Clinical trials: CD - Crohn's Disease
Pharmacokinetics, Safety Issues
A Clinical Study With Adalimumab Biosimilar
The study aims to evaluate the pharmacokinetic profile, safety profile, and immunogenic potential of adalimumab of a new citrate-free formulation of adalimumab (Adalimumab Richmond) [Test Product] vs.
- Trial name
- NCT06291948
- Testing
- Humira® (adalimumab) AC Pen [Reference Product], Adalimumab Richmond [Test Product]
- Where
- Argentina
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Laboratorios Richmond S.A.C.I.F.
Crohn's Disease, Ulcerative Colitis (UC)
A Blood and Tissue Sample Collection Study of Patients Who Have Inflammatory Bowel Disease, Who Have Been Treated With Adalimumab and Who Developed Hepatosplenic T-Cell Lymphoma
To collect and store blood and biopsy samples obtained from CD or UC patients exposed to adalimumab and diagnosed with Hepatosplenic T-cell Lymphoma (HSTCL), for the purpose of identifying potential biomarkers and genetic…
- Conditions
- Crohn's Disease, Ulcerative Colitis (UC), Hepatosplenic T-Cell Lymphoma
- Trial name
- HSTCL (NCT02087878)
- Where
- Italy
- Sponsor
- AbbVie
Colonoscopy, Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Tissue Cytomegalovirus Viral Load and Associated Factors in Pediatric Patients Undergoing Colonoscopy
Introduction and Objectives Patients diagnosed with Inflammatory Bowel Disease (IBD) carry a significantly elevated risk for opportunistic infections and the reactivation of latent pathogens, most notably Cytomegalovirus (CMV).
- Conditions
- Colonoscopy, Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), CMV
- Trial name
- NCT07419204
- Testing
- Colonoscopy after bowel cleansing
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people
- Sponsor
- Gazi University
Crohn Disease
Identification by Cytometry by Mass of Predictive Immunological Profiles of Answer to Treatmentby Biotherapics for Patients With Crohn's Disease
Crohn disease is an inflammatory chronic disease of the bowel the complex physiopathology of which brings in immunological, genetic and environmental factors.
- Trial name
- PICTURE (NCT03712826)
- Testing
- Anti-TNF Drug, Ustekinumab
- Sponsor
- Hospices Civils de Lyon
Crohn's Disease
A Study of SL-325 in Crohn's Disease Patients
The primary purpose of this study is to evaluate the efficacy of SL-325 in adult participants with moderate to severely active Crohn's disease.
- Trial name
- RECEPTIVE-CD1 (NCT07753850)
- Testing
- SL-325
- Where
- 20 sites in United States
- Volunteers
- 232 people
- Sponsor
- Shattuck Labs, Inc.
Crohn's Disease
Reduced Appetite in Crohn's Disease: The Role of the Brain in the Control of Food Intake
Crohn's disease (CD) is becoming more common, specifically in the western world. One of the main features of this disease is weight loss and malnutrition. Although clinically common, these problems are not well understood.
- Trial name
- NCT02772458
- Testing
- Dodecanoate acid and saline
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Crohn Disease (CD), IBD (Inflammatory Bowel Disease)
Abdominally Targeted Management Exercises for Crohn's Disease Patients (TAME-CD)
The goal of this clinical trial is to learn if abdominally targeted exercises can assist to manage disease activity in Crohn disease (CD) patients.
- Trial name
- NCT06917443
- Testing
- Abdominally targeted exercises, General exercises
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Shmuel Kivity, MD
Ulcerative Colitis, Crohn's Disease
The Innate Immune System and Inflammatory Bowel Disease
The study includes individuals with ulcerative colitis, Crohn's disease and healthy controls. The purpose of this study is to examine the innate immune system (IIS) by exposing peripheral blood monocytes to various ligands…
- Trial name
- NCT00516776
- Where
- Norway
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Fibrostenotic Crohn's Disease
NOV-ERA - A Clinical Trial to Assess the Efficacy and Safety of Ontunisertib Compared to Placebo in Patients With Fibrostenosing Crohn's Disease
Many patients with Crohn's disease (CD) develop fibrotic narrowing (strictures) in their bowel, causing obstructive symptoms such as abdominal pain, cramping, or vomiting after meals.
- Trial name
- NCT07683325
- Testing
- Ontunisertib
- Where
- 11 sites in United States, Serbia and 1 more
- Volunteers
- 320 people
- Sponsor
- Agomab Spain S.L.U.
Moderate to Severe Crohn's Disease
NI-0401 in Active Crohn's Disease
The purpose of the study is to assess the safety and tolerability of daily intravenous NI-0401 treatment, compared to matching placebo. And to assess the ability of NI-0401 to modulate the CD3 complex on T-cells.
- Trial name
- NCT00630643
- Testing
- NI-0401 (anti-CD3 mAB)
- Volunteers
- 40 people
- Sponsor
- Light Chain Bioscience - Novimmune SA
Chronic Disease
Integrative Therapy of Chronic Diseases
The observational study aims to investigate the extent to which a two-week stay in an internal medicine clinic for integrative medicine and naturopathy results in an improvement of complaints, impairments, quality of life…
- Trial name
- InteChron (NCT04927403)
- Testing
- multimodal integrative naturopathic therapy concept
- Where
- 3 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Universität Duisburg-Essen
Crohn Disease
Fecal Microbial Transplantation in Patients With Crohn's Disease
Fecal Microbiota Transplantation will be offered to eligible Crohn's disease patient as Investigational New Drug treatment
- Trial name
- NCT03267238
- Testing
- Fecal Microbial Transplantation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stony Brook University
Crohn's Disease (CD)
A Study to Evaluate the Long-Term Efficacy, Safety, and Tolerability of Repeated Administration of Upadacitinib (ABT-494) in Participants With Crohn's Disease
This is a open-label extension (OLE) study designed to evaluate the long-term efficacy, safety, and tolerability of Upadacitinib (ABT-494).
- Trial name
- NCT02782663
- Testing
- ABT-494
- Where
- 61 sites in United States, Belgium and 16 more
- Volunteers
- 107 people
- Sponsor
- AbbVie
Inflammatory Bowel Disease, Crohn's Disease
The Value of I-Scan and Confocal Laser Endomicroscopy for the Assessment of Chronic Inflammatory Bowel Disease
Recently, Confocal Laser Endomicroscopy (CLE) has been developed as a novel technique that actually enables in vivo microscopic analysis of the gastrointestinal tract, during ongoing endoscopy.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis, Dysplasia
- Trial name
- I-Scan-CLE-IBD (NCT02481687)
- Testing
- Confocal laser endomicroscopy
- Where
- Romania
- Volunteers
- 15 people
- Sponsor
- University of Medicine and Pharmacy Craiova
Crohn's Disease
Urinary Prostaglandin E Metabolite (PGE-M), A Metabolite of Prostaglandin E2 (PGE2): A Novel Biomarker of Crohn's Disease Activity
The purpose of this study is to determine whether urinary PGE-M levels correlate with Crohn's disease activity and to compare how well urinary PGE-M correlates with other non-invasive biomarkers of disease activity such as…
- Trial name
- NCT00496548
- Testing
- Fecal calprotectin, Urinary PGE-M Level
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Vanderbilt University Medical Center
Crohn Disease
High-impact Exercise in Adults With Crohn's Disease
Crohn's disease increases the risk of poor musculoskeletal health, as the inflammatory disease process directly inhibits regulatory pathways involved in bone and muscle formation and maintenance.
- Trial name
- IMPACT CD (NCT04273399)
- Testing
- High-impact exercise intervention, Acute response to high-impact exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Crohn's Disease, Ulcerative Colitis
Self-Management Assistance for Recommended Treatment (SMART) Portal
The purpose of the study is to develop, evaluate, and optimize an interactive website (the SMART portal). The SMART portal will use IBD-specific and general assessments and interventions to reduce the burden of common barriers to…
- Conditions
- Crohn's Disease, Ulcerative Colitis, Indeterminate Colitis, Inflammatory Bowel Disease
- Trial name
- SMART (NCT01966744)
- Where
- 2 sites in United States
- Volunteers
- 87 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Inflammatory Bowel Disease, Ulcerative Colitis
Evaluate if Response to Infliximab or Adalimumab May be Regained With an Immunomodulator
The immunogenicity of anti-tumor necrosis factor alpha (anti-TNF) therapy in inflammatory bowel disease (IBD) is an important cause of loss of response to therapy that may lead to escalation of dose or discontinuation of therapy.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's Disease
- Trial name
- NCT02413047
- Testing
- Azathioprine, 6 mercaptopurine, Methotrexate
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Indiana University
Crohn Disease of Intestine
MILESTONE-CD -A Prospective Multiomic Inception Real -Life Study To Evaluate Predictors of Disease Outcomes & respoNse to Biologic Treatment in Crohn's Disease
Crohn's' disease (CD) is a lifelong-chronic inflammatory condition of the digestive tract. CD frequently manifests during the 2nd or 3rd decade; prolonged disease duration frequently results in major structural complications such…
- Trial name
- MILESTONE-CD (NCT04612621)
- Testing
- combination of diagnostic tests
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Crohn's Disease
Assessing the Tolerability of Oligosaccharide Supplementation in Patients With Crohn's Disease
The investigators hypothesize that a novel method for oligosaccharide supplementation, in the form of nutritional bars and/or muesli high in fructans and galacto-oligosaccharides (GOS), will be a safe and tolerable therapeutic…
- Trial name
- NCT02193750
- Testing
- Moderate Oligosaccharide Group, High Oligosaccharide Group
- Where
- 2 sites in Australia, Canada
- Volunteers
- 24 people
- Sponsor
- University of British Columbia
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