study drug in subjects with…
- Conditions
- Immunology, Hematologic Malignancies, CAR-NK
- Trial name
- NCT07117175
- Testing
- Anti-human CD7 CAR-NK cell injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine