Clinical trials: CD - Crohn's Disease
Crohn's Disease, Inflammatory Bowel Disease
Corticosteroid Dosage for Crohn's Disease Flare
Prospective randomized comparative effectiveness trial designed to compare fixed dosing and weight-based dosing of corticosteroids in patients with Crohn's disease flares.
- Trial name
- NCT02392286
- Testing
- Corticosteroid
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Yale University
Crohn Disease, Infliximab
Combined Immunosuppression for Pediatric Crohn's Disease
This is a randomized controlled trial to compare the efficacy and safety of infliximab and immunosuppressives therapy alone or in combination for pediatric Crohn's disease.
- Conditions
- Crohn Disease, Infliximab, Immunosuppression, Children, Only
- Trial name
- NCT05043870
- Testing
- Infliximab and immunosuppressives, Infliximab
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Children's Hospital of Fudan University
Colitis, Ulcerative, Crohn's Disease
A Study of Long-term Effects of Vedolizumab Subcutaneous in Adults With Ulcerative Colitis and Crohn's Disease
The main aim of the study is to check for long-term side effects of Vedolizumab Subcutaneous (also known as Vedolizumab SC) in people with ulcerative colitis (UC) and Crohn's disease (CD).
- Trial name
- NCT02620046
- Testing
- Vedolizumab SC
- Where
- 301 sites in United States, Argentina and 31 more
- Volunteers
- 746 people
- Sponsor
- Takeda
Inflammatory Bowel Disease
Non-invasive Imaging of GI Inflammation Using Microbubble Contrast Enhanced Ultrasonography
Inflammatory bowel disease (IBD) is a common chronic inflammatory disorder, but a noninvasive method of assessing disease location, severity, and extent is currently not available.
- Trial name
- NCT00591669
- Testing
- Definity
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Crohn Disease
Infliximab Blood Test in Crohn's Disease
Ano-perineal lesions are the first signs of Crohn's disease in 1/3 to 1/2 of cases. They are most often associated with a poor prognosis of the disease and their management is complex and difficult because of the dilapidated and…
- Trial name
- NCT03964883
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Crohn's Disease
Reduce Risk for Crohn's Disease Patients
The purpose of this study is to compare the effectiveness of weekly subcutaneously administered Methotrexate for maintaining relapse-free sustained steroid/Enteral Nutrition -free 1-year remission compared with: daily oral…
- Trial name
- RCT (NCT02852694)
- Testing
- Methotrexate, Adalimumab, Azathioprine / 6 Mercaptopurine
- Where
- France
- Volunteers
- 192 people
- Sponsor
- PIBD-Net
Crohn's Disease
A Phase II Efficacy Study in Fistulizing Crohn's Disease Patients
This study will assess the safety and efficacy of QAX576 if patients with fistulizing Crohn's disease.
- Trial name
- NCT01355614
- Testing
- QAX576, Infliximab
- Where
- 6 sites in Germany, Switzerland
- Volunteers
- 10 people
- Sponsor
- Novartis Pharmaceuticals
Crohn's Disease
A Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Intravenous (IV) Infusion and Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Crohn's Disease
Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. CD may cause tiredness, loose stools with or without bleeding, abdominal pain, weight loss, and fever.
- Trial name
- AIM-CD (NCT05068284)
- Testing
- ABBV-154
- Where
- 166 sites in United States, Australia and 22 more
- Volunteers
- 176 people
- Sponsor
- AbbVie
Inflammatory Bowel Diseases
Identification of Scores Associated With a Favorable Clinical Response With Thiopurines in IBD Patients
Inflammatory bowel disease (IBD) groups together Crohn's Disease (CD) and ulcerative colitis (UC). Its prevalence is high representing approximately 0.4% of the population.
- Trial name
- SCORE1 (NCT02367326)
- Testing
- data collection
- Where
- 15 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Crohn's Disease, Complex Perianal Fistula
Long-term Follow-up Study With Darvadstrocel in the Treatment of Complex Perianal Fistula
The main aim is to follow-up on long term side effect and symptom improvement of Darvadstrocel in the treatment of complex perianal fistula in adults. Participants will not receive any drug in this study.
- Trial name
- NCT04075825
- Testing
- Darvadstrocel
- Where
- 58 sites in United States, Belgium and 7 more
- Volunteers
- 150 people
- Sponsor
- Takeda
Crohn Disease, Inflammatory Bowel Diseases
The ADDapt Diet in Reducing Crohn's Disease Inflammation
Crohn's disease (CD) results in chronic intestinal inflammation, is of increasing incidence both in the developed and developing world and has a marked impact on patient quality of life.
- Trial name
- NCT04046913
- Testing
- Dietary education
- Where
- United Kingdom
- Volunteers
- 154 people
- Sponsor
- King's College London
Inflammatory Bowel Disease, Ulcerative Colitis
Evaluation of Urinary Isoprostanes in the Assessment of Children With Inflammatory Bowel Disease
Isoprostanes are compounds that are produced as a result of oxidative damage to cell membranes. Elevated tissue, serum, and urinary isoprostane levels have been described in a number of inflammatory diseases.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's Disease
- Trial name
- NCT00215020
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Crohn's Disease
Fecal Microbial Transplant in Pediatric Crohn's Disease
This is a double blind placebo control trial of fecal microbial transplantation for active Crohn's disease in patients 12 to 21 years of age.
- Trial name
- FMTCD (NCT02272868)
- Testing
- Fecal Microbial transplant, Normal Saline, rifaximin+omeprazole+miralax
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Seattle Children's Hospital
Inflammatory Bowel Diseases, Crohn's Disease
A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease
TARGET-IBD is a 5-year, longitudinal, observational study of adult and pediatric patients (age 2 and above) being managed for Inflammatory Bowel Disease (IBD) in usual clinical practice.
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- TARGET-IBD (NCT03251118)
- Where
- 37 sites in United States
- Volunteers
- 15,000 people
- Sponsor
- Target PharmaSolutions, Inc.
Crohn Disease, Blood Clot
Thrombin Generation in Crohn's Disease
One hundred and fifty patients with Crohn's disease involving the terminal ileum or the colon, in clinical remission, with or without endoscopic activity will be included.
- Conditions
- Crohn Disease, Blood Clot, Thrombosis
- Trial name
- NCT02445690
- Where
- 3 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- University of Sao Paulo General Hospital
Crohn's Disease
Efficacy and Safety of Adalimumab in Pediatric Subjects With Moderate to Severe Crohn's Disease
The purpose of this study is to determine Efficacy, Pharmacokinetics, and Safety of Adalimumab in Pediatric Subjects With Moderate to Severe Crohn's Disease
- Trial name
- NCT00409682
- Testing
- Adalimumab
- Where
- 45 sites in United States, Belgium and 6 more
- Volunteers
- 192 people
- Sponsor
- Abbott
Ulcerative Colitis (UC), Indeterminate Colitis
CEDUR - German IBD Registry
The CEDUR registry systematically collects real-world data on inflammatory bowel disease (IBD) patients in Germany. The registry aims to assess quality of care, disease activity, treatment effectiveness, safety, and…
- Conditions
- Ulcerative Colitis (UC), Indeterminate Colitis, Crohn Disease (CD)
- Trial name
- CEDUR (NCT07319442)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- ImmunoRegister gUG
Crohn's Disease
Adalimumab Intralesional in Intestinal Strictures of Crohn's Disease Patients
We study if the administration of intralesional Adalimumab (directly injected in the stricture) associated to endoscopic dilatation has a higher success rate at week 8 compared with placebo in patients with Crohn's disease who…
- Trial name
- NCT01986127
- Testing
- Adalimumab
- Where
- 13 sites in Spain
- Volunteers
- 26 people
- Sponsor
- Sara Varea
Crohn's Disease
An Efficacy and Safety Study of Omega-3 Free Fatty Acids (Epanova™) for the Maintenance of Symptomatic Remission in Subjects With Crohn's Disease
The purpose of this study is to see if Epanova™ is able to maintain the symptomatic remission in subjects with Crohn's Disease who are responding to steroid induction therapy.
- Trial name
- NCT00074542
- Testing
- Epanova™ (Omega-3 Free Fatty Acids)
- Where
- 31 sites in United States, Canada
- Volunteers
- 364 people
- Sponsor
- Tillotts Pharma AG
Crohn Disease
The Efficacy of Denosumab in Active Crohn's Disease
Denosumab, a fully human monoclonal antibody to RANKL was approved for the treatment of postmenopausal osteoporosis in June 2010.
- Trial name
- NCT02321280
- Testing
- Denosumab
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Manitoba
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